Saito Seiichi

写真a

Title

Professor

Researcher Number(JSPS Kakenhi)

80235043
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Graduate School of Medicine   Professor  

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External Career 【 display / non-display 】

  • 2010.04
    　
    　

    University of the Ryukyus, Graduate School of Medicine, Professor  

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Research Interests 【 display / non-display 】

  • 泌尿器系癌・糖鎖生物学

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Published Papers 【 display / non-display 】

  • Surveillance of urachal abscess in the Kyushu-Okinawa area of Japan.

    Shohei Tobu, Kazuma Udo, et al.

    International journal of urology   28 ( 10 ) 1008 - 1011   2021.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • Stage-specific Embryonic Antigen-4 Expression in Castration-resistant Prostate Cancer and its Correlation With the Androgen Receptor

    Junki Harada, Yasuyoshi Miyata, Seiichi Saito, et al.

    Anticancer Research     2021.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer.

    Shotaro Nakanishi, Masato Goya, Seiichi Saito, et al.

    BMC research notes     2021.06 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder.

    Matsumura E, Kosuge N, Nakanishi S, Suda T, Sugawa A, Fujimura T, Miyagi R, Yoshimi N, Saito S

    The Tohoku journal of experimental medicine ( 東北ジャーナル刊行会 )  252 ( 3 ) 225 - 244   2020.11 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    　View Summary

    <p>Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB. </p>

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  • Relationship Between Stage-specific Embryonic Antigen-4 and Anti-cancer Effects of Neoadjuvant Hormonal Therapy in Prostate Cancer.

    Yuno T, Miyata Y, Matsuo T, Mukae Y, Otsubo A, Mistunari K, Ohba K, Suda T, Saito S, Sakai H

    Anticancer research ( Anticancer Research )  40 ( 10 ) 5567 - 5575   2020.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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