Ogihara Kazuhito



Associate Professor

Researcher Number(JSPS Kakenhi)


Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Faculty of Science   Chemistry, Biology and Marine Science   Associate Professor  

Academic degree 【 display / non-display

  • Hiroshima University -  Doctor of Science

External Career 【 display / non-display

  • 1997.10

    University of the Ryukyus, Faculty of Science, Department of Chemistry, Biology, and Marine Science, Analytical and Inorganic Chemistry, Associate Professor  

Research Interests 【 display / non-display

  • Natural Products Organic Chemistry

Research Areas 【 display / non-display

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Life Science / Bioorganic chemistry

Research Theme 【 display / non-display

  • Study on the Physiologically and Biologically Active Constituents from the Animals and the Plants in Okinawa Isrands.

Published Papers 【 display / non-display

  • Flavonoids and Isoflavonoids from the Fresh Immature Seeds of Sophora tomentosa L.

    Kazuhito OGIHARA,* Takerou OOYA, Eiken KUNIYOSHI, Toshimasa SUZUKA, and Matsutake HIGA

    Bulletin of Faculty ofScience University of Ryukyus   ( 108 ) 27 - 32   2020.03

    Type of publication: Research paper (scientific journal)

  • Friedel–Crafts-Type Alkylation of Indoles in Water Using Amphiphilic Resin-Supported 1,10-Phenanthroline–Palladium Complex under Aerobic Conditions

    Suzuka Toshimasa, Ooshiro Yuto, Ogihara Kazuhito

    Catalysts ( MDPI )  10   193 - 203   2020.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Polymer-Supported Terpyridine–Palladium Complex for the Allylic Alkylation with Arylboronic Acid in Water

    Suzuka Toshimasa, Takayama Naoki, Unten Masanori, Onda Kaoru, Ogihara Kazuhito

    Transactions of the Materials Research Society of Japan ( 一般社団法人 日本MRS )  44 ( 1 ) 41 - 44   2019.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    <p>  A novel homogeneous transition-metal catalyst, a polymer-supported terpyridine–palladium(II) complex, was found to promote the allylic alkylation with phenylborinic acid under phosphine-free conditions in water with good yield. The catalyst was recovered and reused several times without loss of catalytic activity. To our knowledge, this is the first example of the allylic alkylation with pheylboronic acid in water using a polymer-supported terpyridine–palladium(II) complex under aerobic conditions. The stereochemistry of the allylic alkylation with phenylboronic acid was demonstrated to be not net retention. </p>

  • Naphthoquinone Derivatives from Diospyros maritima.

    Higa M, Takashima Y, Yokaryo H, Harie Y, Suzuka T, Ogihara K

    Chemical & pharmaceutical bulletin ( 公益社団法人 日本薬学会 )  65 ( 8 ) 739 - 745   2017.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    <p>From the chloroform extract of the fresh fruits of <i>Diospyros maritima</i> BLUME (Ebenaceae), five new naphthoquinone derivatives, 2,7′-dimethyl-2′,3-bijuglone (27), 2,7′-dimethyl-3,3′-bijuglone (28), 2,7′-dimethyl-6,8′-bijuglone (29), 7,7′-dimethyl-3,3′-ethylidenebijuglone (30), and 2′,7-dimethyl-3,6′-ethylidenebijuglone (31), were isolated, in addition to twenty-one known naphthoquinone derivatives: plumbagin (4), droserone (5), 2,3-epoxyplumbagin (8), 3,3′-biplumbagin (9), chitranone (10), 3,8′-biplumbagin (11), elliptinone (12), maritinone (13), isozeylanone (14), methylene-3,3′-biplumbagin (15), ethylidene-3,3′-biplumbagin (16), ethylidene-3,6′-biplumbagin (17), ethylidene-6,6′-biplumbagin (18), 7-methyl-β-dihydrojuglone (19), 7-methyljuglone (20), 2,3-epoxy-7-methyljuglone (21), neodiospyrin (22), mamegakinone (23), ehretione (24), isoxylospyrin (25) and β-dihydroplumbagin (26). The structures of the new compounds were established by spectral analysis. The quinones obtained from the chloroform extract of the fruits were compared with previously reported quinones obtained from ethanol extracts. The quinones in the fruits were categorized in three groups: quinones from ethanol extract only, quinones from chloroform extract only, and quinones from both extracts. The six naphthoquinones, 19–21, 25, 26, and 29, were examined for their ichthyotoxic activity and germination inhibitory activity. Quinones 19–21, 26, and 29 showed ichthyotoxic activity against Japanese killifish (<i>Oryzias latipes</i> var.) at 10 ppm; quinones 19 to 21 and 26 showed germination inhibitory activity toward lettuce seeds (<i>Lactuca sativa</i> L. var. Great Lakes) at 100 ppm.</p>

  • Recyclable polymer-supported terpyridine–palladium complex for the tandem aminocarbonylation of aryl iodides to primary amides in water using NaN<inf>3</inf> as ammonia equivalent

    Suzuka T. Hiromu Sueyoshi, Kazuhito Ogihara

    Catalysts ( Catalysts )  7 ( 4 )   2017.04 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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