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• histopthological analysis of lung cancer in Okinawa

• molecular and clinical pathology of morule

• association between oncogene induced senescence (OIS) and reactive oxygen species (ROS)

• molecular biology of Kaposi's sarcoma in Okinawa

• association between cancer and Epstein-Barr virus infection

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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Association between Kaposi's sarcoma-associated herpesvirus genotype and clinical types.

  Yogi S, Ishikawa H, Oshiro A, Yamazato R, Sakamoto C, Tanabe Y, Uehara K, Kurima K, Kina S, Takahashi K, Arakawa H, Kinjo T

  Pathology Oncology Research : POR ( Pathology and Oncology Research )  31   1612009   2025 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis

  Akiyuki Sugisawa, Zensei Toyoda, Yasuka Tanabe, Karina Uehara, Aya Oshiro, Reo Yamazato, Chiharu Sakamoto, Shohei Yogi, Kiyoto Kurima, Shinichiro Kina, Michiyo Sakiyama, Takao Kinjo

  Menopause   30 ( 2 ) 193 - 200   2023.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Intraductal carcinoma of the parotid gland

  HIRATA Yukiya, HIGUCHI Kayoko, NAGAO Toshitaka, ZUKERAN Yoko, KINJO Takao, WADA Naoki

  The Journal of the Japanese Society of Clinical Cytology ( The Japanese Society of Clinical Cytology )  61 ( 6 ) 431 - 437   2022

  Type of publication: Research paper (scientific journal)

  　View Summary

  <p><i><b>Background</b></i> : Intraductal carcinoma (IDC) is a rare salivary gland tumor with a good prognosis.</p><p><i><b>Case</b></i> : The patient was a man in his seventies who presented to us with a 10-year history of a small left parotid mass that had started to increase in size approximately one year ago. MRI revealed a 50-mm multilocular cystic mass caudally over the inferior pole of the left parotid gland, and fine-needle aspiration cytology (FNAC) was performed. The FNAC specimen revealed a mildly overlapping epithelial mass in a background of lymphocytes, neutrophils, and macrophages phagocytosing hemosiderin. The nuclei of the tumor cells were relatively small and mildly atypical, with granular chromatin and one or two small nucleoli. The tumor cells contained greenish and vacuolated cytoplasm and intracytoplasmic lumina containing secretions as well as brownish-red granules. Since the cytological findings suggested a low-grade malignant lesion, we categorized the findings as “suspicion for malignancy, low grade" according to The Milan System for Reporting Salivary Gland Cytopathology, with the differential diagnosis including secretory carcinoma and low-grade adenocarcinoma (cystadenocarcinoma).</p><p><i><b>Conclusion</b></i> : IDC may be cytologically similar to secretory carcinoma and low-grade adenocarcinoma (cystadenocarcinoma), which may pose difficulties in accurate estimation of the histological type. However, since IDC has a more favorable prognosis than other malignant salivary gland tumors, it is important to confirm the low-grade malignant nature of the tumor by FNA before surgery.</p>

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• In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system.

  Noguchi H, Miyagi-Shiohira C, Kinjo T, Saitoh I, Watanabe M

  Scientific Reports ( Scientific Reports )  11 ( 1 ) 20290   2021.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage.

  Uehara K, Tanabe Y, Hirota S, Higa S, Toyoda Z, Kurima K, Kina S, Nakasone T, Arasaki A, Kinjo T

  BMC Cancer ( BMC Cancer )  21 ( 1 ) 688   2021.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• 骨肉腫における予後因子としてのミッドカインの発現と抗体による増殖阻害効果

  前原 博樹, 要 匡, 柳 久美子, 半澤 浩明, 金城 貴夫, 大湾 一郎, 成富 研二, 岩政 輝男, 金谷 文則

  日本整形外科学会雑誌 ( (公社)日本整形外科学会 )  79 ( 6 ) S597 - S597   2005.06

   

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• Derrangement of DNA damage response associated with transformation of primary mouse embryonic fibroblasts by dual expression of EBV LMP-1 and HPV16 E6.

  金城 貴夫

  HPV 2015 30th International Papillomavirus Conference  2015.09  -  2015.09 

• Transformation of mouse embryonic fibroblasts by dual expression of EBV LMP-1 and HPV 16 E6.

  金城 貴夫

  EB 2013 (Experimental Biology)  1900.01  -  1900.01 

• Squamous metaplasia induced by transfection of human papillomavirus (HPV) into cultured adenocarcinoma cells.

  金城 貴夫

  XXIII International Congress of the International Academy of Pathology and 14th World Congress of Academic and Environmental Pathology  1900.01  -  1900.01 

• Reactive oxygen species (ROS) by HTLV-I Tax expression induces DNA damage and cellular senescence.

  金城 貴夫

  2011 ASBMB (The American Society for Biochemistry and Molecular Biology) Special symposium: Recent Advances in Pathogenic Human Viruses  1900.01  -  1900.01 

• Prognostic implication of human papillomavirus (HPV) infection in squamous cell carcinoma (SCC) of the lung

  金城 貴夫

  XXIII International Congress of the International Academy of Pathology and 14th World Congress of Academic and Environmental Pathology  1900.01  -  1900.01 

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• PARP activity in HPV-positive oropharyngeal carcinoma: the mechanism of favorable prognosis and development of effective therapy

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 1,050,000 (YEN)  Total: 4,550,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2020.04  -  2023.03 

  Direct: 3,400,000 (YEN)  Overheads: 1,020,000 (YEN)  Total: 4,420,000 (YEN)

• Clarification of molecular biological mechanism targeting EphA4 against the anticancer drug resistance well-differentiated oral squamous cell carcinoma

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2018.04  -  2021.03 

  Investigator(s): Nakasone Toshiyuki 

  Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

  　View Summary

  Well-differentiated tumors are intrinsically chemotherapy resistant. Receptor tyrosine kinase erythropoietin-producing human hepatocellular receptor A4 (EphA4) protein is highly expressed in the well-differentiated tumor-derived cervical cancer cell line. Reactive oxygen species-SFK-EphA4 axis is shown to be new potential drug targets for chemotherapy resistance. Patients who received S-1 were more likely than those who received UFT to have pathological complete response. Neoadjuvant S-1 significantly improved disease-free survival as compared with up-front surgery. A choice of drugs for neoadjuvant metronomic chemotherapy is needed.

• Construction of new therapy method that targets EphA4 which is activated by chemotherapeutic reagents

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): Kina Shinichiro 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

  　View Summary

  Well-differentiated regions of the tumor are intrinsically resistant to chemotherapy. Receptor tyrosine kinase erythropoietin-producing human hepatocellular receptor A4 (EphA4) protein is highly expressed in the well-differentiated tumor-derived cervical cancer cell line , but not in poorly differentiated tumor-derived cervical cancer cell lines. Pharmacological inhibition of EphA4 increased cisplatin-induced cell death in Caski cells.Mechanistically, cisplatin induces chemotherapy resistance of Caski cells by upregulating Lyn, a Src family kinase (SFK) that interacts with EphA4, through a pathway involving reactive oxygen species. Thus, the reactive oxygen species-SFK-EphA4 axis presents new potential drug targets for chemotherapy resistance.

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2016.04  -  2019.03 

  Direct: 3,600,000 (YEN)  Overheads: 1,080,000 (YEN)  Total: 4,680,000 (YEN)

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