Grant-in-Aid for Scientific Research -

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2023.03 

Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2020.04  -  2022.03 

Factors involved in the efficacy and safety of biopharmaceuticals

Grant-in-Aid for Scientific Research(C)

Project Year: 2019.04  -  2022.03 

Investigator(s): Nakamura Katsunori 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

Proper use and selection of antibody drugs are considered to be of clinical significance.The main purpose of this study was to clarify what causes side effects of biological drug and what is the most suitable combination drug for reducing side effects of biological drug.Infusion reactions are controlled by dosing rate, additional doses of corticosteroids, and prophylactic administration of antihistamines and antipyretic analgesics.We analyzed the correlation between the frequency of infusion reactions of rituximab and FcRn genetic polymorphisms.Furthermore, the difference between the combination drugs was examined.

Factors involved in the efficacy and safety of biopharmaceuticals

Grant-in-Aid for Scientific Research(C)

Project Year: 2019.04  -  2022.03 

Investigator(s): Nakamura Katsunori 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

Proper use and selection of antibody drugs are considered to be of clinical significance.The main purpose of this study was to clarify what causes side effects of biological drug and what is the most suitable combination drug for reducing side effects of biological drug.Infusion reactions are controlled by dosing rate, additional doses of corticosteroids, and prophylactic administration of antihistamines and antipyretic analgesics.We analyzed the correlation between the frequency of infusion reactions of rituximab and FcRn genetic polymorphisms.Furthermore, the difference between the combination drugs was examined.

Factors involved in the efficacy and safety of biopharmaceuticals

Grant-in-Aid for Scientific Research(C)

Project Year: 2019.04  -  2022.03 

Investigator(s): Nakamura Katsunori 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

Proper use and selection of antibody drugs are considered to be of clinical significance.The main purpose of this study was to clarify what causes side effects of biological drug and what is the most suitable combination drug for reducing side effects of biological drug.Infusion reactions are controlled by dosing rate, additional doses of corticosteroids, and prophylactic administration of antihistamines and antipyretic analgesics.We analyzed the correlation between the frequency of infusion reactions of rituximab and FcRn genetic polymorphisms.Furthermore, the difference between the combination drugs was examined.

Factors involved in the efficacy and safety of biopharmaceuticals

Grant-in-Aid for Scientific Research(C)

Project Year: 2019.04  -  2022.03 

Investigator(s): Nakamura Katsunori 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

Proper use and selection of antibody drugs are considered to be of clinical significance.The main purpose of this study was to clarify what causes side effects of biological drug and what is the most suitable combination drug for reducing side effects of biological drug.Infusion reactions are controlled by dosing rate, additional doses of corticosteroids, and prophylactic administration of antihistamines and antipyretic analgesics.We analyzed the correlation between the frequency of infusion reactions of rituximab and FcRn genetic polymorphisms.Furthermore, the difference between the combination drugs was examined.

Factors involved in the efficacy and safety of biopharmaceuticals

Grant-in-Aid for Scientific Research(C)

Project Year: 2019.04  -  2022.03 

Investigator(s): Nakamura Katsunori 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

Proper use and selection of antibody drugs are considered to be of clinical significance.The main purpose of this study was to clarify what causes side effects of biological drug and what is the most suitable combination drug for reducing side effects of biological drug.Infusion reactions are controlled by dosing rate, additional doses of corticosteroids, and prophylactic administration of antihistamines and antipyretic analgesics.We analyzed the correlation between the frequency of infusion reactions of rituximab and FcRn genetic polymorphisms.Furthermore, the difference between the combination drugs was examined.

Molecular mechanism in the brain of the change in food preference associated with rapid weight loss after obesity

Grant-in-Aid for Scientific Research(C)

Project Year: 2018.04  -  2021.03 

Investigator(s): Okamoto Shiki 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

It is well known that rapid weight loss is accompanied by picky eating and abnormal eating behavior, which may lead to a rebound, but detailed molecular mechanisms in the brain remain unclear. In the present study, we focused on changes in food preference and analyzed the mechanisms that regulate abnormal eating behavior in the hypothalamus during different periods of weight change. In the post-obesity weight-loss mice (WL), fat intake increased in addition to carbohydrate intake, resulting in an increase in total caloric intake. In the paraventricular nucleus of the WL mice, the expression of fatty acid metabolism genes was increased in addition to several ion channels and neuropeptide receptors, but arachidonic acid metabolism genes were strongly suppressed. We are now analyzing feeding behavior after expression modification using viral vectors encoding these candidate genes for obese memory, and are investigating the regulatory mechanisms in detail.

Molecular mechanism in the brain of the change in food preference associated with rapid weight loss after obesity

Grant-in-Aid for Scientific Research(C)

Project Year: 2018.04  -  2021.03 

Investigator(s): Okamoto Shiki 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

It is well known that rapid weight loss is accompanied by picky eating and abnormal eating behavior, which may lead to a rebound, but detailed molecular mechanisms in the brain remain unclear. In the present study, we focused on changes in food preference and analyzed the mechanisms that regulate abnormal eating behavior in the hypothalamus during different periods of weight change. In the post-obesity weight-loss mice (WL), fat intake increased in addition to carbohydrate intake, resulting in an increase in total caloric intake. In the paraventricular nucleus of the WL mice, the expression of fatty acid metabolism genes was increased in addition to several ion channels and neuropeptide receptors, but arachidonic acid metabolism genes were strongly suppressed. We are now analyzing feeding behavior after expression modification using viral vectors encoding these candidate genes for obese memory, and are investigating the regulatory mechanisms in detail.

Molecular mechanism in the brain of the change in food preference associated with rapid weight loss after obesity

Grant-in-Aid for Scientific Research(C)

Project Year: 2018.04  -  2021.03 

Investigator(s): Okamoto Shiki 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

It is well known that rapid weight loss is accompanied by picky eating and abnormal eating behavior, which may lead to a rebound, but detailed molecular mechanisms in the brain remain unclear. In the present study, we focused on changes in food preference and analyzed the mechanisms that regulate abnormal eating behavior in the hypothalamus during different periods of weight change. In the post-obesity weight-loss mice (WL), fat intake increased in addition to carbohydrate intake, resulting in an increase in total caloric intake. In the paraventricular nucleus of the WL mice, the expression of fatty acid metabolism genes was increased in addition to several ion channels and neuropeptide receptors, but arachidonic acid metabolism genes were strongly suppressed. We are now analyzing feeding behavior after expression modification using viral vectors encoding these candidate genes for obese memory, and are investigating the regulatory mechanisms in detail.

Molecular mechanism in the brain of the change in food preference associated with rapid weight loss after obesity

Grant-in-Aid for Scientific Research(C)

Project Year: 2018.04  -  2021.03 

Investigator(s): Okamoto Shiki 

Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

　View Summary

It is well known that rapid weight loss is accompanied by picky eating and abnormal eating behavior, which may lead to a rebound, but detailed molecular mechanisms in the brain remain unclear. In the present study, we focused on changes in food preference and analyzed the mechanisms that regulate abnormal eating behavior in the hypothalamus during different periods of weight change. In the post-obesity weight-loss mice (WL), fat intake increased in addition to carbohydrate intake, resulting in an increase in total caloric intake. In the paraventricular nucleus of the WL mice, the expression of fatty acid metabolism genes was increased in addition to several ion channels and neuropeptide receptors, but arachidonic acid metabolism genes were strongly suppressed. We are now analyzing feeding behavior after expression modification using viral vectors encoding these candidate genes for obese memory, and are investigating the regulatory mechanisms in detail.

Grant-in-Aid for Scientific Research(C)

Project Year: 2017.04  -  2023.03 

Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2017.04  -  2023.03 

Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

Grant-in-Aid for Scientific Research(C)

Project Year: 2017.04  -  2023.03 

Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)