論文 - 浜田　聡

Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children.

Yonesu H, Hamada S, Sakiyama H, Kiyuna S, Oshiro T, Hyakuna N, Nakanishi K.

EJHaem ( Wiley )  18 ( 6 )   2024年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Introduction: The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear. Methods: In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT. Results: The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%-19.8%) and 30.8% (95% CI, 16.7%-52.2%) in the high and low NRI groups, respectively (p = 0.0037). Conclusion: We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM. Keywords: pediatrics; prognostic factor; stem cell transplantation

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Pediatric erythroblastic transformation of JAK2-mutated prefibrotic primary myelofibrosis with concurrent PHF6 mutations.

Oshiro T, Hamada S, Kiyuna S, Sakiyama H, Hyakuna N, Tamaki T, Muramatsu H, Nakanishi K.

Pediatr Blood Cancer.   70 ( 10 ) e30508   2023年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Azacitidine による橋渡しで 2 回の同種造血幹細胞移植を行った 再発若年性骨髄単球性白血病

大城 登喜子, 百名 伸之, 阿部 仁美, 浜田 聡, 中西 浩一

臨床血液   64 ( 3 ) 187 - 192   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Juxtaglomerular cell tumor with pulmonary metastases: A case report and review of the literature.

Sakiyama H, Hamada S, Oshiro T, Hyakuna N, Kuda M, Hishiki T, Aoyama H, Kuroda N, Yorita K, Wada N, Yoshioka T, Koga Y, Nakanishi K.

Pediatr Blood Cancer.   70 ( 4 ) e30068   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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High-dose methotrexate therapy for a child with B-cell precursor acute lymphoblastic leukemia and congenital solitary kidney

Noboru Hokama , Nobuyuki Hyakuna , Satoru Hamada , Hideo Shiohira , Koichi Nakanishi , Katsunori Nakamura

Pediatr Blood Cancer .     e29567   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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High serum cystatin C levels in juvenile myelomonocytic leukemia patients without abnormal kidney function

Wataru Shimabukuro, Satoru Hamada, Tokiko Oshiro, Shougo Nakada, Nobuyuki Hyakuna & Koichi Nakanishi

Pediatr Nephrol .     2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Myeloid sarcoma concurrent with de novo KMT2A gene-rearranged infantile acute lymphoblastic leukemia

Hitomi Abe,Satoru Hamada,Hideki Sakiyama,Tokiko Oshiro,Miho Kato,Takeshi Yagi,Takehiro Matsuda,Takeshi Higa,Nobuyuki Hyakuna,Koichi Nakanishi

Pediatr Blood Cancer ( Pediatr Blood Cancer . )    229573   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Primary diffuse leptomeningeal atypical teratoid rhabdoid tumor (AT/RT) demonstrating atypical imaging findings in an adolescent patient.

Kayo A, Yogi A, Hamada S, Nakanishi K, Kinjo S, Sugawara K, Ishiuchi S, Nishie A.

Radiolology Case Reports   17 ( 3 ) 485 - 488   2021年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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High dose melphalane-based chemotherapy and autologous stem cell transplantation for high risku osteosarcoma in children: A single-institute experience and review of the literature.

Hideki Sakiyama, Satoru Hamada, Nobuyuki Hyakuna, Takeshi Yagi, Tokiko Oshiro, Taichi Uehara, Shinobu Kiyuna, Jiro Miyamoto, Takehiro Matsuda, Takeshi Higa, Koichi Nakanishi.

Pediatric Hematology Oncology Journal   6 ( 4 ) 171 - 174   2021年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency.

Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, Mishima H, Kinoshita A, Mizushima T, Hamada S, Kaisho T

Nat Communication ( Nature )  12 ( 1 ) 6819   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Domino donor lymphocyte infusion for secondary poor graft function after HLA-mismatched allogeneic stem cell transplantation between HLA-identical sibling pairs with congenital immunodeficiency

Hamada S, Uehara T, Miyamoto J, Kiyuna S, Oshiro T, Yagi T, Kurokawa S, Hyakuna N, Nakanishi K.

Pediatr Blood Cancer. ( Wiley Online Library )  e28851   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Clinical features of children with polycythemia vera, essential thrombocythemia, and primarymyelofibrosis in Japan: A retrospective nationwide survey

Hisashi Ishida, Yuji Miyajima, Nobuyuki Hyakuna, Satoru Hamada, Akira Shimada

eJHaem ( British Journal of Haematology )  1   86 - 93   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs) including polycythaemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are exceedingly rare during childhood. Thus, clinical features of paediatric Ph-negative MPNs remain to be unknown. We administered a retrospective study to collect clinical information of children diagnosed with Ph-negative MPNs during 2000–2016 using questionnaires to qualified institutions in Japan, and combined the results by referring the national registry data. Six children with PV, 50 with ET (44 sustained and 6 transient types according to disease course), and 1 with PMF were identified. The median age at diagnosis was 11.5, 9.0, 7.5, and 0 year, respectively. Male to female ratios were 4:2, 21:23, 4:2, 1:0, respectively. JAK2 V617F mutation was detected 0/6 in PV, 9/39 in sustained ET and 0/4 in transient thrombocythemia. The frequency of complications such as thrombosis and subsequent leukaemia was lower compared to adults. We found two children who developed subsequent leukaemia, which was not reported before. Only one patient died. To the best of our knowledge, this is the first nationally representative survey of children with Ph-negative MPNs. Given their rarity, international collaboration with comprehensive genetic analysis might be needed to fully elucidate their clinical and genetic features.

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横隔膜ヘルニア，先天性肺気道奇形（CPAM）と鑑別を要したDICER1 遺伝子変異を伴う胸膜肺芽腫の一例

阿部仁美，浜田　聡，屋冝　孟，屋良朝太郎，上原朋子，屋良朝雄，百名伸之，中西浩一

日本小児血液・がん学会雑誌   57 ( 2 ) 168 - 172   2020年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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症例は生来健康な1 歳男児．主訴は咳嗽，発熱，多呼吸．レントゲン所見から横隔膜ヘルニアが疑われ紹介となり，血液 検査および画像検査にて感染を合併したCPAM と診断された．抗菌薬投与により症状は改善したが，その後症状が再燃し たため肺部分切除術を施行した．病理検査で胸膜肺芽腫の診断に至り，切除断端は陰性であった．腫瘍細胞の遺伝子解析で DICER1 遺伝子にホモ変異が検出されたが，生殖細胞変異は認めなかった．術後化学療法（IVADo 療法）を施行し，終了後 9 か月時点で寛解生存中である．胸膜肺芽腫は稀な予後不良の悪性腫瘍であり，一部では様々な悪性疾患に関連する DICER1 遺伝子変異を有する．本症例より嚢胞性肺病変の鑑別診断として，胸膜肺芽腫を念頭に置くべきである．また今後 再発や遠隔転移の可能性も含め，長期的なフォローを要する．

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Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation.

Hamada S, Miyamoto J, Oshiro T, Yagi T, Kiyuna S, Uehara T, Matsuda T, Higa T, Hyakuna N, Nakanishi K.

Pediatr Blood Cancer.   65 ( 6 ) e26982   2018年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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PURPOSE: Pericardial effusion (PE) is a potentially life-threatening complication following hematopoietic stem cell transplantation (HCT). A higher incidence of early-onset PE, unrelated to graft-versus-host disease, before day 100 after HCT has been reported in pediatric patients, but the pathogenic mechanism is poorly understood. Aiming to determine the pathogenesis of early-onset PE in pediatric patients, we analyzed the cytokine concentration and cell population in the pericardial fluid of four pediatric patients with PE. METHODS: Between January 2009 and December 2015, four patients requiring pericardiocentesis for clinically significant PE were identified in 60 patients. We evaluated the interleukin-6 (IL-6), interferon-γ, IL-1β, and tumor necrosis factor-α levels in PE. Two patients were available for analysis with intracellular cytokine flow cytometry and a chimerism assay. RESULTS: All patients showed the accumulation of pericardial macrophages and high concentrations of IL-6 in PE. Notably, the accumulated pericardial macrophages were CD163+ CD15+ CD14+ cells of host origin that produced IL-6. CONCLUSION: These IL-6-producing tissue-resident macrophages may be key players in the pathogenesis of early-onset PE.

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胎児水腫にて発症したPeason症候群

大城登喜子、浜田　聡　他

日本小児科学会雑誌 ( 日本小児科学会 )  121 ( 9 ) 1555 - 1559   2017年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D⁺CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus.

Hamada S, Caballero-Benitez A, Duran KL, Stevens AM, Spies T, Groh V

Open journal of immunology   7 ( 1 ) 1 - 17   2017年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

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強皮症様皮膚硬化を認める難治性慢性GVHDに対し短波長紫外線照射が奏功した4症例

浜田 聡, 宮下 倫江, 山本 雄一, 宮本 二郎, 屋冝 孟, 大城 登喜子, 浜田 有為子, 喜友名 しのぶ, 新垣 真弓, 百名 伸之

日本小児血液がん学会雑誌 ( その他の出版社 )  53 ( 5 ) 453 - 458   2016年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes.

Okita Y, Shiono T, Yahagi A, Hamada S, Umemura M, Matsuzaki G

Infection and immunity   84 ( 2 ) 573 - 9   2015年12月

掲載種別: 研究論文（学術雑誌）

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診断に難渋したT-cell/histiocyte rich large B-cell lymphomaの小児例

粕谷百合子、浜田聡　他

日本小児皮膚科学会雑誌   34 ( 2 ) 137 - 142   2015年

掲載種別: 研究論文（学術雑誌）

重症免疫不全症に対する臍帯血ミニ移植後の混合キメリズムの遷延

渡辺恵理、浜田聡、糸洲倫江、渡辺信和　他

Cytometry Research   23 ( 2 ) 41 - 49   2013年

掲載種別: 研究論文（学術雑誌）