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• Suction injury

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Published Papers 【 display / non-display 】

• Acute multiple lesions resulting from segmental arterial mediolysis: An autopsy case report of subarachnoid hemorrhage accompanied by great omentum bleeding

  Shimamoto, M; Ninomiya, K; Yogi, A; Kakazu, K; Ikematsu, N; Fukasawa, M; Takayama, M

  MEDICINE ( Medicine United States )  104 ( 31 ) e43533   2025.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Shaken adult syndrome due to ocean wave: an autopsy case

  Ninomiya, K; Nakaza, E; Yamashiro, T; Abe, T; Ikematsu, N; Nagama, H; Kakazu, K; Fukasawa, M

  FORENSIC SCIENCE MEDICINE AND PATHOLOGY     2023.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Accidental carbon dioxide poisoning due to dry ice during a funeral wake: An autopsy case

  Nakamura, A; Ninomiya, K; Fukasawa, M; Ikematsu, N; Kawakami, Y

  LEGAL MEDICINE ( Legal Medicine )  64   102298 - 102298   2023.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  We report the autopsy case of a male in his 60 s diagnosed with carbon dioxide (CO2) poisoning caused by dry ice for cooling in a coffin during a funeral wake. He was last seen alive, clinging to his family member's body with his head inside the coffin. The autopsy and histological findings did not indicate a specific cause of death. To confirm the concentrations of CO2 and oxygen (O2) in the coffin, an experiment was conducted to reconstruct the scene. Based on the experimental results, 9 h after placing dry ice, the CO2 concentration at the estimated closest point to his head was 24%, a lethal level for CO2 poisoning. Contrastingly, although the concentration of O2 had fallen, it never reached a lethal concentration at any of the determination points during the experiment, thereby ruling out asphyxia as a cause of death. Based on our findings, we concluded that the cause of his death was CO2 poisoning. Forensic pathologists tend to overlook CO2 poisoning unless suspected, as it does not exhibit specific autopsy findings. For the diagnosis of CO2 poisoning, it is essential to collect detailed information about the deceased and the scene of death. The toxicity of CO2 itself is not well known, although dry ice is widely available to the public. In order to make its risk well known, it is necessary to inform people about the dangers of using dry ice.

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• Fatal intoxication of clocapramine, an antipsychotic drug: An autopsy case

  Ikematsu Natsuki, Ninomiya Kenji, Fukasawa Maki, Kakazu Kazumichi, Nagama Hanae

  琉球医学会誌 = Ryukyu Medical Journal ( 琉球医学会 )  42 ( 1-4 ) 51 - 54   2023 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Clocapramine (Clofekton®) is an antipsychotic drug that is not globally approved, except in Japan. Therefore, there are few reports on its use, and the lethal concentration is unknown. We present a rare fatal intoxication case of overdose by clocapramine. A woman in her seventies, who had been suffering from schizophrenia for several decades, died at home. A forensic autopsy was completed 2 days postmortem. Toxicological analysis revealed that in the femoral venous blood and stomach contents as follows: the ethanol concentrations were 1.9mg/ml and 7.4mg/ml, the clocapramine concentrations were 3.0μg/ml and 31mg/ml, the mosapramine concentrations (a metabolite of clocapramine) were 0.15μg/ml and 15μg/ml, and the diazepam concentrations were 1.0μg/ml and 6.0mg/ml, respectively. Overdoses with clocapramine and diazepam were presumed based on their concentrations in gastric contents. The blood clocapramine concentration was 300 times higher than recommended therapeutic levels and 8 times higher than concentrations found in multiple drug overdoses including clocapramine in a previous case report. However, her diazepam blood concentration was within the therapeutic level. Therefore, the main cause of death was judged as fatal clocapramine intoxication. There have been very few reports of deaths due to clocapramine overdose, particularly ones involving concentrations in autopsy specimens. Thus, this case report may provide valuable information. Ryukyu Med. J., 42 (1～4) 51～54, 2023

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• Milk of calcium pericardial effusion confirmed with postmortem computed tomography and autopsy findings: A case report.

  Ninomiya K, Yamashiro T, Fukasawa M, Kawakami Y, Ikematsu N

  Legal medicine (Tokyo, Japan) ( Legal Medicine )  49   101837 - 101837   2021.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  We present the postmortem computed tomography and autopsy findings of a 60-year-old man who developed milk of calcium pericardial effusion and died of constrictive epicarditis. He experienced out-of-hospital cardiopulmonary arrest, and spontaneous circulation returned at the hospital. However, 7 h after recovery, the patient died. He had a swollen neck, had been experiencing coughing from 4 to 5 days earlier, and had no significant medical or surgical history. On computed tomography (CT), highly dense pericardial fluid (CT value: 130-150 Hounsfield units) and multiple calcifications along the epicardium and pericardium were visualized. The epicardium and pericardium were thick, hard, rough, and widely calcified with mild adhesions on autopsy. The pericardial cavity contained a pale, reddish brown, turbid, and highly viscous liquid. Bacteriological tests of pericardial fluid cultures revealed the presence of group G β-hemolytic streptococci. Hence, we diagnosed the patient's cause of death as heart failure due to constrictive epicarditis. We believe that this case of milk of calcium pericardial effusion is the first case confirmed with postmortem CT and autopsy findings.

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• Pregnancy-related maternal deaths in Okinawa, Japan, from 2002 to 2010

  Ihama Y, Ninomiya K, Fukasawa M, Nagai T, Fuke C, Miyazaki T.

  The 8th International Symposium Advances in Legal Medicine(ISALM)  2011  -  2011 

• An autopsy case of spontaneous coronary artery dissection during postpartum period.

  深沢真希、井濱容子、二宮賢司、永井　匠、福家千昭、宮崎哲次

  第95次日本法医学会総会  2011  -  2011 

• An autopsy case of decompression sickness

  二宮賢司、井濱容子、深沢真希、永井　匠、福家千昭、宮崎哲次

  第95次日本法医学会総会  2011  -  2011 

• Experimental study of injury caused by locally applied negative pressure.

  Ninomiya K, Ihama Y, Fukasawa M, Nagai T, Fuke C, Miyazaki T.

  The 8th International Symposium Advances in Legal Medicine(ISALM)  2011  -  2011 

• Pathologic features of 12 cases of shark attack injury.

  Yoko Ihama, Kenji Ninomiya, Masamichi Noguchi, Chiaki Fuke, Tetsuji Miyazaki.

  The 7th International Symposium Advances in Legal Medicine  2008  -  2008 

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Young Scientists(B)

  Project Year: 2015.04  -  2018.03 

  Direct: 3,200,000 (YEN)  Overheads: 960,000 (YEN)  Total: 4,160,000 (YEN)

Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2012.04