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• RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product

  Kathryn K. Crone, Takahiro Jomori, Fredarla S. Miller, Jeffrey Gralnick, Mikael Elias, Michael Freeman.

  RSC Chemical Biology ( The Royal Society of Chemistry )  4   804 - 816   2023年08月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

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    DOI

• Membrane-Vesicle-Mediated Interbacterial Communication Activates Silent Secondary Metabolite Production

  Aya Yoshimura, Rio Saeki, Ryusuke Nakada, Shota Tomimoto, Takahiro Jomori, Keisuke Suganuma, Toshiyuki Wakimoto

  Angewandte Chemie-International Edition ( ドイツ化学会 )    e202307304   2023年07月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

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    DOI

• Amitorin, a Cytotoxic Diterpenoid from a Sponge Halichondria sp.

  Wauke T.

  Chemistry Letters ( 公益社団法人 日本化学会 )  51 ( 11 ) 1080 - 1082   2022年11月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  <p>A new diterpenoid endoperoxide showing cytotoxicity named amitorin (<b>1</b>) was isolated from an extract of a sponge <i>Halichondria</i> sp. Its structure along with relative stereochemistry was elucidated with spectral analysis and calculation studies. The structure and cytotoxicity (IC₅₀ 2.3 µM against NBT-II cells) of the molecule are described herein.</p>

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    CiNii Research

• Insights into phosphatase-activated chemical defense in a marine sponge holobiont

  Takahiro Jomori, Kenichi Matsuda, Yoko Egami, Ikuro Abe, Akira Takai, Toshiyuki Wakimoto

  RSC CHEMICAL BIOLOGY ( ROYAL SOC CHEMISTRY )  2 ( 6 ) 1600 - 1607   2021年12月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  Marine sponges often contain potent cytotoxic compounds, which in turn evokes the principle question of how marine sponges avoid self-toxicity. In a marine sponge Discodermia calyx, the highly toxic calyculin A is detoxified by the phosphorylation, which is catalyzed by the phosphotransferase CalQ of a producer symbiont, "Candidatus Entotheonella" sp. Here we show the activating mechanism to dephosphorylate the stored phosphocalyculin A protoxin. The phosphatase specific to phosphocalyculin A is CalL, which is also encoded in the calyculin biosynthetic gene cluster. CalL represents a new clade and unprecedently coordinates the heteronuclear metals Cu and Zn. CalL is localized in the periplasmic space of the sponge symbiont, where it is ready for the on-demand production of calyculin A in response to sponge tissue disruption.

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    PubMed

• Geographical parthenogenesis in the brown alga Scytosiphon lomentaria (Scytosiphonaceae): Sexuals in warm waters and parthenogens in cold waters

  Masakazu Hoshino, Shimpei F. Hiruta, Maria Emilia Croce, Mitsunobu Kamiya, Takahiro Jomori, Toshiyuki Wakimoto, Kazuhiro Kogame

  MOLECULAR ECOLOGY ( WILEY )  30 ( 22 ) 5814 - 5830   2021年11月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  Geographical parthenogenesis, a phenomenon where parthenogens and their close sexual relatives inhabit distinct geographical areas, has been considered an interesting topic in evolutionary biology. Reports of geographical parthenogenesis from land and freshwater are numerous, but this occurrence has been rarely reported from the sea. Brown algae are mostly marine and are thought to include numerous obligate parthenogens; still, little is known about the distribution, origin and evolution of parthenogens in this group. Here we report a novel pattern of geographical parthenogenesis in the isogamous brown alga Scytosiphon lomentaria. Sex ratio investigation demonstrated that, in Japan, sexual populations grew in the coast along warm ocean currents, whereas female-dominant parthenogenetic populations grew mainly in the coast along a cold ocean current. In the two localities where sexual and parthenogenetic populations were parapatric, parthenogens grew in more wave-exposed areas than sexuals. Population genetic and phylogenetic analyses, including those based on genome-wide single nucleotide polymorphism data, indicated that parthenogens have initially evolved at least twice and subsequent hybridizations between the parthenogens and sexuals have generated multiple new parthenogenetic lineages. The origin of the initial parthenogens is not clear, except that it would not be interspecies hybridization. Interestingly, we found that the production of sex pheromones, which attract male gametes, has been independently lost in the initial two parthenogenetic lineages. This parallel loss of the sexual trait may represent the direct origin of parthenogens, or the regressive evolution of a useless trait under asexuality.

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• 海綿共生細菌による細胞毒性物質の活性化機構, カイメン宿主を守る共生細菌

  城森 啓宏, 脇本 敏幸 ( 担当: 共著 )

  日本農芸化学会「化学と生物；今日の話題」  2022年12月 ( ページ数: 621-623 ,  担当ページ: p.621-623 )

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• 奨励賞

  2020年09月   第61回天然有機化合物討論会   Calyculin A 生合成過程に内在する活性制御機構  

  受賞者: 城森啓宏