Tanaka Junichi

写真a

Title

Professor

Researcher Number(JSPS Kakenhi)

20163529

Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Faculty of Science   Chemistry, Biology and Marine Science   Professor  

External Career 【 display / non-display

  • 2007.04
     
     

    University of the Ryukyus, Faculty of Science, Department of Chemistry, Biology, and Marine Science, Phyical and Organic Chemistry, Professor  

Research Interests 【 display / non-display

  • Marine Natural Products Chemistry

Research Areas 【 display / non-display

  • Life Science / Environmental and natural pharmaceutical resources

Research Theme 【 display / non-display

  • Search for New Bioactive Molecules from Coral Reef Organisms

Published Papers 【 display / non-display

  • Amitorin, a Cytotoxic Diterpenoid from a Sponge Halichondria sp.

    Tsuyoshi Wauke, Novriyandi Hanif, Sean Ohlinger, Nicole Joy de Voogd, Viqqi Kurnianda, Takahiro Jomori, and Junichi Tanaka

    Chemistry Letters ( Chemical Society of Japan )  51 ( 11 ) 1080 - 1082   2022.11 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    A new diterpenoid endoperoxide showing cytotoxicity named amitorin (1) was isolated from an extract of a sponge Halichondria sp. Its structure along with relative stereochemistry was elucidated with spectral analysis and calculation studies. The structure and cytotoxicity (IC50 2.3 µM against NBT-II cells) of the molecule are described herein.

  • Flavokawains, plant-derived chalcones, inhibit differentiation of murine pre-adipocytes

    Novriyandi Hanif, Dyah Iswantini, Yusuke Hioki, Anggia Murni, Masaki Kita, and Junichi Tanaka

    Chemistry Letters ( Chemical Society of Japan )  51 ( 1 ) 54 - 57   2022.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    Efforts to isolate compounds from an Indonesian member of the ginger family, Kaempferia angustifolia, yielded three known molecules, identified as (+)-crotepoxide (1), (+)-pipoxide chlorohydrin (2), and flavokawain A (FKA, 3). All three compounds strongly inhibited triglyceride accumulation in 3T3-L1 murine pre-adipocytes at 10 µg/mL, and compounds 1 and 2 were both cytotoxic at this concentration. To determine the biological activities of natural 3, flavokawains A (3), B (4) and C (5) were synthesized. While 4 was cytotoxic, both 3 and 5 potently inhibited differentiation of murine pre-adipocytes and reduced triglyceride accumulation (EC50 = 64.4 and 26.1 µM, respectively) with relatively weak cytotoxicity. Thus, the electron-donating group on the aromatic B ring may contribute to the highly selective anti-obesity activity.

  • New furan derivatives from <i>Annulohypoxylon spougei</i> fungus.

    Pimjuk P, Noppawan P, Katrun P, Mongkolthanaruk W, Suwannasai N, Tanaka J, McCloskey S

    Journal of Asian natural products research     1 - 8   2021.11 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Oxy-Polybrominated Diphenyl Ethers from the Indonesian Marine Sponge, <i>Lamellodysidea herbacea</i>: X-ray, SAR, and Computational Studies.

    Hanif N, Tyas TA, Hidayati L, Dinelsa FF, Provita D, Kinnary NR, Prasetiawan FM, Khalik GA, Mubarok Z, Tohir D, Setiawan A, Farid M, Kurnianda V, Murni A, de Voogd NJ, Tanaka J

    Molecules (Basel, Switzerland)   26 ( 21 )   2021.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Use of halichondramide as a probe for actin-related studies

    Chiaki Tanaka, Viqqi Kurnianda, Masaya Morita, Toshimasa Suzuka, Junichi Tanaka

    Phytochemistry Letters   44   35 - 41   2021.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    A marine macrolide halichondramide (1) was used as the basis for several actin-related studies as: a medium for affinity chromatography for G-actin; derivatives targeting G-actin; and fluorescent derivatives for staining cellular actin. The binding affinity to G-actin of halishigamide A (6) and its epimer 7 was compared with that of 1, as well as determining the configuration at C-5 of 6 by applying chiral derivatizing method.

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Other Papers 【 display / non-display

  • Actin-binding toxin 'tail' wags the dog,

    J. Tanaka 他

    Chem. ( Elsevier )  15 ( 3 ) 205 - 207   2008.03

     

    DOI