古堅　誠 (フルゲン　マコト)

Furugen Makoto

写真a

職名

講師

科研費研究者番号

70732791
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  • 専任   琉球大学   医学部   附属病院   講師  

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  • 琉球大学 -  博士(医学)  医学

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  • 2014年01月
    -
    2018年03月

      琉球大学大学院 医学研究科 感染症・呼吸器・消化器内科学講座 助教  

  • 2018年04月
    -
    2020年03月

      琉球大学医学部附属病院第一内科 講師  

  • 2020年04月
    -
    継続中

      琉球大学病院第一内科 講師  

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  • 呼吸器疾患・呼吸器腫瘍

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  • Efficacy and Safety of Sitafloxacin in Treating Low-risk Febrile Neutropenia in Patients with Lung Cancer.

    On R, Matsumoto T, Ebi N, Doi S, Ishii H, Furugen M, Fujita J, Ide M, Kishimoto J, Okamoto I, Fujita M, Lung Oncology Group in Kyushu (LOGIK)

    JMA journal ( 公益社団法人 日本医師会 / 日本医学会 )  5 ( 3 ) 334 - 340   2022年07月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    <p><b>Introduction:</b> Febrile episodes in patients with cancer and chemotherapy-induced neutropenia can be life-threatening and generally require prompt administration of broad-spectrum antimicrobials. However, little evidence exists for treating patients with solid tumors and febrile neutropenia (FN) with oral antimicrobials.</p><p><b>Methods:</b> In this prospective study, we aimed to determine the efficacy and safety of sitafloxacin (STFX) for treating FN in lung cancer patients. In this prospective study, low-risk FN patients with lung cancer received STFX. The primary endpoint was response rate, defined as 5 sequential days of absence of fever without adverse events. The study was registered as UMIN000010911.</p><p><b>Results:</b> As a result, STFX was administered to 26 patients, all of whom survived during its administration. Of the 26, 14 completed primary endpoint (53.85%). The low response rate was attributed to occurrence of fevers of unknown cause rather than failure of FN treatment. Only two patients received antibacterial agents other than STFX. If response rate omitted absence of fever and been defined only as recovery from FN without changing microbial agents or serious complications, the response rate would have been 91.67%. Adverse events occurred in eight patients, none of which were serious.</p><p><b>Conclusions:</b> In conclusion, STFX might be used to treat low-risk FN in patients with lung cancer; however, a more detailed study will be required in future.</p>

  • A long-term survivor keeping in a complete response without treatment after pemetrexed maintenance therapy for advanced non-squamous non-small cell lung cancer.

    Makoto Furugen, Daisuke Shibahara, Tomo Kiyuna, Wakaki Kami, Kazuya Miyagi, Shusaku Haranaga, Toru Kubota, Hirofumi Matsumoto, Naoki Yoshimi, Jiro Fujita

    Clinical case reports   9 ( 2 ) 927 - 931   2021年02月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    Pemetrexed has significant efficacy for some non-squamous non-small cell lung cancer cases, as demonstrated in the current case. For those patients, pemetrexed administration should be carefully considered.

  • Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review.

    Shinzato A, Kinjo T, Miyagi T, Yamazato S, Kaneku K, Nishiyama M, Miyagi K, Furugen M, Fujita J

    Clinical case reports ( Clinical Case Reports )  8 ( 12 ) 3510 - 3514   2020年12月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare paraneoplastic syndrome. Our literature review shows the location of arthralgia and existence of edema are referable information for the differential diagnosis in paraneoplastic arthralgia.

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  • Radiation-induced sarcoma in a 10-year survivor with stage IV EGFR-mutated lung adenocarcinoma.

    Shibahara D, Furugen M, Kasashima S, Kaneku K, Yamashiro T, Arakaki W, Ariga T, Atsumi E, Aoyama H, Matsumoto H, Maehara H, Fujita J

    Respiratory medicine case reports ( Respiratory Medicine Case Reports )  28   100889 - 100889   2019年 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    A 70-year-old Japanese man with stage IV EGFR-mutated lung adenocarcinoma complained of right mild back pain. The patient had been heavily treated with several cytotoxic or molecular targeted agents for 10 years and received a palliative radiation therapy of 2nd sacral vertebra 5 years ago. Computed tomography showed the abnormal lesion in right iliopsoas muscle. A pathological examination confirmed undifferentiated pleomorphic sarcoma, consistent with the diagnosis of radiation-induced sarcoma (RIS). Since RIS is a rare late-onset complication of radiation therapy, to our knowledge, this is the first report of RIS that was associated with advanced lung cancer and detected after palliative radiation therapy. The careful long-term follow-up is thus necessary even after palliative radiation therapy and we have to be aware of the existence of RIS.

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  • 糞線虫過剰感染症候群における呼吸器合併症と画像所見

    鍋谷 大二郎, 平田 哲生, 原永 修作, 兼久 梢, 喜友名 朋, 新垣 若子, 金城 武士, 宮城 一也, 古堅 誠, 外間 昭, 健山 正男, 藤田 次郎

    Clinical Parasitology   29 ( 1 ) 18 - 20   2018年12月

    掲載種別: 研究論文（その他学術会議資料等）

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