論文 - 金城　武士

Detection of community-acquired respiratory viruses during COVID-19 pandemic in subtropical region in Japan

Wakaki Kami, Takeshi Kinjo, Hiroe Hashioka, Wakako Arakaki, Ami Takahashi, Shohei Yogi, Kohei Uechi, Shiro Maeda, Kazuko Yamamoto, Jiro Fujita

European Journal of Clinical Microbiology & Infectious Diseases ( Springer )    2024年09月 [ 査読有り ]

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Complete genome sequence of a metallo-β-lactamase-producing Aeromonas dhakensis strain, RYU-Ah62, isolated from a patient with an abdominal abscess

Naoya Nishiyama, Kohei Uechi, Wakako Arakaki, Daisuke Utsumi, Yukuto Sato, Masashi Nakamatsu, Takeshi Kinjo, Kazuko Yamamoto

Microbiology Resource Announcements ( American Society for Microbiology )  13 ( 7 ) e0001024   2024年07月 [ 査読有り ]

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Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity

Etsuhisa Takahashi, Takako Sawabuchi, Tetsuya Homma, Yosuke Fukuda, Hironori Sagara, Takeshi Kinjo, Kaori Fujita, Shigeru Suga, Takashi Kimoto, Satoko Sakai, Keiko Kameda, Hiroshi Kido

Viruses   15 ( 8 ) 1662   2023年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Effect of voluntary human mobility restrictions on vector-borne diseases during the COVID-19 pandemic in Japan: A descriptive epidemiological study using a national database (2016 to 2021)

Hibiya K, Shinzato A, Iwata H, Kinjo T, Tateyama M, Yamamoto K, Fujita J.

PLoS One   18 ( 5 )   2023年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Rebound mortality rate of Legionella pneumonia in Japan

Yamasue M, Komiya K, Kinjo T, Ito A, Yamaguchi T, Iwanaga N, Ishii M, Tateda K, Kawakami K.

Respiratory Investigation   61 ( 4 )   2023年05月 [ 査読有り ]

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Respiratory virus infections of the lower respiratory tract elevate bronchoalveolar lavage eosinophil fraction: a clinical retrospective study and case review

Nabeya D, Setoguchi M, Ueno S, Kinjo T.

BMC Pulmonary Medicine   23 ( 1 ) 111   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Impact of G29179T mutation on two commercial PCR assays for SARS-CoV-2 detection

Kami W, Kinjo T, Hashioka H, Arakaki W, Uechi K, Takahashi A, Oki H, Tanaka K, Motooka D, Nakamura S, Nakamatsu M, Maeda S, Yamamoto K, Fujita J.

Journal of Virological Methods     2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Characteristics of patients with viral infections of the lower respiratory tract: A retrospective study

Nabeya Daijiro, Kinjo Takeshi, Ueno Shiho, Setoguchi Michika, Nishiyama Naoya, Kami W, Arakaki Wakaki, Haranaga Shusaku, Fujita Jiro

Medicine ( Medicine (United States) )  101 ( 38 ) e30819 - e30819   2022年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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While the impact of respiratory virus infections has been well researched in some respiratory diseases, no clinical studies have discussed the subject of who would be more likely to develop respiratory virus infections among patients with various respiratory illnesses who come from different backgrounds. This study aimed to identify respiratory diseases that are frequently associated with respiratory virus infections along with the characteristics of patients who develop such infections in clinical settings. Tested specimens were obtained from the lower respiratory tract by bronchoscopy to provide more accurate data. Data of bronchoscopies at Ryukyu University Hospital between August 2012 and September 2016 were reviewed, and patients who underwent multiplex polymerase chain reaction (PCR) tests for detecting respiratory viruses in bronchoscopy specimens were retrospectively recruited for descriptive statistics. Differences among patients' primary pulmonary diseases and backgrounds were compared between the PCR-positive and -negative patients, and multivariate statistical analysis was performed to analyze factors associated with a positive PCR test result. Overall, 756 bronchoscopies were performed during the study period and PCR tests were performed for 177 patients. Of them, 27 tested positive for respiratory viruses, mainly parainfluenza virus and rhinovirus, and out of those, 7 were hospitalized for >1 month. Overall, all patients did not experience typical upper respiratory infection symptoms. In positive patients, 13 and 7 had diagnoses of interstitial lung disease and bacterial pneumonia, respectively. The diagnoses of 3 bacterial pneumonia cases were changed to viral pneumonia after receiving their PCR-positive tests. Respiratory virus infections were confirmed in 14 patients on immunosuppressant therapy and 4 on maintenance dialysis. Multivariate analysis revealed that immunosuppressant therapy and maintenance dialysis were independently associated with respiratory virus infections. Viruses were commonly detected in patients with interstitial lung diseases and bacterial pneumonia, while few patients were diagnosed with pure viral pneumonia. These illnesses were considered to be induced by respiratory infections. Immunosuppressant therapy and maintenance dialysis were associated with respiratory virus infections. Multiplex PCR testing is an essential diagnostic tool for respiratory virus infections in immunocompromised patients.

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Radiological findings in nontuberculous mycobacterial pulmonary diseases: A comparison between the Mycobacterium avium complex and the Mycobacterium abscessus complex

Nagano Hiroaki, Kinjo Takeshi, Fujita Jiro, Kishaba Tomoo

PLoS One ( PLoS ONE )  17 ( 7 ) e0271660 - e0271660   2022年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The Mycobacterium abscessus complex (MABC) comprises rapidly growing mycobacteria and has received increasing attention recently, with an increasing number of associated infections reported worldwide. However, the clinical features of MABC pulmonary disease (MABC-PD), especially in terms of the chest computed tomography (CT) findings, are not fully understood. Thus, this retrospective, cross-sectional study aimed to evaluate the clinical background and chest high-resolution CT (HRCT) findings of MABC-PD in comparison with those of Mycobacterium avium complex PD (MAC-PD). Accordingly, 36 patients with MABC-PD and 65 patients with MAC-PD (defined according to the American Thoracic Society criteria), who were newly diagnosed at four major hospitals in Okinawa (Japan) between January 2012 and December 2017, were analyzed. With respect to their clinical background, only cardiovascular diseases were significantly more common in patients with MABC-PD than in those with MAC-PD (38.9% vs. 18.5%, p = 0.0245). HRCT revealed a significantly higher incidence of low attenuation in patients with MABC-PD than in those with MAC-PD (63.9% vs. 10.8%, p<0.0001). On analyzing only never-smokers (20 and 47 patients with MABC-PD and MAC-PD, respectively), this significant difference remained (65.0% vs. 8.5%, p<0.0001), suggesting MABC infection itself caused low attenuation. In terms of the distribution of abnormal shadows, the involvement of the right lower, left upper, and left lower lobes was more common in patients with MABC-PD than in those with MAC-PD. Furthermore, the mean number of involved lung lobes was significantly higher in patients with MABC-PD than in those with MAC-PD (5.6 vs. 4.7, p<0.001). Although further studies are needed, we assume that the aforementioned radiological features of MABC-PD are due to the high virulence of MABC.

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Ascariasis Resulting from Swine-to-Human Transmission in Okinawa, Japan

Kinjo Takeshi, Toma Hiromu, Fujita Jiro

The American journal of tropical medicine and hygiene. ( American Journal of Tropical Medicine and Hygiene )  106 ( 6 ) 1583 - 1584   2022年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan.

Yoshida M, Chien JY, Morimoto K, Kinjo T, Aono A, Murase Y, Fujiwara K, Morishige Y, Nagano H, Jou R, Hasegawa N, Ato M, Hoshino Y, Hsueh PR, Mitarai S

Microbiology spectrum ( Microbiology Spectrum )  10 ( 3 ) e0057122   2022年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Mycobacterium abscessus complex (MABC) is a group of emerging, highly antimicrobial-resistant non-tuberculous mycobacteria. Specific MABC clones are spreading globally in patients with cystic fibrosis (CF); however, associated genomic epidemiology is lacking in East Asia, with very few patients with CF. Here, we investigated MABC populations derived from non-CF patients in Japan and Taiwan. Analysis of whole-genome sequencing data of 220 MABC isolates revealed that 112, 105, and 3 were M. abscessus subsp. abscessus (ABS), M. abscessus subsp. massiliense (MAS), and M. abscessus subsp. bolletii (BOL), respectively. Moreover, >50% of ABS and >70% of MAS were related to four predominant clones in the region. Known mutations conferring macrolide resistance were rare (1.4%) and were not enriched in the predominant clones. Conversely, the macrolide-susceptible erm(41) T28C mutation was significantly enriched in one predominant ABS clone. The most predominant ABS clone was genetically related to the previously described dominant circulating clone (DCC)1 in patients with CF, whereas no isolates were related to DCC2; isolates related to DCC3 were not necessarily predominant in our sample set. We found that the erm(41) T28C mutants spread globally, and some of them reacquired the functional erm(41) gene through both point mutation and recombination. This study revealed predominant MABC clones in Japan and Taiwan and their relationship with the globally superadding clones in the patient community with CF. Our study provides insights into the genetic characteristics of globally dominant and area-specific strains isolated from patients with or without CF and differences between globally spread and regionally specific strains. IMPORTANCE Members of Mycobacterium abscessus complex (MABC) are frequently isolated from patients. Studies have reported that predominant clones of MABC (known as dominant circulating clones; DCCs) are distributed worldwide and transmitted from humans to humans in patients with cystic fibrosis (CF). However, associated genomic epidemiology has not yet been conducted in East Asia, including Japan and Taiwan, where there are only a few patients with CF. Using whole-genome sequencing data derived from non-CF patients in Japan and Taiwan, we revealed prevalent clones and the incidence of macrolide resistance-associated mutations in the MABC population in this region. We also clarified the associations between these predominant clones and DCCs in the global CF patient community. Our results would assist further studies in elucidating the genetic characteristics of strains isolated from patients with or without CF, the differences between globally spread and regionally specific strains, and the adaptive evolution of MABC within the host.

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Unilateral digital clubbing in hemiplegia due to a putaminal hemorrhage.

Kinjo T, Arakaki W, Fujita J

Clinical case reports   10 ( 3 ) e05519   2022年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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National survey of physicians in Japan regarding their use of diagnostic tests for legionellosis.

Kinjo T, Ito A, Ishii M, Komiya K, Yamasue M, Yamaguchi T, Imamura Y, Iwanaga N, Tateda K, Kawakami K

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  28 ( 2 ) 129 - 134   2022年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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INTRODUCTION: Bacterial culture remains the gold standard for the diagnosis of legionellosis. However, past reports indicate that most physicians use the urinary antigen test (UAT) alone. Combining it with other tests is important, especially in patients with negative UAT results. The aim of this study was to investigate the current situation of legionellosis diagnostics and clarify the issues that need to be addressed. METHODS: Between March 1, 2021 and April 30, 2021, a questionnaire survey was conducted in an anonymous manner among physicians working in Japan. Questionnaires were generated on a website and asked questions in a multiple-choice format. RESULTS: Valid responses were received from 309 physicians during the study period. Most (92.9%) physicians reported using UAT as the initial test for patients suspected of having legionellosis, and <10% reported using other tests (e.g., culture, nucleic acid amplification test [NAAT], Gimenez staining, and serum antibody titer measurement [ATM]). When the initial test result was negative, 63% of physicians reported not conducting additional tests. Even when they chose to run additional tests, at most 27.8%, 23.6%, 12.3%, and 10.4% of all physicians used NAAT, culture, Gimenez staining, and serum ATM, respectively. The major reasons for not using tests other than UAT were "unavailability in the medical facility," "long turn-around time," and "difficult to collect sputum." CONCLUSIONS: The present survey revealed that most physicians in Japan used UAT alone for diagnosing legionellosis. Eliminating barriers to creating a reasonable environment and edification of physicians are needed to improve the current situation.

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Community-acquired Respiratory Virus Cases Mimic COVID-19 on Lung Computed Tomography.

Nabeya D, Kinjo T, Maeda A, Nagano H, Yokoyama S, Takakura S, Shiiki S, Fujita J, Kishaba T

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  61 ( 1 ) 111 - 114   2022年01月

掲載種別: 研究論文（学術雑誌）

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<p>We herein report four patients with community-acquired respiratory virus (CRV) infection. Although they had no history of contact with any individual with coronavirus disease 2019 (COVID-19), they were suspected of having COVID-19 based on findings of high-resolution computed tomography (CT) of the lungs. Among the four patients, two were infected with rhinovirus, one with metapneumovirus, and one with influenza A. Their chest CT findings were similar to those of COVID-19 patients reported in previous studies. Both CRV infection and COVID-19 can show various patterns on chest CT. CRV infection is thus indistinguishable from COVID-19 based on CT findings alone. </p>

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Successive disappearance of summer influenza in the Okinawa prefecture during the severe acute respiratory syndrome coronavirus 2 pandemic.

Sunagawa S, Iha Y, Kinjo T, Nakamura K, Fujita J

Respiratory investigation ( Respiratory Investigation )  60 ( 1 ) 184 - 186   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility from respiratory specimens: a case-control study.

Nishiyama N, Kinjo T, Uechi K, Parrott G, Nakamatsu M, Tateyama M, Fujita J

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ( European Journal of Clinical Microbiology and Infectious Diseases )  41 ( 1 ) 1 - 8   2022年01月 [ 査読有り ]

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Incidence of common infectious diseases in Japan during the COVID-19 pandemic.

Hibiya K, Iwata H, Kinjo T, Shinzato A, Tateyama M, Ueda S, Fujita J

PloS one ( PLoS ONE )  17 ( 1 ) e0261332   2022年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Recent reports indicate that respiratory infectious diseases were suppressed during the novel coronavirus disease-2019 (COVID-19) pandemic. COVID-19 led to behavioral changes aimed to control droplet transmission or contact transmission. In this study, we examined the incidence of common infectious diseases in Japan during the COVID-19 pandemic. COVID-19 data were extracted from the national data based on the National Epidemiological Surveillance of Infectious Diseases (NESID). Common infectious diseases were selected from notifiable infectious diseases under the NESID. The epidemic activity of the diseases during 2015-2020 was evaluated based on the Infectious Disease Weekly Reports published by the National Institute of Infectious Diseases. Each disease was then categorized according to the route of transmission. Many Japanese people had adopted hygienic activities, such as wearing masks and hand washing, even before the COVID-19 pandemic. We examined the correlation between the time-series of disease counts of common infectious diseases and COVID-19 over time using cross-correlation analysis. The weekly number of cases of measles, rotavirus, and several infections transmitted by droplet spread, was negatively correlated with the weekly number of cases of COVID-19 for up to 20 weeks in the past. According to the difference-in-differences analysis, the activity of influenza and rubella was significantly lower starting from the second week in 2020 than that in 2015-2019. Only legionellosis was more frequent throughout the year than in 2015-2019. Lower activity was also observed in some contact transmitted, airborne-transmitted, and fecal-oral transmitted diseases. However, carbapenem-resistant Enterobacteriaceae, exanthema subitum, showed the same trend as that over the previous 5 years. In conclusion, our study shows that public health interventions for the COVID-19 pandemic may have effectively prevented the transmission of most droplet-transmitted diseases and those transmitted through other routes.

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50%ブドウ糖液による胸膜癒着術を施行した難治性気胸・胸水8症例の報告

兼久梢, 鍋谷大二郎, 金城武士, 上野志穂, 瀬戸口倫香, 宮城一也, 原永修作, 藤田次郎

呼吸臨床   5 ( 11 ) e00140   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

50%ブドウ糖液による胸膜癒着術を施行した難治性気胸・胸水8症例の報告

兼久梢, 鍋谷大二郎, 金城武士, 上野志穂, 瀬戸口倫香, 宮城一也, 原永修作, 藤田次郎

呼吸臨床   5 ( 11 ) e00140   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Spontaneously shrinking lung mass due to <i>Mycobacterium avium</i> mimicking lung cancer.

Kinjo T, Uechi K, Kami W, Fujita J

Clinical case reports ( Clinical Case Reports )  9 ( 11 ) e05006   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Tuberculous shadow in <i>Klebsiella oxytoca</i> pneumonia: An unexpected denouement.

Kinjo T, Hanaki Y, Nakamoto A, Fujita J

Clinical case reports ( Clinical Case Reports )  9 ( 11 ) e05053   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Uncommon Presentation of Tuberculosis as an Incidentally Discovered Solitary Pleural Tuberculoma.

Kinjo T, Shimoji M, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  106 ( 2 ) 376 - 377   2021年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Rapid and simultaneous identification of three mutations by the Novaplex™ SARS-CoV-2 variants I assay kit.

Kami W, Kinjo T, Arakaki W, Oki H, Motooka D, Nakamura S, Fujita J

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology ( Journal of Clinical Virology )  141   104877   2021年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background:. The emergence of SARS-CoV-2 variants has caused an unexpected rebound globally. The World Health Organization has listed three variants (B.1.1.7, B.1.351, and P.1) as variants of concern. To understand the epidemiology and thereby plan appropriate safety measures, differential identification of the variants is indeed critical. Objectives:. Although whole-genome sequencing is the gold standard for variant identification, it is time-consuming and relatively expensive. Therefore, a rapid, easy, and cost-effective platform targeting multiple regions of the genome is required. Here, we assessed the usefulness of the Novaplex™ SARS-CoV-2 Variants I Assay kit in identifying mutations in the variants. Study design:. We retrospectively examined 30 stored nasal swabs from COVID-19-positive patients tested between November 2020 and March 2021. RNA extracted from these swabs was subjected to the commercial kit and real-time reverse transcription-PCR was performed. To determine the genome sequences of SARS-CoV-2 in the collected samples and deduce the consensus sequences among the identified variants, genome sequencing libraries were prepared and mapped to the reference genome. Results:. Four of the tested samples were determined as variants. Of them, two harbored both H69/V70 deletion and N501Y substitution, whereas two harbored E484K substitution alone. Conclusions:. The variant with E484K substitution alone (“R.1”) has been now categorized as a variant of interest in Japan. Additionally, the kit-based assay was found to be feasible, convenient, and user-friendly in identifying the abovementioned mutations with a turnaround time of only 2 h.

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Emergence of a multidrug-resistant plasmid encoding <i>bla</i> _NDM-1, <i>bla</i> _OXA-420 and <i>armA</i> in a clinical isolate of <i>Acinetobacter variabilis</i> in Japan.

Uechi K, Tohya M, Tada T, Tome T, Takahashi A, Kinjo T, Maeda S, Kirikae T, Fujita J

Journal of medical microbiology ( Journal of Medical Microbiology )  70 ( 8 )   2021年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Acinetobacter variabilis (formerly genospecies 15 sensu Tjernberg and Ursing) has been isolated from humans and animals and was proposed to be a novel species in 2015. A multidrug-resistant A. variabilis isolate, RYU24, was obtained in 2012 from an inpatient in Okinawa, Japan, with no record of overseas travel. The isolate was resistant to carbapenems, aminoglycosides and ciprofloxacin, with minimum inhibitory concentrations (MICs) of 32 µg ml-1 for imipenem and meropenem; > 1024 µg ml-1 for amikacin, arbekacin, gentamicin and tobramycin; and 8 µg ml-1 for ciprofloxacin. The isolate was found to harbour a 68-kbp plasmid carrying bla NDM-1, which encodes New Delhi metallo-β-lactamase-1 (NDM-1); bla OXA-420, which encodes an OXA-58-like carbapenemase and; armA, which encodes ArmA 16S rRNA methylase conferring pan-aminoglycoside resistance. To our knowledge, this is the first report of a plasmid harbouring the three major drug-resistance genes, bla NDM-1, bla OXA-420 and armA.

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False-positive for SARS-CoV-2 antigen test in a man with acute HIV infection.

Yamaniha K, Kinjo T, Akamine M, Setoguchi M, Tateyama M, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  27 ( 7 ) 1112 - 1114   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Critical respiratory failure in pregnancy complicated with COVID-19: A case report.

Chinen Y, Kinjyo Y, Mekaru K, Kinjo T, Higure Y, Kinjo T, Miyagi K, Yamada H, Masamoto H, Goya H, Yoshida T, Maeshiro S, Nakamatsu M, Fujita J, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  30   e00309   2021年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The case is presented of a 29-year-old primiparous woman who was COVID-19-positive at 34 weeks of gestation and who developed severe acute respiratory distress syndrome. After a four-day history of fever and mild dyspnea, she was referred to hospital. Ciclesonide, dexamethasone, heparin sodium, and sulbactam/ampicillin were initiated, followed by remdesivir and tocilizumab. On the fourth day after admission (at 34 weeks 5 days of gestation), respiratory failure required ventilator management. An emergency cesarean section was performed and a 2565-g male infant was delivered with an Apgar score of 8/8 and negative COVID-19 status. However, on the following day the patient's respiratory condition deteriorated and mechanical ventilation was initiated. Subsequently, her respiratory condition quickly improved and mechanical ventilation was terminated 4 days after intubation. She was discharged 12 days after cesarean delivery. Our case provides additional evidence that raises concerns regarding the unfavorable maternal consequences of COVID-19 infection during pregnancy.

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Case Report: Ischemic Enterocolitis Associated with Coronavirus Disease 2019: Two Case Reports and a Review of the Literature.

Kinjo T, Hokama A, Nakamura H, Miyagi K, Higure Y, Otsuki M, Nishiyama N, Nakamatsu M, Kinjo T, Tateyama M, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  104 ( 5 ) 1655 - 1658   2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The COVID-19 pandemic has caused serious health and social concerns worldwide. Although the primary target of SARS-CoV-2 is the respiratory tract, SARS-CoV-2 infection also causes extrapulmonary symptoms. Previous articles have reported ischemic colitis in COVID-19 patients; however, information regarding its clinical manifestations and pathophysiology is limited. In this case report, we present two cases of ischemic enterocolitis in COVID-19 patients and review past case reports. Our literature review has shown that computed tomography rather than endoscopy was used for the diagnosis, and any region of the intestine was affected. Because the elevation of the D-dimer, which suggested a hypercoagulable state, was reported in most cases, we assumed that thrombosis at any level in the artery and vein was involved in the pathophysiology of COVID-19-associated enterocolitis. SARS-CoV-2-induced endotheliitis can cause both coarctation of the vessels and thrombosis; therefore, both patterns of ischemic colitis, occlusive and nonocclusive, may be involved in COVID-19-associated enterocolitis.

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Case Report: Iliopsoas Hematoma during the Clinical Course of Severe COVID-19 in Two Male Patients.

Nakamura H, Ouchi G, Miyagi K, Higure Y, Otsuki M, Nishiyama N, Kinjo T, Nakamatsu M, Tateyama M, Kukita I, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  104 ( 3 ) 1018 - 1021   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Anticoagulation plays a major role in reducing the risk of systematic thrombosis in patients with severe COVID-19. Serious hemorrhagic complications, such as intracranial hemorrhage, have also been recognized. However, intra-abdominal hemorrhage is under-recognized because of its rare occurrence, despite high mortality. Here, we discuss two cases of spontaneous iliopsoas hematoma (IPH) likely caused by anticoagulants during the clinical course of COVID-19. We also explored published case reports to identify clinical characteristics of IPH in COVID-19 patients. The use of anticoagulants may increase the risk of lethal IPH among COVID-19 patients becsuse of scarce data on optimal dosage and adequate monitoring of anticoagulant effects. Rapid diagnosis and timely intervention are crucial to ensure good patient outcomes.

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Serum KL-6 can distinguish between different phenotypes of severe COVID-19.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Journal of medical virology ( Journal of Medical Virology )  93 ( 1 ) 158 - 160   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Role of zanamivir is likely to end in Okinawa, Japan.

Sunagawa S, Iha Y, Kinjo T, Nakamura K, Fujita J

Respiratory investigation ( Respiratory Investigation )  59 ( 1 ) 159 - 161   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Disappearance of summer influenza in the Okinawa prefecture during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

Sunagawa S, Iha Y, Kinjo T, Nakamura K, Fujita J

Respiratory investigation ( Respiratory Investigation )  59 ( 1 ) 149 - 152   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Emergence of clinical isolates of <i>Pseudomonas asiatica</i> and <i>Pseudomonas monteilii</i> from Japan harbouring an acquired gene encoding a carbapenemase VIM-2.

Tohya M, Uechi K, Tada T, Hishinuma T, Kinjo T, Ohshiro T, Maeda S, Kirikae T, Fujita J

Journal of medical microbiology ( Microbiology Society )  70 ( 1 )   2021年01月

掲載種別: 研究論文（学術雑誌）

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<jats:p> <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">Pseudomonas asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">Pseudomonas monteilii</jats:ext-link> </jats:named-content> </jats:italic>, belonging to the <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2674" xlink:type="simple">Pseudomonas putida</jats:ext-link> </jats:named-content> </jats:italic> phylogenetic group, are occasionally isolated from clinical samples, partly because they are often misidentified as <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2674" xlink:type="simple">P. putida</jats:ext-link> </jats:named-content> </jats:italic> in clinical laboratories. There are five reports describing carbapenem-resistant clinical isolates of these species. Carbapenem-resistant strains of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> were isolated from stool samples. These isolates were sequenced using Illumina MiSeq and reidentified using average nucleotide identity (ANI) based on comparisons of their whole-genome sequences using the OrthoANI algorithm. The clonal relatedness of the isolates was assessed by pulse-field gel electrophoresis (PFGE). The size of plasmids conveying <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> was examined by Southern blotting. A total of six carbapenem-resistant clinical isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> (two isolates) and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> (four isolates) were obtained from stool samples from five patients in a Japanese hospital. All isolates harboured <jats:italic>bla<jats:sub>VIM-2</jats:sub> </jats:italic>. The two isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> had a different pattern in the PFGE analysis, with both having a 23 kb plasmid. Of the four isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> with similar patterns in the PFGE analysis, three had 320 kb plasmids and one had a 240 kb plasmid. The genetic environments of the 320/240 kb and 23 kb plasmids differed. The results strongly indicated that carbapenem-resistant <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> producing metallo-β-lactamase are emerging in Japan. This is the first report of carbapenem-resistant <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> in Japan.</jats:p>

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Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review.

Shinzato A, Kinjo T, Miyagi T, Yamazato S, Kaneku K, Nishiyama M, Miyagi K, Furugen M, Fujita J

Clinical case reports ( Clinical Case Reports )  8 ( 12 ) 3510 - 3514   2020年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare paraneoplastic syndrome. Our literature review shows the location of arthralgia and existence of edema are referable information for the differential diagnosis in paraneoplastic arthralgia.

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Acute Hypertriglyceridaemia Caused by Tocilizumab in a Patient with Severe COVID-19.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  59 ( 22 ) 2945 - 2949   2020年11月

掲載種別: 研究論文（学術雑誌）

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<p>Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor. </p>

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Clinical characteristics of community-acquired pneumonia due to Moraxella catarrhalis in adults: a retrospective single-centre study.

Hirai J, Kinjo T, Koga T, Haranaga S, Motonaga E, Fujita J

BMC infectious diseases ( BMC Infectious Diseases )  20 ( 1 ) 821 - 821   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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BACKGROUND: Although Moraxella catarrhalis (M. catarrhalis) is a common cause of community-acquired pneumonia (CAP), studies investigating clinical manifestations of CAP due to M. catarrhalis (MC-CAP) in adults are limited. Since S. pneumoniae is the leading cause of CAP globally, it is important to distinguish between MC-CAP and CAP due to S. pneumoniae (SP-CAP) in clinical practice. However, no past study compared clinical characteristics of MC-CAP and SP-CAP by statistical analysis. We aimed to clarify the clinical characteristics of MC-CAP by comparing those of SP-CAP, as well as the utility of sputum Gram staining. METHODS: This retrospective study screened CAP patients aged over 20 years visiting or admitted to Okinawa Miyako Hospital between May 2013 and April 2018. Among these, we included patients whom either M. catarrhalis alone or S. pneumoniae alone was isolated from their sputum by bacterial cultures. RESULTS: We identified 134 MC-CAP and 130 SP-CAP patients. Although seasonality was not observed in SP-CAP, almost half of MC-CAP patients were admitted in the winter. Compared to those with SP-CAP, MC-CAP patients were older (p < 0.01) and more likely to have underlying pulmonary diseases such as asthma and bronchiectasis (p < 0.01). Approximately half of asthmatic MC-CAP and SP-CAP patients had asthma attacks. Although winter is an influenza season in Japan, co-infection with influenza virus was less common in MC-CAP compared to SP-CAP patients (3% vs. 15%, p < 0.01). Bronchopneumonia patterns on X-ray, as well as bronchial wall thickening, bilateral distribution, and segmental pattern on CT were more common in MC-CAP patients than in SP-CAP patients (p < 0.01). Sputum Gram stain was highly useful method for the diagnosis in both MC-CAP and SP-CAP (78.4% vs. 89.2%), and penicillins were most frequently chosen as an initial treatment for both pneumonias. CONCLUSIONS: This is the first study to show that MC-CAP occurred in older people compared to SP-CAP, influenza virus co-infection was less common in MC-CAP than SP-CAP, and that MC-CAP frequently caused asthma attacks. Gram stain contributed for the appropriate treatment, resulting in conserving broad-spectrum antibiotics such as cephalosporins and fluoroquinolones in both MC-CAP and SP-CAP patients.

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Seizure followed by lung edema: An intriguing link between the brain and the lung.

Arakaki W, Kinjo T, Nakamura H, Fujita J

Clinical case reports ( Clinical Case Reports )  8 ( 11 ) 2291 - 2292   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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When observing diffuse ground-glass opacities in both lungs, physicians should consider several diseases, including heart failure, interstitial lung diseases, and pulmonary infections. However, brain diseases rarely cause lung infiltration. We present an instructive case of neurologic pulmonary edema showing a pathological link between the brain and the lung.

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Use of the interleukin 6 inhibitor tocilizumab in Japanese patients with cytokine release syndrome caused by COVID-19-related acute respiratory distress syndrome: A case series.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Respiratory investigation ( Respiratory Investigation )  58 ( 6 ) 510 - 512   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Use of steroids to treat anti-tumor necrosis factor α induced tuberculosis-associated immune reconstitution inflammatory syndrome: Case report and literature review.

Nabeya D, Kinjo T, Yamaniha K, Yamazato S, Tome R, Miyagi K, Nakamura H, Kinjo T, Haranaga S, Higa F, Fujita J

Medicine ( Medicine )  99 ( 43 ) e22076   2020年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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INTRODUCTION: Individuals with tuberculosis (TB) who are being treated with anti-tumor necrosis factor α (anti-TNFα) for coexisting conditions may experience unexpected exacerbations of TB after the initiation of antituberculous therapy, so-called anti-TNFα-induced TB-immune reconstitution inflammatory syndrome (anti-TNFα-induced TB-IRIS). Anti-TNFα-induced TB-IRIS is often treated empirically with corticosteroids; however, the evidence of the effectiveness of corticosteroids is lacking and the management can be a challenge. PATIENT CONCERNS: A 32-year-old man on long-term infliximab therapy for Crohn disease visited a clinic complaining of persistent fever and cough that had started 1 week previously. His most recent infliximab injection had been administered 14 days before the visit. A chest X-ray revealed a left pleural effusion, and he was admitted to a local hospital. DIAGNOSIS: A chest computed tomography (CT) scan revealed miliary pulmonary nodules; acid-fast bacilli were found in a sputum smear and a urine sediment sample; and polymerase chain reaction confirmed the presence of Mycobacterium tuberculosis in both his sputum and the pleural effusion. He was diagnosed with miliary TB. INTERVENTIONS: Antituberculous therapy was started and he was transferred to our hospital for further management. His symptoms initially improved after the initiation of antituberculous therapy, but 2 weeks later, his symptoms recurred and shadows on chest X-ray worsened. A repeat chest CT scan revealed enlarged miliary pulmonary nodules, extensive ground-glass opacities, and an increased volume of his pleural effusion. This paradoxical exacerbation was diagnosed as TB-IRIS associated with infliximab. A moderate-dose of systemic corticosteroid was initiated [prednisolone 25 mg/day (0.5 mg/kg/day)]. OUTCOMES: After starting corticosteroid treatment, his radiological findings improved immediately, and his fever and cough disappeared within a few days. After discharge, prednisolone was tapered off over the course of 10 weeks, and he completed a 9-month course of antituberculous therapy uneventfully. He had not restarted infliximab at his most recent follow-up 14 months later. CONCLUSION: We successfully managed a patient with anti-TNFα-induced TB-IRIS using moderate-dose corticosteroids. Due to the limited evidence currently available, physicians should consider the necessity, dosage, and duration of corticosteroids for each case of anti-TNFα-induced TB-IRIS on an individual patient-by-patient basis.

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Where is Chlamydophila pneumoniae pneumonia?

Fujita J, Kinjo T

Respiratory investigation ( Respiratory Investigation )  58 ( 5 ) 336 - 343   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Serum levels of receptor-interacting protein kinase-3 in patients with COVID-19.

Nakamura H, Kinjo T, Arakaki W, Miyagi K, Tateyama M, Fujita J

Critical care (London, England) ( Critical Care )  24 ( 1 ) 484 - 484   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Analysis of bronchoalveolar lavage samples collected from 30 patients with drug-induced pneumonitis.

Yamauchi M, Haranaga S, Parrott G, Kinjo T, Yamashiro T, Tsubakimoto M, Ohtsu H, Ueda S, Fujita J

Respiratory investigation ( Respiratory Investigation )  58 ( 3 ) 204 - 211   2020年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background: Drug-induced pneumonitis is a disease encountered by pulmonologists in the clinical setting. The diagnosis generally considers the patient's clinical course and the results of peripheral blood tests, radiological examinations, and often bronchoscopic examinations. However, few studies have reported the association between radiological patterns such as ground-glass opacity (GGO) or consolidation, and bronchoalveolar lavage fluid (BALF) cell fractions. This study aimed to clarify this association. Methods: Patients with a Naranjo's score of probable or definite were enrolled, and all 30 patients were categorized under probable. Data such as patient background, blood examination results, radiological findings, and BALF cell fractions were retrospectively collected. The association between BALF cell fractions and other factors such as chest computed tomography (CT) findings was evaluated. Results: The most common radiological finding in patients with lymphocyte-dominant BALF was GGO, with only one patient exhibiting consolidation. However, patients with eosinophil-dominant BALF were more likely to have consolidation; only three cases showed crazy paving and one showed GGO. In addition, patients with a GGO-dominant pattern on CT had an increased lymphocyte fraction of 41.0%; those with a consolidation-dominant pattern showed a relatively high eosinophil fraction of 5.2%; and those with a crazy paving pattern showed elevated eosinophil and neutrophil fractions of 19.1% and 9.9%, respectively. Conclusions: In this study, a remarkable difference in radiological findings was observed among different BALF patterns.

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レボフロキサシン投与が診断遅れの要因となったと考えられる介護施設における結核集団感染事例

平井潤, 原永修作, 柴原大典, 金城武士, 百瀬匡, 與那覇忠宏, 与那覇翔, 涌川朝雅, 本永英治, 藤田次郎

結核   95 ( 2 ) 67 - 72   2020年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

レボフロキサシン投与が診断遅れの要因となったと考えられる介護施設における結核集団感染事例

平井潤, 原永修作, 柴原大典, 金城武士, 百瀬匡, 與那覇忠宏, 与那覇翔, 涌川朝雅, 本永英治, 藤田次郎

結核 ( (一社)日本結核・非結核性抗酸菌症学会 )  95 ( 2 ) 67 - 72   2020年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

誤嚥性肺炎の診断でレボフロキサシン(LVFX)が投与された症例が初発患者と推測される介護施設での結核集団感染事例を経験したので報告する。80代男性(症例1)が発熱を主訴に受診。当初誤嚥性肺炎として治療されたが,最終的に肺結核と判明し抗結核薬で治療を行った。その1ヵ月後,症例1と同室の80代女性(症例2)が7ヵ月前から繰り返す発熱・咳嗽の精査で来院。胸部画像で多発空洞を認め,精査後に肺結核と診断された。症例2は過去7ヵ月間に複数回誤嚥性肺炎の診断でLVFX投与が行われていたことが判明し,臨床経過・画像などから初発患者と判断した。その後の接触者健診で,入所者11人,職員30人の結核感染が判明し,症例2を含む肺結核と診断された入所者3名に対し誤嚥性肺炎の診断でLVFXの投与が行われていた。LVFX投与により発熱・咳嗽などの症状が一時的に軽快し,結核感染の発見が遅れ集団感染へとつながったと推測された。本邦の新登録結核患者は80代以上で最も多い状況のため,特に高齢者が入所する施設においては安易にフルオロキノロン系薬剤(FQ)の使用は避けるべきであり,「FQを使用する際には必ず結核を除外する」ことを厳守する必要がある。(著者抄録)

寝たきり高齢者における肺結核の胸部CT所見の検討

平井潤, 原永修作, 柴原大典, 金城武士, 百瀬匡, 與那覇忠宏, 与那覇翔, 涌川朝雅, 本永英治, 藤田次郎

結核   95 ( 3 ) 93 - 98   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The First Case of Community-Acquired Pneumonia Due to Capsular Genotype K2-ST86 Hypervirulent <i>Klebsiella pneumoniae</i> in Okinawa, Japan: A Case Report and Literature Review.

Hirai J, Sakanashi D, Kinjo T, Haranaga S, Fujita J

Infection and drug resistance ( Infection and Drug Resistance )  13   2237 - 2243   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Hypervirulent Klebsiella pneumoniae (HV-KP) typically causes pyogenic liver abscess and bacteremia with metastatic infections. Community-acquired pneumonia (CAP) due to HV-KP is uncommon and details of its clinical and microbiological features are limited. We report the first case of CAP due to capsular genotype K2-ST86 HV-KP in Okinawa, Japan and review infections caused by the K2-ST86 strain. A 79-year-old woman presenting with fever and productive cough persisting for the past three days was admitted to hospital. Her vital signs indicated septic shock. Lung examination by auscultation revealed holo-crackle and lobar pneumonia in chest radiography, and Streptococcus pneumoniae was suspected. However, sputum and blood cultures revealed Gram-negative coccus identified as K. pneumoniae. Genetic analysis identified the isolated strain as the K2 serotype harboring rmpA, iutA, entB, and mrkD. Therefore, we identified the isolated strain as hypervirulent. The isolate belonged to ST86 as determined by multilocus sequence typing. The case was not complicated by predisposing factors such as diabetes mellitus and malignancy related to HV-KP infection; thus, this CAP-causing HV-KP strain may differ from the typical HV-KP strain that induces liver abscess. A literature review identified only nine cases with CAP due to HV-KP. In all cases, the disease mainly occurred in older males with diabetes mellitus, which makes the present case unusual, and had high rates of septic shock and death. No case, including ours, was complicated by metastatic infection, suggesting that CAP due to HV-KP poses little distant metastasis risk, even in patients with bloodstream infection. In our review, consistent with our case, K2-ST86 was the most common strain of HV-KP in patients with CAP. Therefore, studies are needed to elucidate the clinical and microbiological features of HV-KP CAP, with a focus on the K2-ST86 strain. Physicians should always consider K. pneumoniae in cases of sepsis CAP with lobar pneumonia.

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Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia.

Yamauchi M, Kinjo T, Parrott G, Miyagi K, Haranaga S, Nakayama Y, Chibana K, Fujita K, Nakamoto A, Higa F, Owan I, Yonemoto K, Fujita J

PloS one ( PLoS ONE )  15 ( 1 ) e0227636   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Serum markers that differentiate between tuberculous and non-tuberculous pneumonia would be clinically useful. However, few serum markers have been investigated for their association with either disease. In this study, serum levels of interferon gamma (IFN-γ), matrix metalloproteinases 1 and 9 (MMP-1 and MMP-9, respectively), and periostin were compared between 40 pulmonary tuberculosis (PTB) and 28 non-tuberculous pneumonia (non-PTB) patients. Diagnostic performance was assessed by analysis of receiver-operating characteristic (ROC) curves and classification trees. Serum IFN-γ and MMP-1 levels were significantly higher and serum MMP-9 levels significantly lower in PTB than in non- PTB patients (p < 0.001, p = 0.002, p < 0.001, respectively). No significant difference was observed in serum periostin levels between groups. ROC curve analysis could not determine the appropriate cut-off value with high sensitivity and specificity; therefore, a classification tree method was applied. This method identified patients with limited infiltration into three groups with statistical significance (p = 0.01), and those with MMP-1 levels < 0.01 ng/ mL and periostin levels ≥ 118.8 ng/mL included only non-PTB patients (95% confidence interval 0.0-41.0). Patients with extensive infiltration were also divided into three groups with statistical significance (p < 0.001), and those with MMP-9 levels < 3.009 ng/mL included only PTB patients (95% confidence interval 76.8-100.0). In conclusion, the novel classification tree developed using MMP-1, MMP-9, and periostin data distinguished PTB from non- PTB patients. Further studies are needed to validate our cut-off values and the overall clinical usefulness of these markers.

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Case Report of Primary Lung Abscesses Due to Hypervirulent <i>Klebsiella pneumoniae</i> (Serotype K2, Sequence Type 375): an Emerging Isolate in Okinawa, Japan.

Hirai J, Sakanashi D, Momose M, Koga T, Kinjo T, Haranaga S, Motonaga E, Fujita J

Infection and drug resistance ( Infection and Drug Resistance )  13   1691 - 1695   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Hypervirulent Klebsiella pneumoniae (HV-KP) is typically associated with community-acquired liver abscess and bacteremia with metastatic infection; however, primary lung abscess (PLA) caused by HV-KP is rare, with only one such case report to date. A 69-year-old man with a history of diabetes mellitus (DM) was admitted to hospital complaining of slight bloody sputum. Chest imaging showed multiple consolidations with cavities in both lung fields. A culture of bronchoalveolar lavage fluid confirmed the presence of K. pneumoniae. Genetic analyses identified the isolate as serotype K2 and sequence type 375 (K2-ST375), and that it harbored the rmpA gene. The patient was an Asian middle-aged male with DM, all of which are risk factors for HV-KP infection. Although complicating DM and the presence of the rmpA gene are more likely to induce disseminated infection, metastatic infections were not found in this patient. The clinical and microbiological characteristics of our patient were different from those of a previous reported case, although in both cases the patient was from Asia and had DM. Therefore, DM appears to be one of the predisposing factors for HV-KP lung abscesses and physicians should pay attention to emerging HV-KP lung abscess infection, particularly in Asian countries. Previous studies have also revealed that K2-ST375 is one of the major clones causing HV-KP infection, and that it is mainly isolated from patients with liver abscess. Interestingly, including the present case, most of the infectious cases caused by K2-ST375 have been reported from Okinawa Prefecture in Japan. Therefore, the trend of the K2-ST375 strain should be carefully monitored, particularly in Okinawa, Japan. The serotype of HV-KP that causes PLA is still unknown and further study is needed to elucidate the etiology of PLA due to HV-KP and the relationship between the strain K2-ST375 and PLA.

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A Case Report of Cerebral Meningitis Caused by Penicillin-Non-Susceptible Group B <i>Streptococcus</i> in an Immunocompromised Adult Patient.

Hirai J, Kinjo T, Haranaga S, Fujita J

Infection and drug resistance ( Infection and Drug Resistance )  13   2155 - 2160   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is the leading cause of bacteremia and meningitis in neonates; however, it also causes meningitis in adults, although much less frequently. After the detection of penicillin-non-susceptible GBS (PRGBS) for the first time in 2008 by Japanese researchers, clinical PRGBS isolates have been reported worldwide. These isolates need to be given due attention for being non-susceptible to multiple drugs. Herein, we present the first clinical report of meningitis caused by PRGBS. A 41-year-old Japanese male receiving an immunosuppressant visited hospital complaining of fever. Although he did not have meningitis-related symptoms or physical findings, determination of the cause of fever by Gram-staining of the spinal fluid revealed gram-positive cocci in pairs and chains. Initially, he was hospitalized on the diagnosis of cerebral meningitis caused by Streptococcus pneumoniae. However, culture of the spinal fluid revealed the β-hemolytic colonies on blood agar. Biochemical testing and mass spectrometry revealed the isolated organism as GBS (serotype Ib). The minimum inhibitory concentration (MIC) of penicillin G for the isolated strain was 0.5 μg/mL, which is greater than the MIC criteria for "susceptibility" to penicillin G for beta-hemolytic streptococci according to Clinical and Laboratory Standards Institute standards. The isolated strain was also resistant to macrolide (MIC ≥ 8 μg/mL) and fluoroquinolone (MIC ≥ 8 μg/mL). The patient recovered without neurologic sequelae upon treatment with ceftriaxone, vancomycin, and corticosteroids for 4 days, and subsequently with ampicillin for 17 days. The rate of isolation of PRGBS in the clinics has gradually increased, particularly in Japan. Although PRGBS isolated in the present case was susceptible to ampicillin and cephalosporins, strains not susceptible to ampicillin, cefotaxime, and ceftriaxone have already been isolated, indicating the prospects for limited range of effective antibiotics against PRGBS infections, including meningitis, in the near future.

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Chest Computed Tomography Abnormalities and Their Relationship to the Clinical Manifestation of Respiratory Syncytial Virus Infection in a Genetically Confirmed Outbreak.

Nabeya D, Kinjo T, Parrott GL, Nakachi S, Yamashiro T, Ikemiyagi N, Arakaki W, Masuzaki H, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  59 ( 2 ) 247 - 252   2020年

掲載種別: 研究論文（学術雑誌）

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<p>Studies reporting chest images of respiratory syncytial virus (RSV)-induced lower respiratory tract infection (LRTI) in an outbreak setting and their relationship to the clinical manifestation are limited. During a genetically confirmed RSV outbreak, eight patients underwent both chest X-ray and computed tomography (CT). Among these, 5 cases had newly appearing abnormalities on CT, although chest X-ray was able to detect abnormalities in only 2 cases (40%). Although bronchial wall thickening was common, other findings and their distribution were variable, even in an outbreak setting. All patients with both a history of anticancer chemotherapy against hematological cancer and lower respiratory symptoms, such as wheezing, sputum, and hypoxemia, had abnormalities on CT, suggesting that these two factors might be important for predicting the existence of LRTI in RSV-infected patients. </p>

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寝たきり高齢者における肺結核の胸部CT所見の検討

平井潤, 原永修作, 柴原大典, 金城武士, 百瀬匡, 與那覇忠宏, 与那覇翔, 涌川朝雅, 本永英治, 藤田次郎

結核 ( (一社)日本結核・非結核性抗酸菌症学会 )  95 ( 3 ) 93 - 98   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

[目的]単一老健施設において肺結核のアウトブレイクを経験したため,寝たきり高齢者(入所者)と健常者(職員)における胸部CT画像所見の比較を行う。[対象]X年10月〜X+1年9月に,肺結核を発症し,胸部CTを撮影した入所者と職員。[方法]患者背景や胸部CT所見を後方視的に検討した。[結果]対象は入所者7例,職員9例の合計16例。職員との比較で,入所者は発熱や体重減少,炎症反応高値を示す傾向を認めた。胸部CTでは,入所者は気管支壁肥厚,気管支拡張症,結節影を全例に認め,職員は小葉中心性結節影を全例に認めた。入所者は全例で両側びまん性に陰影を呈し,職員よりも下葉に陰影を呈する傾向を認めた。[考察]本検討と過去の報告から,低栄養,PS不良の場合には,典型的な肺尖部優位の陰影は呈さず,下葉や両側びまん性に陰影を呈する傾向にあることが示唆された。また,高齢者の肺結核は高齢者の市中肺炎や医療介護関連肺炎と比べて,結節影やtreein-budの所見が多く,びまん性に陰影を示す傾向を認めた。[結論]寝たきり高齢者の肺結核は下葉にも高頻度で起こるため誤嚥性肺炎との鑑別を有し,細菌性肺炎と比較して多数の肺野に陰影を呈する傾向を示す。(著者抄録)

Development of Lung Emphysema Due to APRV.

Kami W, Kinjo T, Miyagi K, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  58 ( 20 ) 3061 - 3061   2019年10月

掲載種別: 研究論文（学術雑誌）

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Spontaneous Pneumomediastinum in a Previously Healthy Patient.

Hashioka H, Kinjo T, Shinzato A, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  58 ( 20 ) 3063 - 3063   2019年10月

掲載種別: 研究論文（学術雑誌）

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呼吸器内科でのシングルユースビデオ気管支鏡の使用経験

當銘 玲央, 宮城 一也, 喜友名 朋, 金城 武士, 原永 修作, 健山 正男, 藤田 次郎

気管支学 ( 特定非営利活動法人 日本呼吸器内視鏡学会 )  41 ( 4 ) 411 - 416   2019年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p><b>背景．</b>シングルユース（単回使用）の気管支鏡はその特性から集中治療室や救急部での使用経験が報告されているが，呼吸器内科での使用経験の報告は少ない．当院でシングルユースビデオ気管支鏡を使用した症例について報告する．<b>症例．</b>2016年4月から2017年3月の間に，11例延べ14件に対しシングルユースビデオ気管支鏡が使用された．代表的な2例を示す．症例7は77歳男性．右膿胸の治療中に喀血にて挿管となった．シングルユースビデオ気管支鏡を用いて血餅除去を行ったが気管粘膜と血塊の判別が難しく，通常の気管支鏡へ変更とした．症例9は63歳男性．両側誤嚥性肺炎，左膿胸の診断で入院となった．左右主気管支内に多量の喀痰が貯留するため数日おきに吸痰を行ったが，時間外はシングルユースビデオ気管支鏡を使用した．上記2例を含め，14件中7件は緊急または時間外使用であった．<b>結論．</b>シングルユースビデオ気管支鏡は通常の気管支鏡に取って代わるものではないが，軽量で設定も簡便なため特に緊急時に有用であった．また，気管支鏡の損傷を気にせず手技を行うことができ，交差感染が起きないことも利点である．</p>

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Pseudomonas asiatica sp. nov., isolated from hospitalized patients in Japan and Myanmar.

Tohya M, Watanabe S, Teramoto K, Uechi K, Tada T, Kuwahara-Arai K, Kinjo T, Maeda S, Nakasone I, Zaw NN, Mya S, Zan KN, Tin HH, Fujita J, Kirikae T

International journal of systematic and evolutionary microbiology ( Microbiology Society )  69 ( 5 ) 1361 - 1368   2019年05月

掲載種別: 研究論文（学術雑誌）

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POM-1型メタロ-β-ラクタマーゼ産生を有するPseudomonas otitidisを分離した6例

西山直哉, 上地幸平, 當銘高明, 下地真里有, 大城健哉, 仲松正司, 金城武士, 健山正男, 藤田次郎

日本臨床微生物学会雑誌   29 ( 2 ) 73 - 77   2019年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Comprehensive subspecies identification of 175 nontuberculous mycobacteria species based on 7547 genomic profiles.

Matsumoto Y, Kinjo T, Motooka D, Nabeya D, Jung N, Uechi K, Horii T, Iida T, Fujita J, Nakamura S

Emerging microbes & infections ( Informa UK Limited )  8 ( 1 ) 1043 - 1053   2019年

掲載種別: 研究論文（学術雑誌）

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POM-1型メタロ-β-ラクタマーゼ産生を有するPseudomonas otitidisを分離した6例

西山直哉, 上地幸平, 當銘高明, 下地真里有, 大城健哉, 仲松正司, 金城武士, 健山正男, 藤田次郎

日本臨床微生物学会雑誌   29 ( 2 ) 73 - 77   2019年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Clinical Features of Human Metapneumovirus Pneumonia in Non-Immunocompromised Patients: An Investigation of Three Long-Term Care Facility Outbreaks.

Karimata Y, Kinjo T, Parrott G, Uehara A, Nabeya D, Haranaga S, Higa F, Tateyama M, Miyagawa K, Kishaba T, Otani K, Okamoto M, Nishimura H, Fujita J

The Journal of infectious diseases ( Journal of Infectious Diseases )  218 ( 6 ) 868 - 875   2018年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Distribution of cytomegalovirus genotypes among ulcerative colitis patients in Okinawa, Japan.

Nahar S, Hokama A, Iraha A, Ohira T, Kinjo T, Hirata T, Kinjo T, Parrott GL, Fujita J

Intestinal research ( Intestinal Research )  16 ( 1 ) 90 - 98   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Comparison of two screening tests for HIV-Associated Neurocognitive Disorder suspected Japanese patients with respect to cART usage.

Kami-Onaga K, Tateyama M, Kinjo T, Parrott G, Tominaga D, Takahashi-Nakazato A, Nakamura H, Tasato D, Miyagi K, Maeda S, Arae H, Uehara H, Miyagi K, Haranaga S, Fujita J

PloS one ( PLoS ONE )  13 ( 6 ) e0199106   2018年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

In this study, we demonstrated the pervasiveness of HIV-associated neurocognitive disorders (HAND) among a selection of Japanese patients as well as evaluated and compared the Mini Mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS) for use as a screening tool among combination anti-retroviral therapy (cART)-naïve and cART experienced patients. The MMSE and the IHDS have both been used as HAND screening tests around the world with variable success. It has been reported the increased usage of cART the utility of these screening tests may have been diminished due to the decreased severity of impairment and the altered pattern of neurocognitive impairments in cART era HAND patients. It is therefore possible the MMSE and the IHDS may still be useful among cART-naïve patients even in the cART era. However, only one study has investigated and compared the screening results of the IHDS among cART-naïve and cART experienced patients. All HIV positive patients who visited, or were admitted, to the Ryukyu University Hospital between January 2009 and March 2014 were evaluated for inclusion. Selected patients (n = 49) had data without omission for all tests. The overall prevalence of HAND in our cohort was 44%. The area under the curve (AUC), for all subjects using the MMSE and the IHDS, were 0.60 and 0.69, respectively. However, the AUC among cART-naïve patients were 0.58 and 0.76 for the MMSE and the IHDS, respectively. Whereas, cART experienced patients had an AUC of 0.60 and 0.61, respectively. Overall, the MMSE demonstrated a poor screening ability for HAND, regardless of cART usage (the cut-off value of 27 had a Youden's J-Index of 0.1, in all groups). Alternatively, the IHDS was moderately useful for HAND screening among cART-naïve patients (the cut-off value of 11 had a Youden's J-Index of 0.4), but performed poorly as a screening test among cART experienced patients (the cut-off value of 11 had a Youden's J-Index of 0.1).

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Evaluation of Anyplex™ II RV16 and RB5 real-time RT-PCR compared to Seeplex^® RV15 OneStep ACE and PneumoBacter ACE for the simultaneous detection of upper respiratory pathogens.

Parrott G, Kinjo T, Nabeya D, Uehara A, Nahar S, Miyagi K, Haranaga S, Tateyama M, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  23 ( 12 ) 859 - 861   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Do infections with disseminated <i>Mycobacterium avium</i> complex precede sweet's syndrome? A case report and literature review.

Hibiya K, Miyagi K, Tamayose M, Nabeya D, Kinjo T, Takeshima S, Ikemiyagi N, Yamada K, Fujita A, Hashioka H, Kami W, Inamine M, Shibahara D, Nakamura H, Furugen M, Haranaga S, Higa F, Tateyama M, Fujita J

International journal of mycobacteriology   6 ( 4 ) 336 - 343   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Sweet's syndrome is reportedly associated with preceding nontuberculous mycobacterial infections (NTMIs). Here, we report on a systemic Mycobacterium intracellulare infection in a patient on corticoid therapy for Sweet's syndrome. Literature searches show that 69.1% of patients with Sweet's syndrome and NTMIs developed this syndrome later than NTMIs and 89.3% of them developed during the clinical course of a rapidly growing mycobacterial infection. The residual cases were associated with slow-growing mycobacteria (14.3%), but only three cases of Mycobacterium avium complex (MAC) infections before the onset of Sweet's syndrome have been reported, and all of them were caused by disseminated MAC disease. One of these cases developed during corticoid therapy for Sweet's syndrome, while another case had underlying diabetes mellitus. Hence, the occurrence of systemic MAC disease may be an inevitable consequence of long-term steroid use and underlying diseases. Literature searches also show that cervical lymphadenitis was a predominant symptom in NTMIs (90.5%). The present case did not have cervical lymphadenitis although the previously reported MAC cases did experience it. Therefore, lymphadenitis from NTMIs may be related to the pathogenesis of Sweet's syndrome. Hence, should a patient have systemic infection without lymphadenitis, it will be more difficult to clinically confirm that MAC disease is a predisposing factor for Sweet's syndrome.

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

Journal of medical virology ( Wiley )  89 ( 8 ) 1364 - 1372   2017年08月

掲載種別: 研究論文（学術雑誌）

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Etiological analysis and epidemiological comparison among adult CAP and NHCAP patients in Okinawa, Japan.

Parrott G, Nebeya D, Kinjo T, Miyagi K, Haranaga S, Higa F, Tateyama M, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  23 ( 7 ) 452 - 458   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases.

Nabeya D, Haranaga S, Parrott GL, Kinjo T, Nahar S, Tanaka T, Hirata T, Hokama A, Tateyama M, Fujita J

BMC infectious diseases ( BMC Infectious Diseases )  17 ( 1 ) 320   2017年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature.

Hirai J, Hagihara M, Haranaga S, Kinjo T, Hashioka H, Kato H, Sakanashi D, Yamagishi Y, Mikamo H, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  23 ( 4 ) 245 - 249   2017年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan.

Nagano H, Kinjo T, Nei Y, Yamashiro S, Fujita J, Kishaba T

PloS one ( PLoS ONE )  12 ( 10 ) e0186826   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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8年間で気管支鏡的結石除去を7回行った気管支結石症の1例

鍋谷 大二郎, 宮城 一也, 上 若生, 橋岡 寛恵, 金城 武士, 古堅 誠, 原永 修作, 藤田 次郎

気管支学 ( 特定非営利活動法人 日本呼吸器内視鏡学会 )  39 ( 3 ) 246 - 250   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p><b>背景．</b>気管支結石症は，本邦では結核感染による石灰化リンパ節が原因として多かったが，近年は気道分泌物由来の結石症が増加している．今回，繰り返し気管支鏡的除去術を要した分泌物由来の気管支結石症を経験した．<b>症例．</b>51歳女性．結核感染症の既往や石灰化リンパ節はない．高度の側弯症があり，若年時より下気道感染を繰り返していた．38歳時には胸部CTで気管支拡張と気管支内腔の結石を指摘されていた．43歳時に呼吸不全の改善を目的に気管支鏡下に最初の除石術を行った．その後も同様の理由で度々除石術を要し，8年間で計7回の除石術を行った．除石術に関連する合併症は認めなかった．結石の主成分は炭酸カルシウムであった．気道の加湿の改善と排痰方法の変更の後は，2年以上再発を認めていない．<b>結論．</b>側弯症と気管支拡張による持続的な気道クリアランス不良により，分泌物由来の気管支結石を繰り返したと考えられる．気管支内腔に遊離する結石であったため，気管支鏡による除石術は安全で実用的であった．</p>

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Bacteremia due to Citrobacter braakii: A case report and literature review.

Hirai J, Uechi K, Hagihara M, Sakanashi D, Kinjo T, Haranaga S, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  22 ( 12 ) 819 - 821   2016年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Meningococcal pneumonia in Japan: A case report and literature review.

Hirai J, Kinjo T, Tome T, Hagihara M, Sakanashi D, Nakamura H, Haranaga S, Mikamo H, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  22 ( 12 ) 833 - 836   2016年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Case-control study of pneumonia patients with Streptococcus anginosus group bacteria in their sputum.

Hirai J, Sakanashi D, Haranaga S, Kinjo T, Hagihara M, Kato H, Suematsu H, Yamagishi Y, Fujita J, Mikamo H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  22 ( 12 ) 794 - 799   2016年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Comparative epidemiology of influenza A and B viral infection in a subtropical region: a 7-year surveillance in Okinawa, Japan.

Iha Y, Kinjo T, Parrott G, Higa F, Mori H, Fujita J

BMC infectious diseases ( BMC Infectious Diseases )  16 ( 1 ) 650   2016年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Osteomyelitis caused by Veillonella species: Case report and review of the literature.

Hirai J, Yamagishi Y, Kinjo T, Hagihara M, Sakanashi D, Suematsu H, Fujita J, Mikamo H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  22 ( 6 ) 417 - 20   2016年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Relationship Among Strongyloides stercoralis Infection, Human T-Cell Lymphotropic Virus Type 1 Infection, and Cancer: A 24-Year Cohort Inpatient Study in Okinawa, Japan.

Tanaka T, Hirata T, Parrott G, Higashiarakawa M, Kinjo T, Kinjo T, Hokama A, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  94 ( 2 ) 365 - 370   2016年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A Compendium for Mycoplasma pneumoniae.

Parrott GL, Kinjo T, Fujita J

Frontiers in microbiology ( Frontiers in Microbiology )  7 ( APR ) 513   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Yellow Broncho-alveolar Lavage Fluid in Eosinophilic Pneumonia.

Nabeya D, Kinjo T, Miyagi K, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 21 ) 3227 - 3228   2016年

掲載種別: 研究論文（学術雑誌）

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An Epidemiological Analysis of Summer Influenza Epidemics in Okinawa.

Sunagawa S, Iha Y, Taira K, Okano S, Kinjo T, Higa F, Kuba K, Tateyama M, Nakamura K, Nakamura S, Motooka D, Horii T, Parrott GL, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 24 ) 3579 - 3584   2016年

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p><b>Objective </b>This study evaluates the difference between winter influenza and summer influenza in Okinawa. </p><p><b>Methods </b>From January 2007 to June 2014, weekly rapid antigen test (RAT) results performed in four acute care hospitals were collected for the surveillance of regional influenza prevalence in the Naha region of the Okinawa Islands. </p><p><b>Results </b>An antigenic data analysis revealed that multiple H1N1 and H3N2 viruses consistently co-circulate in Okinawa, creating synchronized seasonal patterns and a high genetic diversity of influenza A. Additionally, influenza B viruses play a significant role in summer epidemics, almost every year. To further understand influenza epidemics during the summer in Okinawa, we evaluated the full genome sequences of some representative human influenza A and influenza B viruses isolated in Okinawa. Phylogenetic data analysis also revealed that multiple H1N1 and H3N2 viruses consistently co-circulate in Okinawa. </p><p><b>Conclusion </b>This surveillance revealed a distinct epidemic pattern of seasonal and pandemic influenza in this subtropical region. </p>

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「一目瞭然！目で診る症例」問題・解答

金城 武士, 藤田 次郎

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  105 ( 7 ) 1303 - 1305   2016年

掲載種別: 研究論文（その他学術会議資料等）

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Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis.

Nahar S, Iraha A, Hokama A, Uehara A, Parrott G, Ohira T, Kaida M, Kinjo T, Kinjo T, Hirata T, Kinjo N, Fujita J

World journal of gastroenterology ( World Journal of Gastroenterology )  21 ( 44 ) 12667 - 75   2015年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab.

Tamaki K, Kinjo T, Aoyama H, Tomoyose T, Nakachi S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Taira N, Fujita J, Yoshimi N, Fukushima T, Masuzaki H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  21 ( 11 ) 820 - 3   2015年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

We report a case of fatal pneumonia and viremia due to human parainfluenza virus type 1 (HPIV-1) in a 65-year-old male patient with adult T-cell leukemia-lymphoma (ATL) treated with mogamulizumab, a brand-new therapeutic agent for ATL. To our knowledge, this is the first report describing viremia due to HPIV-1. After administering mogamulizumab, lymphocyte count in the blood was drastically decreased and the patient suffered from complicated infections including gram-negative bacterial sepsis, cytomegalovirus antigenemia and aspergillosis. Although these infections were successfully controlled by broad spectrum antimicrobial therapy, patchy ground-grass opacities in the both lungs were gradually worsened. He finally died due to acute respiratory failure. Since findings of the chest CT was consistent with typical patterns of viral pneumonia, we screened major respiratory viruses in the peripheral blood with multiplex PCR, and it turned out that RNA of HPIV-1 was positive. Although ATL cells were not detected in the autopsied lungs and a variety of other tissues, cytoplasmic inclusion bodies, which are commonly observed in RNA viral infection, were abundantly observed in the autopsied lung tissue. These findings suggest that mogamulizumab accomplished complete remission of ATL, while the chemotherapy-induced prolonged lymphopenia caused fatal pneumonia and viremia due to HPIV-1. As it has been well recognized that community respiratory viruses including HPIV-1 often cause fatal pneumonia in patients with leukemia, but also there is no specific treatment for HPIV-1, we have to enforce standard precautions especially when we treat leukemic patients with intensively immunosuppressive agents such as mogamulizumab.

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Interleukin-17A in Legionella pneumonia: a retrospective study.

Higa F, Haroon A, Iha Y, Tasato D, Nakamura H, Kinjo T, Tamayose M, Furugen M, Miyagi K, Haranaga S, Tateyama M, Fujita J

Japanese journal of infectious diseases ( 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会 )  68 ( 2 ) 148 - 50   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Interleukin (IL)-17A affects the immune system of the lung. <i>Legionella</i> infection can potentially lead to severe pneumonia. The present study aimed to evaluate the role of IL-17A in <i>Legionella</i> pneumonia. Serum IL-17A levels were quantified in both patients with <i>Legionella</i> pneumonia and control subjects; IL-17 was detected in sera from 4 out of 31 patients with <i>Legionella</i> pneumonia but in any controls. There were no differences in peripheral white blood cell counts or other serum biomarkers (C-reactive protein, and lactate dehydrogenase) between IL-17A-positive and IL-17A-negative patients. All IL-17A-positive patients in this cohort survived, where 8 of 27 IL-17A-negative patients did not. IL-17A was detected in available bronchoalveolar (BA) fluid samples from 7 patients with <i>Legionella</i> pneumonia within our cohort. However, the IL-17A and IFN-γ concentrations in BA fluids did not correlate with each other. IL-17A might play a significant role in some cases of <i>Legionella</i> pneumonia.

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Falciparum Malaria Incidentally Pretreated with Azithromycin.

Shibahara D, Kinjo T, Nishiyama N, Kami W, Nabeya D, Haranaga S, Higa F, Tateyama M, Shinzato T, Toma H, Kishimoto H, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 19 ) 2513 - 6   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

A 65-year-old man, who recently returned from Liberia, visited a clinic complaining of fever, and azithromycin was prescribed. The patient presented to a general hospital 5 days after the onset of symptoms, however, a blood smear examination failed to detect malaria. Contrary to the blood smear result, a rapid antigen test in our hospital was strongly-positive for falciparum malaria, indicating a high level of malarial antigen in the blood. Moreover, laboratory examinations on admission showed a tendency for improvement. We assumed that the administration of azithromycin partially treated malaria, thus complicating the blood smear diagnosis. We should be careful in prescribing azithromycin, which is widely used in clinics, to travelers returning from malaria-endemic countries.<br>

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Beau's Lines and Mees' Lines Formations after Chemotherapy.

Kinjo T, Shibahara D, Higa F, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 17 ) 2281 - 2281   2015年

掲載種別: 研究論文（学術雑誌）

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An Autopsy Case of Two Distinct, Acquired Drug Resistance Mechanisms in Epidermal Growth Factor Receptor-mutant Lung Adenocarcinoma: Small Cell Carcinoma Transformation and Epidermal Growth Factor Receptor T790M Mutation.

Furugen M, Uechi K, Hirai J, Aoyama H, Saio M, Yoshimi N, Kinjo T, Miyagi K, Haranaga S, Higa F, Tateyama M, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 19 ) 2491 - 6   2015年

掲載種別: 研究論文（学術雑誌）

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We herein describe the case of a 63-year-old man who died from relapsed <i>epidermal growth factor receptor</i> gene (<i>EGFR</i>) exon 19 deletion lung adenocarcinoma treated with erlotinib. According to the autopsy results, he was confirmed to have small cell carcinoma without the <i>EGFR</i> T790M mutation in his pancreas and left kidney metastatic specimens, while the adenocarcinoma metastatic lesion in his right kidney had the <i>EGFR</i> T790M mutation; both retained the somatic <i>EGFR</i> exon 19 deletion. We herein report an autopsy case of resistance to an EGFR tyrosine kinase inhibitor via small cell carcinoma transformation and the <i>EGFR</i>T790M mutation in separate metastatic organs.<br>

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Acute respiratory distress syndrome due to Strongyloides stercoralis infection in a patient with cervical cancer.

Kinjo T, Nabeya D, Nakamura H, Haranaga S, Hirata T, Nakamoto T, Atsumi E, Fuchigami T, Aoki Y, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 1 ) 83 - 7   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

A 62-year-old woman complained of diarrhea and vomiting after receiving chemotherapy for cervical cancer in association with high doses of corticosteroids. Two months later, the patient developed acute respiratory distress syndrome, and numerous <i>Strongyloides stercoralis</i> parasites were found in the intrabronchial discharge. Ivermectin was administered daily until nematodes were no longer detected in the sputum, and the patient's condition was successfully rescued. Antibodies for human T-cell lymphotropic virus-1 (HTLV-1) were positive. HTLV-1 infection and the administration of corticosteroids are known risk factors for strongyloides hyperinfection syndrome. Therefore, physicians should consider this disease in the differential diagnosis of patients from endemic areas who present with gastrointestinal symptoms under these risk factors.<br>

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Clinical evaluation of high mobility group box 1 protein in Legionella pneumophila pneumonia

Higa F, Furugen M, Koide M, Karimata Y, Nabeya D, Iha Y, Kinjo T, Miyagi K, Haranaga S, Hokama A, Tateyama M, Fujita J

Journal of Infection and Chemotherapy   20 ( 5 ) 289 - 292   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Rhinovirus Pneumonia in a Patient Infected with HIV

Haranaga S, Kinjo T, Tateyama M, Fujita J

Internal Medicine   53 ( 17 ) 2027 - 2028   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Orange Sputum in a Patient with Legionella pneumophila Pneumonia

Kinjo T, Nabeya D, Higa F, Fujita J

Internal Medicine   53 ( 17 ) 2029 - 2030   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis

Bode C, Kinjo T, Alvord WG, Klinman DM

Carcinogenesis   35 ( 5 ) 1078 - 1083   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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大学病院におけるCDIに対するmetronidazoleの使用状況

比嘉太, 狩俣洋介, 仲松正司, 仲村秀太, 田里大輔, 金城武士, 宮城一也, 原永修作, 健山正男, 藤田次郎

日本嫌気性菌感染症研究   42   73 - 76   2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

沖縄病院におけるGaffky 1号症例の検討　抗酸菌塗抹陽性例は入院適応か？

藤田香織, 上若生, 知花賢治, 仲本敦, 大湾勤子, 久場睦夫, 名嘉山裕子, 金城武士, 藤田次郎, 城間留奈, 宮城茂

沖縄医学会雑誌   52 ( 2 ) 16 - 20   2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy

Kinjo T, Tomaru K, Haines DC, Klinman DM

Respiratory research   13 ( 1 ) 47 - 47   2012年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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第3世代新規抗がん剤で効果が認められた胸腺上皮性腫瘍の2例

古堅誠, 上地華代子, 金城武士, 新里彰, 平井潤, 稲嶺盛史, 渡慶次賀博, 田里大輔, 狩俣洋介, 仲村秀太, 玉寄真紀, 仲松正司, 宮城一也, 熱海恵理子, 原永修作, 屋良さとみ, 比嘉太, 健山正男, 藤田次郎

沖縄医学会雑誌   51 ( 2 ) 36 - 39   2012年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas

Ikeuchi H, Kinjo T, Klinman DM

Cancer Prevention Research   4 ( 5 ) 752 - 757   2011年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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TLR-based immune adjuvants

Steinhagen F, Kinjo T, Bode C, Klinman DM

Vaccine   29 ( 17 ) 3341 - 3355   2011年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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CpG DNA as a vaccine adjuvant

Bode C, Zhao G, Steinhagen F, Kinjo T, Klinman DM

Expert Review of Vaccines   10 ( 4 ) 499 - 511   2011年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Addison's disease due to tuberculosis that required differentiation from SIADH

Kinjo T, Higuchi D, Oshiro Y, Nakamatsu Y, Fujita K, Nakamoto A, Owan I, Miyagi S, Kuba M, Fujita J

Journal of Infection and Chemotherapy   15 ( 4 ) 239 - 242   2009年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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当院で経験した好酸球性肺炎の4例

藤田香織, 仲松裕子, 金城武士, 城間留奈, 仲本敦, 大湾勤子, 宮城茂, 久場睦夫, 加藤誠也

国立   28   20 - 23   2008年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

多発嚢胞性陰影を呈した肺腺癌

藤田香織, 仲松裕子, 金城武士, 城間留奈, 仲本敦, 大湾勤子, 宮城茂, 久場睦夫

国立沖縄病院医学雑誌   28   6 - 8   2008年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Role of interferon-gamma in Valpha14+ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs

Nakamatsu M, Yamamoto N, Hatta M, Nakasone C, Kinjo T, Miyagi K, Uezu K, Nakamura K, Nakayama T, Taniguchi M, Iwakura Y, Kaku M, Fujita J, Kawakami K

Microbes and Infection   9 ( 3 ) 364 - 374   2007年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection

Nakasone C, Yamamoto N, Nakamatsu M, Kinjo T, Miyagi K, Uezu K, Nakamura K, Higa F, Ishikawa H, O'Brien RL, Ikuta K, Kaku M, Fujita J, Kawakami K

Microbes and Infection   9 ( 3 ) 251 - 258   2007年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans

Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, Akira S, Adachi Y, Ohno N, Kinjo T, Nakamura K, Kawakami K, Iwakura Y

Nature Immunology   8 ( 1 ) 39 - 46   2007年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Dectin-1 Is Not Required for the Host Defense to Cryptococcus neoformans

Nakamura K, Kinjo T, Saijo S, Miyazato A, Adachi Y, Ohno N, Fujita J, Kaku M, Iwakura Y, Kawakami K

Microbiology and Immunology   51 ( 11 ) 1115 - 1119   2007年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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肺分画症

久場睦夫, 宮城茂, 大湾勤子, 仲本敦, 藤田香織, 仲松裕子, 金城武士, 大城康二

国立沖縄病院医学雑誌   27   12 - 13   2007年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

特発性血小板減少性紫斑病を合併した肺癌の1例

仲松裕子, 藤田香織, 金城武士, 仲本敦, 大湾勤子, 宮城茂, 久場睦夫

国立   27   30 - 32   2007年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

クォンテイフェロン検査（QuantiFERON TB-2G）の臨床的検討

久場睦夫, 藤田香織, 金城武士, 仲松裕子, 仲本敦, 大湾勤子, 宮城茂

国立沖縄病院医学雑誌   27   14 - 18   2007年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Adjuvant Effect of CpG-Oligodeoxynucleotide in Anti-Fungal Chemotherapy against Fatal Infection with Cryptococcus neoformans in Mice

Kinjo T, Miyagi K, Nakamura K, Higa F, Gang X, Miyazato A, Kaku M, Fujita J, Kawakami K

Microbiology and Immunology   51 ( 8 ) 741 - 746   2007年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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NKT cells play a limited role in the neutrophilic inflammatory responses and host defense to pulmonary infection with Pseudomonas aeruginosa

Kinjo T, Nakamatsu M, Nakasone C, Yamamoto N, Kinjo Y, Miyagi K, Uezu K, Nakamura K, Higa F, Tateyama M, Takeda K, Nakayama T, Taniguchi M, Kaku M, Fujita J, Kawakami K

Microbes and Infection   8 ( 12 ) 2679 - 2685   2006年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans

Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, Kinjo T, Akamine M, Fujita J, Kawamura I, Mitsuyama M, Adachi Y, Ohno N, Takeda K, Akira S, Miyazato A, Kaku M, Kawakami K

FEMS Immunology and Medical Microbiology   47 ( 1 ) 148 - 154   2006年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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CpG oligodeoxynucleotides promote the host protective response against infection with Cryptococcus neoformans through induction of interferon-gamma production by CD4 T cells

Miyagi K, Kawakami K, Kinjo Y, Uezu K, Kinjo T, Nakamura K, Saito A

Clinical and Experimental Immunology   140 ( 2 ) 220 - 229   2005年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with Mycobacterium tuberculosis

Yamashiro S, Kawakami K, Uezu K, Kinjo T, Miyagi K, Nakamura K, Saito A

Clinical and Experimental Immunology   139 ( 1 ) 57 - 64   2005年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma

Yamamoto N, Kawakami K, Kinjo Y, Miyagi K, Kinjo T, Uezu K, Nakasone C, Nakamatsu M, Saito A

Microbes and Infection   6 ( 14 ) 1241 - 1249   2004年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Accumulation of gamma-delta T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans

Uezu K, Kawakami K, Miyagi K, Kinjo Y, Kinjo T, Ishikawa H, Saito A

Journal of Immunology   172 ( 12 ) 7629 - 7634   2004年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18

Kawakami K, Kinjo Y, Uezu K, Miyagi K, Kinjo T, Yara S, Koguchi Y, Miyazato A, Shibuya K, Iwakura Y, Takeda K, Akira S, Saito A

Microbes and Infection   6 ( 4 ) 339 - 349   2004年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection

Kawakami K, Yamamoto N, Kinjo Y, Miyagi K, Nakasone C, Uezu K, Kinjo T, Nakayama T, Taniguchi M, Saito A

European Journal of Immunology   33 ( 12 ) 3322 - 3330   2003年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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