Published Papers - Fukushima Takuya

A Comprehensive Study of the Immunophenotype and its Clinicopathologic Significance in Adult T-Cell Leukemia/Lymphoma.

Tomoko Tamaki, Kennosuke Karube, Shugo Sakihama, Yuma Tsuruta, Ryoko Awazawa, Masaki Hayashi, Norihiro Nakada, Hirofumi Matsumoto, Nobutake Yagi, Kazuiku Ohshiro, Iwao Nakazato, Sakiko Kitamuraj , Yukiko Nishij , Takuya Miyagi, Sayaka Yamaguchi, Sawako Nakachi, Satoko Morishima, Hiroaki Masuzaki, Kenzo Takahashi, Takuya Fukushima, Naoki Wada

Modern Pathology   38 ( 8 ) 100169   2023.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL)

Tanaka Y, Tanaka R, Imaizumi N, Mizuguchi M, Takahashi Y, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Masuzaki H, Fukushima T.

Frontier Immunology     2022.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Clinically amyopathic dermatomyositis manifested after the allogeneic haematopoietic stem cell transplantation: Case presentation and literature review

Riko Miyagi, Sawako Nakachi, Yasutaro Tamaki, Mototsugu Doi, Tomo Nakajima, Sakiko Kitamura, Shohei Tomori, Taeko Hanashiro, Keita Tamaki, Kazuho Morichika, Yukiko Nishi, Satoko Morishima, Takuya Fukushima, Hiroaki Masuzaki

Modern Rheumatology Case Reports   7 ( 1 ) 102 - 107   2022.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood

Mariko Mizuguchi, Mitsuyoshi Takatori, Shugo Sakihama, Manami Yoshita-Takahashi, Naoki Imaizumi, Yoshiaki Takahashi, Hiroo Hasegawa, Kennosuke Karube, Takuya Fukushima, Masataka Nakamura, Yuetsu Tanaka

Cancer Gene Therapy   29 ( 11 ) 1570 - 1577   2022.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia

Kato M, Imaizumi N, Tanaka R, Mizuguchi M, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Todoroki J, Karube K, Masuzaki H, Tanaka Y, Fukushima T.

Viruses   14 ( 4 ) 751   2022.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Impact of anti-diabetic sodium-glucose cotransporter 2 inhibitors on tumor growth of intractable hematological malignancy in humans.

Nakachi S, Okamoto S, Tamaki K, Nomura I, Tomihama M, Nishi Y, Fukushima T, Tanaka Y, Morishima S, Imamura M, Maeda S, Tsutsui M, Matsushita M, Masuzaki H.

Biomedicine & Pharmacotherapy   149   112864   2022.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Full-length HLA sequencing in adult T cell leukemia-lymphoma uncovers multiple gene alterations

Tamaki K, Morishima S, Suzuki S, Shigenari A, Nomura I, Yokota Y, Morichika K, Nishi Y, Nakachi S, Okamoto S, Fukushima T, Shiina T, Masuzaki H.

Leukemia   35 ( 10 ) 2998 - 3001   2021.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The Positivity of Phosphorylated STAT3 Is a Novel Marker for Favorable Prognosis in Germinal Center B-Cell Type of Diffuse Large B-Cell Lymphoma

Morichika K, Karube K, Sakihama S, Watanabe R, Kawaki M, Nishi Y, Nakachi S, Okamoto S, Takahara T, Satou A, Shimada S, Shimada K, Tsuzuki T, Fukushima T, Morishima S, Masuzaki H.

The American Journal of Surgical Pathology   45 ( 6 ) 832 - 840   2021.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Genetic profile of adult T-cell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV-1 strains

Sakihama S, Morichika K, Saito R, Miyara M, Miyagi T, Hayashi M, Uchihara J, Tomoyose T, Ohshiro K, Nakayama S, Nakachi S, Morishima S, Sakai K, Nishio K, Masuzaki H, Fukushima T, Karube K.

Cancer Science   112 ( 3 ) 1300 - 1309   2021.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1-infected Hodgkin and Reed-Sternberg-like cells

Karube K, Takatori M, Sakihama S, Tsuruta Y, Miyagi T, Morichika K, Kitamura S, Nakada N, Hayashi M, Tomori S, Nakazato I, Ohshiro K, Imaizumi N, Kikuti YY, Nakamura N, Morishima S, Masuzaki H, Fukushima T.

Blood Advances   5 ( 1 ) 198 - 206   2021.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1.

Takatori M, Sakihama S, Miyara M, Imaizumi N, Miyagi T, Ohshiro K, Nakazato I, Hayashi M, Todoroki J, Morishima S, Masuzaki H, Fukushima T, Karube K

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ( Modern Pathology )    2020.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Ultra-high sensitivity HBsAg assay can diagnose HBV reactivation following rituximab-based therapy in patients with lymphoma.

Kusumoto S, Tanaka Y, Suzuki R, Watanabe T, Nakata M, Sakai R, Fukushima N, Fukushima T, Moriuchi Y, Itoh K, Nosaka K, Choi I, Sawa M, Okamoto R, Tsujimura H, Uchida T, Suzuki S, Okamoto M, Takahashi T, Sugiura I, Onishi Y, Kohri M, Yoshida S, Kojima M, Takahashi H, Tomita A, Atsuta Y, Maruyama D, Tanaka E, Suzuki T, Kinoshita T, Ogura M, Ueda R, Mizokami M

Journal of hepatology   73 ( 2 ) 285 - 293   2020.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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BACKGROUND & AIMS: The purpose of this post hoc analysis was to evaluate the efficacy of an ultra-high sensitive HBsAg assay using prospectively stored samples of HBV DNA monitoring study for lymphoma patients with resolved HBV infection following anti-CD20 antibody, rituximab-containing chemotherapy (UMIN000001299). METHODS: HBV reactivation defined as HBV DNA levels of 11 IU/mL or more was confirmed in 22 of 252 patients. Conventional HBsAg assay (ARCHITECT, cut-off value: 0.05 IU/mL) and ultra-high sensitive HBsAg assay employing a semi-automated immune complex transfer chemiluminescence enzyme technique (ICT-CLEIA, cut-off value: 0.0005 IU/mL) were measured at baseline, at confirmed HBV reactivation and monitored after HBV reactivation. RESULTS: Baseline HBsAg was detected using ICT-CLEIA in 4 patients, in all of whom precore mutants with high replication capacity were reactivated. Of the 6 patients with HBV DNA detected below the level of quantification at baseline, 5 showed HBV reactivation and 3 of the 5 had precore mutations. Sensitivity for detection by ARCHITECT and ICT-CLEIA HBsAg assays at HBV reactivation or the next sampling after HBV reactivation was 18.2% (4 of 22) and 77.3% (17 of 22), respectively. Of the discrepant 5 patients undetectable by ICT-CLEIA, 2 patients resolved spontaneously. All 6 patients reactivated with precore mutations including preS deletion could be diagnosed by ICT-CLEIA HBsAg assay at an early stage of HBV reactivation. Multivariate analysis showed that an anti-HBs titer of less than 10 mIU/mL, detected HBV DNA below the level of quantification, and detected ICT-CLEIA HBsAg at baseline were independent risk factors for HBV reactivation (adjusted hazard ratios, 15.4, 31.2 and 8.7, respectively; p<0.05). CONCLUSIONS: A novel ICT-CLEIA HBsAg assay would be an alternative method to diagnose HBV reactivation.

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Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL.

Guerrero CLH, Yamashita Y, Miyara M, Imaizumi N, Kato M, Sakihama S, Hayashi M, Miyagi T, Karimata K, Uchihara J, Ohshiro K, Todoroki J, Nakachi S, Morishima S, Karube K, Tanaka Y, Masuzaki H, Fukushima T

Blood advances ( Blood Advances )  4 ( 6 ) 1062 - 1071   2020.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.

Nagate Y, Ezoe S, Fujita J, Okuzakis D, Motooka D, Ishibashi T, Ichii M, Tanimura A, Kurashige M, Morii E, Fukushima T, Suehiro Y, Yokota T, Shibayama H, Oritani K, Kanakura Y

Leukemia ( Leukemia )    2020.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan.

Mizuguchi M, Takahashi Y, Tanaka R, Fukushima T, Tanaka Y

Pathogens (Basel, Switzerland) ( Pathogens )  9 ( 2 )   2020.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Approximately one-tenth of the 10 million individuals living with human T-cell leukemia virus type-1 (HTLV-1) worldwide live in Japan. Most of these infected individuals live in the southwest region of Japan, including Okinawa prefecture; however, currently no prophylactic vaccine against HTLV-1 infection is available. For preventing the HTLV-1 spread, we previously generated a humanized monoclonal antibody (hu-LAT-27) that mediates both neutralization and antibody-dependent cellular cytotoxicity (ADCC). The neutralization epitope of LAT-27 is a linear amino acid sequence from residue 191 to 196 (Leu-Pro-His-Ser-Asn-Leu) of the HTLV-1 envelope gp46 protein. Here, we found that the LAT-27 epitope is well conserved among HTLV-1 clinical isolates prevalent in Okinawa. The hu-LAT-27 treatment inhibited syncytium formation by these clinical HTLV-1 isolates. Although an amino acid substitution at residue 192 in the LAT-27 epitope from proline to serine was found in a few HTLV-1 isolates, hu-LAT-27 could still react with a synthetic peptide carrying this amino acid substitution. These findings demonstrate the wide spectrum of hu-LAT-27 reactivity, suggesting that hu-LAT-27 may be a candidate drug for prophylactic passive immunization against HTLV-1 infection.

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Transplant-related complications are impediments to the success of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia patients in non-complete remission.

Tomori S, Morishima S, Nishi Y, Nakachi S, Tamaki K, Morichika K, Tedokon I, Shimabukuro N, Hanashiro T, Kitamura S, Uchibori S, Miyagi R, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tomoyose T, Karube K, Fukushima T, Masuzaki H

Bone marrow transplantation ( Bone Marrow Transplantation )  55 ( 1 ) 233 - 241   2020.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

Naito T, Ushirogawa H, Fukushima T, Tanaka Y, Saito M

Virology journal ( Virology Journal )  16 ( 1 ) 160   2019.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer science ( Cancer Science )  110 ( 9 ) 2982 - 2991   2019.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transpl Immunol   55   101205 - 101205   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Possibility of a risk-adapted treatment strategy for untreated aggressive adult T-cell leukaemia-lymphoma (ATL) based on the ATL prognostic index: a supplementary analysis of the JCOG9801.

Toyoda K, Tsukasaki K, Machida R, Kadota T, Fukushima T, Ishitsuka K, Maruyama D, Nagai H

British journal of haematology ( British Journal of Haematology )  186 ( 3 ) 440 - 447   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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