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detailes

Tsutsui Masato

  • Faculty: Graduate School of MedicinePosition: Professor
  • Address: 207 Uehara, Nishihara-cho, Okinawa
  • TEL: +81-98-895-1133FAX: +81-98-895-1411
  • Mail Address: tsutsui@med.u-ryukyu.ac.jp
  • Web Site:

Profile

Academic Societies

Academic Societies
  • The American Heart Association
  • The American Physiological Society
  • The Japanese Circulation Society
  • The Japanese Society of Internal Medicine
  • Phisiological Society of Japan
Committee of Academic Societies
  • , Councilor
  • , Councilor
  • , Councilor

Academic Background

Graduate School
  • University of Occupational and Environmental Health, Japan , (Doctor course , Graduate School, Division of Medicine) , 1995(Completed)
College
  • University of Occupational and Environmental Health, Japan , ( , Faculty of Medicine) , 1988(Graduated)
Degree
  • Doctor of Medical Sciences , University of Occupational and Environmental Health, Japan

Awards

  • 2003 , Young Investigator Award, Winner
  • 2001
  • 1997 , Young Investigator Award in Cardiovascular Science

Research Career

Research Career
  • 2010 - , University of the Ryukyus, Graduate School of Medicine, Department of Pharmacology, Professor
  • 2009 - 2010 , University of the Ryukyus, Faculty of Medicine, School of Medicine, Department of Bioregulatory Medicine, Professor
  • 2001 - 2009 , Associate Professor in the Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan
  • 2001 - 2001 , Assistant Professor in the Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • 1998 - 2001 , Research Assistant in the Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • 1995 - 1997 , Research Fellow in the Department of Anesthesiology and Pharmacology, Mayo Clinic, USA (Professor Zvonimir S. Katusic’s Laboratory)

Research

Books, Articles, etc.

Articles
  • Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
    , Cell Metabolism 2011
    Author:1. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
  • Pathophysiological relevance of NO signaling in cardiovascular system: novel insight form mice lacking all NO synthases.
    , Pharmacol Ther , 128:499-508 2010
    Author:Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N.
  • Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.
    , Cardiovasc Res , 87:675-682 2010
    Author:Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M.
  • Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms
    , Circulation , 72(Supplement):2211-2223 2008
    Author:Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K, Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N
  • Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice
    , J Exp Med , 205:2053-2063 2008
    Author:Takaki A, Morikawa K, Tsutsui M, Murayama Y, Tekes E, Yamagishi H, Yanagihara N, Shimokawa H
  • Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kB pathway
    , Arterioscler Thromb Vasc Biol , 27(1):92-98 2007
    Author:Nakata S, Tsutsui M, Shimokawa H, Yamashita T, Tanimoto A, Tasaki H, Ozumi K, Sabanai K, Morishita T, Suda O, Hirano H, Sasaguri Y, Nakashima Y, Yanagihara N.
  • Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms
    , Proc Natl Acad Sci USA , 102(30):10616-10621 2005
    Author:Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N
  • Vascular neuronal nitric oxide synthase is selectively upregulated by platelet-derived growth factor: Involvement of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway
    , Arterioscler Thromb Vasc Biol , 25(12):2502-2508 2005
    Author:Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, Suda O, Ueno S, Toyohira Y, Nakashima Y, Yanagihara N
  • Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes.
    , Arterioscler Thromb Vasc Biol , 24(1):106-111 2004
    Author:Horiuchi M, Tsutsui M, Tasaki H, Morishita T, Suda O, Nakata S, Nihei S, Miyamoto M, Kouzuma R, Okazaki M, Yanagihara N, Adachi T, Nakashima Y
  • Long-term Treatment with Nw-nitro-L-arginine methyl ester causes arteriosclerotic coronary Lesions in endothelial nitric oxide synthase-deficient mice
    , Circulation , 106(13):1729-1735 2002
    Author:Suda O, Tsutsui M, Morishita T, Tanimoto A, Horiuchi M, Tasaki H, Huang PL, Sasaguri Y, Yanagihara N, Nakashima Y
  • Vasculoprotective roles of neuronal nitric oxide synthase
    , FASEB J , 88(Supplement):266 2002
    Author:Morishita T, Tsutsui M, Shimokawa H, Horiuchi M, Tanimoto A, Suda O, Tasaki H, Huang PL, Sasaguri Y, Yanagihara N, Nakashima Y
  • Adventitial expression of recombinant endothelial nitric oxide synthase gene restores nitric oxide production in arteries without endothelium
    , Arterioscler Thromb Vasc Biol , 18:1231-1241 1998
    Author:Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic ZS
  • Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery
    , Circ Res , 80:327-335 1997
    Author:Chen AF, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS
  • Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries
    , Circ Res , 79:336-342 1996
    Author:Tsutsui M, Milstien S, Katusic ZS

Research Grants

Cooperative research with industry
  • 2010 - 2013 , 慢性腎臓病に対するIrbesartan療法の確立
  • 2009 - 2012 , 拡張期心不全に対する01mesartan療法の確立:一酸化窒素合成酵素系完全欠損マウスにおける検討

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