論文 - 池上　太郎

Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.

Hirakawa H, Ikegami T, Kise N, Kinjyo H, Kondo S, Agena S, Hasegawa N, Kawakami J, Maeda H, Suzuki M

Journal of personalized medicine ( Journal of Personalized Medicine )  13 ( 4 ) 657   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis.

Yamada S, Itoh T, Ikegami T, Imai A, Mochizuki D, Nakanishi H, Ishikawa R, Kita J, Nakamura Y, Takizawa Y, Okamura J, Noda Y, Iwashita T, Hariyama T, Suzuki M, Misawa K, Kawasaki H

Scientific reports ( Scientific Reports )  13 ( 1 ) 5514   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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副鼻腔内反性乳頭腫と副鼻腔癌の基礎と臨床

平川 仁, 池上 太郎, 當山 昌那, 鈴木 幹男

日本鼻科学会会誌 ( 日本鼻科学会 )  61 ( 1 ) 179 - 180   2022年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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  CiNii Research

【総説】喉頭乳頭腫におけるHPVの時空間的遺伝子発現

池上太郎 , 喜友名朝則 , 喜瀬乗基 , 鈴木幹男

喉頭   33 ( 2 ) 69 - 75   2021年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Development of Antibodies Against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma

Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Mikio Suzuki, Narutoshi Tsukahara, Akikazu Murakami, Asanori Kiyuna, Shinya Agena, Katsunori Tanaka, Narumi Hasegawa, Junko Kawakami, Akira Ganaha, Hiroyuki Maeda, Hitoshi Hirakawa

Viruses   13 ( 10 ) 2024   2021年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Prognostic significance of hypoxia-inducible factor-1α expression in advanced pharyngeal cancer without human papillomavirus infection

Agena S, Hirakawa H, Ikegami T, Kinjyo H, Kise N, Maeda M, Uezato J, Kondo S, Kiyuna A, Yamashita Y, Hasegawa N, Suzuki M, Ganaha A

Journal of Laryngology and Otology ( Journal of Laryngology and Otology )  135 ( 7 ) 625 - 633   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Coordinated Expression of HPV-6 Genes with Predominant E4 and E5 Expression in Laryngeal Papilloma.

Ikegami T, Hirakawa H, Tsukahara N, Murakami A, Kise N, Kiyuna A, Kosugi T, Agena S, Kinjyo H, Hasegawa N, Touyama M, Kondo S, Maeda H, Suzuki M, Ganaha A

Microorganisms ( Microorganisms )  9 ( 3 ) 520 - 18   2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma.

Kondo S, Hirakawa H, Ikegami T, Uehara T, Agena S, Uezato J, Kinjyo H, Kise N, Yamashita Y, Tanaka K, Hasegawa N, Kiyuna A, Maeda H, Suzuki M, Gahana A

BMC cancer ( BMC Cancer )  21 ( 1 ) 87   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Induction Chemotherapy in Hypopharyngeal Cancer: Influence of DNA Repair Gene Polymorphisms.

Hirakawa H, Ikegami T, Azechi S, Agena S, Uezato J, Kinjyo H, Yamashita Y, Kiyuna A, Tanaka K, Kondo S, Maeda H, Suzuki M, Ganaha A

Anticancer research   40 ( 6 ) 3277 - 3285   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Melatonin inhibits reproductive activity through changes of serotonergic activity in the brain of freshwater catfish (Mystus cavasius)

Badruzzaman M, Ikegami T, Amin AKMR, Shahjahan Md

Aquaculture ( Aquaculture )  in press   2020年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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下咽頭癌におけるDNA修復酵素遺伝子多型と発癌についての検討

疇地里衣, 平川仁, 池上太郎, 長谷川成海, 山下懐, 安慶名信也, 上原貴行, 田中克典, 上里迅, 真栄田裕行, 鈴木幹男

耳鼻と臨床   66   35 - 40   2020年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

ERCC1 C8092A polymorphism predicts fair survival outcome in Japanese patients with pharyngo-laryngeal squamous cell carcinoma.

Hirakawa H, Ikegami T, Azechi S, Agena S, Uezato J, Kinjyo H, Yamashita Y, Tanaka K, Kondo S, Maeda H, Suzuki M, Gahana A

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery ( European Archives of Oto-Rhino-Laryngology )  277 ( 2 ) 601 - 610   2020年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens.

Yamashita Y, Ikegami T, Suzuki M, Hirakawa H, Maeda H, Yamada S, Deng Z, Kondo S, Kinjyo H, Kiyuna A, Agena S, Uehara T, Ganaha A

Journal of cancer research and therapeutics ( Journal of Cancer Research and Therapeutics )  15 ( 3 ) 556 - 563   2019年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Preparatory Mechanisms for Salinity Tolerance in Two Congeneric Anuran Species Inhabiting Distinct Osmotic Habitats.

Haramura T, Ikegami T, Wong MKS, Takei Y

Zoological science ( Zoological Science )  36 ( 3 ) 215 - 222   2019年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Staging and prognosis of oropharyngeal carcinoma according to the 8th Edition of the American Joint Committee on Cancer Staging Manual in human papillomavirus infection.

Yamashita Y, Ikegami T, Hirakawa H, Uehara T, Deng Z, Agena S, Uezato J, Kondo S, Kiyuna A, Maeda H, Suzuki M, Ganaha A

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery ( European Archives of Oto-Rhino-Laryngology )  276 ( 3 ) 827 - 836   2019年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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High-risk type human papillomavirus infection and p16 expression in laryngeal cancer.

Kiyuna A, Ikegami T, Uehara T, Hirakawa H, Agena S, Uezato J, Kondo S, Yamashita Y, Deng Z, Maeda H, Suzuki M, Ganaha A

Infectious agents and cancer ( Infectious Agents and Cancer )  14 ( 1 ) 8   2019年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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HPV関連中咽頭癌（p16陽性）死亡例の検討

金城 秀俊, 鈴木 幹男, 山下 懐, 池上 太郎, 嘉陽 祐紀, 上里 迅, 安慶名 信也, 上原 貴行, 平川 仁, 真栄田 裕行

頭頸部癌 ( 日本頭頸部癌学会 )  45 ( 4 ) 397 - 402   2019年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

AJCC第8版ではp16免疫染色によりHPV関連中咽頭癌をその他の中咽頭癌とは異なる病期分類を用いるようになった。HPV関連中咽頭癌は一般的に予後がよいが，再発・転移を来たし予後不良である症例も経験する。　2006年12月から2014年11月までに当科で治療した中咽頭癌新鮮例100例中，p16陽性例は34例であった。このうち2019年1月の時点で死亡例は4例（男性3名，女性1名）であった。臨床病期はAJCC7版ではStageⅢが1例，StageⅣが3例であったが，8版ではStageⅡが1例，StageⅢが3例であった。予後不良因子として喫煙，局所進行，年齢，重複癌が示唆された。HPV関連癌は再発・遠隔転移を生じても死亡までの期間が比較的長いことが臨床的特徴と思われた。そのため，可能な範囲で追加治療を行うことは妥当であると推察した。

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ヒトパピローマウイルス(HPV)のウイルス粒子様タンパク質の作製 HPV受容体の同定を目指して

赤嶺 もな, 池上 太郎, 鈴木 幹男

琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 140 - 140   2018年12月

掲載種別: 研究論文（大学，研究機関紀要）

頭頸部腫瘍におけるγグルタミルトランスフェラーゼ1とジペプチジルペプチターゼ-4の発現

屋島 福太郎, 池上 太郎, 鈴木 幹男

琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 139 - 139   2018年12月

掲載種別: 研究論文（大学，研究機関紀要）

ヒトパピローマウイルス6型感染・喉頭乳頭腫におけるE4遺伝子発現細胞の同定

前田 和俊, 池上 太郎, 鈴木 幹男

琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 140 - 140   2018年12月

掲載種別: 研究論文（大学，研究機関紀要）

Detection of human papillomavirus in branchial cleft cysts.

Ikegami T, Uehara T, Deng Z, Kondo S, Maeda H, Kiyuna A, Agena S, Hirakawa H, Yamashita Y, Ganaha A, Suzuki M

Oncology letters ( Oncology Letters )  16 ( 2 ) 1571 - 1578   2018年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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ヒトパピローマウイルス(HPV)関連頭頸部癌におけるHPVのホストゲノムへの組み込み位置同定

冨山 嘉月, 池上 太郎, 鈴木 幹男

琉球医学会誌 ( 琉球医学会 )  36 ( 1-2 ) 54 - 54   2017年12月

掲載種別: 研究論文（大学，研究機関紀要）

喉頭乳頭腫における成長因子受容体遺伝子の発現

宮城 翔, 池上 太郎, 鈴木 幹男

琉球医学会誌 ( 琉球医学会 )  36 ( 1-2 ) 44 - 44   2017年12月

掲載種別: 研究論文（大学，研究機関紀要）

Methylation of CpG sites in the upstream regulatory region, physical status and mRNA expression of HPV-6 in adult-onset laryngeal papilloma.

Deng Z, Ikegami T, Kiyuna A, Zhang C, Zhang T, Matayoshi S, Uehara T, Maeda H, Suzuki M, Ganaha A

Oncotarget ( IMPACT JOURNALS LLC )  8 ( 49 ) 85368 - 85377   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The methylation status of HPV-6 upstream regulatory region (URR) in adult-onset laryngeal papillomatosis (AO-LP) remains unclear. The purpose of this study was to investigate the methylation status of URR and the physical status of HPV-6, as well as the dynamic variations of viral load and mRNA expression in AO-LP. We examined 18 specimens from 11 patients with AO-LP by real-time polymerase chain reaction (PCR), bisulfite-sequencing PCR, and amplification of papilloma oncogene transcripts. HPV-6 was identified in 9 of 11 patients (81.8%), and all the 15 specimens derived from 9 HPV-6-positive cases contained only episomal HPV-6 transcripts with intact E2. Three HPV-6-positive patients developed recurrent lesions, and HPV-6 copy numbers and mRNA expression decreased after surgical treatment. Among the 96 CpG sites (16/case), 67 (69.8%) were unmethylated, while 23 (30.2%) were heterogeneous (>= 1 methylated CpG clone). High viral loads and episomal status of HPV-6 were frequently observed in AO-LP; thus, persistent E6/E7 mRNA expression of LR-HPV-6 may be associated with AO-LP recurrences. Hypomethylation and scattered patterns of methylated CpGs at the URR of HPV-6 were identified in AO-LP.

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Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report.

Maeda H, Deng Z, Ikegami T, Matayoshi S, Agena S, Kiyuna A, Yamashita Y, Uehara T, Ganaha A, Suzuki M

Oncology letters ( SPANDIDOS PUBL LTD )  12 ( 3 ) 2087 - 2091   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Branchiogenic carcinoma (BC) usually appears as a mass lesion with a predominant cystic component. Since lymph node metastasis from oropharyngeal carcinoma (OPC) has a cystic appearance, it is occasionally difficult to distinguish between BC and nodal metastases from clinically silent OPC. Factors associated with the malignant transformation process in BC remain obscure. The present study reports the case of a 56-year-old man with a right cystic cervical mass that was diagnosed as squamous cell carcinoma based on examination by fine-needle aspiration biopsy. The primary tumor could not be detected despite several imaging examinations, a pan-endoscopy of the head and neck, esophagus and stomach, biopsies of the head and neck regions, and bilateral tonsillectomies. The pathological findings of the surgical specimens from a radical neck dissection were consistent with the histological characteristics of BC, with evidence of transition from dysplasia through intraepithelial carcinoma to invasive carcinoma. Normal squamous epithelium and dysplastic and cancerous portions in the BC showed strong p16(INK4a) immunoreactivity. The expression of p16(INK4a) was also observed in all 9 nodal metastases in the neck dissection specimens. The cystic formation observed in the BC was not observed in the nodal metastases. As the presence of human papillomavirus-16 in the tumor was confirmed by polymerase chain reaction, quantitative polymerase chain reaction was employed for the measurement of human papillomavirus-16 viral load and integration. The results showed that the viral load of human papillomavirus-16 was 3.01x107/50 ng genomic DNA, and the E2/E6 ratio was 0.13, so the integration state was judged to be the mixed type. To the best of our knowledge, this is the first report of BC associated with high-risk-type human papillomavirus infection. The study indicates that a human papillomavirus-positive neck mass may not necessarily be OPC, but that it could be BC with a poor prognosis. This report lends support to the existence of BC and proposes that the etiology is human papillomavirus infection.

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Increase in telencephalic dopamine and cerebellar norepinephrine contents by hydrostatic pressure in goldfish: the possible involvement in hydrostatic pressure-related locomotion

Ikegami T, Takemura A, Choi E, Suda A, Badruzzaman M, Furuse M

Fish Physiology and Biochemistry ( その他の出版社 )  41 ( 5 ) 1105   2015年10月

掲載種別: 研究論文（その他学術会議資料等）

Environmental control of annual reproductive cycle and spawning rhythmicity of spinefoots

Takemura A, Takeuchi Y, Ikegami T, Hur SP, Soliman V, Ayson F, Jesus-Ayson GD, Susilo ES

Kuroshio Science   9 ( 1 ) 31 - 38   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Increase in telencephalic dopamine and cerebellar norepinephrine contents by hydrostatic pressure in goldfish: the possible involvement in hydrostatic pressure-related locomotion.

Ikegami T, Takemura A, Choi E, Suda A, Tomonaga S, Badruzzaman M, Furuse M

Fish physiology and biochemistry ( SPRINGER )  41 ( 5 ) 1105 - 15   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Fish are faced with a wide range of hydrostatic pressure (HP) in their natural habitats. Additionally, freshwater fish are occasionally exposed to rapid changes inHPdue to heavy rainfall, flood and/or dam release. Accordingly, variations in HP are one of the most important environmental cues for fish. However, little information is available on how HP information is perceived and transmitted in the central nervous system of fish. The present study examined the effect of HP (water depth of 1.3 m) on the quantities of monoamines and their metabolites in the telencephalon, optic tectum, diencephalon, cerebellum (including partial mesencephalon) and vagal lobe (including medulla oblongata) of the goldfish, Carassius auratus, using high-performance liquid chromatography. HP affected monoamine and metabolite contents in restricted brain regions, including the telencephalon, cerebellum and vagal lobe. In particular, HP significantly increased the levels of dopamine (DA) in the telencephalon at 15 min and that of norepinephrine (NE) in the cerebellum at 30 min. In addition, HP also significantly increased locomotor activity at 15 and 30 min after HP treatment. It is possible that HP indirectly induces locomotion in goldfish via telencephalic DA and cerebellar NE neuronal activity.

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Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16INK4a in sinonasal diseases

Yamashita Y, Hasegawa M, Deng Z, Maeda H, Kondo S, Kyuna S, Matayoshi S, Agena S, Uehara T, Kouzaki H, Shimizu T, Ikegami T, Ganaha A,Suzuki M

Infectious Agents and Cancer ( その他の出版社 )  10 ( 23 ) 1   2015年08月

掲載種別: 研究論文（その他学術会議資料等）

Effects of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment on ovarian development of the sapphire devil, Chrysiptera cyanea.

Badruzzaman M, Imamura S, Takeuchi Y, Ikegami T, Takemura A

Fish physiology and biochemistry ( SPRINGER )  41 ( 1 ) 61 - 71   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

In the neuroendocrine system controlling fish reproduction, dopamine (DA) acts as a gonadotropin inhibitory factor and plays a role in regulating gonadal development of certain species. The present study examined the effects of chemical destruction of dopaminergic neurons in the brain on DA production and ovarian development in the sapphire devil Chrysiptera cyanea, a reef-associated damselfish. The avidin-biotin-peroxidase complex method using an antibody against tyrosine hydroxylase (TH), a critical enzyme in the DA synthesis pathway, identified a population of dopaminergic neurons with somata in the anteroventral preoptic nucleus of the diencephalon and fibers terminating in the proximal pars distalis of the pituitary. Maintaining fish in seawater containing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) at 0.02 and 0.2 A mu g/mL for 2 days resulted in decreases in DA, 3,4-dihydroxyphenylacetic acid (DOPAC; DA metabolite), and DA metabolic rate in the whole brain. The number of TH-positive neurons in the diencephalon decreased after 0.02 A mu g/mL MPTP treatment for 2 days. These results suggest that MPTP treatment destroys TH-positive neurons in the diencephalon, thereby decreasing the synthesis and release of DA from the brain. This treatment rescued ovarian development in fish with artificially retracted ovaries during the spawning season. The gonadosomatic index of MPTP-treated fish 5 and 7 days after treatment was significantly higher than that of control fish. Oocytes in the vitellogenic stages were observed in the ovaries of MPTP-treated fish, but not in control fish. These results suggest that DA in the brain drives ovarian development in the sapphire devil.

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Ultradian oscillation in expression of four melatonin receptor subtype genes in the pineal gland of the grass puffer, a semilunar-synchronized spawner, under constant darkness

Ikegami T, Maruyama Y, Doi H, Hattori A, Ando H

Frontiers in Neuroscience ( その他の出版社 )  9 ( 9 ) 1   2015年01月

掲載種別: 研究論文（その他学術会議資料等）

Ultradian oscillation in expression of four melatonin receptor subtype genes in the pineal gland of the grass puffer, a semilunar-synchronized spawner, under constant darkness.

Ikegami T, Maruyama Y, Doi H, Hattori A, Ando H

Frontiers in neuroscience ( FRONTIERS RESEARCH FOUNDATION )  9 ( 9 ) 9 - 10   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Melatonin receptor gene expression as well as melatonin synthesis and secretion activities were examined in the pineal gland of the grass puffer, which exhibits unique lunar/tidal cycle-synchronized mass spawing: spawning occurs before high tide on the day of spring tide during spawing season. Melatonin synthesizing activity was assessed by the abundance of arylalkylamine N-acetyltransferase 2 (AANAT2) mRNA. The amount of aanat2 mRNA was low during light phase and initiated to increase after the light was turned off. The secretion of melatonin from primary pineal organ culture was stimulated after the light was turned off and ceased immediately after the light was turned on. The expression levels of four melatonin receptor subtype genes (me/(1a)1.4, me/(1a)1.7, me/1b, and me/1c) showed synchronous variations, and the levels tended to be high during the dark phase under light/dark conditions. These results suggest that the action of melatonin on the pineal gland is highly dependent on light and photoperiod, possibly with stronger action during night time. Under constant darkness, the expression of four melatonin receptor subtype genes showed unique ultradian oscillations with the period of 14.0-15.4 h, suggesting the presence of a circatidal oscillator in the pineal gland. The present results indicate that melatonin may serve local chronobiological functions in the pineal gland. These cyclic expressions of melatonin receptor genes in the pineal gland may be important in the control of the lunar/tidal cycle-synchronized mass spawning in the grass puffer.

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Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases.

Yamashita Y, Hasegawa M, Deng Z, Maeda H, Kondo S, Kyuna A, Matayoshi S, Agena S, Uehara T, Kouzaki H, Shimizu T, Ikegami T, Ganaha A, Suzuki M

Infectious agents and cancer ( BIOMED CENTRAL LTD )  10 ( 23 ) 23 - 8   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background: We aimed to clarify the possible role of human papillomavirus (HPV) infection in the malignant transformation of sinonasal inverted papilloma (IP). Methods: Subjects comprised 32 patients with chronic rhinosinusitis (CRS), 17 with IP, 5 with IP and squamous cell carcinoma (IP + SCC), and 16 with primary sinonasal SCC. HPV presence, viral loads, and physical status were investigated using polymerase chain reaction. Retinoblastoma (pRb), p53, and p16(INK4a) gene products were investigated by immunohistochemistry. Results: HPV DNA was detected in 6.3 % of cases with CRS, 29.4 % with IP, 40 % with IP + SCC, and 25 % with SCC. IP cases had significantly higher HPV presence than CRS cases (p = 0.04). High-risk HPV-16 was the most frequently encountered subtype (10/13, 76.9 %). HPV-16 viral loads varied from 2.5 to 7953 E6 copies/50 ng genomic DNA. Patients in the SCC and IP + SCC groups had significantly higher viral loads than those in the IP and CRS groups (p < 0.01). All SCC and IP + SCC patients with HPV-16 demonstrated mixed-type integration, whereas 4 of 5 HPV-16 patients in the IP and CRS groups showed episomal type infection (p = 0.04). Positivity to pRb was found in 78.1 % of CRS, 35.3 % of IP, and 68.8 % of SCC cases. The presence of HPV DNA negatively correlated with pRb expression in SCC (p = 0.029) and IP (P = 0.049) groups. Although 62.5 % of SCC cases exhibited p53 positivity, only 5.9 % of IP, and no CRS cases were positive. Regardless of HPV status, p16(INK4a) positivity was frequently detected in IP cases (82.4 %), less in SCC (12.5 %) cases, and was not detected in the CRS group. Neither the IP nor SCC cohorts showed any correlation between HPV presence and the expression of either p53 or p16(INK4a). Conclusions: HPV infection was more frequent in the IP, IP + SCC, and SCC groups than the CRS group. Higher viral loads and integration observed in the IP + SCC and SCC groups, and an inverse correlation between HPV presence and positive pRb indicated that persistent infection and integration play a part in tumorigenesis and malignant transformation in certain IP cases. However, p16(INK4a) is not a reliable surrogate marker for HPV infection in IP.

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