Itoh Ryuichi

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

50322681
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Faculty of Science   Chemistry, Biology and Marine Science   Associate Professor  

  • Charge of Lecture   University of the Ryukyus   Graduate School of Engineering and Science   Marine and Environmental Sciences   Associate Professor  

  • Charge of Lecture   University of the Ryukyus   Graduate School of Engineering and Science   Chemistry, Biology and Marine Science   Associate Professor  

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External Career 【 display / non-display 】

  • 2005.04
    　
    　

    University of the Ryukyus, Faculty of Science, Department of Chemistry, Biology, and Marine Science, Cell and Functional Biology, Associate Professor  

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Research Interests 【 display / non-display 】

  • Plant Cell Biology

  • Plant Cell Biology

  • 植物の細胞生物学

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Research Areas 【 display / non-display 】

  • Life Science / Plant molecular biology and physiology

  • Life Science / Plant molecular biology and physiology

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Research Theme 【 display / non-display 】

  • Replication and Morphogenesis of Plastids

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Published Papers 【 display / non-display 】

  • Spatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton Homeostasis

    Yamasaki, H; Itoh, RD; Mizumoto, KB; Yoshida, YS; Otaki, JM; Cohen, MF

    ANTIOXIDANTS & REDOX SIGNALING ( Antioxidants and Redox Signaling )    2024.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • The <i>tgd5</i> Mutation Affects Plastid Structure and Causes Giant Lipid Droplet Formation in Trichomes of <i>Arabidopsis</i>

    Kanae Matsuoka, Hiroko Kubotera, Rina Miyazaki, Shota Moriyama, Makoto Fujiwara, Ryuuichi Itoh

    International Journal of Plant Biology   15 ( 1 ) 46 - 53   2024.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • Total Synthesis, Absolute Configuration, and Phytotoxic Activity of Foeniculoxin

    Yamagishi, A; Egoshi, Y; Fujiwara, MT; Suzuki, N; Taniguchi, T; Itoh, RD; Suzuki, Y; Masuyama, Y; Monde, K; Usuki, T

    CHEMISTRY-A EUROPEAN JOURNAL ( Chemistry - A European Journal )  29 ( 8 ) e202203396   2023.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    　View Summary

    Foeniculoxin is a major phytotoxin produced by Italian strains of Phomopsis foeniculi. The first total synthesis is described utilizing the ene reaction and Sonogashira cross-coupling reaction as key steps. The absolute configuration of the C6' was determined using chiral separation and advanced Mosher's method. The phytotoxicity of the synthesized compound was demonstrated via syringe-based infiltration into Chenopodium album and Arabidopsis thaliana leaves. Synthetic foeniculoxin induced various defects in A. thaliana leaf cells before lesion formation, including protein leakage into the cytoplasm from both chloroplasts and mitochondria and mitochondrial rounding and swelling. Furthermore, foeniculoxin and the antibiotic hygromycin B caused similar agglomeration of mitochondria around chloroplasts, highlighting this event as a common component in the early stages of plant cell death.

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  • Tubular extensions of plant organelles and their implications on retrograde signaling

    Ryuuichi D. Itoh

    Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale   96 ( 2 )   2023 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • TGD5 is required for normal morphogenesis of non-mesophyll plastids, but not mesophyll chloroplasts, in Arabidopsis

    Itoh R.D.

    Plant Journal ( Plant Journal )  107 ( 1 ) 237 - 255   2021.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    Stromules are dynamic membrane-bound tubular structures that emanate from plastids. Stromule formation is triggered in response to various stresses and during plant development, suggesting that stromules may have physiological and developmental roles in these processes. Despite the possible biological importance of stromules and their prevalence in green plants, their exact roles and formation mechanisms remain unclear. To explore these issues, we obtained Arabidopsis thaliana mutants with excess stromule formation in the leaf epidermis by microscopy-based screening. Here, we characterized one of these mutants, stromule biogenesis altered 1 (suba1). suba1 forms plastids with severely altered morphology in a variety of non-mesophyll tissues, such as leaf epidermis, hypocotyl epidermis, floral tissues, and pollen grains, but apparently normal leaf mesophyll chloroplasts. The suba1 mutation causes impaired chloroplast pigmentation and altered chloroplast ultrastructure in stomatal guard cells, as well as the aberrant accumulation of lipid droplets and their autophagic engulfment by the vacuole. The causal defective gene in suba1 is TRIGALACTOSYLDIACYLGLYCEROL5 (TGD5), which encodes a protein putatively involved in the endoplasmic reticulum (ER)-to-plastid lipid trafficking required for the ER pathway of thylakoid lipid assembly. These findings suggest that a non-mesophyll-specific mechanism maintains plastid morphology. The distinct mechanisms maintaining plastid morphology in mesophyll versus non-mesophyll plastids might be attributable, at least in part, to the differential contributions of the plastidial and ER pathways of lipid metabolism between mesophyll and non-mesophyll plastids.

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Other Papers 【 display / non-display 】

  • Conservative and innovative systems of chloroplast division

    Itoh.R

    Rec Res Dev Plant Mol Biol ( その他の出版社 )  ( 1 ) 113 - 125   2003.03

     

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2023.04  -  2026.03 

    Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2019.04  -  2023.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2022.03 

    Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2014.04  -  2017.03 

    Direct: 3,900,000 (YEN)  Overheads: 1,170,000 (YEN)  Total: 5,070,000 (YEN)

  • Regulation of stromule formation and its relation to plastid differentiation

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2014.04  -  2017.03 

    Investigator(s): ITOH Ryuuichi, FUJIWARA Makoto 

    Direct: 3,900,000 (YEN)  Overheads: 5,070,000 (YEN)  Total: 1,170,000 (YEN)

    　View Summary

    Generally, non-green plastids tend to possess highly developed stromule(s). In our previous study, the author obtained two mutants of Arabiodopsis in which overformation of stromules were observed in leaf epidermis. Using these mutants, the author studied the regulation of stromule formation and obtained some insights as follows: (i) SUBA1 is involved in the regulation of stromule formation globally over various tissues, (ii) SUBA2 might interact with MinD/E, (iii) suba mutations affect plastid morphology and/or movement in pollen grains and tubes.

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Social Activity 【 display / non-display 】

  • 2013.09
    　
    　

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