Kohagura Kentaro

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

60359990
6
To the head of this page.▲

Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Hospital   Associate Professor  

To the head of this page.▲

Study abroad experiences 【 display / non-display 】

  • 1998.04
    -
    2001.03

    Tohoku University  

To the head of this page.▲

Academic degree 【 display / non-display 】

  • Tohoku University -  Doctor of Medical Science

To the head of this page.▲

External Career 【 display / non-display 】

  • 2009.12
    　
    　

    - , University of the Ryukyus, University Hospital, Assistant Professor  

  • 2009.12
    　
    　

     

  • 2009.12
    -
    2015.03

    University of the Ryukyus, University Hospital, Assistant Professor  

  • 2015.04
    -
    2020.03

     

  • 2020.04
    　
    　

     

To the head of this page.▲

Research Interests 【 display / non-display 】

  • 内科学,腎臓病学

  • 腎臓病学

  • 内科学

To the head of this page.▲

Research Areas 【 display / non-display 】

  • Life Science / Nephrology

To the head of this page.▲

Published Papers 【 display / non-display 】

  • Efficacy of silver ion-containing dressing in the management of exit site granuloma in patients on peritoneal dialysis: A case series

    Oshiro, N; Tsuneyoshi, S; Kohagura, K; Okumura, H; Sugiyama, S; Kusunose, K

    JOURNAL OF VASCULAR ACCESS ( Journal of Vascular Access )    11297298261418356   2026.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    • Access this article
      DOI
    • Search related information
      PubMed

  • Reply to a letter to the editor regarding "Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage".

    Kohagura K

    Hypertension research : official journal of the Japanese Society of Hypertension ( Hypertension Research )  48 ( 12 ) 3315 - 3316   2025.09 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    • Access this article
      DOI
    • Search related information
      PubMed

  • Sustained eGFR improvement after dapagliflozin in a patient with antiretroviral therapy-related chronic kidney disease.

    Arae H, Hoshino S, Moromi N, Tokumine K, Kohagura K

    CEN case reports ( Cen Case Reports )  14 ( 6 ) 805 - 808   2025.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    • Access this article
      DOI
    • Search related information
      PubMed

  • Role of time in target range in blood pressure management for preventing renal decline in type 2 diabetes.

    Kohagura K

    Hypertension research : official journal of the Japanese Society of Hypertension ( Hypertension Research )  48 ( 7 ) 2119 - 2121   2025.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage

    Kohagura, K; Zamami, R; Oshiro, N; Shinzato, Y; Uesugi, N

    HYPERTENSION RESEARCH ( Springer Nature )  47 ( 12 ) 3383 - 3396   2024.12

    Type of publication: Research paper (scientific journal)

    　View Summary

    Hypertension, aging, and other factors are associated with arteriosclerosis and arteriolosclerosis, primary morphologicalfeatures of nephrosclerosis. Although such pathological changes are not invariably linked with renal decline but areprevalent across chronic kidney disease (CKD), understanding kidney damage progression is more pragmatic than preciselydiagnosing nephrosclerosis itself. Hyalinosis and medial thickening of the afferent arteriole, along with intimal thickening ofsmall arteries, can disrupt the autoregulatory system, jeopardizing glomerular perfusion pressure given systemic bloodpressure (BP) fluctuations. Consequently, such vascular lesions cause glomerular damage by inducing glomerularhypertension and ischemia at the single nephron level. Thus, the interaction between systemic BP and afferent arteriolopathymarkedly influences BP-dependent renal damage progression in nephrosclerosis. Both dilated and narrowed types of afferentarteriolopathy coexist throughout the kidney, with varying proportions among patients. Therefore, optimizingantihypertensive therapy to target either glomerular hypertension or ischemia is imperative. In recent years, clinical trialshave indicated that combining renin–angiotensin system inhibitors (RASis) and sodium–glucose transporter 2 inhibitors(SGLT2is) is superior to using RASis alone in slowing renal function decline, despite comparable reductions in albuminuria.The superior efficacy of SGLT2is may arise from their beneficial effects on both glomerular hypertension and renalischemia. A comprehensive understanding of the interaction between systemic BP and heterogeneous afferent arteriolopathyis pivotal for optimizing therapy and mitigating renal decline in patients with CKD of any etiology. Therefore, in thiscomprehensive review, we explore the role of afferent arteriolopathy in BP-dependent renal damage.

display all >>

To the head of this page.▲