論文 - 荒川　雅志

アフターコロナの旅と健康 : ウェルビーイングを達成する新しいウェルネス,ウェルネスツーリズムの定義

荒川雅志

プレシジョンメディシン   6 ( 2 ) 145 - 148   2023年02月

掲載種別: 研究論文（その他学術会議資料等）

沖縄県の温泉について 沖縄の温泉に関する基礎的研究(3)

荒川 雅志, 姜 享淑, 狩俣 栄作, 石井 宏子

温泉   91 ( 1 ) 30 - 32   2023年02月

掲載種別: 研究論文（その他学術会議資料等）

沖縄県の温泉についてー沖縄の温泉に関する基礎的研究(2)

荒川 雅志, 姜 享淑, 狩俣 栄作, 石井 宏子

温泉   90 ( 4 ) 32 - 35   2022年11月

掲載種別: 研究論文（研究会，シンポジウム資料等）

沖縄県の温泉についてー沖縄の温泉に関する基礎的研究(1)

荒川雅志, 姜 享淑, 狩俣 栄作, 石井 宏子

温泉   90 ( 3 ) 34 - 37   2022年09月

掲載種別: 研究論文（その他学術会議資料等）

海と健康,ウェルネス : 海洋療法と観光の融合

荒川雅志

人間生活工学   23 ( 2 ) 24 - 28   2022年09月

掲載種別: 研究論文（学術雑誌）

Electron counting in cationic and anionic silver clusters doped with a 3d transition-metal atom: endo- vs. exohedral geometry

Kento Minamikawa, Shun Sarugaku, Masashi Arakawa, Akira Terasaki

Physical Chemistry Chemical Physics ( Royal Society of Chemistry (RSC) )  24 ( 3 ) 1447 - 1455   2022年

掲載種別: 研究論文（学術雑誌）

　概要を見る

<jats:p>Cationic and anionic Ag<jats:sub><jats:italic>N</jats:italic></jats:sub>M<jats:sup>+/−</jats:sup> (M = Sc–Ni) clusters are explored to examine the electron-counting rule. Among 18-valence-electron clusters, endohedrally doped ones are stable due to superatomic electron-shell closure involving delocalized 3d electrons.</jats:p>

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

Maternal consumption of soy and isoflavones during pregnancy and risk of childhood behavioural problems: the Kyushu Okinawa Maternal and Child Health Study.

Miyake Y, Tanaka K, Okubo H, Sasaki S, Tokinobu A, Arakawa M

International journal of food sciences and nutrition ( Informa UK Limited )  72 ( 8 ) 1118 - 1127   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Perinatal maternal depressive symptoms and risk of behavioral problems at five years.

Yamada M, Tanaka K, Arakawa M, Miyake Y

Pediatric research ( Springer Science and Business Media LLC )    2021年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal Use of Induction Heating Cookers During Pregnancy and Birth Outcomes: The Kyushu Okinawa Maternal and Child Health Study.

Tokinobu A, Tanaka K, Arakawa M, Miyake Y

Bioelectromagnetics ( Wiley )  42 ( 4 ) 329 - 335   2021年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study.

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Akiko Tokinobu, Masashi Arakawa

Nutritional neuroscience     1 - 9   2021年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVES: Lower maternal metal intake during pregnancy might affect childhood development. The current prebirth cohort study investigated the relationship between maternal intake of zinc, magnesium, iron, copper, and manganese during pregnancy and behavioral problems in Japanese children aged five years. METHODS: Subjects were 1199 mother-child pairs. Dietary intake during the preceding month was assessed using a diet history questionnaire. Emotional, conduct, hyperactivity, and peer problems and low prosocial behavior were assessed using the Strengths and Difficulties Questionnaire. Maternal age, gestation at baseline, region of residence, number of children, maternal and paternal education, household income, maternal depressive symptoms during pregnancy, maternal alcohol intake during pregnancy, maternal smoking during pregnancy, child's birth weight, child's sex, breastfeeding duration, smoking in the household during the first year of life, and some dietary confounders that were associated with outcomes under study in this population were adjusted for. RESULTS: Compared with maternal magnesium intake during pregnancy in the first quartile, magnesium intake in the second, third, and fourth quartiles was independently inversely related to childhood hyperactivity problems, but not to emotional, conduct, or peer problems or low prosocial behavior: the adjusted odds ratio between extreme quartiles was 0.48 (95% confidence interval: 0.23-0.99, P for trend = 0.04). No evident associations were observed between maternal intake of zinc, iron, copper, or manganese during pregnancy and childhood emotional, conduct, hyperactivity, or peer problems or low prosocial behavior. CONCLUSIONS: The present study suggests that higher maternal magnesium intake during pregnancy is inversely associated with hyperactivity problems in Japanese children.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal caffeine intake during pregnancy and risk of food allergy in young Japanese children.

Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa, Yoshihiro Miyake

Journal of paediatrics and child health ( Wiley )  57 ( 6 ) 903 - 907   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

AIM: To examine the association between maternal caffeine intake during pregnancy and the development of food allergy in young Japanese children up to 3 years of age. METHODS: The study involved 1522 mother-child pairs. Data on maternal caffeine intake during pregnancy were assessed with a validated diet history questionnaire. Food allergy was defined by a self-reported claim of having a physicians' diagnosis of food allergy or of having an acute reaction to a food. RESULTS: Compared with the lowest tertile of maternal caffeine intake during pregnancy, the second tertile, but not the highest tertile, was significantly associated with an increased risk of food allergy. Further adjustment on suspicion or diagnosis of atopic eczema at around 4 months postpartum in a follow-up survey did not substantially change the association between maternal caffeine intake during pregnancy and the risk of food allergy in children: further adjusted hazard ratios (95% confidence intervals) for the second (T2), the highest tertiles (T3) and the second and the highest tertiles combined (T2 + T3) were 1.46 (1.10-1.96), 1.16 (0.85-1.56) and 1.31 (1.01-1.70), respectively. CONCLUSIONS: Our findings suggest that maternal caffeine intake during pregnancy may be positively associated with the risk of food allergy in children.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Cesarean section is associated with increased risk of postpartum depressive symptoms in Japan: the Kyushu Okinawa Maternal and Child Health Study.

Maki Yokoyama, Keiko Tanaka, Takashi Sugiyama, Masashi Arakawa, Yoshihiro Miyake

Journal of affective disorders   278 ( 278 ) 497 - 501   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: The association between cesarean section and the risk of postpartum depressive symptoms remains controversial. The present prebirth cohort study examined this issue in Japan. METHODS: Study subjects were 1310 women. Information under study was obtained using a self-administered questionnaire. Postpartum depressive symptoms were defined as a total Edinburgh Postnatal Depression Scale score of nine or higher between three and four months postpartum. Multivariate logistic regression analysis was used to adjust for age, body mass index, gestational weeks at baseline, gestational weeks at delivery, number of children at baseline, previous miscarriage or stillbirth, previous abortion, history of depression, family history of depression, region of residence, employment status, educational level, household income, family structure, breastfeeding status, smoking during pregnancy, infant's birthweight, and infant's sex. RESULTS: Postpartum depressive symptoms were identified in 8.2%. After adjustment for the confounding factors, compared with vaginal delivery, cesarean section was independently associated with an increased risk of postpartum depressive symptoms: the adjusted odds ratio (OR) was 1.95 (95% confidence interval [CI]: 1.16-3.23). This positive association was more apparent among those who had no other children at baseline than among those who already had one or more children: the adjusted ORs were 2.94 (95% CI: 1.35-6.26) and 1.45 (95% CI: 0.68-2.92), respectively; however, this interaction was not significant. LIMITATIONS: Information on whether each cesarean section was emergency or elective and other obstetric complications was not available. CONCLUSIONS: Cesarean section may be associated with an increased risk of postpartum depressive symptoms, especially among women without children at baseline.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

ウェルネスの本質

荒川 雅志

TRAVEL JOURNAL   58(35)   10 - 11   2021年

掲載種別: 研究論文（学術雑誌）

• 関連情報を調べる
  CiNii Research

Reaction of nitric oxide molecules on transition-metal-doped silver cluster cations: size- and dopant-dependent reaction pathways

Masashi Arakawa, Masataka Horioka, Kento Minamikawa, Tomoki Kawano, Akira Terasaki

Physical Chemistry Chemical Physics ( Royal Society of Chemistry (RSC) )  23 ( 40 ) 22947 - 22956   2021年

掲載種別: 研究論文（学術雑誌）

　概要を見る

<jats:p>A rich variety of reaction channels is observed for Ag<jats:sub><jats:italic>n</jats:italic></jats:sub>M<jats:sup>+</jats:sup> interacting with NO, ranging from the character of the dopant atom modified by the presence of Ag atoms at small sizes through the behaviors of undoped Ag clusters at large sizes.</jats:p>

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

Reaction Kinetics of Nitric Oxide on Size-Selected Silver Cluster Cations

Masashi Arakawa, Masataka Horioka, Kento Minamikawa, Tomoki Kawano, Akira Terasaki

The Journal of Physical Chemistry C ( American Chemical Society (ACS) )  124 ( 49 ) 26881 - 26888   2020年11月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study

K. Tanaka, M. Arakawa, Y. Miyake

Allergologia et Immunopathologia ( Codon Publications )  48 ( 6 ) 530 - 536   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI

Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes.

Matsushita M, Muramoto A, Nomura E, Eguchi Y, Kato A, Sano Y, Kabayama M, Arakawa M, Oguma Y, Yabe D, Matsunaga M, Yatsuya H, Arima H, Tsushita K

Nutrition & diabetes   10 ( 1 ) 34   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI 学術リポジトリ
• 関連情報を調べる
  PubMed

Associations of job type, income, and education with postpartum depressive symptoms: The Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

Psychiatry Research ( Elsevier BV )  291   113224 - 113224   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal B vitamin intake during pregnancy and childhood behavioral problems in Japan: The Kyushu Okinawa Maternal and Child Health Study.

Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M

Nutritional neuroscience   23 ( 9 ) 706 - 713   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

旅の力を活かした新たな健康増進,ウェルネス健康経営プログラムの開発 : ウェルネスツーリズム・ウェルネスサードプレイスの実際 (研究者の最新動向)

荒川 雅志

Precision medicine = プレシジョンメディシン ( 北隆館 )  3 ( 10 ) 905 - 910   2020年09月

掲載種別: 研究論文（学術雑誌）

　概要を見る

健康な従業員こそが収益性の高い会社をつくるという「ヘルシーカンパニー」の提唱をもとに、社員の健康管理を経営的な視点で考え戦略的に実践する「健康経営」が健康寿命の延伸に向けて日本再興戦略に位置付けられている。健康に対する多様なアプローチとして健康を総合的に捉えた「ウェルネス」概念で旅の力を活かした新たな健康増進プログラムの開発事例を紹介し、ポストコロナ時代のリモートワーク、働き方改革、そして新しい生き方に寄与するウェルネスツーリズム、ウェルネスサードプレイスの考え方を解説する。(著者抄録)

The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes.

Madoka Matsushita, Akiko Muramoto, Eri Nomura, Yukari Eguchi, Ayako Kato, Yoshiko Sano, Mai Kabayama, Masashi Arakawa, Yuko Oguma, Daisuke Yabe, Masaaki Matsunaga, Hiroshi Yatsuya, Hiroshi Arima, Kazuyo Tsushita

Nutrition & diabetes   10 ( 1 ) 33 - 33   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: The aim of this study was to determine the effectiveness of the Smart Life Stay (SLS) program, which is an experience-oriented stayover program, in combination with health tourism and mandatory health guidance on glucose metabolism after 2 years. METHODS: The participants of the SLS program (n = 792) were recruited from a database of 23 medical insurers. They underwent a mandatory health examination termed Specific Health Checkups in 2014. The participants were included if they had diabetes or were at a high risk of diabetes and if they satisfied the following inclusion criteria: (1) body mass index (BMI; kg/m2) > 25, or (2) waist circumference (WC; cm) > 85 for men and > 90 for women, or (3) hemoglobin A1c (HbA1c; %) > 5.6, or (4) fasting plasma glucose (FPG; mg/dl) > 100. Individuals who corresponded to one or more items were included as study participants. The control subjects (n = 3645) were nonparticipants of the program who were selected from the database and met the inclusion criteria. The lifestyle changes and changes in mean BMI, WC, FPG, and HbA1c in both groups from baseline to 2-year follow-up were compared by inverse probability weighting of a propensity score. RESULTS: The percentage of people who exercised regularly increased significantly in the SLS group compared with the control group. In the SLS group, BW, BMI, and WC significantly decreased by 1.75 kg, 0.60 kg/m2, and 1.45 cm, respectively, whereas in the control group, WC, FPG, and HbA1c increased significantly by 0.38 cm, 3.37 mg/dl, and 0.12%, respectively. The comparison between groups revealed that the BW, BMI, WC, FPG, and HbA1c improved significantly in the SLS group. CONCLUSIONS: The SLS program is suggested to help improve glucose metabolism. This program could be a feasible option as a lifestyle intervention program for diabetes.

• この論文にアクセスする
  DOI 学術リポジトリ
• 関連情報を調べる
  PubMed

BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

Journal of Neural Transmission ( Springer Science and Business Media LLC )  127 ( 7 ) 1081 - 1087   2020年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

地域資源をヘルスケア資源へ～宿泊型新保健指導の実際～

荒川雅志

Precision Medicine   3 ( 3 ) 96 - 100   2020年03月

掲載種別: 研究論文（学術雑誌）

Maternal consumption of vegetables, fruit, and antioxidants during pregnancy and risk for childhood behavioral problems

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

Nutrition ( Elsevier BV )  69   110572 - 110572   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

旅の力を活かした新たな健康増進,ウェルネス健康経営プログラムの開発 : ウェルネスツーリズム・ウェルネスサードプレイスの実際

荒川 雅志

Precision medicine   3(10)   905 - 910   2020年

掲載種別: 研究論文（学術雑誌）

• 関連情報を調べる
  CiNii Research

地域資源をヘルスケア資源へ～宿泊型新保健指導の実際～

荒川 雅志

Precision Medicine   3   96 - 100   2020年

掲載種別: 研究論文（学術雑誌）

• 関連情報を調べる
  CiNii Research

Calcium intake during pregnancy is associated with decreased risk of emotional and hyperactivity problems in five-year-old Japanese children.

Takahashi K, Tanaka K, Nakamura Y, Okubo H, Sasaki S, Arakawa M, Miyake Y

Nutritional neuroscience     1 - 8   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal caffeine intake in pregnancy is inversely related to childhood peer problems in Japan: The Kyushu Okinawa Maternal and Child Health Study.

Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M

Nutritional neuroscience   22 ( 11 ) 817 - 824   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Electronic and Geometric Effects on Chemical Reactivity of 3d-Transition-Metal-Doped Silver Cluster Cations toward Oxygen Molecules

Shun Sarugaku, Masashi Arakawa, Tomoki Kawano, Akira Terasaki

The Journal of Physical Chemistry C ( American Chemical Society (ACS) )  123 ( 42 ) 25890 - 25897   2019年09月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

Preterm birth is associated with higher prevalence of wheeze and asthma in a selected population of Japanese children aged three years

N. Takata, K. Tanaka, C. Nagata, M. Arakawa, Y. Miyake

Allergologia et Immunopathologia ( Elsevier BV )  47 ( 5 ) 425 - 430   2019年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Adsorption Kinetics of Nitrogen Molecules on Size-Selected Silver Cluster Cations

Tomonori Ito, Masashi Arakawa, Yuki Taniguchi, Akira Terasaki

Zeitschrift für Physikalische Chemie ( Walter de Gruyter GmbH )  233 ( 6 ) 759 - 770   2019年04月

掲載種別: 研究論文（学術雑誌）

　概要を見る

<jats:title>Abstract</jats:title> <jats:p>We present adsorption processes of dinitrogen on size-selected silver cluster cations, Ag<jats:sub> <jats:italic>n</jats:italic> </jats:sub> <jats:sup>+</jats:sup> (<jats:italic>n</jats:italic> = 1–10), studied by kinetics measurement using an ion trap. The cluster ions showed sequential adsorption of N<jats:sub>2</jats:sub> molecules when the ion trap was cooled down to 105 K, excluding <jats:italic>n</jats:italic> = 8 and 9 that were exceptionally inactive at this temperature. Termolecular rate coefficients of each adsorption step are determined by analyzing time-dependent changes in the reactant and product ion signals. The first-step rate coefficients were found to increase exponentially from <jats:italic>n</jats:italic> = 1 to 7 due to increased internal degrees of freedom at larger sizes, which are favorable for accommodating the adsorption energy in a free cluster. In contrast, the adsorption rate turned to decrease for <jats:italic>n</jats:italic> > 7 due to weaker binding of dinitrogen as revealed by density-functional-theory (DFT) calculation. Adsorption sites on Ag<jats:sub> <jats:italic>n</jats:italic> </jats:sub> <jats:sup>+</jats:sup> are further discussed on the basis of the maximum number of adsorbing N<jats:sub>2</jats:sub> molecules observed in the experiment.</jats:p>

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

Charge-state analysis of small barium-oxide clusters by x-ray absorption spectroscopy.

Hayakawa T, Arakawa M, Ando K, Kiyomura Y, Kawano T, Terasaki A

Journal of physics. Condensed matter : an Institute of Physics journal   31 ( 13 ) 134003   2019年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

ウェルネス、ウェルネスツーリズムと沖縄

荒川 雅志

南方資源利用技術研究会誌 = Journal of the Society of Tropical Resources Technologists ( 南方資源利用技術研究会 )  34 ( 1 ) 1 - 6   2019年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

運動によるState-Trait Anxiety Inventory得点及びCenter for Epidemiologic Studies Depression Scale得点への影響 無作為化比較試験

本村 純, 荒川 雅志, 與古田 孝夫, 粟田 久多佳

琉球医学会誌 ( 琉球医学会 )  38 ( 1-4 ) 35 - 45   2019年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

メタボリックシンドローム(MetS)またはMetS予備群の30歳代から50歳代の沖縄県民45名を対象に、同一の運動強度の海水運動と陸上運動が与えるState-Trait Anxiety Inventory(STAI)及びCenter for Epidemiologic Studeis Depression Scale(CES-D)得点への影響について検討した。対象は海水プールでの運動群、陸上運動群、運動を行わない非運動群(各15名)に分け、10週間の介入試験を行った。検討内容は介入前後のBMI、STAI状態不安得点、STAI特性不安得点、CES-D得点の変化とした。その結果、有意差を認めたのは、BMIで陸上群と非運動群間、STAI状態不安得点の変化率で海水群と非運動群間、陸上群と非運動群間であった。

ITIH3 and ITIH4 polymorphisms and depressive symptoms during pregnancy in Japan: the Kyushu Okinawa Maternal and Child Health Study.

Miyake Y, Tanaka K, Arakawa M

Journal of neural transmission (Vienna, Austria : 1996)   125 ( 10 ) 1503 - 1509   2018年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Maternal fat intake during pregnancy and behavioral problems in 5-y-old Japanese children

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

Nutrition ( Elsevier Inc. )  50   91 - 96   2018年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: The aim of this cohort study was to investigate the relationship between maternal fat consumption during pregnancy and behavioral problems in 1199 Japanese children at age 5 y. Methods: Dietary intake of mothers during pregnancy was assessed using a diet history questionnaire. Emotional, conduct, hyperactivity, and peer problems in children were assessed using the Strengths and Difficulties Questionnaire the four scale scores were dichotomized, comparing children with borderline and abnormal scores to children with normal scores. Logistic regression analysis was applied to estimate adjusted odds ratios and 95% confidence intervals for each behavioral problem according to the quartile of dietary factors under study, adjusting for potential confounding factors. Results: Higher maternal intake of monounsaturated fatty acids, α-linolenic acid, ω-6 polyunsaturated fatty acids, and linoleic acid during pregnancy was independently associated with an increased risk for childhood emotional problems. The adjusted odds ratios between extreme quartiles (95% confidence intervals, Ptrend) were 1.85 (1.11 − 3.17, 0.04), 1.60 (0.99 − 2.60, 0.03), 2.06 (1.24 − 3.46, 0.002), and 2.09 (1.26 − 3.51, 0.002), respectively. No such positive associations were observed for the other outcomes. No relationships were found between maternal intake of total fat, saturated fatty acids, ω-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, or cholesterol, or the ratio of ω-3 to ω-6 polyunsaturated fatty acid intake during pregnancy and any of the outcomes. Conclusions: Maternal consumption of monounsaturated fatty acids, α-linolenic acid, ω-6 polyunsaturated fatty acids, and linoleic acid during pregnancy may increase the risk for childhood emotional problems.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Breastfeeding duration is inversely associated with asthma in Japanese children aged 3 years.

Watanabe JI, Tanaka K, Nagata C, Furukawa S, Arakawa M, Miyake Y

The Journal of asthma : official journal of the Association for the Care of Asthma   55 ( 5 ) 511 - 516   2018年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Soy isoflavone intake and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa

European Journal of Nutrition ( Dr. Dietrich Steinkopff Verlag GmbH and Co. KG )  57 ( 2 ) 441 - 450   2018年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: Several observational studies and trials examined the relationship between isoflavones or soybeans and depressive symptoms among peri- and postmenopausal women. We cross-sectionally evaluated the associations between intake of soy products and isoflavones and depressive symptoms during pregnancy in Japan. Methods: Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined by a score of 16 or over in the Center for Epidemiologic Studies Depression Scale. Results: Higher intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones was independently related to a lower prevalence of depressive symptoms during pregnancy: The adjusted prevalence ratios (95 % confidence intervals, P for trend) between extreme quartiles were 0.63 (0.47–0.85, 0.002), 0.72 (0.54–0.96, 0.007), 0.74 (0.56–0.98, 0.04), 0.57 (0.42–0.76, OpenSPiltSPi0.0001), 0.73 (0.55–0.98, 0.03), 0.65 (0.49–0.87, 0.003), and 0.63 (0.46–0.86, 0.002), respectively. A significant positive exposure–response relationship was found between miso intake and depressive symptoms during pregnancy. No material relationship was observed between soymilk intake and depressive symptoms during pregnancy. Conclusions: Our study is the first to show independent inverse relationships between intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones and depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Dietary patterns and depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa

JOURNAL OF AFFECTIVE DISORDERS ( ELSEVIER SCIENCE BV )  225   552 - 558   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Only one Brazilian study has examined the association between dietary patterns and depressive symptoms during pregnancy. The current cross-sectional study examined this issue in Japan. Methods: Study subjects were 1744 pregnant women. Between April 2007 and March 2008, information under study was obtained. Dietary patterns were derived from a factor analysis of 33 predefined food groups based on a self-administered diet history questionnaire. Depressive symptoms were defined as a Center for Epidemiological Studies Depression Scale score &gt;= 16. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure, employment, household income, education, and body mass index. Results: Three dietary patterns were identified: 'healthy', characterized by high intake of green and yellow vegetables, other vegetables, mushrooms, pulses, seaweed, potatoes, fish, sea products, miso soup, sugar, and shellfish; 'Japanese', characterized by high intake of rice and miso soup; and 'Western', characterized by high intake of beef and pork, processed meat, vegetable oil, chicken, eggs, shellfish, and salt-containing seasonings. The healthy and Japanese patterns were independently inversely associated with depressive symptoms during pregnancy: the adjusted prevalence ratios (95% confidence intervals, P for trend) between extreme quartiles were 0.56 (0.43-0.73,&lt; 0.0001) and 0.72 (0.55-0.94, 0.008), respectively. No association was observed between the Western pattern and depressive symptoms during pregnancy. Limitations: Information was obtained between the 5th and 39th week of pregnancy. Conclusions: The healthy and Japanese dietary patterns may be inversely associated with depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Parental occupations, educational levels, and income and prevalence of dental caries in 3-year-old Japanese children

Hiromasa Kato, Keiko Tanaka, Ken Shimizu, Chisato Nagata, Shinya Furukawa, Masashi Arakawa, Yoshihiro Miyake

Environmental Health and Preventive Medicine ( BioMed Central Ltd. )  22 ( 1 ) 80   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Most studies have investigated the association between parental socioeconomic factors and dental caries in children based on educational and income levels studies focusing on parental occupation, however, have been relatively limited. This cross-sectional study examined the associations between parental occupations and levels of education and household income and the prevalence of dental caries in Japanese children aged 3 years. Methods: Study subjects were 6315 children. Oral examination results were obtained from the parents or guardians, who transcribed the information recorded by medical staff at a public health center from their maternal and child health handbooks to our self-administered questionnaire. Children were classified as having dental caries if one or more primary teeth had decayed or had been filled. Adjustment was made for sex, age, region of residence, breastfeeding duration, between-meal snack frequency, toothbrushing frequency, use of fluoride, regular dental check-ups, maternal smoking during pregnancy, and living with at least one household smoker. Results: The prevalence of dental caries was 14.7%. Compared with having an unemployed father, having a father employed in professional and engineering, clerical, sales, security, or manufacturing process was significantly associated with a lower prevalence of dental caries. Compared with having an unemployed mother, having a mother employed in professional and engineering or service was significantly inversely associated with the prevalence of dental caries. Significant inverse associations were observed between parental levels of education and household income and the prevalence of dental caries. Conclusions: The findings of our study suggest that parental occupation affects the prevalence of dental caries in children. We confirm that higher levels of parental education and household income decreased the prevalence of dental caries.

• この論文にアクセスする
  DOI 学術リポジトリ
• 関連情報を調べる
  PubMed

日本人3歳児の虫歯罹患率とその親の職業、教育水準および所得との関連(Parental occupations, educational levels, and income and prevalence of dental caries in 3-year-old Japanese children)

Kato Hiromasa, Tanaka Keiko, Shimizu Ken, Nagata Chisato, Furukawa Shinya, Arakawa Masashi, Miyake Yoshihiro

Environmental Health and Preventive Medicine ( (一社)日本衛生学会 )  22 ( December ) 1 - 7   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

日本人3歳児6315名の口腔検査の結果を両親や保護者から得た。乳歯の虫歯が1つ以上あるか、詰め物ありの場合に、「虫歯あり」に分類した。性別、年齢、居住地域、母乳育児期間、おやつの頻度、歯磨き頻度、フッ化物の使用、定期的な歯科検診、妊娠中の母親の喫煙、少なくとも1人の家庭内喫煙者との生活について補正した。虫歯の有病率は14.7%であった。父親が無職の小児と比較して、父親が専門職および技術職、事務職、販売員、警備員、製造工程員の小児は虫歯の発生率が低いことと有意に関連していた。母親が無職の小児と比較すると、専門職や技術職またはサービス職に雇用されている母親の小児は虫歯の有病率と有意な逆相関がみられた。親の教育レベルおよび家計所得と虫歯発生率との間に有意な逆相関が認められた。

• この論文にアクセスする
  学術リポジトリ

The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Takashi Hanioka, Shinya Furukawa, Nobuyuki Miyatake, Masashi Arakawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE ( TOHOKU UNIV MEDICAL PRESS )  243 ( 3 ) 159 - 164   2017年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in periodontitis and its polymorphisms might modulate the individual susceptibility to periodontitis. Only a limited number of studies on the association between IL18 single-nucleotide polymorphisms (SNPs) and the risk of periodontitis have been realized, however. The aim of this case-control study among young post-partum Japanese women (18 to 45 years) was to determine the impact of SNPs, rs1946518 (-607 C/A) and rs187238 (-137G/C), on periodontitis. The two SNPs may be located within a transcription factor-binding element, thereby influencing transcription from the IL18 promoter. Subjects were 131 cases who had at least one tooth with a probing pocket depth of &gt;= 4.0 mm and 1,017 periodontally healthy controls. Probing pocket depth measurements were performed between 1 and 12 months post-partum. In this population, the A allele of rs1946518 and the C allele of rs187238 are more common. After adjustment for age, education, smoking, and use of an interdental brush, compared with subjects with the AA or AC genotype of SNP rs1946518, those with the CC genotype had a significantly reduced risk of periodontitis (adjusted odds ratio = 0.54, 95% confidence interval = 0.29-0.97). No significant association was observed between rs187238 and the risk of periodontitis. Our study did not reveal any evidence of interaction between the IL18 polymorphisms and smoking. Our findings indicate that the IL18 promoter SNP, rs1946518, is a potential risk factor of periodontitis among young Japanese women.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Pre- and Postnatal Smoking Exposure and Risk of Atopic Eczema in Young Japanese Children: A Prospective Prebirth Cohort Study

Keiko Tanaka, Yoshihiro Miyake, Shinya Furukawa, Masashi Arakawa

NICOTINE & TOBACCO RESEARCH ( OXFORD UNIV PRESS )  19 ( 7 ) 804 - 809   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Epidemiological evidence regarding the effect of perinatal smoking exposure on atopic eczema in children continues to be inconclusive. The aim of this prospective prebirth cohort study was to investigate the association between prenatal smoking exposure and postnatal living with household smokers and the risk of atopic eczema in Japanese children aged 23 to 29 months. Study subjects were 1354 Japanese mother-child pairs. Information on the variables under study was obtained through questionnaires which were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, and 24 months after delivery. Eczema in the last 12 months was defined according to the criteria of the International Study of Asthma and Allergies in Childhood. Physician-diagnosed atopic eczema was considered present if reported by mothers. Compared with no perinatal smoking exposure, prenatal smoking exposure only was associated with an increased risk of physician-diagnosed atopic eczema (adjusted odds ratio = 7.11, 95% confidence interval: 1.43 to 27.8). Postnatal living with at least one household smoker only was not associated with the risk of physician-diagnosed atopic eczema; neither was the combination of both prenatal smoking exposure and postnatal living with at least one household smoker. No association was observed between perinatal smoking exposure status and the risk of eczema as defined according to the International Study of Asthma and Allergies in Childhood criteria. Our findings suggest that maternal smoking during pregnancy may increase the risk of atopic eczema in young children. In the present prebirth cohort study, we assessed the independent and additive effects of pre- and postnatal exposure to tobacco smoking on atopic eczema in children. Compared with no perinatal smoking exposure, prenatal smoking exposure only was significantly associated with an increased risk of atopic eczema. Postnatal smoking exposure only was not associated with the risk of atopic eczema; neither was the combination of both pre- and postnatal smoking exposure. This is the first epidemiological study to show a positive association between prenatal smoking exposure only and the risk of atopic eczema.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Secondhand smoke exposure and risk of wheeze in early childhood: a prospective pregnancy birth cohort study

Keiko Tanaka, Yoshihiro Miyake, Shinya Furukawa, Masashi Arakawa

TOBACCO INDUCED DISEASES ( BIOMED CENTRAL LTD )  15   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Evidence regarding the independent and additive effects of both pre- and postnatal smoking exposure on the risk of wheeze in children is limited. The purpose of this prospective pregnancy birth cohort study was to examine the association between prenatal and postnatal tobacco smoke exposure during the first year of life and the risk of wheeze in Japanese children aged 23 to 29 months. Methods: Study subjects were 1354 Japanese mother-child pairs. Information on the variables under study was obtained using repeated questionnaires that were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, and 24 months after delivery. Wheeze was defined according to the criteria of the International Study of Asthma and Allergies in Childhood. Results: Compared with no maternal smoking during pregnancy, maternal smoking throughout pregnancy was significantly associated with an increased risk of wheeze in children, yet there were no associations between maternal smoking in the first trimester only or in the second and/or third trimesters and the risk of wheeze. No association was observed between postnatally living with at least one household smoker and the risk of wheeze. An analysis to assess the additive effect of prenatal and postnatal smoking exposure revealed that, compared with children not exposed to maternal smoking during pregnancy and not postnatally living with at least one household smoker, those who were both exposed to maternal smoking during pregnancy and postnatally living with at least one household smoker had twofold odds of developing wheeze. Conclusions: Our findings suggest that maternal smoking throughout pregnancy might be associated with an increased risk of wheeze in children. There is also the possibility of a positive additive effect of pre- and postnatal smoking exposure on the risk of childhood wheeze.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Smoking and secondhand smoke exposure and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yuri Kawasaki, Yoshihiro Miyake, Keiko Tanaka, Shinya Furukawa, Masashi Arakawa

TOBACCO INDUCED DISEASES ( BIOMED CENTRAL LTD )  15   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiological evidence on the relationship between smoking and secondhand smoke (SHS) exposure and depressive symptoms during pregnancy has been limited. The present cross-sectional study examined this issue in Japan. Methods: Between April 2007 and March 2008, 1757 pregnant women who lived in one of seven prefectures on Kyushu Island in southern Japan or in Okinawa Prefecture, an island chain in the southwest of Japan, participated in the Kyushu Okinawa Maternal and Child Health Study, a prebirth cohort study. In the present study, data on 1745 pregnant women were available for analysis. Information on smoking, SHS exposure, depressive symptoms, and potential confounding factors was obtained through a self-administered questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Adjustment was made for age, gestation, region of residence, number of children, family structure, household income, education, job type, history of depression, and family history of depression. Results: The prevalence of depressive symptoms during pregnancy was 19.2%. Compared with having never smoked, both former and current smoking was independently associated with a higher prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) were 1.39 (95% CI: 1.06-1.83) and 2.49 (95% CI: 1.36-4.45), respectively. Also, 3.0 to 7.9 and 8.0 or more pack-years of smoking were independently positively related to depressive symptoms during pregnancy: the adjusted ORs were 1.55 (95% CI: 1.08-2.22) and 1.97 (95% CI: 1.26-3.03), respectively (P for trend = 0.0005). Among the 1183 subjects who had never smoked, current SHS exposure at home was independently positively associated with depressive symptoms during pregnancy: the adjusted OR was 1.51 (95% CI: 1.003-2.30). Conclusions: Former and current smoking, 3.0 or more pack-years of smoking, and current SHS exposure at home may be positively associated with depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI

Reply to letter to the editor to "Soy isoflavone intake and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study".

Miyake Y, Tanaka K, Okubo H, Sasaki S, Furukawa S, Arakawa M

European journal of nutrition   56 ( 4 ) 1791 - 1792   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Reply to Letter to the Editor to "Soy isoflavone intake and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study".

Miyake Y, Tanaka K, Okubo H, Sasaki S, Furukawa S, Arakawa M

European journal of nutrition   56 ( 4 ) 1795   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Manganese intake is inversely associated with depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa

JOURNAL OF AFFECTIVE DISORDERS ( ELSEVIER SCIENCE BV )  211 ( 211 ) 124 - 129   2017年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: One epidemiological study in Canada has addressed the association between zinc intake and depressive symptoms during pregnancy while another epidemiological study in Korea has examined the association between iron intake and depressive symptoms during pregnancy. The present cross-sectional study in Japan examined the association between intake of zinc, magnesium, iron, copper, and manganese and depressive symptoms during pregnancy. Methods: Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined as a score &gt;= 16 on the Center for Epidemiologic Studies Depression Scale. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, education, body mass index, and intake of saturated fatty acids, eicosapentaenoic acid plus docosahexaenoic acid, calcium, vitamin D, and isoflavones. Results: In crude analysis, significant inverse associations were observed between intake levels of zinc, magnesium, iron, copper, and manganese and the prevalence of depressive symptoms during pregnancy. After adjustment for confounding factors, only manganese intake was independently inversely associated with depressive symptoms during pregnancy: the adjusted prevalence ratio between extreme quartiles was 0.74 (95% confidence interval:0.56-0.97, P for trend=0.046). Limitations: Information was obtained between the 5th and 39th week of pregnancy. Conclusions: The current cross-sectional study of Japanese women demonstrated higher manganese intake to be independently associated with a lower prevalence of depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Adsorption and Subsequent Reaction of a Water Molecule on Silicate and Silica Cluster Anions

Masashi Arakawa, Tsubasa Omoda, Akira Terasaki

The Journal of Physical Chemistry C ( American Chemical Society (ACS) )  121 ( 20 ) 10790 - 10795   2017年01月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

宿泊型新保健指導(Smart Life Stay)における体験型プログラムが食習慣に与える効果について

佐野 喜子, 中村 誉, 安田 実加, 栄口 由香里, 野村 恵里, 松下 まどか, 村本 あき子, 矢部 大介, 小熊 祐子, 八谷 寛, 荒川 雅志, 樺山 舞, 津下 一代

日本病態栄養学会誌 ( (一社)日本病態栄養学会 )  20 ( Suppl. ) S - 134   2016年12月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Perinatal smoking exposure and behavioral problems in Japanese children aged 5 years: The Kyushu Okinawa Maternal and Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Shinya Furukawa, Masashi Arakawa

ENVIRONMENTAL RESEARCH ( ACADEMIC PRESS INC ELSEVIER SCIENCE )  151   383 - 388   2016年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiological evidence regarding the relationship between maternal secondhand smoke (SHS) exposure during pregnancy and postnatal SHS exposure and childhood behavioral problems is scarce. Objective: The present prebirth cohort study investigated the association between perinatal smoking exposure and behavioral problems in Japanese children aged 5 years. Methods: Subjects were 1200 mother-child pairs. Data on variables under study were obtained using parent questionnaires. Emotional problems, conduct problems, hyperactivity problems, and peer problems were assessed using the Strengths and Difficulties Questionnaire. Adjustment was made for maternal age, gestation at baseline, region of residence at baseline, number of children at baseline, maternal and paternal education, household income, maternal depressive symptoms during pregnancy, maternal alcohol intake during pregnancy, child's birth weight, child's sex, and breastfeeding duration. Results: Maternal smoking during pregnancy was independently associated with increased risk of conduct problems and hyperactivity problems (adjusted odds ratios: ORs [95% confidence intervals: CIs]= 1.93 [1.15-3.17] and 1.89 [1.03-3.33], respectively). Maternal SHS exposure at work during pregnancy was independently positively related to conduct problems and hyperactivity problems (adjusted ORs [95% CI]=1.54 [1.01-2.31] and 1.69 [1.04-2.67], respectively). Smoking by any household member, and especially by the child's father, during the first year of life was independently associated with an increased risk of emotional problems (adjusted ORs [95% CI]=1.55 [1.06-2.26] and 1.63 [1.11-2.40], respectively). Conclusions: Maternal smoking and maternal SHS exposure at work during pregnancy may increase the risk of conduct problems and hyperactivity problems. Smoking by any household member, and especially by the child's father, may increase the risk of emotional problems. (C) 2016 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

Milk intake during pregnancy is inversely associated with the risk of postpartum depressive symptoms in Japan: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa

NUTRITION RESEARCH ( PERGAMON-ELSEVIER SCIENCE LTD )  36 ( 9 ) 907 - 913   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Only one epidemiologic study has investigated the association between dairy product intake during pregnancy and postpartum depressive symptoms. Epidemiologic evidence on the relationships between calcium and vitamin D intake during pregnancy and postpartum depressive symptoms is also lacking. The present prospective study examined these issues in Japan. Study subjects were 1319 women. During pregnancy, dietary intake during the preceding month was assessed using a self-administered diet history questionnaire in the baseline survey. Postpartum depressive symptoms were defined as present when subjects had an Edinburgh Postnatal Depression Scale score of 9 or higher between 3 and 4 months postpartum. Adjustment was made for age, gestation at baseline, region of residence, number of children, family structure, history of depression, family history of depression, job type, education, body mass index, having smoked during pregnancy, cesarean delivery, baby's sex, baby's birth weight, and total energy intake. After adjustment for the confounding factors, compared with milk intake in the lowest quartile, intake levels in the second and fourth quartiles were independently associated with a reduced risk of postpartum depressive symptoms, although the inverse exposure-response relationship was not significant: the adjusted odds ratio between extreme quartiles was 0.51 (95% confidence interval, 0.28-0.93; P for trend = .12). No material relationships were observed between intake of total dairy products, yogurt, cheese, calcium, or vitamin D and the risk of postpartum depressive symptoms. The present prospective cohort study in Japan suggests that higher milk intake during pregnancy is associated with a reduced risk of postpartum depressive symptoms. (C) 2016 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

宿泊型新保健指導(スマート・ライフ・ステイ)

村本 あき子, 松下 まどか, 栄口 由香里, 野村 恵里, 中村 誉, 矢部 大介, 小熊 祐子, 佐野 喜子, 樺山 舞, 八谷 寛, 荒川 雅志, 津下 一代

臨床栄養 ( 医歯薬出版(株) )  128 ( 3 ) 278 - 279   2016年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

沖縄におけるレジャーライフスタイルと健康の研究

DONG Erwei, Arakawa Masashi, 荒川 雅志

観光科学 = Journal of Tourism Sciences ( 琉球大学大学院観光科学研究科 )  7 ( 7 ) 21 - 31   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

余暇（レジャー）が人々の健康に及ぼす影響について異文化間において検証された研究はこれまでほとんどみられず、日本において余暇活動および制約要因と健康との関係を明らかにしたものはない。本研究では、長寿地域として知られる沖縄県を対象に、本島都市部郊外部の間に位置し県高齢化人口比率に近似する北中城村において、余暇活動および余暇制約要因と健康に関するアンケート調査を実施した。調査表の回収総数は250（男性134名、女性116名）、回答者の平均年齢は71.1歳であった。分析の結果、余暇活動と制約要因と心身の健康に有意な関連が認められた。年齢、教育レベルと余暇活動および余暇制約要因にも関連が認められた。社会経済因子と健康には関連が認められなかった。ケースが少なく更なる調査が必要であるが、社会経済要因や文化背景要因が異なるアメリカ、台湾、韓国、中国で筆者らが実施してきた先行研究と比較可能な研究と考えられる。

沖縄のスポーツツーリズムとホスピタリティに関する比較研究 : 「ECOスピリットライド＆ウォークin南城市」と「GREAT EARTH 石垣島ライド」における事例から

塩月 亮子, 渡辺 律子, 荒川 雅志, Shiotsuki Ryoko, Watanabe Ritsuko, Arakawa Masashi

観光科学 = Journal of Tourism Sciences ( 琉球大学大学院観光科学研究科 )  ( 7 ) 1 - 20   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

As a participatory type of tourism, sports tourism enables sustained economic benefits stemming from tourism since some tourists, if they enjoyed the sporting events, will make another visit in order to participate again. Additionally, we can expect revitalized communities and a sense of solidarity within those communities since the establishment of such events requires the cooperation of local residents. Working under the hypothesis that areas falling under the category of hospitality – such as the degree of local engagement as well as ingenuity and enthusiasm in entertaining guests, among other things – have a significant correlation with sporting event participants' levels of satisfaction, in this study we conducted a questionnaire survey targeting event participants and collaborators from the ECO Spirit Ride & Walk in Nanjo City (Feb. 23, 2014) and the GREAT EARTH Ishigaki Ride (Oct. 27, 2013) in order to investigate the relationship between sporting events and hospitality.Looking at the results of the free-response section, we found that event collaborators were satisfied that they could contribute to the publicity and revitalization of their community, that they enjoyed meeting many people at the events, and that they even felt delight themselves in seeing the delight of the participants. When asked about the degree to which they were satisfied with their participation in the event, over 90% of event collaborators were satisfied. It was also found that over 90% of event participants were satisfied. Moreover, almost all respondents answered that they would like to participate in the event again the following year. It was also clear from the free-response section of the questionnaire that event participants were attracted by the locally-oriented food and the fact that it was provided by local hotels and community residents.It is clear from these two case studies that areas falling under the category of hospitality, such as the engagement of locals as well as ingenuity and enthusiasm in entertaining guests, among other things, have a significant correlation on the level of satisfaction of event participants.

Association of prenatal exposure to maternal smoking and postnatal exposure to household smoking with dental caries in 3-year-old Japanese children

Keiko Tanaka, Yoshihiro Miyake, Chisato Nagata, Shinya Furukawa, Masashi Arakawa

ENVIRONMENTAL RESEARCH ( ACADEMIC PRESS INC ELSEVIER SCIENCE )  143 ( Pt A ) 148 - 153   2015年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiological studies of the association between smoking exposure and dental caries are limited. Objective: The purpose of this cross-sectional study was to examine the association between prenatal and postnatal secondhand smoke (SHS) exposure and the prevalence of dental caries in primary dentition in young Japanese children. Methods: Study subjects were 6412 children aged 3 years. Information on exposure to maternal smoking during pregnancy and postnatal SHS exposure at home was collected via parent questionnaire. Children were classified as having dental caries if one or more primary teeth had decayed or had been filled. Results: Compared with never smoking during pregnancy, maternal smoking in the first trimester of pregnancy was significantly associated with an increased prevalence of dental caries in children (adjusted odds ratio= 1.37, 95% confidence interval: 1.03-1.80). Postnatal SHS exposure was also positively associated with dental caries, with a significant positive exposure response relationship. Compared with children not exposed to prenatal maternal smoking or postnatal SHS at home, those exposed to both prenatal and postnatal smoking had higher odds of dental caries (adjusted odds ratio=1.62, 95% confidence interval: 1.23-2.11). Conclusion: Our findings suggest that maternal smoking during pregnancy and postnatal SHS exposure may be associated with an increased prevalence of dental caries in primary dentition. (C) 2015 Published by Elsevier Inc.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Properties of Ferroelectric Ice

Hiroshi Fukazawa, Masashi Arakawa, Hiroki Yamauchi, Yurina Sekine, Riki Kobayashi, Yoshiya Uwatoko, Songxue Chi, Jaime A. Fernendez-Baca

Proceedings of the 2nd International Symposium on Science at J-PARC — Unlocking the Mysteries of Life, Matter and the Universe — ( Journal of the Physical Society of Japan )    2015年09月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  CiNii Research

日本再興戦略における日本型ヘルスツーリズムの再構成、メンタルヘルスツーリズムの展開 (特集 今求められる、こころを軽やかにするツーリズム)

荒川 雅志

観光研究 : 日本観光研究学会機関誌 ( 日本観光研究学会 )  27 ( 1 ) 18 - 23   2015年09月

掲載種別: 研究論文（学術雑誌）

Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Shinichi Hitsumoto, Keiko Tanaka, Masashi Arakawa

INFLAMMATION ( SPRINGER/PLENUM PUBLISHERS )  38 ( 4 ) 1663 - 1668   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

We examined the association between thymic stromal lymphopoietin (TSLP) single nucleotide polymorphisms (SNPs) and eczema in young adult Japanese women. Cases were 188 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for eczema. Controls were 565 women without eczema according to the ISAAC criteria, who had not been diagnosed with asthma, atopic eczema, and/or allergic rhinitis by a doctor and who had no asthma as defined by the European Community Respiratory Health Survey criteria and no rhinoconjunctivitis according to the ISAAC criteria. Compared with women with the TT genotype of SNP rs1837253, those with the TC or CC genotype had a significantly increased risk of eczema after adjustment for age and smoking, although this association was not significant in crude analysis. There were no relationships between SNP rs3806933 or rs2289276 and eczema. The TC and CC genotypes combined of SNP rs1837253 may be significantly positively associated with eczema.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children

Keiko Tanaka, Shinichi Hitsumoto, Yoshihiro Miyake, Hitorni Okubo, Satoshi Sasaki, Nobuyuki Miyatake, Masashi Arakawa

ANNALS OF EPIDEMIOLOGY ( ELSEVIER SCIENCE INC )  25 ( 8 ) 620 - 625   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: The intrauterine environment, including maternal nutrition status, may affect the development, formation, and mineralization of children's teeth. We assessed the relationship between self-reported maternal dietary vitamin D intake during pregnancy and the risk of dental caries among young Japanese children. Methods: This study is based on a prospective analysis of 1210 Japanese mother-child pairs. Information on maternal intake during pregnancy was collected using a validated diet history questionnaire. Data on oral examination at 36-46 months of age were obtained from the mothers, who transcribed the information from their maternal and child health handbooks to our self-administered questionnaire. Children were classified as having dental caries if one or more primary teeth had decayed or had been filled. Results: Compared with the lowest quartile of maternal vitamin D intake during pregnancy, adjusted odds ratios (95% confidence intervals) for quartiles 2, 3, and 4 were 1.06 (0.72-1.56), 0.53 (0.34-0.81), and 0.67 (0.44-1.02), respectively (P for trend =.01). When maternal vitamin D intake was treated as a continuous variable, the adjusted odds ratio (95% confidence interval) was 0.94 (0.89-0.995). Conclusions: Higher maternal vitamin D intake during pregnancy may be associated with a lower risk of dental caries in children. (C) 2015 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

なぜ海は体にいいのか? : 海洋療法と観光の融合をどう図る (体に効く海・遊ぶ海)

荒川 雅志

Kaiun = 海運 : 総合物流情報誌 ( 日本海運集会所 )  1054 ( 1054 ) 77 - 80   2015年07月

掲載種別: 研究論文（学術雑誌）

Authors' reply re: Intake of dairy products and calcium and prevalence of depressive symptoms during pregnancy in Japan: A cross-sectional study

Y. Miyake, K. Tanaka, H. Okubo, S. Sasaki, M. Arakawa

BJOG: An International Journal of Obstetrics and Gynaecology ( Blackwell Publishing Ltd )  122 ( 4 ) 586 - 587   2015年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

IL5RA polymorphisms, smoking and eczema in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Y. Miyake, K. Tanaka, M. Arakawa

INTERNATIONAL JOURNAL OF IMMUNOGENETICS ( WILEY-BLACKWELL )  42 ( 1 ) 52 - 57   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The present case-control study examined the relationship between IL5RASNPs and eczema in young adult Japanese women. Cases and control subjects were selected from pregnant women who participated in the baseline survey of the Kyushu Okinawa Maternal and Child Health Study, which is an ongoing prebirth cohort study. Cases comprised 188 women with eczema in the previous 12months as defined according to the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC), regardless of the presence of a doctor's diagnosis of atopic eczema. Control subjects comprised 1130 women without eczema as defined according to the ISAAC criteria who also had not been diagnosed with atopic eczema by a doctor. Compared with the AA genotype of IL5RASNP rs17881144, the AT genotype, but not the TT genotype, was significantly associated with a decreased risk of eczema. The ATTAGA haplotype and the GTAGCA haplotype of rs17882210, rs3804797, rs334809, rs9831572, rs6771148 and rs17881144 were significantly associated with an increased risk of eczema. In contrast, the GCTGCA haplotype was significantly related to a decreased risk of eczema. Multiplicative interactions between IL5RASNPs rs334809 and rs17881144 and smoking with respect to eczema were marginally significant (P=0.07 and 0.07, respectively). This is the first study to show significant associations between IL5RASNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. Smoking may modify the relationships between SNPs rs334809 and rs17881144 and eczema.

• この論文にアクセスする
  DOI

Intake of dairy products and calcium and prevalence of depressive symptoms during pregnancy in Japan: a cross-sectional study

Y. Miyake, K. Tanaka, H. Okubo, S. Sasaki, M. Arakawa

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY ( WILEY-BLACKWELL )  122 ( 3 ) 336 - 343   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective To examine the relationship between the intake of dairy products and calcium and the prevalence of depressive symptoms during pregnancy. Design Cross-sectional study. Setting Kyushu Okinawa Maternal and Child Health Study (KOMCHS). Sample A cohort of 1745 pregnant Japanese women. Methods Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Scores of 16 or higher on the Center for Epidemiologic Studies Depression Scale denoted depressive symptoms. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure at home and at work, job type, household income, education, and body mass index. In our analyses regarding dairy products in general, adjustment was also made for fish intake; in our analysis regarding calcium, adjustment was also made for the intake of saturated fatty acids, eicosapentaenoic acid plus docosahexaenoic acid, and vitamin D. Main outcome measures Depressive symptoms during pregnancy. Results Higher intake levels of yogurt and calcium were independently related to a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios between extreme quartiles were 0.69 (95% CI 0.48-0.99, P for trend = 0.03) and 0.59 (95% CI 0.40-0.88, P for trend = 0.006), respectively. No relationships were observed between the intake of all dairy products, milk, or cheese and depressive symptoms during pregnancy. Conclusions The current results suggest that a higher intake of yogurt and calcium may be associated with a lower prevalence of depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI

Health Tourism in Japan

Arakawa M, Takahashi Y, Kinoshita F

Travel and Tourism Research Association     100 - 101   2015年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Dietary vitamin D intake and prevalence of depressive symptoms during pregnancy in Japan

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

NUTRITION ( ELSEVIER SCIENCE INC )  31 ( 1 ) 160 - 165   2015年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: Although the relationship between vitamin D levels and depressive symptoms has been explored, the results are inconsistent. Epidemiologic evidence concerning the relationship between dietary vitamin D intake and depressive symptoms in pregnancy is nonexistent. The aim of this current cross-sectional study was to examine this issue in Japan. Methods: The study included 1745 pregnant women. Depressive symptoms were defined as present when women had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure at home and at work, job type, household income, education, body mass index, intake of saturated fatty acids, and intake of eicosapentaenoic acid plus docosahexaenoic acid. Results: The prevalence of depressive symptoms during pregnancy was 19.3%. Higher dietary vitamin D intake was significantly associated with a lower prevalence of depressive symptoms during pregnancy, independent of potential dietary and nondietary confounding factors. Multivariate odds ratios (95% confidence intervals) for depressive symptoms during pregnancy in the first, second, third, and fourth quartiles of assessed intake of vitamin D were 1 (reference), 0.79 (0.55-1.11), 0.73 (0.49-1.07), and 0.52 (0.30-0.89), respectively (P for trend = 0.02). Conclusion: The current cross-sectional study in Japan suggests that higher vitamin D intake may be associated with a lower prevalence of depressive symptoms during pregnancy. (C) 2015 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

日本再興戦略における日本型ヘルスツーリズムの再構成、メンタルヘルスツーリズムの展開

荒川 雅志

観光研究   27   18 - 23   2015年

掲載種別: 研究論文（学術雑誌）

• 関連情報を調べる
  CiNii Research

Calcium intake is associated with decreased prevalence of periodontal disease in young Japanese women

Keiko Tanaka, Yoshihiro Miyake, Hitomi Okubo, Takashi Hanioka, Satoshi Sasaki, Nobuyuki Miyatake, Masashi Arakawa

NUTRITION JOURNAL ( BIOMED CENTRAL LTD )  13 ( 1 )   2014年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: We investigated the relationships between calcium intake and the prevalence of periodontal disease. Methods: This cross-sectional study included 1162 women with a mean age of 31.5 years. Information on dietary factors was collected using a diet history questionnaire during pregnancy. Oral examinations were performed between one and twelve months postpartum. Periodontal disease was defined as positive if a woman had at least one tooth with a pocket depth of 4.0 mm or deeper. Adjustment was made for age, region of residence, smoking status, toothbrushing frequency, use of an interdental brush, household income, and education. Results: Compared with the lowest quartile of calcium intake, the highest quartile was significantly associated with a lower prevalence of periodontal disease; however, the inverse linear trend fell just short of the significance level: the adjusted odds ratio was 0.53 (95% confidence interval: 0.30-0.94, P for trend =0.07). Conclusions: Our findings suggest that higher calcium intake may be inversely associated with the prevalence of periodontal disease.

• この論文にアクセスする
  DOI 学術リポジトリ

行動変容型旅行を組み込んだ特定保健指導プログラムの事例研究

山城 美紀, 荒川 雅志, Yamashiro Miki, Arakawa Masashi

観光科学 = Journal of Tourism Sciences ( 琉球大学大学院観光科学研究科 )  6 ( 6 ) 13 - 25   2014年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

In recent years, a behavioral science approach has been adopted in the specific counseling guidance system in Japan. In this research, we implemented a health program of 6 health guidance subjects with an average age of 46.7, which included a two-day and one-night trip to Okinawa. This program was composed of nutritional guidance, exercise guidance, and wellness activities to encourage behavior modification in the early stages of the specific health guidance as a measure against lifestyle-related diseases. We evaluated the changes in health awareness and actions from the start of the research before the trip to 6 months afterwards, using a behavioral change and a visual analog scale. In addition, we studied the possibility of establishing this health program as a holiday product, as well as other questions, through an oral survey. There was variety of changes of displayed by the research subjects in their dietary and motor behaviors directly after the trip. Opinions drawn from the results of oral survey indicated that research subjects could take part and enjoy the research program simply because it was a trip. The sample of people used in this research was small, so we can only comment on the results in a general sense. It will be necessary to gather more definitive research cases in the future.

Seaweed consumption and prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

BMC PREGNANCY AND CHILDBIRTH ( BIOMED CENTRAL LTD )  14 ( 1 )   2014年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Seaweed is a popular traditional food in Japan and is a rich source of bioactive metabolites. The neuroprotective properties of seaweed have attracted attention; to date, however, there has been no epidemiological evidence regarding the relationship between seaweed consumption and depression. The current cross-sectional study investigated the association between seaweed consumption and depressive symptoms during pregnancy in Japan. Methods: Study subjects were 1745 pregnant women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Dietary consumption during the preceding month was assessed using a self-administered diet history questionnaire. Adjustment was made for age; gestation; region of residence; number of children; family structure; history of depression; family history of depression; smoking; secondhand smoke exposure at home and at work; job type; household income; education; body mass index; and intake of fish and yogurt. Results: The prevalence of depressive symptoms during pregnancy was 19.3%. After adjustment for possible dietary and non-dietary confounding factors, higher seaweed consumption was independently associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (95% confidence intervals) for depressive symptoms during pregnancy in the first, second, third, and fourth quartiles of seaweed consumption were 1 (reference), 0.72 (0.51-1.004), 0.71 (0.50-1.01), and 0.68 (0.47-0.96), respectively (P for trend = 0.03). Conclusions: The present results suggest that seaweed consumption may be inversely associated with the prevalence of depressive symptoms during pregnancy in Japanese women.

• この論文にアクセスする
  DOI 学術リポジトリ

Association Between 17q12-21 Variants and Asthma in Japanese Women: rs11650680 Polymorphism as Potential Genetic Marker for Asthma

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

DNA AND CELL BIOLOGY ( MARY ANN LIEBERT, INC )  33 ( 8 ) 531 - 536   2014年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Epidemiological evidence on the relationship between single-nucleotide polymorphisms (SNPs) rs7216389 and rs11650680 on chromosome 17q12-21 and asthma is inconsistent. We examined this issue in young adult Japanese women. Case subjects were 202 women who had been diagnosed with asthma by a doctor, while 1290 women without doctor-diagnosed asthma served as control subjects. Adjustments were made for age and the presence of older siblings. There were no significant associations between SNP rs7216389 and asthma. Compared with the CC genotype of SNP rs11650680, the CT genotype, but not the TT genotype, was significantly inversely associated with asthma: the adjusted odds ratio for the CT genotype was 0.67 (95% confidence interval: 0.46-0.96). This inverse relationship was significant in women with late-onset asthma, but not in those with early-onset asthma. Under the dominant model, a significant inverse association was found between rs11650680 and asthma in women without older siblings, but not in those with older siblings; the interaction, however, was not significant. This is the first study to show that the CT genotype of SNP rs11650680 was significantly inversely associated with asthma, especially adult-onset asthma. We could not find evidence for interactions between rs11650680 and older siblings affecting asthma.

• この論文にアクセスする
  DOI

Maternal consumption of dairy products, calcium, and vitamin D during pregnancy and infantile allergic disorders

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY ( ELSEVIER SCIENCE INC )  113 ( 1 ) 82 - 87   2014年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiologic evidence of the association between maternal intake of dairy foods, calcium, and vitamin D during pregnancy and childhood allergic disorders is inconclusive. Objective: To examine the association between maternal intake of dairy foods, calcium, and vitamin D during pregnancy and childhood allergic disorders in Japanese children aged 23 to 29 months. Methods: Study participants were 1,354 mother-child pairs. Maternal intake during pregnancy was assessed with a validated diet history questionnaire administered between April 2007 and March 2008. Wheeze and eczema, defined according to criteria of the International Study of Asthma and Allergies in Childhood, and physician-diagnosed asthma and atopic eczema were assessed via a questionnaire completed by mothers. Results: Higher maternal intake of total dairy products during pregnancy was significantly associated with a reduced risk of infantile eczema (adjusted odds ratio [OR] between extreme quartiles, 0.64; 95% confidence interval [CI], 0.42-0.98). Higher maternal intake of cheese during pregnancy was significantly related to a reduced risk of physician-diagnosed infantile asthma (adjusted OR between extreme quartiles, 0.44; 95% CI, 0.18-0.97). Maternal intake levels of yogurt and calcium during pregnancy were significantly inversely associated with physician-diagnosed infantile atopic eczema (adjusted ORs between extreme quartiles, 0.49 and 0.34; 95% CI, 0.20-1.16 and 0.12-0.84; P for trend = .01 and .03, respectively). Maternal intake of vitamin D during pregnancy was significantly positively associated with infantile eczema (adjusted OR between extreme quartiles, 1.63; 95% CI, 1.07-2.51). Conclusion: Higher maternal intake of total dairy products, cheese, yogurt, and calcium during pregnancy may reduce the risk of infantile eczema, physician-diagnosed asthma, physician-diagnosed atopic eczema, and physician-diagnosed atopic eczema, respectively. Higher maternal intake of vitamin D during pregnancy may increase the risk of infantile eczema. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

IL3 rs40401 Polymorphism and Interaction with Smoking in Risk of Asthma in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study

Y. Miyake, K. Tanaka, M. Arakawa

SCANDINAVIAN JOURNAL OF IMMUNOLOGY ( WILEY )  79 ( 6 ) 410 - 414   2014年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Three previous genetic association studies conducted in Korea and China investigated the relationship between IL3 single nucleotide polymorphism (SNP) rs40401 and asthma, but their results were inconsistent. We examined this relationship and the possibility of an interaction between IL3 SNP rs40401 and smoking in young adult Japanese women. Included were 89 women who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma. Control subjects were 700 women without asthma according to the ECRHS criteria who had not been diagnosed with asthma and/or allergic rhinitis by a doctor and/or who had not met the criteria of the International Study of Asthma and Allergies in Childhood for rhinoconjunctivitis. A significant positive association was found between SNP rs40401 and the risk of asthma, with the TT genotype as the reference under the additive model: the adjusted odds ratio was 1.39 (95% CI: 1.004-1.93). The positive association was not statistically significant in any other genetic model. Compared with subjects with the TT or TC genotype of SNP rs40401 who had never smoked, those with the CC genotype who had ever smoked had a significantly increased risk of asthma: the adjusted OR was 2.67 (95% CI: 1.23-5.79); the additive interaction, but not the multiplicative interaction, was significant. This study suggests that IL3 SNP rs40401 is significantly associated with the risk of asthma in young adult Japanese women and reveals that the combination of ever smoking and having the CC genotype of IL3 SNP rs40401 is significantly positively associated with asthma.

• この論文にアクセスする
  DOI

Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women

Keiko Tanaka, Yoshihiro Miyake, Takashi Hanioka, Masashi Arakawa

DNA AND CELL BIOLOGY ( MARY ANN LIEBERT, INC )  33 ( 4 ) 227 - 233   2014年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1 alpha (rs1800587) and IL-1 beta (rs1143634 and rs16944) and the risk of periodontal disease among young Japanese women. A case-control study was performed with a total of 1150 women, including 131 subjects who had at least one tooth with a probing pocket depth of 4 mm or deeper and 1019 periodontally healthy controls. Compared with a reference group of women with the GG genotype of SNP rs16944, those with the GA genotype had a significantly reduced risk of periodontal disease, while there was no significant relationship between the AA genotype and periodontal disease. No evident relationships were observed between SNP rs1800587 or rs1143634 and periodontal disease. Our study did not reveal any evidence of interaction between the IL1 polymorphisms and smoking. The results of this study showed that the heterozygous variant genotype of the IL1 rs16944 was significantly associated with a reduced risk of periodontal disease in young Japanese women. Smoking did not significantly modify the gene-disease associations under study.

• この論文にアクセスする
  DOI

Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

BMC PREGNANCY AND CHILDBIRTH ( BIOMED CENTRAL LTD )  14 ( 79 )   2014年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: A recent meta-analysis showed no relationships between light to moderate alcohol consumption during pregnancy and the risk of low birth weight (LBW), preterm birth (PTB), or small-for-gestational-age (SGA). Here, we present the first epidemiological study on this topic in Japan. Methods: Study subjects were 1565 Japanese mothers with singleton pregnancies and the babies born from these pregnancies. Alcohol consumption during pregnancy was assessed using a self-administered diet history questionnaire. Alcohol consumption during pregnancy was classified into three categories (none, &lt;1 g/day, and = 1 g/day). Results: The mean birth weight of the babies was 3006.3 g. 7.7% were classified as LBW, 4.0% as PTB, and 7.8% as SGA. The range of maternal alcohol consumption during pregnancy was 0.0 to 11.7 g per day: 1356 (86.7%) mothers were abstainers and the 95th percentile value was 0.84 g per day. Compared with abstinence, alcohol consumption of 1.0 g or more per day during pregnancy was significantly associated with an increased risk of PTB with a significant positive linear trend: the adjusted OR for PTB associated with maternal alcohol consumption of 1.0 g or more per day was 2.58 (95% CI: 1.004-5.80, P for trend = 0.03). No significant relationships were observed between maternal alcohol consumption during pregnancy and the risk of LBW or SGA, and there was no material association between maternal alcohol consumption during pregnancy and birth weight. Conclusions: This is the first study in Japan to show that maternal alcohol consumption during pregnancy of 1.0 g or more per day was significantly positively associated with the risk of PTB, but not LBW or SGA.

• この論文にアクセスする
  DOI 学術リポジトリ

Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

CYTOKINE ( ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD )  65 ( 2 ) 138 - 142   2014年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiological research on the relationship between single nucleotide polymorphisms (SNPs) in the IL5RA gene and allergic disorders is limited. We examined the relationship between IL5RA SNPs and risk of rhinoconjunctivitis in young adult Japanese women. Methods: Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education. Results: Compared with the CC genotype of SNP rs6771148, the CG genotype, but not the GG genotype, was significantly associated with a reduced risk of rhinoconjunctivitis: the adjusted OR for the CG genotype was 0.76 (95% CI: 0.58-0.99). No evident associations were found between SNPs rs17882210, rs3804797, rs334809, rs9831572, or rs17881144 and rhinoconjunctivitis. The ACTAGA haplotype of rs17882210, rs3804797, rs334809, rs9831572, rs6771148, and rs17881144 was significantly inversely associated with rhinoconjunctivitis (crude OR = 0.58, 95% CI: 0.37-0.88) while the GTAGCA haplotype was significantly positively related to rhinoconjunctivitis (crude OR = 1.74, 95% CI: 1.14-2.65). No significant interactions affecting rhinoconjunctivitis were observed between any of the six SNPs and smoking. Conclusion: This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. We did not find evidence for interactions affecting rhinoconjunctivitis between any of the IL5R4 SNPs and smoking. (C) 2013 Elsevier Ltd. All rights reserved.

• この論文にアクセスする
  DOI

Salivary Cotinine Concentrations and Prevalence of Periodontal Disease in Young Japanese Women: The Kyushu Okinawa Maternal and Child Health Study

Keiko Tanaka, Ryoichi Matsuse, Yoshihiro Miyake, Takashi Hanioka, Masashi Arakawa

JOURNAL OF PERIODONTOLOGY ( AMER ACAD PERIODONTOLOGY )  84 ( 12 ) 1724 - 1729   2013年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: The authors investigated the relationship between objectively assessed tobacco smoke exposure and periodontal disease. Methods: This cross-sectional study included 1,103 women with a mean age of 31.5 years. Information on potential confounding factors was obtained through a self-administered questionnaire. Periodontal disease was defined as positive if a woman had at least one tooth with a probing depth of &gt;= 3.5 mm. Exposure to tobacco smoke was determined based on salivary cotinine concentration. Adjustment was made for age, region of residence, household income, education, toothbrushing frequency, and use of an interdental brush. Results: The prevalence of periodontal disease was 11.3%. Salivary cotinine concentration was independently positively associated with the prevalence of periodontal disease: the adjusted odds ratio for every 1-unit (ng/mL) increase in salivary cotinine was 1.004 (95% confidence interval: 1.000 to 1.007). Conclusion: Salivary cotinine concentrations were positively associated with the prevalence of periodontal disease among young women.

• この論文にアクセスする
  DOI

Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

ANNALS OF EPIDEMIOLOGY ( ELSEVIER SCIENCE INC )  23 ( 11 ) 674 - 680   2013年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and-eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive. Methods: Subjects were 1354 Japanese mother-child pairs. Data on maternal intake during pregnancy were assessed with a validated diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood. Results: Significant inverse exposure-response relationships were observed between maternal intake of eicosapentaenoic acid (EPA) and EPA plus docosahexaenoic acid (DHA) during pregnancy and infantile wheeze although the adjusted odds ratios between extreme quartiles fell just short of the significance level. No such inverse relationships were detected for infantile eczema. Maternal intake of total fat, saturated fatty acids, monounsaturated fatty acids, total n-3 polyunsaturated fatty acids (PUFA), alpha-linolenic acid, DHA, total n-6 PUFA, linoleic acid, arachidonic acid, cholesterol, fish, and meat and the ratio of n-3 to n-6 PUFA consumption were not significantly related to infantile wheeze or eczema. Conclusions: Higher maternal intake of EPA and EPA plus DHA during pregnancy may reduce the risk of infantile wheeze. (C) 2013 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

Active and passive smoking and prevalence of periodontal disease in young Japanese women

K. Tanaka, Y. Miyake, T. Hanioka, M. Arakawa

JOURNAL OF PERIODONTAL RESEARCH ( WILEY-BLACKWELL )  48 ( 5 ) 600 - 605   2013年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background and Objective: Studies reporting on the association between smoking and periodontal disease have mostly focused on active smoking. The purpose of this study was to examine the relationships between active smoking and exposure to second-hand smoke at home and at work and the prevalence of periodontal disease among young Japanese women. Material and methods: Study subjects were 1167 postpartum women with a mean age of 31.5years. Information on smoking and potential confounding factors was obtained through a self-administered questionnaire. Partial-mouth recording was used to determine probing pocket depth at six sites per tooth for six teeth in the mouth. Periodontal disease was defined as positive if a woman had at least one tooth with a probing pocket depth of 3.5mm or deeper. Adjustment was made for age, region of residence, household income, education, toothbrushing frequency and use of an interdental brush. Results: Compared with never smoking, ever smoking was independently positively associated with the prevalence of periodontal disease: the adjusted odds ratio was 1.56 (95% confidence interval: 1.02-2.36). There was a marginally significant positive dose-response relationship between pack-years of smoking and the prevalence of periodontal disease (p for linear trend=0.08). No material associations were observed between second-hand smoke exposure at home or at work and periodontal disease. Conclusion: Our findings suggest that active smoking, but not passive smoking, might be associated with an increased prevalence of periodontal disease among young women in Japan.

• この論文にアクセスする
  DOI

IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: The Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

CYTOKINE ( ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD )  64 ( 1 ) 86 - 89   2013年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: No studies have investigated the relationship between IL3 single nucleotide polymorphism (SNP) rs40401 and allergic rhinitis. We performed a case-control study to examine this issue and to assess interactions between the SNP and smoking or older siblings in young adult Japanese women. Methods: Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. Results: Compared with women with the TT genotype of SNP rs40401, those with the CC genotype had a significantly increased risk of rhinoconjunctivitis: the adjusted OR was 1.52 (95% CI: 1.05-2.19). This positive relationship was significant under the additive model: the adjusted OR was 1.23 (95% CI: 1.02-1.47). The positive association fell just short of the significance level under the dominant or recessive model. There was no significant interaction between SNP rs40401 and smoking with respect to rhinoconjunctivitis. Compared with subjects with the TT or TC genotype of IL3 SNP rs40401 who had one or more older siblings, those with the CC genotype who had no older siblings had a 2.33-fold increased risk of rhinoconjunctivitis; nevertheless, the interaction was not significant. Conclusion: This is the first study to show a significant positive association between IL3 SNP rs40401 variant and the risk of rhinoconjunctivitis. We could not find evidence for interactions between SNP rs40401 and smoking or older siblings affecting rhinoconjunctivitis. (c) 2013 Elsevier Ltd. All rights reserved.

• この論文にアクセスする
  DOI

VDRGene Polymorphisms, Interaction with Smoking and Risk of Periodontal Disease in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study

K. Tanaka, Y. Miyake, T. Hanioka, M. Arakawa

SCANDINAVIAN JOURNAL OF IMMUNOLOGY ( WILEY-BLACKWELL )  78 ( 4 ) 371 - 377   2013年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Abstract Epidemiological evidence on the relationship between vitamin D receptor (VDR) polymorphisms and periodontal disease is inconsistent. We investigated associations between four VDR single-nucleotide polymorphisms (SNPs) including rs731236 (TaqI), rs7975232 (ApaI), rs1544410 (BsmI) and rs2228570 (FokI), and the risk of periodontal disease among young Japanese women. Cases included 131 women who had at least one tooth with a probing depth of 3.5 mm or deeper. Controls included 1019 women without periodontal disease. Adjustment was made for age, region of residence, education, toothbrushing frequency and use of an interdental brush. Compared with the AA genotype of SNP rs731236, the GG genotype had a significantly increased risk of periodontal disease: the adjusted OR was 3.68 (95% confidence interval: 1.06-12.78). There were no significant relationships between SNPs rs7975232, rs1544410 or rs2228570 and periodontal disease. None of the haplotypes were significantly related to periodontal disease. Compared with subjects with the AA or AG genotype of SNP rs731236 who had never smoked, those with the GG genotype who had ever smoked had a significantly increased risk of periodontal disease; nevertheless, neither multiplicative nor additive interaction was significant. The additive interaction between SNP rs7975232 and smoking was significant, although the multiplicative interaction was not statistically significant. No multiplicative or additive interactions were observed between the other SNPs and smoking. Our results indicated that VDR SNP rs731236 might be associated with periodontal disease. In addition, we present new evidence for a biological interaction between VDR SNP rs7975232 and smoking that affects periodontal disease.

• この論文にアクセスする
  DOI

Active and passive maternal smoking during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC PREGNANCY AND CHILDBIRTH ( BIOMED CENTRAL LTD )  13   2013年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: In Western countries, active maternal smoking during pregnancy is recognized as the most important preventable risk factor for adverse birth outcomes. However, the effect of passive maternal smoking is less clear and has not been extensively studied. In Japan, there has been only one epidemiological study which examined the effects of active smoking during early pregnancy on birth outcomes although the effects of passive smoking were not assessed. Methods: Study subjects were 1565 mothers with singleton pregnancies and the babies born from these pregnancies. Data on active maternal smoking status in the first, second, and third trimesters and maternal environmental tobacco smoke (ETS) exposure at home and work were collected with self-administered questionnaires. Results: Compared with children born to mothers who had never smoked during pregnancy, children born to mothers who had smoked throughout their pregnancy had a significantly increased risk of small-for-gestational-age (SGA) (adjusted odd ratio [OR] = 2.87; 95% confidence interval: 1.11-6.56). However, active maternal smoking only in the first trimester and active maternal smoking in the second and/or third trimesters but not throughout pregnancy were not significantly associated with SGA. With regard to the risk of preterm birth, the adjusted ORs for the above-mentioned three categories were not significant; however, the positive linear trend was significant (P for trend = 0.048). No significant association was found between active maternal smoking during pregnancy and the risk of low birth weight. There was a significant inverse relationship between active maternal smoking during pregnancy and birth weight; newborns of mothers who had smoked throughout pregnancy had an adjusted mean birth weight reduction of 169.6 g. When classifying babies by gender, a significant positive association between active maternal smoking throughout pregnancy and the risk of SGA was found only in male newborns, however, the interaction was not significant. Maternal ETS exposure at home or work was not significantly associated with any birth outcomes. Conclusions: This is the first study in Japan to show that active maternal smoking throughout pregnancy, but not during the first trimester, is significantly associated with an increased risk of SGA and a decrease in birth weight. Thus, women who smoke should quit smoking as soon as possible after conception.

• この論文にアクセスする
  DOI 学術リポジトリ

Case-Control Study of Eczema in Relation to IL4Rα Genetic Polymorphisms in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study

Miyake Y, Tanaka K, Arakawa M

Scandinavian Journal of Immunology   77 ( 5 ) 413 - 418   2013年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする
  DOI

Fish and fat intake and prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

JOURNAL OF PSYCHIATRIC RESEARCH ( PERGAMON-ELSEVIER SCIENCE LTD )  47 ( 5 ) 572 - 578   2013年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The present study aimed to examine the relationship between consumption of meat, fish, and specific types of fatty acids and the prevalence of depressive symptoms during pregnancy in Japan. Study subjects were 1745 pregnant women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Information on dietary factors was collected using a self-administered diet history questionnaire. The prevalence of depressive symptoms during pregnancy was 19.3%. Higher intake levels of fish, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were independently associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) between extreme quartiles (95% confidence intervals [CIs], P for trend) were 0.61 (0.42-0.87, 0.01), 0.66 (0.46-0.95, 0.02) and 0.64 (0.44-0.93, 0.007), respectively. Higher intake levels of total fat and saturated fatty acids were independently related to a higher prevalence of depressive symptoms during pregnancy: the adjusted ORs between extreme quartiles (95% CIs, P for trend) were 1.42 (1.00-2.03, 0.06) and 1.74 (1.22-2.49, 0.001), respectively. There were no significant associations between intake of monounsaturated fatty acids, n-3 polyunsaturated fatty acids (PUFAs), alpha-linolenic acid, n-6 PUFAs, linoleic acid, arachidonic acid, or cholesterol or the ratio of n-3 to n-6 PUFA intake and depressive symptoms during pregnancy. Intake levels of fish, EPA, and DHA may be inversely associated with depressive symptoms during pregnancy while intake levels of total fat and saturated fatty acids may be positively related to depressive symptoms during pregnancy. (C) 2013 Elsevier Ltd. All rights reserved.

• この論文にアクセスする
  DOI

Relationship between polymorphisms in IL4 and asthma in Japanese women: The Kyushu Okinawa Maternal and child health study

Yoshihiro Miyake, K. Tanaka, M. Arakawa

Journal of Investigational Allergology and Clinical Immunology   23 ( 4 ) 242 - 247   2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Interleukin (IL) 4 plays a critical role in immune responses by acting as a growth factor for type 2 helper T cells and inducing immunoglobulin (Ig) class switching to IgE. Epidemiological evidence of the relationship between single-nucleotide polymorphisms (SNPs) in IL4 and asthma is inconsistent. Objectives: We examined the association between the IL4 SNPs rs2243250, rs2070874, rs2227284, and rs2243290 and asthma in young adult Japanese women. Methods: The study population comprised 89 women who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma. The control group comprised 1281 nonasthmatic women (ECRHS criteria) who had not been diagnosed with asthma by a physician. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education. Results: Compared with the AA genotype of rs2243290, the AC genotype, but not the CC genotype, was significantly associated with a reduced risk of asthma: the adjusted odds ratio for the AC genotype was 0.62 (95%CI, 0.39-0.996). No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. None of the haplotypes were significantly associated with asthma. No significant interactions were found between the 4 SNPs under study and smoking with respect to the risk of asthma. Conclusions: Ours is the first study in a non-Western population to show that the IL4 SNP rs2243290 was significantly associated with the risk of asthma. Smoking did not significantly modify the gene-disease associations under study. © 2013 Esmon Publicidad.

• この論文にアクセスする
  学術リポジトリ
• 関連情報を調べる
  PubMed

Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: The Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

HUMAN IMMUNOLOGY ( ELSEVIER SCIENCE INC )  73 ( 10 ) 1046 - 1049   2012年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Epidemiological evidence on the relationship between IL4 single nucleotide polymorphisms (SNPs) and allergic rhinitis is limited. We conducted a case-control study to investigate this issue in young adult Japanese women. Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 703 women without rhinoconjunctivitis based on the ISAAC criteria who had not been diagnosed with allergic rhinitis and/or asthma by a doctor. Compared with the TT genotype of IL4 SNP rs2227284, the GG genotype, occurring in 10.2% of control subjects, was significantly inversely associated with the risk of rhinoconjunctivitis: the adjusted OR was 0.60 (95% CI: 0.37-0.98). There were no significant relationships between SNP rs2243250, rs2070874, or rs2243290 and rhinoconjunctivitis. None of the haplotypes were significantly related to rhinoconjunctivitis. A significant inverse relationship between the combination of the TG and GG geno-types of SNP rs2227284 and rhinoconjunctivitis was observed in women who had never smoked, but not in those who had ever smoked (P for interaction = 0.11). This is the first study to demonstrate a significant relationship between IL4 SNP rs2227284 and rhinoconjunctivitis. Smoking may modify the relationship between SNP rs2227284 and rhinoconjunctivitis. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

Employment, income, and education and prevalence of depressive symptoms during pregnancy: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC PSYCHIATRY ( BIOMED CENTRAL LTD )  12 ( 117 )   2012年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Epidemiological evidence for the association of socioeconomic status with prenatal depression has been inconsistent. The current cross-sectional study examined the association between employment, job type, household income, and educational level and the prevalence of depressive symptoms during pregnancy. Methods: Subjects were 1741 Japanese women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Adjustment was made for age, gestation, region of residence, family structure, personal and family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, and education. Results: The prevalence of depressive symptoms during pregnancy was 19.3%. Compared with unemployment, employment, part-time employment, and full-time employment were significantly associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) were 0.65 (95% confidence interval [CI]: 0.50 - 0.86), 0.66 (95% CI: 0.46 - 0.95), and 0.66 (95% CI: 0.48 - 0.90), respectively. Regarding the job type held, women with a professional or technical job and those with a clerical or related occupation had a significantly lower prevalence of depressive symptoms during pregnancy: the adjusted ORs were 0.67 (95% CI: 0.47 - 0.96) and 0.62 (95% CI: 0.43 - 0.90), respectively. Sales, service, production, and other occupations were not significantly related to the prevalence of depressive symptoms during pregnancy. There were no relationships between household income or education and the prevalence of depressive symptoms during pregnancy. Conclusions: Employment, whether full-time or part-time, and holding a professional or technical job or a clerical or related occupation may be inversely associated with the prevalence of depressive symptoms during pregnancy.

• この論文にアクセスする
  DOI 学術リポジトリ

日本の子供における食事の自己申告速度と肥満の危険性 琉球小児健康調査(Self-Reported Rate of Eating and Risk of Overweight in Japanese Children: Ryukyus Child Health Study)

Murakami Kentaro, Miyake Yoshihiro, Sasaki Satoshi, Tanaka Keiko, Arakawa Masashi

Journal of Nutritional Science and Vitaminology ( (公社)日本栄養・食糧学会 )  58 ( 4 ) 247 - 252   2012年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

食事速度と肥満の状況の関連性について検討した。15974名の子供(6-11歳、男子7956名、女子8018名)を対象とした。BMIは子供が申告した体重と身長から計算した。肥満の判定はInternational Obesity Task Forceの年齢と性別に特異的な切り捨て値に基づいて行った。全体の肥満の割合は13.2%であった。タンパク質、脂質、および食物繊維の摂取量とは独立に食事速度は体重超過の危険性と正に相関していた。食事速度ごとの肥満の多変量オッズ比(95%信頼区間)は男児で極めて低速が0.31、やや低速が0.49、中程度が1(基準値)、やや高速が2.81、極めて高速が4.49であり、女児で順に0.42、0.49、1(基準値)、2.74、5.69であった。成人男性については順に0.13、0.43、1(基準値)、2.31、そして3.84であった。成人女性で順に0.55、0.46、1(基準値)、1.30、1.49であった。すべて集団で食事の速度と肥満は有意に相関していた。日本の小児と成人において食事速度の速さが肥満の危険性の増加と独立かつ正に相関していた。

• この論文にアクセスする
  DOI

ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Y. Miyake, K. Tanaka, M. Arakawa

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ( INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) )  16 ( 7 ) 974 - 979   2012年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

SETTING: Multiple A disintegrin and metalloprotease 33 (ADAM33) single nucleotide polymorphisms (SNPs) have been shown to be associated with asthma, but results have been inconsistent. OBJECTIVES: To examine the association between ADAM33 SNPs rs2787094, rs628977, rs2280089, rs2280090, rs2280091, rs2853209, rs528557 and rs612709 and asthma in young adult Japanese women, and to perform haplotype analyses and assess interactions between SNPs and smoking. DESIGN: A total of 89 cases who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma were included in the study. Control subjects were 1281 women without asthma, as per ECRHS criteria, who had not been diagnosed with asthma by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking and education. RESULTS: Under a co-dominant model, the AA genotype of the rs612709 SNP was significantly positively associated with asthma compared with the GG genotype: the adjusted OR was 4.27 (95%CI 1.49-12.25). A significant positive relationship was found between the CCGGAAGA haplotype and asthma. Interactions between SNPs rs628977 and rs528557 and smoking were marginally significant (P = 0.09 and 0.095, respectively). CONCLUSIONS: ADAM33 SNP rs612709 and the CCGGAAGA haplotype may be associated with asthma. Smoking may modify the associations between SNPs rs628977 and rs528557 and asthma.

• この論文にアクセスする
  DOI

An energy-dense diet is cross-sectionally associated with an increased risk of overweight in male children, but not in female children, male adolescents, or female adolescents in Japan: the Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

NUTRITION RESEARCH ( PERGAMON-ELSEVIER SCIENCE LTD )  32 ( 7 ) 486 - 494   2012年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Epidemiologic evidence concerning the role of dietary energy density in increased body weight status during childhood and adolescence is limited, particularly in non-Western populations. We investigated the hypothesis that higher dietary energy density is associated with increasing risk of overweight in Japanese children and adolescents. This Japanese cross-sectional study included 15974 children (6-11 years old; 7956 boys and 8018 girls) and 8202 adolescents (12-15 years old; 3944 boys and 4258 girls). Dietary intake was assessed using a self-administered diet history questionnaire for children and adolescents. Dietary energy density was calculated based on foods only (excluding beverages). Body mass index (BMI) was calculated from self-reported body weight and height. Overweight (including obesity) was defined according to the International Obesity Task Force age- and sex-specific BMI cutoffs, which correspond to an adult BMI of at least 25 kg/m(2). The overall prevalence of overweight was 13.2%. Mean dietary energy density was 5.02 (standard deviation, 0.59) kJ/g. After adjustment for potential confounding factors, dietary energy density was positively associated with the risk of overweight in male children (P for trend = .048). No such associations were observed among female children, male adolescents, or female adolescents. In conclusion, this large cross-sectional study in Japan suggests that an energy-dense diet is associated with an increased risk of overweight in male children, but not in female children, male adolescents, or female adolescents. (C) 2012 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

Characteristics of under- and over-reporters of energy intake among Japanese children and adolescents: The Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

NUTRITION ( ELSEVIER SCIENCE INC )  28 ( 5 ) 532 - 538   2012年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: Evidence on factors associated with misreporting of energy intake in children and adolescents is sparse, particularly in non-Western countries. We examined the characteristics of under- and over-reporters of energy intake in Japanese children and adolescents. Methods: This study included 25 761 Japanese boys and girls 6 to 15 y old. Energy intake was assessed using a self-administered diet history questionnaire developed for Japanese children and adolescents. Estimated energy requirement was calculated from self-reported body weight with the use of equations from the Food and Agriculture Organization (FAO)/World Health Organization (WHO)/United Nations University (UNU) Expert Consultation Report on Human Energy Requirements. Under-reporters, acceptable reporters, and over-reporters of energy intake were identified based on the ratio of energy intake to estimated energy requirement (&lt;0.76, 0.76 to 1.24, and &gt;1.24, respectively). The risk of being an under- or over-reporter of energy intake compared with being an acceptable reporter was analyzed using logistic regression. Results: The percentages of under-, acceptable, and over-reporters of energy intake were 31.6%, 53.2%, and 15.2%, respectively. Under-reporting was associated with female sex, older age, overweight and obesity, low parental education, and completion of the dietary questionnaire without the cooperation of parent(s)/caregiver(s). Over-reporting was associated with younger age, normal weight, low parental education, and completion of the dietary questionnaire by the child/adolescent alone (compared with completion by the child/adolescent and parent[s]/caregiverls]). Conclusions: Although under- and over-reporting of energy intake were common and differential in this study of Japanese children and adolescents, the cooperation of parent(s)/caregiver(s) in answering the dietary questionnaire seemed to improve the quality of dietary intake data. (C) 2012 Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

ADAM33 genetic polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

HUMAN IMMUNOLOGY ( ELSEVIER SCIENCE INC )  73 ( 4 ) 411 - 415   2012年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Two previous studies have demonstrated a significant relationship between ADAM33 single nucleotide polymorphisms (SNPs) and allergic rhinitis. Here, we investigated this issue in young adult Japanese women. The study included 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls included 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. The GC genotype of rs2787094, the CT genotype of rs628977, and the haplotype containing the rs2787094 C allele, the rs628977 T allele, the rs2853209 T allele, and the rs612709 G allele were significantly inversely associated with rhinoconjunctivitis. The AA genotype of rs2853209, the GA genotype of rs612709, and the haplotype carrying the rs2787094 G allele, the rs628977 C allele, the rs2853209 A allele, and the rs612709 G allele were significantly positively associated with rhinoconjunctivitis. A significant inverse relationship between rs628977 and rhinoconjunctivitis was demonstrated only in women who had never smoked, indicating a significant interaction between rs628977 and smoking. Our results suggest that SNPs and haplotypes in the ADAM33 gene are associated with rhinoconjunctivitis. This study is the first to demonstrate an interaction between rs628977 and smoking that affects rhinoconjunctivitis. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

• この論文にアクセスする
  DOI

Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

NUTRITION JOURNAL ( BIOMED CENTRAL LTD )  11   2012年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Dietary fat exerts numerous complex effects on proinflammatory and immunologic pathways. Several epidemiological studies have examined the relationships between intake of fatty acids and/or foods high in fat and allergic rhinitis, but have provided conflicting findings. The current cross-sectional study investigated such relationships in Japan. Methods: Study subjects were 1745 pregnant women. The definition of rhinoconjunctivitis was based on criteria from the International Study of Asthma and Allergies in Childhood. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Adjustment was made for age; gestation; region of residence; number of older siblings; number of children; smoking; secondhand smoke exposure at home and at work; family history of asthma, atopic eczema, and allergic rhinitis; household income; education; and body mass index. Results: The prevalence of rhinoconjunctivitis in the past 12 months was 25.9%. Higher meat intake was significantly associated with an increased prevalence of rhinoconjunctivitis: the adjusted odds ratio between extreme quartiles was 1.71 (95% confidence interval: 1.25-2.35, P for trend = 0.002). No measurable association was found between fish intake and rhinoconjunctivitis. Intake of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, a-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, linoleic acid, arachidonic acid, and cholesterol and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not evidently related to the prevalence of rhinoconjunctivitis. Conclusions: The current results suggest that meat intake may be positively associated with the prevalence of rhinoconjunctivitis in young adult Japanese women.

• この論文にアクセスする
  DOI 学術リポジトリ

Smoking and prevalence of allergic disorders in Japanese pregnant women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa

ENVIRONMENTAL HEALTH ( BIOMED CENTRAL LTD )  11   11 - 15   2012年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Studies on the associations between smoking and allergic diseases have mostly focused on asthma. Epidemiological studies in adults on the effects of smoking on allergic diseases other than asthma, such as eczema and rhinoconjunctivitis, have been limited, and the information that is available has been inconsistent. The aim of this study was to investigate the association between smoking status and environmental tobacco smoke (ETS) exposure and the prevalence of allergic diseases. Methods: Study subjects were 1743 pregnant Japanese women. The definitions of wheeze and asthma were based on criteria from the European Community Respiratory Health Survey whereas those of eczema and rhinoconjunctivitis were based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age; region of residence; family history of asthma, atopic eczema, and allergic rhinitis; household income; and education. Results: Compared with never smoking, current smoking and &gt;= 4 pack-years of smoking were independently positively associated with the prevalence of wheeze. There were no associations between smoking status and the prevalence of asthma, eczema, or rhinoconjunctivitis. When subjects who had never smoked were classified into four categories based on the source of ETS exposure (never, only at home, only at work, and both), exposure occurring both at home and at work was independently associated with an increased prevalence of two outcomes: wheeze and rhinoconjunctivitis. No relationships were observed between exposure to ETS and the prevalence of asthma or eczema. Conclusions: Our results provide evidence that current smoking and ETS exposure may increase the likelihood of wheeze. The possibility of a positive association between ETS exposure and rhinoconjunctivitis was also suggested.

• この論文にアクセスする
  DOI 学術リポジトリ

Dairy food, calcium and vitamin D intake and prevalence of allergic disorders in pregnant Japanese women

Y. Miyake, K. Tanaka, H. Okubo, S. Sasaki, M. Arakawa

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ( INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) )  16 ( 2 ) 255 - 261   2012年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

SETTING : Epidemiological evidence for the associations between intake of dairy products, calcium and vitamin D and allergic disorders has been inconsistent. OBJECTIVES: To examine such associations in Japan. DESIGN: This cross-sectional study enrolled 1745 pregnant women. The definitions of wheeze and asthma were based on European Community Respiratory Health Survey criteria, whereas those of eczema and rhinoconjunctivitis were based on International Study of Asthma and Allergies in Childhood criteria. Information on dietary factors was collected using a validated self-administered diet history questionnaire. RESULTS: Intake of total dairy products, milk, yoghurt, cheese and calcium was not related to the prevalence of wheeze, asthma, eczema or rhinoconjunctivitis. After adjustment for potential confounders, vitamin D intake was found to be independently positively associated with the prevalence of asthma: the adjusted ORs for asthma in the first, second, third and fourth quartiles were respectively 1.00 (reference), 1.26 (95%CI 0.65-2.50), 2.08 (95%CI 1.13-3.94), and 1.82 (95%CI 0.97-3.51, P for trend = 0.03). There were no relationships between vitamin D consumption and the prevalence of wheeze, eczema or rhinoconjunctivitis. CONCLUSIONS: These findings suggest that vitamin D intake may be positively related to the prevalence of asthma in young adult Japanese women.

• この論文にアクセスする
  DOI

Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC MEDICAL GENETICS ( BIOMED CENTRAL LTD )  12 ( 143 ) 142   2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Six previous studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and allergic rhinitis, but the results have been inconsistent. However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis. We investigated the associations between IL13 SNPs rs1800925 and rs20541 and the risk of rhinoconjunctivitis in Japanese women. Methods: Included were 393 cases who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Control subjects were 767 women without rhinoconjunctivitis according to the ISAAC criteria, who had also not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, family history of allergic rhinitis, and education. Results: Compared with the GG genotype of IL13 SNP rs20541, the AA genotype, occurring in 7.1% of control subjects, was significantly positively related to the risk of rhinoconjunctivitis: the adjusted odds ratio was 1.65 (95% confidence interval: 1.05 - 2.60). SNP rs1800925 was not associated with rhinoconjunctivitis. The haplotype comprising the rs1800925 C allele and the rs20541 A allele was significantly positively related to rhinoconjunctivitis. The multiplicative interactions between the two SNPs under study and smoking on the risk of rhinoconjunctivitis were not statistically significant. Based on the recessive model, however, the additive interaction between SNP rs1800925, but not rs20541, and smoking was significant. Conclusions: This study suggests that the minor genotype of IL13 SNP rs20541 and the CA haplotype are significantly positively associated with the risk of rhinoconjunctivitis. In addition, a new pattern of biological interaction that affects the risk of rhinoconjunctivitis is described between SNP rs1800925 and smoking.

• この論文にアクセスする
  DOI

Organochlorine concentrations in breast milk and prevalence of allergic disorders in Japanese women

Yoshihiro Miyake, Keiko Tanaka, Yuko Masuzaki, Nobuyuki Sato, Yoshirou Ikeda, Youichi Chisaki, Masashi Arakawa

CHEMOSPHERE ( PERGAMON-ELSEVIER SCIENCE LTD )  85 ( 3 ) 374 - 378   2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Persistent organic pollutants have been shown to have immunomodulating effects in humans. However, epidemiological evidence regarding the relationships between organochlorine compound exposure and allergic disorders coming from studies of children has been limited and inconsistent. The current cross-sectional study examined the associations between the concentrations of beta-hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), p,p'-dichlorodiphenyldichloroethylene (DDE), and trans-nonachlordane in breast milk and the prevalence of allergic disorders in 124 adult Japanese women. The definition of wheeze and asthma was based on criteria from the European Community Respiratory Health Survey whereas that of eczema and rhinoconjunctivitis was based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age, smoking, family history of allergic disorders, and education. The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the past 12 months were 9.7%, 4.8%, 13.7%, and 29.8%, respectively. The median concentrations of beta-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk were 28.3, 7.0, 71.6, and 23.9 ng g(-1) lipid, respectively (range, 4.5-253, 2.1-14.5, 7.5-362, and 1.8-130 ng g(-1) lipid, respectively). When the exposures were treated as continuous variables, no significant associations were found between concentrations of HCB, beta-HCH, p,p'-DDE, or trans-nonachlordane and the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis. Our results suggest that concentrations of beta-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk are not evidently associated with the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis in young female Japanese adults. (C) 2011 Elsevier Ltd. All rights reserved.

• この論文にアクセスする
  DOI

IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC MEDICAL GENETICS ( BIOMED CENTRAL LTD )  12 ( 142 ) 142   2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Several genetic association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and eczema, and have provided contradictory results. We investigated the relationship between the IL13 SNPs rs1800925 and rs20541 and the risk of eczema in Japanese young adult women. Methods: Included were 188 cases who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for eczema. Control subjects were 1,082 women without eczema according to the ISAAC criteria, who had not been diagnosed with atopic eczema by a doctor and who had no current asthma as defined by the European Community Respiratory Health Survey criteria. Adjustment was made for age, region of residence, number of children, smoking, and education. Results: The minor TT genotype of SNP rs1800925 was significantly associated with an increased risk of eczema in the co-dominant model: the adjusted odds ratio was 2.19 (95% confidence interval: 1.03-4.67). SNP rs20541 was not related to eczema. None of the haplotypes were significantly associated with eczema. Compared with women with the CC or CT genotype of SNP rs1800925 who had never smoked, those with the TT genotype who had ever smoked had a 2.85-fold increased risk of eczema, though the adjusted odds ratio was not statistically significant, and neither multiplicative nor additive interaction was statistically significant. Conclusions: Our findings suggest that the IL13 SNP rs1800925 is significantly associated with eczema in Japanese young adult women. We could not find evidence for an interaction between SNP rs1800925 and smoking with regard to eczema.

• この論文にアクセスする
  DOI 学術リポジトリ

U-Shaped Association between Body Mass Index and the Prevalence of Wheeze and Asthma, but not Eczema or Rhinoconjunctivitis: The Ryukyus Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa, Satoshi Sasaki, Yukihiro Ohya

JOURNAL OF ASTHMA ( INFORMA HEALTHCARE )  48 ( 8 ) 804 - 810   2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background. Studies reporting on the association between obesity and allergies have mostly focused on asthma. Little is known about the relationship of obesity to other allergic diseases, and the information that is available has been inconsistent. We examined the association between body mass index (BMI) and the prevalence of wheeze, asthma, eczema, and rhinoconjunctivitis in Japanese schoolchildren. Methods. Study subjects were 24,399 children aged 6-15 years in Okinawa, Japan. Outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. BMI was categorized into five groups; &lt;5th, 5th to 35th, &gt;35th to 65th, &gt;65th to 95th, and &gt;95th percentile groups. Adjustment was made for sex, age, region of residence, number of siblings, smoking in the household, physical activity, paternal and maternal history of allergic disorders, and paternal and maternal educational levels. Results. The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the previous 12 months were 10.8%, 7.6%, 6.9%, and 7.6%, respectively. Compared with the referent category (&gt;35th to 65th percentile group), higher percentile categories were positively associated with the prevalence of wheeze. A U-shaped relationship between BMI and asthma was observed. No material associations between BMI percentile categories and the prevalence of eczema or rhinoconjunctivitis were found. Conclusion. These findings suggested that being either underweight or overweight might increase the likelihood of asthma among Japanese schoolchildren.

• この論文にアクセスする
  DOI

Dietary glycemic index and glycemic load in relation to risk of overweight in Japanese children and adolescents: the Ryukyus Child Health Study

K. Murakami, Y. Miyake, S. Sasaki, K. Tanaka, M. Arakawa

INTERNATIONAL JOURNAL OF OBESITY ( NATURE PUBLISHING GROUP )  35 ( 7 ) 925 - 936   2011年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: Epidemiologic evidence concerning the role of dietary glycemic index (GI) and glycemic load (GL) in obesity during childhood and adolescence is limited, particularly in non-Western populations. We examined the association between dietary GI and GL as well as dietary fiber intake and overweight status in Japanese children and adolescents. Subjects: This Japanese cross-sectional study included 15 974 children (6-11 years; 7956 boys and 8018 girls) and 8202 adolescents (12-15 years; 3944 boys and 4258 girls). Methods: Dietary intake was assessed using a self-administered diet history questionnaire for children and adolescents. Body mass index (BMI) was calculated from self-reported body weight and height. Overweight was defined according to the International Obesity Task Force age-and sex-specific BMI cutoffs, which correspond to an adult BMI of &gt;= 25 kgm(-2). Results: The overall prevalence of overweight was 13.2%. Mean (s.d.) dietary GI was 63.0 (3.1), mean dietary GL was 85.0 (12.4) per 4184 kJ (1000 kcal) and mean dietary fiber intake was 5.9 (1.2) g/4184 kJ. After adjustment for potential confounding factors, dietary GL was positively associated with the risk of overweight in male children, female children and male adolescents (P for trend &lt;0.0001, &lt;0.0001 and 0.006, respectively), but not in female adolescents. No such independent associations were observed for dietary GI or fiber intake. Conclusion: This large cross-sectional study in Japan suggests that higher dietary GL is associated with increasing risk of overweight in male and female children and male adolescents, but not female adolescents. International Journal of Obesity (2011) 35, 925-936; doi: 10.1038/ijo.2011.59; published online 29 March 2011

• この論文にアクセスする
  DOI

Sibling number and prevalence of allergic disorders in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC PUBLIC HEALTH ( BIOMED CENTRAL LTD )  11 ( 561 )   2011年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Although an inverse relationship between number of siblings and likelihood of allergic disorders has been shown in many epidemiological studies, the biological mechanism underlying this phenomenon has not yet been identified. There is no epidemiological research regarding the sibling effect on allergic disorders in Japanese adults. The current cross-sectional study examined the relationship between number of siblings and prevalence of allergic disorders among adult women in Japan. Methods: Subjects were 1745 pregnant women. This study was based on questionnaire data. The definitions of wheeze and asthma were based on criteria from the European Community Respiratory Health Survey whereas those of eczema and rhinoconjunctivitis were based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age, region of residence, pack-years of smoking, secondhand smoke exposure at home and at work, family history of asthma, atopic eczema, and allergic rhinitis, household income, and education. Results: The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the past 12 months were 10.4%, 5.5%, 13.0%, and 25.9%, respectively. A significant inverse exposure-response relationship was observed between the number of older siblings and rhinoconjunctivitis, but not wheeze, asthma, or eczema (P for trend = 0.03); however, the adjusted odds ratio (OR) for having 2 or more older siblings was not significant although the adjusted OR for having 1 older sibling was statistically significant (adjusted OR = 0.71 [95% CI: 0.56-0.91]). Number of total siblings and number of younger siblings were not related to wheeze, asthma, eczema, or rhinoconjunctivitis. Conclusions: This study found a significant inverse relationship between the number of older siblings and the prevalence of rhinoconjunctivitis among pregnant Japanese women. Our findings are likely to support the intrauterine programming hypothesis; however, we could not rule out the hygiene hypothesis.

• この論文にアクセスする
  DOI 学術リポジトリ

Polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in Japanese children: The Ryukyus Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Satoshi Sasaki, Masashi Arakawa

BMC PUBLIC HEALTH ( BIOMED CENTRAL LTD )  11 ( 358 )   2011年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: The recent increase in the prevalence of allergic disorders might be a consequence of increased intake of n-6 polyunsaturated fatty acids (PUFAs) and reduced intake of n-3 PUFAs. The current cross-sectional study examined the association between intake levels and the prevalence of eczema and rhinoconjunctivitis in Japanese children. Methods: Subjects were 23,388 schoolchildren aged 6-15 years residing in Okinawa. The presence of eczema and/or rhinoconjunctivitis was determined according to the criteria of the International Study of Asthma and Allergies in Childhood. A brief diet history questionnaire for children and adolescents was administered to acquire information on dietary factors. Adjustment was made for age, sex, residential municipality, number of siblings, smoking in the household, body mass index, paternal and maternal history of allergic diseases, and paternal and maternal educational level. Results: The prevalences of eczema and rhinoconjunctivitis in the previous 12 months were 7.0% and 8.0%, respectively. Consumption of PUFAs, n-3 PUFAs, alpha-linolenic acid, n-6 PUFAs, and linoleic acid was positively associated with the prevalence of eczema: the adjusted odds ratios (ORs) between extreme quintiles (95% confidence intervals [CIs], P for trend) were 1.26 (1.07-1.48, 0.04), 1.31 (1.11-1.54, 0.009), 1.31 (1.12-1.55, 0.003), 1.26 (1.07-1.48, 0.01), and 1.27 (1.08-1.49, 0.01), respectively. Arachidonic acid intake was independently inversely related to eczema: the adjusted OR between extreme quintiles was 0.81 (0.69-0.95, 0.0008). Eczema was not associated with eicosapentaenoic or docosahexaenoic acid intake, or with the ratio of n-3 to n-6 PUFA intake. Only arachidonic acid intake was statistically significantly related to the prevalence of rhinoconjunctivitis, showing a clear inverse linear trend: the adjusted OR between extreme quintiles was 0.86 (0.74-0.997, 0.03). Conclusions: Consumption of n-3 and n-6 PUFAs, especially alpha-linolenic acid and linoleic acid, may be positively associated with eczema. Arachidonic acid intake may be inversely related to eczema and rhinoconjunctivitis.

• この論文にアクセスする
  DOI 学術リポジトリ

Dietary Folate, Riboflavin, Vitamin B-6, and Vitamin B-12 and Depressive Symptoms in Early Adolescence: The Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

PSYCHOSOMATIC MEDICINE ( LIPPINCOTT WILLIAMS & WILKINS )  72 ( 8 ) 763 - 768   2010年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: To examine the association between dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in a group of adolescents. Methods: This cross-sectional study, conducted in all public junior high schools in Naha City and Nago City, Okinawa, Japan, included 3,067 boys and 3,450 girls aged 12 years to 15 years (52.3% of eligible sample). Dietary intake was assessed using a validated, self-administered diet history questionnaire. Depressive symptoms were defined as present when participants had a Center for Epidemiologic Studies Depression Scale score of &gt;= 16. Results: The prevalence of depressive symptoms was 22.5% for boys and 31.2% for girls. Folate intake was inversely associated with depressive symptoms in both boys (adjusted odds ratio (OR) [95% confidence interval (CI)] in the highest (compared with the lowest) quintile, 0.60 [0.45, 0.79]; p for trend = .002) and girls (OR [95% CI], 0.61 [0.48, 0.77]; p for trend = &lt;.001). Vitamin B-6 intake was inversely associated with depressive symptoms in both boys (OR [95% Cl], 0.73 [0.54, 0.98]; p for trend = .02) and girls (OR [95% Cl], 0.72 [0.56, 0.92]; p for trend = .002). Riboflavin intake was inversely associated with depressive symptoms in girls (OR [95% Cl], 0.85 [0.67, 1.08]; p for trend = .03), but not in boys. No clear association was seen between vitamin B-12 intake and depressive symptoms in either sex. Conclusions: This study suggests that higher intake of dietary B vitamins, particularly folate and vitamin B-6, is independently associated with a lower prevalence of depressive symptoms in early adolescence.

• この論文にアクセスする
  DOI

Fish and n-3 Polyunsaturated Fatty Acid Intake and Depressive Symptoms: Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

PEDIATRICS ( AMER ACAD PEDIATRICS )  126 ( 3 ) E623 - E630   2010年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Epidemiologic evidence on the role of fish and long-chain n-3 polyunsaturated fatty acid intake on depression during adolescence is sparse. OBJECTIVE: We examined the association between fish, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) intake and depressive symptoms in a group of adolescents. SUBJECTS AND METHOD: This cross-sectional study, conducted in all public junior high schools in Naha City and Nago City, Okinawa, Japan, included 3067 boys and 3450 girls aged 12 to 15 years (52.3% of the eligible sample). Dietary intake was assessed by using a validated, self-administered diet-history questionnaire. Depressive symptoms were defined as present when participants had a Center for Epidemiologic Studies Depression scale score of &gt;= 16. RESULTS: The prevalence of depressive symptoms was 22.5% for boys and 31.2% for girls. For boys, fish intake was inversely associated with depressive symptoms (adjusted odds ratio [OR] for depressive symptoms in the highest [compared with the lowest] quintile of intake: 0.73 [95% confidence interval (CI): 0.55-0.97]; P for trend = .04). EPA intake showed an inverse association with depressive symptoms (OR: 0.71 [95% CI: 0.54-0.94]; P = .04). DHA intake also showed a similar inverse, albeit nonsignificant, association (OR: 0.79 [95% CI: 0.59-1.05]; P = .11). In addition, intake of EPA plus DHA was inversely associated with depressive symptoms (OR: 0.72 [95% CI: 0.55-0.96]; P = .08). Conversely, no such associations were observed among girls. CONCLUSIONS: Higher intake of fish, EPA, and DHA was independently associated with a lower prevalence of depressive symptoms in early male, but not female, adolescents. Pediatrics 2010;126:e623-e630

• この論文にアクセスする
  DOI

Household smoking and dental caries in schoolchildren: the Ryukyus Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa, Satoshi Sasaki, Yukihiro Ohya

BMC PUBLIC HEALTH ( BIOMED CENTRAL LTD )  10 ( 10 ) 335 - 344   2010年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Secondhand smoke exposure (SHSe) is perhaps one of the most important toxic exposures in childhood. However, epidemiological studies on the relation between SHSe and dental caries are limited and have yielded inconsistent results. The present cross-sectional study examined the potential association between SHSe at home and the prevalence of dental caries in children. Methods: Subjects were 20,703 schoolchildren aged 6 to 15 years in Okinawa, Japan. Information on SHSe at home and potential confounding factors was obtained through questionnaires. Data on dental caries were obtained from school records. Children were classified as having decayed and/or filled teeth (DFT) if a dentist diagnosed these conditions. Additionally, we analyzed decayed teeth (DT) and filled teeth (FT) separately. Adjustment was made for sex, age, region of residence, toothbrushing frequency, use of fluoride, sugar intake, and paternal and maternal educational level. Results: The prevalence of DFT was 82.0%. Compared with never smoking in the household, former and current household smoking were independently associated with an increased prevalence of DFT (adjusted prevalence ratios [95% confidence intervals] for former household smoking and current light and heavy household smoking were 1.03 [1.00-1.05], 1.04 [1.02-1.05], and 1.04 [1.03-1.06], respectively); when analyzed separately there was an increased prevalence of DT (adjusted prevalence ratios [95% confidence intervals] for former household smoking and current light and heavy household smoking were 1.06 [1.02-1.11], 1.10 [1.06-1.13], and 1.10 [1.07-1.14], respectively) but not FT. A statistically significant dose-response relationship between cumulative smoking in the household and the prevalence of DFT and DT (P for trend &lt; 0.0001), but not FT, was observed. In an analysis of 2 subgroups, subjects who had at least 1 deciduous tooth and subjects who had at least 1 permanent tooth, household smoking exposure was associated with an increased prevalence of DFT and DT not only in those with deciduous but also those with permanent dentition. Conclusion: Our findings suggested that household smoking might be associated with an increased prevalence of dental caries in children.

• この論文にアクセスする
  DOI 学術リポジトリ

スパセラピーのエビデンス －ヘルスツーリズム振興に向けた学術基盤整備－

荒川 雅志, Arakawa Masashi

琉球大学観光科学 = Journal of tourism sciences, University of the Ryukyus ( 琉球大学観光産業科学部観光科学科 )  2 ( 2 ) 47 - 62   2010年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Spa therapy is one of the most commonly used non-pharmacological approaches for health or medical tourism, but its health effects are not completely known. From the point of view in construction of knowledge in the field of health tourism, author constructed the evidence-table of spa therapy. The procedure of selection of the spa therapy is as follows; excluded "Not humans" (n=445), "Not English or Japanese" (n=456), "Not Randomized Controlled Trial" (n=897), "Not spa therapy or balneotherapy" (n=61). Finally, 41 interventional studies were extracted from approximately 20 million papers. Furthermore, we conducted spa intervention study in Okinawa. The participants (22 women, 42.6 +/- 8.2 years) were randomly assigned into two groups, an intervention group receiving spa therapy tour in Okinawa, and a control group carrying out normal daily life in study period. This study observed a significant improvement of evaluated sleep parameters at the end of spa therapy tour in Okinawa. This is the first epidemiological study to estimate the spa health evidence and its effects among health tourism in Japan

Sibship size and prevalence of allergic disorders in Japan: The Ryukyus Child Health Study

Satoko Ohfuji, Yoshihiro Miyake, Masashi Arakawa, Keiko Tanaka, Satoshi Sasaki

PEDIATRIC ALLERGY AND IMMUNOLOGY ( WILEY-BLACKWELL PUBLISHING, INC )  20 ( 4 ) 377 - 384   2009年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

A number of epidemiological studies have reported an inverse association between increasing sibship size and allergic disorders. The present cross-sectional study assessed the association between the number of siblings and the prevalence of allergic disorders during the past 12 months in Japanese schoolchildren. Study subjects were 22,750 children aged 6-15 yr in Okinawa. The outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age, gender, maternal age at childbirth, duration of breastfeeding, region of residence, smoking in the household, paternal and maternal history of asthma, atopic eczema, and allergic rhinitis, and paternal and maternal educational level. Significant exposure-response associations were observed between increasing total sibship size and all outcomes under investigation. Having two or more older siblings was significantly inversely related to the prevalence of atopic eczema and allergic rhinoconjunctivitis, but not wheeze or asthma. Having two or more younger siblings was independently associated with a decreased prevalence of atopic eczema, but not wheeze, asthma, or allergic rhinoconjunctivitis. The inverse relationships between sibship size and the prevalence of allergic disorders under study were weakened with advancing age, although the interactions between age groups were not statistically significant. No significant interactions were found in the association of having three or more siblings with allergic disorders between children with a positive or negative parental allergic history. These results are likely to support the in utero programming hypothesis because it is probable that the in utero environment would change with parity, although our observations could not refute the hygiene hypothesis.

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

沖縄観光の展望―健康保養型観光を目指した我々の取り組み事例から―

平良一彦, 荒川雅志

観光科学 ( その他の出版社 )  1   137 - 149   2009年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

海水フローティングの心身のリラクセーション効果に関する無作為割付比較試験

本村 純, 荒川 雅志, 豊里 竹彦, 與古田 孝夫

心身医学 ( 一般社団法人 日本心身医学会 )  49 ( 10 ) 1101 - 1109   2009年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

海洋療法は主に海水の浮力抵抗,粘性や成分特性,海にまつわる素材を生かした施術により治療効果やリラクセーションを図る代替療法であるが,その科学的根拠は十分ではない.本研究では,海水を用いたリラクセーションプログラムの1つであるフローティングの効果について,心臓自律神経系活動,精神特異的ストレスマーカー唾液中クロモグラニンA(CgA),心理的評価STAIを用い無作為割付クロスオーバー比較試験を採用して検討した.その結果,海水フローティング群のみにセッション終了後CgAは有意に減少し,STAIによる状態不安得点では両群ともに有意な減少が認められ,介入後の群間比較では海水フローティング群により大きな減少が認められた.一方,得られたリラクセーション効果が海水特性によるものかは本研究では明らかにされず,今後さらなる検討が必要と考えられた.

• この論文にアクセスする
  DOI

Fatty acid intake and asthma symptoms in Japanese children: The Ryukyus Child Health Study

Y. Miyake, S. Sasaki, M. Arakawa, K. Tanaka, K. Murakami, Y. Ohya

CLINICAL AND EXPERIMENTAL ALLERGY ( WILEY-BLACKWELL )  38 ( 10 ) 1644 - 1650   2008年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background It has been hypothesized that increased consumption of n-6 polyunsaturated fatty acids and decreased consumption of n-3 polyunsaturated fatty acids have contributed to the recent increased prevalence of asthma. Objectives The present cross-sectional study examined the association of intake of specific types of fatty acids with the prevalence of asthma symptoms using data from the Ryukyus Child Health Study. Methods Study subjects were 25033 schoolchildren aged 6-15 years in Okinawa, Japan. Symptoms of wheeze and asthma were defined according to diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Information on dietary factors was collected using a self-administered brief diet history questionnaire for children. Adjustment was made for age, sex, number of siblings, smoking in the household, body mass index, paternal and maternal history of allergic diseases, and paternal and maternal educational level. Results Intake of polyunsaturated fatty acids, n-3 and n-6 polyunsaturated fatty acids and linoleic acid (18 : 2 n-6) was independently associated with an increased prevalence of wheeze - the multivariate odds ratios for the highest quintile were 1.19 (95% confidence interval [CI], 1.05-1.35), 1.17 (95% CI, 1.03-1.34), 1.19 (95% CI, 1.04-1.35), and 1.20 (95% CI, 1.06-1.37), respectively. There was no measurable relationship of consumption of alpha-linolenic (18 : 3 n-3), eicosapentaenoic (20 : 5 n-3), docosahexaenoic (22 : 6 n-3) or arachidonic acid (20 : 4 n-6) or the ratio of n-3 to n-6 polyunsaturated fatty acids with the prevalence of wheeze. Consumption of total fat, saturated fatty acids, monounsaturated fatty acids and cholesterol were not evidently related to wheeze. No material dose-response association was found between the intake of any of the types of fatty acids considered and the prevalence of asthma. Conclusions The findings suggest that consumption of both n-3 and n-6 polyunsaturated fatty acids, especially linoleic acid, may be associated with an increased prevalence of wheeze.

• この論文にアクセスする
  DOI

Tuberculin reactivity and allergic disorders in schoolchildren, Okinawa, Japan

Y. Miyake, M. Arakawa, K. Tanaka, S. Sasaki, Y. Ohya

CLINICAL AND EXPERIMENTAL ALLERGY ( BLACKWELL PUBLISHING )  38 ( 3 ) 486 - 492   2008年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background Bacillus Calmette-Guerin (BCG) vaccination triggers a T-helper type 1 response. Whether BCG vaccination and positive tuberculin reactivity are preventive against allergic disorders remains controversial. Objective The current cross-sectional study investigated the relationship of BCG vaccination and tuberculin reactivity with the prevalence of allergic disorders using data from the Ryukyus Child Health Study (RYUCHS). Methods Subjects were 5717 schoolchildren aged 8-11 years in Okinawa, Japan. The RYUCHS collected information on symptoms of allergic disorders and potential confounding factors. The outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Data on BCG vaccination and tuberculin tests were obtained from school records. Allowance was made for grade, sex, sibship size, smoking in the household, paternal and maternal history of asthma, atopic eczema, and allergic rhinitis, and paternal and maternal educational level. Results No measurable relationship was found between BCG vaccination in infants and the prevalence of allergic disorders. Among 5567 BCG-vaccinated children, positive tuberculin reactivity (induration &gt;= 10 mm) in the first grade was independently associated with a decreased prevalence of wheeze, asthma, and atopic eczema: the multivariate odds ratios for wheeze, asthma, and atopic eczema were 0.80 (95% confidence interval [CI], 0.67-0.94), 0.78 (95% CI, 0.64-0.95), and 0.77 (95% CI, 0.62-0.95), respectively. The inverse associations were more pronounced in children with a negative parental allergic history than in those with a positive parental allergic history. There was no significant relationship between tuberculin reactivity and allergic rhinoconjunctivitis. Conclusions The findings suggest that positive tuberculin reactivity may be inversely associated with the prevalence of wheeze, asthma, and atopic eczema, but not allergic rhinoconjunctivitis, especially among Japanese children without a parental allergic history.

• この論文にアクセスする
  DOI

Correlation between eating habit and the bone mineral density of the children in Yanji City.

Xu Xian-ji, Han Chun-ji, Xu Song-ji, Arakawa M

Chinese Journal of Health Statistics ( その他の出版社 )  25 ( 1 ) 44 - 45   2008年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Dental Caries and Allergic Disorders in Japanese Children: The Ryukyus Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa, Satoshi Sasaki, Yukihiro Ohya

JOURNAL OF ASTHMA ( INFORMA HEALTHCARE )  45 ( 9 ) 795 - 799   2008年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background. Dental caries is an infectious disease and is highly prevalent among children. In the etiology of allergic diseases, the hygiene hypothesis contends that infections might confer protection against the development of allergic diseases. The aim of this cross-sectional study was to investigate the association between dental caries and the prevalence of allergic disorders. Methods. Study subjects were 21,792 children 6 to 15 years of age in Okinawa, Japan. Outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Data on dental caries were obtained from school records. Children were classified as having dental caries if one or more teeth had decayed and/or had been filled. Adjustment was made for sex, age, region of residence, number of siblings, smoking in the household, paternal and maternal history of asthma, atopic eczema, or allergic rhinitis, and paternal and maternal educational level. Results. The prevalence of wheeze, asthma, atopic eczema, and allergic rhinoconjunctivitis in the previous 12 months was 10.8%, 7.6%, 6.8%, and 7.6%, respectively. In an overall analysis, no measurable relationship was found between dental caries and the prevalence of wheeze, asthma, atopic eczema, or allergic rhinoconjunctivitis. However, dental caries was significantly inversely associated with the prevalence of allergic rhinoconjunctivitis only among children with a positive parental allergic history: The adjusted odds ratio was 0.84 (95% confidence interval: 0.72, 0.99). Conclusions. The present findings do not support the hypothesis that dental caries was protective against allergic diseases. However, a parental allergic history may affect the association between dental caries and allergic rhinoconjunctivitis.

• この論文にアクセスする
  DOI

Effects of Floating in Seawater on Stress Reduction.

J MOTOMURA, M ARAKAWA, T YOKOTA

The 39th Conference of the Asia-Pacific Academic Consortium for Public Health, Japan ( その他の出版社 )    2007年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Randomized Controlled Crossover Trial(RCT) of Relaxative Effect in Seawater Floating on Human Physiological Responses.

Arakawa M, Motomura J, Yokota T

The8th International Congress of Physiological Anthropology(ICPA) ( その他の出版社 )    308   2007年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Prevalence of asthma and wheeze in relation to passive smoking in Japanese children

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa, Satoshi Sasaki, Yukihiro Ohya

ANNALS OF EPIDEMIOLOGY ( ELSEVIER SCIENCE INC )  17 ( 12 ) 1004 - 1010   2007年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: Evidence remains inconclusive as to whether environmental tobacco smoke is a risk factor for allergic disorders in childhood. The present large-scale cross-sectional study examined the relationship between passive smoking at home and the prevalence of allergic disorders in Japanese schoolchildren. METHODS: Study subjects were 23,044 children aged 6 to 15 years in Okinawa, Outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for sex, age, region of residence, number of siblings, paternal and maternal history of asthma, atopic eczema, or allergic rhinitis, as well as paternal and maternal educational level. RESULTS: The prevalence of wheeze, asthma, atopic eczema, and allergic rhinoconjunctivitis in the previous 12 months was 10.7%, 7.6%, 6.8%, and 7.7%, respectively. Current heavy passive smoking and 7.0 or more pack-years of smoking in the household were independently related to an increased prevalence of wheeze and asthma, especially in children 6 to 10 years of age and children with a positive parental allergic history. There was no dose-response relationship between pack-years of smoking in the household and atopic eczema or allergic rhinoconjunctivitis. CONCLUSIONS: Our findings suggested that environmental tobacco smoke might be associated with an increased prevalence of wheeze and asthma in Japanese children.

• この論文にアクセスする
  DOI

Cross-sectional study of allergic disorders associated with breastfeeding in Japan: The Ryukyus Child Health Study

Yoshihiro Miyake, Masashi Arakawa, Keiko Tanaka, Satoshi Sasaki, Yukihiro Ohya

PEDIATRIC ALLERGY AND IMMUNOLOGY ( BLACKWELL PUBLISHING )  18 ( 5 ) 433 - 440   2007年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Uncertainties remain as to whether breastfeeding is protective against childhood allergic disorders. Positive relationships of breastfeeding with asthma and atopic eczema were observed in two previous Japanese studies. This cross-sectional study investigated the association between the feeding pattern after birth and the prevalence of allergic disorders during the past 12 months in Japanese schoolchildren. Study subjects were 24,077 children aged 6-15 yr in Okinawa. The outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. Allowance was made for age, sex, number of siblings, smoking in the household, paternal and maternal history of asthma, atopic eczema, and allergic rhinitis, and paternal and maternal educational level. Breastfeeding, regardless of exclusivity, for 13 months or longer and exclusive breastfeeding for 4-11 months were independently associated with a higher prevalence of atopic eczema, particularly among children without a parental allergic history. A clear positive dose-response relationship was observed between prolonged duration of breastfeeding, regardless of exclusivity, but not exclusive breastfeeding, and the prevalence of atopic eczema. We found a significant positive trend for atopic eczema across the three categories (formula milk, partial and exclusive breastfeeding) in the first 4 months of life although the odds ratio for exclusive breastfeeding was not statistically significant. No material association was found between the feeding pattern after birth and the prevalence of wheeze or allergic rhinoconjunctivitis. Prolonged breastfeeding may be associated with a higher prevalence of atopic eczema in Japanese children.

• この論文にアクセスする
  DOI

沖縄における新百歳長寿者の生活及び健康

平良一彦, 荒川雅志

琉球大学アジア太平洋島嶼研究センター報 ( その他の出版社 )    65 - 113   2007年03月

掲載種別: 研究論文（大学，研究機関紀要）

沖縄型健康保養観光の展望 : 健康科学と観光の融合を目指す当分野の先行的研究事例

平良 一彦, 荒川 雅志, 笠原 大吾, Taira Kazuhiko, Arakawa Masashi, Kasahara Daigo

琉球大学観光科学 = Journal of tourism sciences. University of the Ryukyus ( 琉球大学法文学部 )  ( 1 ) 137 - 149   2007年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

When Okinawa tourism is in the process of quantitative and qualitative change, it is now strongly expected to utilize healthy resources of "Longevity Prefecture Okinawa" and establish unique tourism for health and recuperation. Now we are scientifically evaluating subjective and objective effects using keywords such as "natural environment of Okinawa," "Spiritual climate," "healing," "health of mind and body" and "food," and trying to contribute to development of health and recuperation tourism program and business in Okinawa. We use intellectual resources of the University of Ryukyus and develop the tourism program in collaboration with private sectors. We also conduct basic experiments on use of marine resources of Okinawa for spa. Spa and esthetic technology and branding will greatly influence the future stay-type tourism. One of our goals is to increase the level of the spa and esthetic technology and branding. We are making our efforts to achieve the goal and constantly getting results. This paper will show some of our achievements.

地域在宅高齢者における日常生活体力の実態

平良 一彦, 荒川 雅志, 笠原 大吾, 嘉手苅 初子, 新城 澄枝, 東盛 キヨ子, 大塚 千絵, 渡部 善喜, Taira Kazuhiko, Arakawa Masashi, Kasahara Daigo, Kadekaru Hatuko, Shinjo Sumie, Higashimori Kiyoko, Otuka Chie, Watanabe Zenki

琉球大学教育学部紀要 ( 琉球大学教育学部 )  67   231 - 241   2005年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

To examine levels of functional fitness of elderly people living at home, a cross-sectional survey was conducted targeting 385 persons, who were 65 years old and over.The functional fitness for daily life was measured by the following 4 tests: standing test, walking test, hand performance test and self-care performance test. Results of standing and walking tests showed that males stand up and walk significantly faster than females. With advancing age their performance for all 4 tests got slower, and there was statistically significant difference between the young-old age group and the old-old age group.The results suggest that the aging strongly affects levels of functional fitness of elderly people living at home.

• この論文にアクセスする
  学術リポジトリ

Hypertension and stroke in centenarians, Okinawa, Japan

M Arakawa, Y Miyake, K Taira

CEREBROVASCULAR DISEASES ( KARGER )  20 ( 4 ) 233 - 238   2005年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objective: To investigate the relationship between a history of hypertension, cigarette smoking and alcohol intake and the lifetime prevalence of stroke in the oldest-old population. Design: A cross-sectional study. Subjects: All of the Japanese centenarians in the Okinawa Prefecture (266 men and 1,378 women). Methods: Okinawa Prefectural Government conducted health surveys among all of the centenarians in Okinawa. The variables used for analysis were sex, history of stroke, age at the first diagnosis of stroke, history of hypertension, cigarette smoking and alcohol intake. We used multiple logistic regression analysis taking the history of stroke as the dependent variable. Results: The lifetime prevalence value for stroke was 11.0% in Japanese centenarians. Hypertension was independently associated with an increased lifetime prevalence of stroke (adjusted odds ratio=2.97 and 95% confidence interval: 2.16-4.08). There was no material relationship between sex, cigarette smoking, or alcohol intake and the prevalence of stroke. When the lifetime prevalence of stroke was divided according to whether stroke had been diagnosed for the first time at the age of 90 years or less or over the age of 90, a significant positive association between hypertension and stroke was more pronounced in centenarians with a diagnosis of stroke at the age of 90 years or less than in those over the age of 90. Conclusions: The findings suggest that hypertension may increase the likelihood of stroke in Japanese centenarians in Okinawa although the association between hypertension and stroke was more pronounced in those having stroke at 90 years or younger. Copyright (C) 2005 S. Karger AG, Basel.

• この論文にアクセスする
  DOI

ストレッチング,レジスタンス運動を中心とした高齢者向け体操プログラムの開発とその評価

荒川 雅志, 平良 一彦, 田中 秀樹

保健の科学 ( 杏林書院 )  46 ( 10 ) 769 - 774   2004年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

ストレッチングを中心にレジスタンス運動を取り入れた高齢者向けの体操プログラムを開発し,地域の高齢者20名(うち,女性15名.平均年齢72.6±3.6歳)を対象にその効果と安全性を検討した.心拍計・心電図装着による運動強度の測定から,高齢者でも安全に実施できるプログラムであることが確認できた.また,体力検査の結果から,柔軟性や下肢筋力に有意な改善が認められ,転倒リスクを軽減する可能性が示唆された

地域高齢者の睡眠健康とPsychological Distress(PD)との関連

荒川 雅志, 田中 秀樹, 平良 一彦

医学と生物学 ( 緒方医学化学研究所医学生物学速報会 )  148 ( 7 ) 8 - 11   2004年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

高齢者における睡眠健康と情緒的適応度との関連--長寿県沖縄の長寿村、大宜味村における睡眠健康調査

平良 一彦, 荒川 雅志, 田中 秀樹, Taira Kazuhiko, Arakawa Masashi, Tanaka Hideki

琉球大学教育学部紀要 ( 琉球大学教育学部 )  63   257 - 261   2003年09月 [ 査読有り ]

掲載種別: 研究論文（大学，研究機関紀要）

　概要を見る

We used standardized questionnaire on sleep-health and lifestyle, and conducted a research on sleep of the elderly of Ogimi Village in Okinawa, the Prefecture of Longevity.We evaluated the total score of five sleep factors, or "sleep-health risk index," to ascertain general sleep-health. According to the sleep-health index, we ranked elderly Ogimi villagers who were subject to the research, and grouped them into a "good sleep-health group" and a "poor sleep-health group." Compared to the poor sleep-health group, Morale Score of the good sleep-health group were significantly higher, showing their higher level of emotional adaptability. Results of our research indicates that their sleep-health greatly affects their Morale, that is, the sleep-health affects the mental health.

高齢者における昼寝と運動による睡眠の質と精神衛生の改善(Short naps and exercise improve sleep quality and mental health in the elderly)

Tanaka Hideki, Taira Kazuhiko, Arakawa Masashi, Urasaki Chisae, Yamamoto Yukari, Okuma Hiromi, Uezu Eiko, Sugita Yoshiro, Shirakawa Shuichiro

Psychiatry and Clinical Neurosciences ( John Wiley & Sons Australia, Ltd )  56 ( 3 ) 233 - 234   2002年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

高齢者11名(73.8±5.4歳)を対象として,昼食後に昼寝と夕方に中等度の運動を4週間施行させた.その結果,夜間睡眠時の覚醒時間が有意に減少し,睡眠効率の有意な増加が認められ,睡眠の質が向上した.又,午後の居眠りの頻度が有意に減少した.以上の結果より,午後の適切な覚醒状態の維持は,夜間睡眠の質の改善に有効であると考えられた.又,昼寝と運動負荷により,精神的健康及び意欲,身体的健康も睡眠の質向上に伴い改善した

• この論文にアクセスする
  DOI

中学生における睡眠衛生,ライフスタイル及び精神衛生の調査(An examination of sleep health, lifestyle and mental health in junior high school students)

Tanaka Hideki, Taira Kazuhiko, Arakawa Masashi, Masuda Atushi, Yamamoto Yukari, Komoda Yoko, Kadegaru Hathuko, Shirakawa Shuichiro

Psychiatry and Clinical Neurosciences ( John Wiley & Sons Australia, Ltd )  56 ( 3 ) 235 - 236   2002年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

中学生805名を対象として質問紙調査を行い,睡眠衛生及び精神衛生に影響を及ぼすライフスタイル因子について検討した.午前中に気分が悪い,又は朝食を欠食すると回答した中学生では,睡眠状態が有意に不良であった.規則的に運動を行っているものでは,睡眠不足の割合が有意に低かった.睡眠良好群と睡眠不足群を比較した場合,睡眠不足群では疾患数が多く,更に一般健康質問票のスコアが不良であった.以上の結果より,睡眠衛生は身体及び精神衛生の療法に密接に関連し,運動習慣や規則正しい睡眠,食事習慣は睡眠健康の維持・改善に重要であることが示唆された

• この論文にアクセスする
  DOI

沖縄の都市域と郊外における高齢者の睡眠健康及びライフスタイルに関する比較研究(Comparative study on sleep health and lifestyle of the elderly in the urban areas and suburbs of Okinawa)

Arakawa Masashi, Tanaka Hideki, Toguchi Hiroki, Shirakawa Shuichiro, Taira Kazuhiko

Psychiatry and Clinical Neurosciences ( John Wiley & Sons Australia, Ltd )  56 ( 3 ) 245 - 246   2002年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

長寿県である沖縄県の郊外に居住する高齢者は,都市部高齢者に比較して,睡眠健康及び日常生活動作(ADL)が有意に良好であった.都市部高齢者では睡眠に関する愁訴が多く,入眠時間が有意に遅く,夜型のライフスタイルが睡眠衛生の悪化に関連することが示唆された.郊外居住高齢者では,多数のものが規則的に昼寝を取っており,午後に運動を行っていた.短時間の昼寝や午後の適切な運動等の生活習慣は良好な睡眠に関連しており,更に睡眠衛生は高齢者のADLに関連することが示唆された

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

長寿の村,大宜味における高齢者の睡眠衛生とライフスタイル(Sleep health and lifestyle of elderly people in Ogimi, a village of longevity)

Taira Kazuhiko, Tanaka Hideki, Arakawa Masashi, Nagahama Naoki, Uza Miyoko, Shirakawa Shuichiro

Psychiatry and Clinical Neurosciences ( John Wiley & Sons Australia, Ltd )  56 ( 3 ) 243 - 244   2002年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

長寿県である沖縄県の大宜味村に居住する高齢者を対象として,睡眠衛生に関連したライフスタイルについて解析した.睡眠衛生が良好な群では昼寝の習慣があり,居眠りする者が有意に少なく,更に多くの者が規則的な運動或いは歩行を行っていた.又,睡眠衛生良好群では,多くの者が規則正しい食習慣を有しており,海藻や魚類の摂取が多かった.老人クラブへの参加も高く,高い感情的適応能力を反映していた.以上より,高齢者におけるライフスタイルと睡眠衛生との関連が示唆され,睡眠衛生の悪化は身体及び精神衛生に関連するものと考えられた

• この論文にアクセスする
  DOI

中学生の睡眠・生活習慣と夜型化の影響 : 沖縄県の中学生3,754名における実態調査結果

荒川 雅志, 田中 秀樹, 白川 修一郎, 嘉手苅 初子, 平良 一彦

学校保健研究 ( 学術雑誌目次速報データベース由来 )  43 ( 5 ) 388 - 398   2001年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

沖縄の中学生を対象とした睡眠・生活習慣の調査を行い,睡眠習慣と朝食欠食,生徒の日中の眠気や授業中の居眠りとの関連を中心に,夜型化の影響について検討した.朝食を欠食する生徒や,睡眠不足,睡眠時間の不規則,授業中の居眠りをする生徒は,高学年に有意に多かった.学年を追う毎に就床時刻,起床時刻の有意な遅延,睡眠時間の有意な短縮がみられた.睡眠不足,睡眠時間の不規則な生徒,授業中に居眠りをする生徒は2年生で増加し,朝食を欠食する生徒は3年生で顕著な増加を示すことが明らかとなった.生活の夜型化している群,就床遅延群では,朝食欠食の割合が非遅延群の2倍以上と,顕著な差であることが判明した

Junior High School Students’ Sleep Habit and Lifestyle.

Arakawa M, Tanaka H, Shirakawa S

Jpn J school Health suppl ( その他の出版社 )  42 ( Suppl. ) 26 - 27   2001年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

A survey of junior high school students’ sleep habit and lifestyle in Okinawa.

Arakawa M, Taira K, Tanaka H

Psychiatry Clin. Neurosci ( その他の出版社 )  55 ( 3 ) 211 - 212   2001年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

沖縄の14中学校の生徒3714名について,睡眠や生活様式について検討した.高学年になるにつれ,就床が遅くなり,青春期,後期青春期には睡眠不足,目覚め悪く,朝食を取らないなど,睡眠の乱れ,食習慣の乱れ,疲労感,教室での眠気を引き起こすこと等が認められた

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

睡眠障害の高齢者における短時間昼寝と運動の影響(Effects of short nap and exercise on elderly people having difficulty in sleeping)

Tanaka Hideki, Taira Kazuhiko, Arakawa Masashi, Toguti Hiroki, Urasaki Chisae, Yamamoto Yukari, Uezu Eiko, Hori Tadao, Shirakawa Shuichiro

Psychiatry and Clinical Neurosciences ( John Wiley & Sons Australia, Ltd )  55 ( 3 ) 173 - 174   2001年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

睡眠障害の高齢者の睡眠の質に対する昼寝と運動の影響を,昼食後の短時間昼寝と夕方の適度運動を4週間続けて検討した.その結果,入眠後の覚醒時間が減少し,夕方の居眠りも減少した.これは夕方の覚醒を保ったことが睡眠効率を上昇させ,睡眠の質を改良することを示した

• この論文にアクセスする
  DOI
• 関連情報を調べる
  PubMed

研究報告 思春期における心身の健康保全に係わる適正な睡眠確保の為の生活習慣についての検討

田中 秀樹, 平良 一彦, 荒川 雅志

学校メンタルヘルス ( 日本学校メンタルヘルス学会 )  3   57 - 62   2000年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

不眠高齢者に対する短時間昼寝・軽運動による生活指導介入の試み

田中 秀樹, 平良 一彦, 荒川 雅志

老年精神医学雑誌 ( ワ-ルドプランニング )  11 ( 10 ) 1139 - 1147   2000年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

睡眠健康危険度得点の信頼性を確認するために,睡眠健康危険度得点により睡眠健康良好群および非良好群に分類された高齢者各9人の夜間睡眠状態を活動量測定により比較検討した.その結果,非良好群は睡眠健康良好群に比べて中途覚醒が多く,睡眠効率の有意な低下や睡眠の質の悪化も判明し,睡眠健康危険度得点の信頼性が実証された.非良好群高齢者6人に,昼食後30分間の昼寝と夕方30分間の軽運動指導を4週間介入的に行い,睡眠健康の改善効果を検討した.その結果,中途覚醒の有意な減少や睡眠効率の有意な増加を認め,夜間睡眠の改善に伴い,精神健康も改善した.不眠高齢者に対する短時間昼寝と軽運動による介入の,現場応用への有効性が示唆された

Survey of sleep-health and lifestyle of the elderly in Okinawa

E Uezu, K Taira, H Tanaka, M Arakawa, C Urasakii, H Toguchi, Y Yamamoto, E Hamakawa, S Shirakawa

PSYCHIATRY AND CLINICAL NEUROSCIENCES ( BLACKWELL SCIENCE ASIA )  54 ( 3 ) 311 - 313   2000年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

A total of 788 people (aged from 60 to 93 years) living in the Okinawa prefecture, renowned for the long life expectancy of its citizens, were randomly chosen as subjects. A questionnaire based on lifestyle and sleep-health was distributed. Following this, subjects were chosen in groups of nine from the good sleep-health group and then from. the poor sleep-health group based on the results of the survey; their physical activities were then recorded using actigraphs for 1 week. This study suggested that lifestyle, such as exercise, walking and short naps, occupies an important position in the maintenance and improvement of sleep-health. It also verified the reliability of the sleep-health risk index and the questionnaire.

• この論文にアクセスする
  DOI

沖縄県の中学生における夏休み中の睡眠習慣--生涯健康の観点からの検討

田中 秀樹, 平良 一彦, 荒川 雅志

精神保健研究 ( 国立精神・神経センタ-精神保健研究所 )  13 ( 13 ) 65 - 71   2000年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）