論文 - 銘苅　桂子

Diffusion lacunae: a novel MR imaging finding on diffusion-weighted imaging for diagnosing placenta accreta spectrum.

Iraha Y, Fujii S, Tsuchiya N, Azama K, Yonamine E, Mekaru K, Kinjo T, Sekine M, Nishie A

Japanese journal of radiology     2024年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI 学術リポジトリ
• 関連情報を調べる
  PubMed

Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey.

Ono M, Takai Y, Harada M, Horie A, Dai Y, Kikuchi E, Miyachi M, Yamamoto T, Fujii N, Kajiyama H, Manabe A, Yasuoka T, Katsuragi S, Mekaru K, Maezawa T, Horage Y, Kataoka S, Nakayama R, Nakajima TE, Kimura F, Shimizu C, Sugimoto K, Takae S, Yumura Y, Nishi H, Furui T, Morishige KI, Watanabe C, Osuga Y, Suzuki N

International journal of clinical oncology ( International Journal of Clinical Oncology )    2024年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

How Effective Is Cervical Ripening Using the Controlled-Release Dinoprostone Vaginal Delivery System for Primiparas with Unruptured Membranes?

Yoshino Kinjyo* , Yukiko Chinen, Tadatsugu Kinjo, Shuko Chinen, Keiko Mekaru

Open Journal of Obstetrics and Gynecology     2024年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. Aims: To compare the effectiveness of a controlled-release dinoprostone vaginal delivery system for cervical dilatation (PROPESS) with that of mechanical dilation for labor induction in primiparous women with unruptured membranes. Materials and Methods: We retrospectively analyzed the data of 90 primiparas with unruptured membranes (41 and 49 in the PROPESS and mechanical dilation groups, respectively). The primary outcome was the cesarean section (CS) rate. The secondary outcomes were the prevalence of vaginal delivery within 12 or 24 h after the initial insertion, oxytocin usage rate, chorioamnionitis, additional use of mechanical dilation in the PROPESS group, and neonatal outcomes. Results: The CS rate was significantly lower in the PROPESS group than in the mechanical dilation group (p = 0.02). A total of 13 patients (31.7%) delivered within 24 h with PROPESS alone, indicating a significantly higher rate of delivery within 24 h in the PROPESS group (p = 0.02). Fewer patients required additional oxytocin in the PROPESS group than in the mechanical dilation group (p = 0.001). However, 14 (34%) patients in the PROPESS group required additional mechanical cervical dilation, resulting in a longer time to delivery than mechanical dilation. Conclusions: PROPESS significantly reduced CS rates and increased delivery rates 24 h after the initial insertion in primiparas with unruptured membranes compared to mechanical dilatation. However, failure to respond to PROPESS resulted in an overall longer delivery time than that of the conventional mechanical dilation group; therefore, identifying predictors of response to PROPESS is necessary.

• この論文にアクセスする

  DOI 学術リポジトリ

Relationship between the serum creatinine concentrations of preterm neonates within 24 h of birth and their mothers before delivery

Shimabukuro, W; Nakada, S; Shimada, K; Tsukayama, M; Hamada, K; Goya, H; Kinjo, N; Yoshida, T; Mekaru, K; Nakanishi, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY ( Clinical and Experimental Nephrology )  28 ( 4 ) 293 - 299   2024年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Perinatal Morbidity, Mortality, and Neurodevelopmental Outcomes of Neonates with Fetal Growth Restriction

Natsuki Tamashiro, Shuko Chinen, Yoshino Kinjyo, Yukiko Chinen, Tadatsugu Kinjo, Keiko Mekaru

Open Journal of Obstetrics and Gynecology     2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI 学術リポジトリ

Evaluation of brain development and damage using magnetic resonance imaging of congenital diaphragmatic hernia survivors: An analysis using the global brain abnormality score.

Yoshida T, Goya H, Tsukayama M, Kuda M, Yogi A, Mekaru K, Nakanishi K

Pediatrics and neonatology ( Pediatrics and Neonatology )  65 ( 2 ) 127 - 132   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Placenta Accreta Spectrum with Ureteral Invasion due to Progression of Cesarean Scar Pregnancy

Yara, N; Kinjyo, Y; Chinen, Y; Kinjo, T; Mekaru, K

CASE REPORTS IN OBSTETRICS AND GYNECOLOGY ( Case Reports in Obstetrics and Gynecology )  2023   9065978   2023年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

女性医師支援から働き方改革へ～ダイバーシティの実現は組織を変えるか～

銘苅 桂子

日本気管食道科学会会報 ( 特定非営利活動法人 日本気管食道科学会 )  74 ( 2 ) 173 - 175   2023年04月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Vaginal Microbiota and Pregnancy Outcomes of Patients with Conization Histories.

Hashiramoto S, Kinjo T, Tanaka SE, Arai W, Shimada M, Ashikawa K, Sakuraba Y, Yuji O, Yara N, Kinjyo Y, Chinen Y, Nagai Y, Mekaru K, Aoki Y

Journal of women's health (2002) ( Journal of Women's Health )  32 ( 3 ) 375 - 384   2023年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: One of the major risks of preterm birth is a history of conization. However, the risk of infection due to this procedure is still not well known. Using next-generation sequencing, we aimed to reveal the influence of conization on vaginal microbiota in the following pregnancy, and their relationship between spontaneous preterm birth (sPTB). Methods: We conducted a prospective cohort study including 133 pregnant patients, of whom 25 had conization histories and 108 did not. Vaginal microbiome samples were collected using swabs by an obstetrician upon inclusion in the first trimester and during delivery. V1-V2 of the 16S rRNA gene were amplified and analyzed to identify the bacteria. Results: The conization group had a significantly lower delivery week (34 weeks vs. 36 weeks, p = 0.003) and higher sPTB rate (64% vs. 8.3%, p ≤ 0.001) than the control group. In the conization group, alpha (Chao 1, p = 0.02; phylogenetic diversity whole tree, p = 0.04) and beta diversity (permutational multivariate analysis of variance test, p = 0.04) of the vaginal microbiota was significantly higher during delivery in patients who delivered preterm than in those who delivered term. Community-state type IV in the first trimester was significantly associated with sPTB (overall odds ratio 3.80, 95% confidence interval 1.33-10.8, p = 0.01). Conclusions: Conization is a risk factor for sPTB. Increased risk of sPTB in patients after conization may belong to the vulnerable defense mechanism, due to the shortened cervix and decreased cervical mucus.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Effect of the Concentration of Various Polyunsaturated Fatty Acids in Human Follicular Fluid on Oocyte Maturation and Fertilization

Keiko Mekaru*1, Misako Aoyama-Shimoji2, Rie Nakamura1, Sugiko Oishi1, Maho Miyagi1, Kozue Akamine1, Yoichi Aoki1

CEOS Obstetrics and Gynecology     2023年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Risk Factors of Preterm Birth in Okinawa Prefecture, the Southernmost Island Prefecture of Japan.

Kinjyo Y, Kinjo T, Mekaru K, Nagai Y, Moromizato T, Ohata T, Iseki C, Iseki K, Aoki Y

Maternal and child health journal ( Maternal and Child Health Journal )  27 ( 1 ) 92 - 100   2023年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVES: A high rate of preterm birth has been reported in Okinawa Prefecture, the southernmost island prefecture of Japan. Hence, this study aimed to identify the risk factors for preterm birth in this prefecture. METHODS: This retrospective study included data from January 2013 to December 2019 from three facilities in Okinawa Prefecture. Of 13,468 cases of preterm birth at ≥ 22 weeks of gestation, 11,868 were included in this study. Stillbirth and multiparity cases were excluded. First, we compared the overall preterm and full-term birth groups by categorizing the patient background, obstetric, and fetal risk factors. Further, we categorized preterm births into three groups (22-27, 28-33, and 34-36 weeks of gestation) and examined patient background factors to identify potential risk factors for the occurrence of preterm birth in each group. RESULTS: Preterm births accounted for 21.2% (2,521 cases) of all cases, with the rates of 2.6% (317 cases), 6.7% (800 cases), and 11.8% (1,404 cases) at 22-27, 28-33, and 34-36 weeks of gestation, respectively. To prevent preterm birth in Okinawa Prefecture, the present study specifically focused on patient background characteristics. In the multinomial logistic regression, the risk factors for preterm birth at 22-27 weeks of gestation were previous preterm birth (P < 0.0001) and lower age (P = 0.026); at 28-33 weeks of gestation, the risk factors were previous preterm birth (P < 0.0001) and history of cervical conization (P = 0.009); and at 34-36 weeks of gestation, only previous preterm birth (P < 0.0001) was a risk factor. CONCLUSIONS FOR PRACTICE: Previous preterm birth, younger age, and history of cervical conization were risk factors for Preterm birth in Okinawa. To reduce premature births in Okinawa Prefecture, it is important to pick up women with these risk factors and provide them with appropriate guidance and education on an ongoing basis.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

臨床におけるジノプロストン腟内留置の効果と注意点

銘苅 桂子

日本周産期・新生児医学会雑誌 ( 一般社団法人 日本周産期・新生児医学会 )  58 ( 4 ) 659 - 661   2023年

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>　<b>頸管熟化の機序とプロスタグランジン</b></p><p>　妊娠から分娩時にかけての頸管の変化は，軟化（softening），熟化・開大（ripening・dilation），分娩後の修復（post partum repair）からなり，これをCervical remodelingとよぶ^1）．子宮頸管は線維芽細胞，単球マクロファージなどの間質細胞，細胞外マトリクスにより構成され，正期産における子宮頸管の変化では，未熟コラーゲン線維やヒアルロナンの産生増加による水分含量の増加による熟化が起こる^1）．マウスの子宮頸管コラーゲン繊維断面の電子顕微鏡所見は，妊娠初期から後期にかけて，子宮頸管のマトリックスが劇的に変化することで，頸管が軟化していることを示している^2）．また，プロゲステロンの低下は頸管熟化や開大のため重要と考えられているが，マウスの頸管上皮ではプロゲステロンの代謝に必要なSteroid 5 alphareductase type 1（SRD5a1）の発現を認めると報告されている^2）．加えて，プロスタグランジン（PG）は子宮の収縮と頸管熟化の作用を有する．PGEの受容体にはEP1からEP4までの4つのサブタイプが存在し，EP1とEP3は子宮収縮作用，EP2とEP4は平滑筋弛緩作用により頸管熟化を促すとされる（図1）^3）．PGE2はEP1からEP4までのすべての受容体に作用することで，子宮収縮作用と頸管熟化作用の両方を有する．</p>

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

特集 Controversies in perinatology 2023 産科編 出血を伴う胎盤遺残-TAE

金城 忠嗣, 銘苅 桂子

周産期医学 ( 東京医学社 )  52 ( 12 ) 1737 - 1740   2022年12月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Endometrial and vaginal microbiomes influence assisted reproductive technology outcomes.

Miyagi M, Mekaru K, Tanaka SE, Arai W, Ashikawa K, Sakuraba Y, Nakamura R, Oishi S, Akamine K, Aoki Y

JBRA assisted reproduction ( Jornal Brasileiro de Reproducao Assistida )  27 ( 2 ) 267 - 281   2022年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVE: The role of Lactobacillus-dominant microbiota in the endometrium in reproductive function is unclear. We therefore aimed to explore the impact of the balance of Lactobacillus and pathological bacteria in the endometrial and vaginal microbiomes on the pregnancy outcomes of women treated with assisted reproductive technology (ART). METHODS: This study included 35 women with infertility submitted to good-quality embryo transfers. The cutoff values for abundance of Lactobacillus species (spp.) and pathological bacteria in the endometrium and vagina were calculated. Women with Lactobacillus spp. and pathological bacteria abundance above the cutoff values were categorized in the high-abundance group, whereas those with abundance below cutoff values were categorized in the low abundance group. We divided the patients into four groups based on the combination of high/low abundance of Lactobacillus spp. and pathological bacteria. RESULTS: The 35 cases of good-quality embryo transfer resulted in 21 pregnancies. Pregnant women were present in significantly higher proportions in the high Lactobacillus spp. abundance and low pathological bacteria abundance group, whereas the opposite combination (i.e., low Lactobacillus spp. abundance and high pathological bacteria abundance) saw a significantly higher proportion of nonpregnant women (p=0.022). CONCLUSIONS: The balance between Lactobacillus and pathological bacterial abundance in the endometrial and vaginal microbiomes is associated with pregnancy from ART.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Is Music therapy effective for pain and anxiety during vaginal delivery in primiparous women?

Hayase Nitta1, 2, Tadatsugu Kinjo1, 2, Yoshino Kinjyo1, 2, Nana Yara1, 2, Yukiko Chinen1, 2, Miyuki Nishi2, Izumi Higa2, Shinobu Orita2, Mirai Miura2, Sakie Miyaguni2, Itomi Kaneshima1, Kumiko Nishihira1, Hitoshi Masamoto2, Keiko Mekaru2, and Yoichi Aoki1

Ryukyu Medical journal     2022年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Low-set umbilicus in a pregnant woman with bladder pseudoexstrophy: A case report.

Taira Y, Yara N, Kinjo Y, Kinjo T, Mekaru K, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  36   e00467   2022年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

Bladder pseudoexstrophy is a rare form of bladder exstrophy. Bladder exstrophy occurs in 1 in every 30,000 to 50,000 live births. Because bladder pseudoexstrophy is asymptomatic, it may be undiagnosed even in adulthood. A 31-year-old woman with uterus bicornis unicollis and a low-set umbilicus underwent emergency cesarean delivery during the 37th week of pregnancy for chorioamnionitis. Perioperatively, asymptomatic anatomical abnormalities were identified, which included separated rectus abdominis muscles and diastasis of the symphysis pubis. The urinary tract was normal. The patient was diagnosed with bladder pseudoexstrophy. A low-set umbilicus may be a potential marker for the diagnosis of bladder pseudoextrophy.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

特集 見て,聞いて,触って,身体所見から考える妊産褥婦の異常とその対応 顔面まで浮腫がある

金城 忠嗣, 銘苅 桂子, 青木 陽一

周産期医学 ( 東京医学社 )  52 ( 8 ) 1073 - 1076   2022年08月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

増刊号 最新の不妊診療がわかる!-生殖補助医療を中心とした新たな治療体系 第3章　生殖補助医療の調節卵巣刺激 内因性LHサージ抑制法 Long法・Short法

銘苅 桂子

臨床婦人科産科 ( 株式会社医学書院 )  76 ( 4 ) 160 - 162   2022年04月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

今月の臨床 妊娠初期の経過異常とその対処-流産・異所性妊娠・絨毛性疾患の診断と治療 異所性妊娠 異所性妊娠のMRI診断

伊良波 裕子, 銘苅 桂子

臨床婦人科産科 ( 株式会社医学書院 )  76 ( 2 ) 233 - 238   2022年03月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

妊娠中に先行化学療法を施行した子宮頸癌の一例 当科の過去の症例と比較して

友寄 江梨佳, 仲本 朋子, 金城 淑乃, 渡部 俊陽, 高江洲 朋子, 大木 悠司, 下地 裕子, 仲宗根 忠栄, 新垣 精久, 平良 祐介, 久高 亘, 金城 忠嗣, 銘苅 桂子, 青木 陽一

沖縄産科婦人科学会雑誌 ( 沖縄産科婦人科学会 )  44   69 - 75   2022年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

妊娠合併子宮頸癌IB2期症例に対し化学療法を施行し生児を得た症例を経験したので当科の過去の症例との比較を交え報告する。症例は31歳1妊0産、妊娠22週で診断的円錐切除術を施行し子宮頸癌IB2期(FIGO 2018)と診断した。妊娠25週よりパクリタキセル、カルボプラチン療法を開始し計3コース施行。母体の有害事象や胎児の異常を認めなかった。妊娠35週4日に帝王切開+広汎子宮全摘術を施行。術後補助化学療法を行い現在まで再発なく経過している。2006〜2020年に当科で治療した妊娠合併子宮頸癌16例中、IB2期以上で生児を得たのは2例のみで、いずれも妊娠後期で診断されていた。本症例では妊娠中に化学療法を行い癌に対する治療の遅延なく妊娠を継続することができた。妊娠中の子宮頸癌に対する化学療法は治療の選択肢となりうるが、症例ごとに慎重な検討が必要である。(著者抄録)

広汎子宮全摘出術を行った骨盤リンパ節陽性子宮頸部腺癌の治療成績

渡部 俊陽, 平良 祐介, 友寄 絵梨佳, 高江洲 朋子, 柱本 真, 下地 裕子, 新垣 精久, 仲本 朋子, 久高 亘, 銘苅 桂子, 青木 陽一

沖縄産科婦人科学会雑誌 ( 沖縄産科婦人科学会 )  44   5 - 12   2022年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

子宮頸部腺癌の診断で、広汎子宮全摘出術(RH:Radical Hysterectomy)が施行された骨盤リンパ節転移陽性例の治療成績を明らかにするため、2004年4月〜2019年7月に当院でRHを行った子宮頸部腺癌(日産婦2011:IB-IIB期)で、病理組織学的に診断した骨盤リンパ節転移陽性19例と陰性49例について、診療録を後方視的に検討した。全生存率(OS)と無病生存率(DFS)に関する予後因子として、複数個のリンパ節転移のみが多変量解析で独立した予後因子と判明した。骨盤リンパ節転移陰性49例、単発転移7例、複数個転移12例の3群の患者背景に差はなく、転移陽性18例(94.7%)で術後補助療法(化学療法17例、放射線療法1例)が施行された。5年OSは100%、83.3%、40.1%(p<0.001)、5年DFSは87.1%、83.3%、10.0%(p<0.001)であった。再発は18例に認め、リンパ節転移なしでは6例(12.2%)、単発転移例では2例(28.6%)、複数個転移例では12例10例(83.3%)であった。複数個転移例の再発部位は骨盤内7例、骨盤外3例であり、骨盤内再発が高率であった。7例が放射線療法、1例が手術療法、4例が化学療法施行し、放射線療法2例と手術療法1例で無病生存が得られた。リンパ節複数個転移例に対する術後療法として、局所制御率の高い放射線療法や同時化学放射線療法の適応も検討すべきと考えられた。(著者抄録)

特集 産婦人科　働き方改革へのロードマップ 10.沖縄県における女性医師支援と働き方改革

銘苅 桂子

産婦人科の実際 ( 金原出版 )  71 ( 1 ) 63 - 68   2022年01月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

A Neonatal Case of Mild Encephalopathy/Encephalitis with a Reversible Splenial Lesion.

Oki Y, Yoshida T, Yogi A, Kurokawa S, Goya H, Tsukayama M, Nakamura S, Mekaru K, Nakanishi K

Child neurology open   9   2329048X221111716   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The neurological symptoms of pediatric mild encephalopathy/encephalitis with a reversible splenial lesion (MERS) are mild and have a good prognosis. However, some aspects of neonatal MERS are unclear due to a lack of clinical knowledge. We present a neonatal case of MERS with features of poor activity and prolonged poor oxygenation after birth without asphyxia. He was diagnosed with MERS by brain magnetic resonance imaging (MRI) on day10, because the diffusion restriction of the splenium of the corpus callosum (SCC) seen on diffusion-weighted MRI on day 5 was attenuating. He was discharged due to good progress on day 26, but growth issues and developmental delay were observed in the follow up from 1-10 months. In rare neonatal cases, many aspects of the clinical course and prognosis are thus unclear. MERS should be considered in newborns who show unexplained non-neural or other encephalopathic symptoms.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Microbiome analysis in women with endometriosis: Does a microbiome exist in peritoneal fluid and ovarian cystic fluid?

Oishi S, Mekaru K, Tanaka SE, Arai W, Ashikawa K, Sakuraba Y, Nishioka M, Nakamura R, Miyagi M, Akamine K, Aoki Y

Reproductive medicine and biology ( Wiley )  21 ( 1 ) e12441   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: To investigate the relationship between the microbiome of the female genital tract and endometriosis. METHODS: This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome. RESULTS: Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02). CONCLUSION: Peritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.

• この論文にアクセスする

  DOI 学術リポジトリ
• 関連情報を調べる
  PubMed

Two cases of polycystic ovary syndrome with onset of severe ovarian hyperstimulation syndrome following controlled ovarian stimulation with aromatase inhibitors for fertility preservation before breast cancer treatment.

Oishi S, Mekaru K, Nakamura R, Miyagi M, Akamine K, Heshiki C, Aoki Y

Taiwanese journal of obstetrics & gynecology ( Taiwanese Journal of Obstetrics and Gynecology )  60 ( 5 ) 931 - 934   2021年09月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

OBJECTIVE: The risks of ovarian hyperstimulation syndrome (OHSS) involve high estrogen (E2) levels. We report two breast cancer patients with polycystic ovarian syndrome who underwent fertility preservation and had severe OHSS; their E2 levels were lowered using aromatase inhibitors (AI). CASE REPORTS: A 36-year-old woman underwent controlled ovarian stimulation (COS) with AI and cryopreserved 10 blastocysts. She was hospitalized with OHSS (E2 = 139.1 pg/mL). She improved with infusion alone. A 31-year-old woman underwent COS with AI and cryopreserved 8 blastocysts. She was hospitalized for OHSS (E2: 429 pg/mL). Her vascular endothelial growth factor (VEGF) levels were high (62 pg/mL) at 8 days after the procedure. She needed hospitalization for 9 days. The planned adjuvant therapy was delayed for a week in both cases. CONCLUSION: Elevated VEGF levels should be considered as a risk factor of OHSS even if E2 levels are low with AI treatment.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Live birth outcomes from IVF treatments in younger patients with low AMH.

Miyagi M, Mekaru K, Nakamura R, Oishi S, Akamine K, Heshiki C, Aoki Y

JBRA assisted reproduction ( Jornal Brasileiro de Reproducao Assistida )  25 ( 3 ) 417 - 421   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVE: Anti-Müllerian hormone (AMH) is used to predict in vitro fertilization outcomes. However, predicting live birth is difficult in younger patients with low AMH. Thus, this study aimed to determine the live birth rates from younger patients with low anti-Müllerian hormone levels. METHODS: A total of 296 infertile patients with AMH measured (younger group, aged 25-38 years; older group, aged 39-42 years) were included in this study. In vitro fertilization outcomes between patients with AMH levels of <1.0ng/mL and ≥1.0ng/mL were compared. RESULTS: Younger patients with AMH levels <1.0ng/mL (younger low AMH group) exhibited lower number of oocytes retrieved than patients with AMH levels ≥1.0ng/mL (younger normal AMH group). However, there were no significant differences in cumulative pregnancy or cumulative live birth rates between groups. Older patients with AMH levels ≥1.0ng/mL (older normal AMH group) had significantly better outcomes as per mean number of oocytes, cumulative pregnancy rate, and cumulative live birth rate than older patients with AMH levels <1.0ng/mL (older low AMH group). In the younger low AMH group, the frequency of oocyte retrieval was significantly higher in patients who achieved live birth. In addition, the blastocyst transfer rate was significantly higher in individuals with live births versus subjects with non-live births. CONCLUSIONS: AMH is a predictor of live birth among older, but not younger, women. Our report suggests that younger women may become pregnant even with low AMH levels when they obtain blastocysts from frequent oocyte retrievals.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Sex ratio of infants born through in vitro fertilization and embryo transfer: Results of a single-institution study and literature review.

Nagata C, Mekaru K, Gibo K, Nakamura R, Oishi S, Miyagi M, Akamine K, Aoki Y

JBRA assisted reproduction ( Jornal Brasileiro de Reproducao Assistida )  25 ( 3 ) 337 - 340   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVE: The possible effects of Assisted Reproductive Technology (ART) on sex ratio at birth are extremely significant. This study aimed to determine whether ART affects the sex ratio of infants born through in vitro fertilization and embryo transfer (IVF-ET). MATERIALS AND METHODS: We ran this retrospective study on 290 singleton infants born following IVF-ET from February 2014 to August 2018 at a single institution. We compared the sex ratios of these infants with respect to insemination versus intracytoplasmic sperm injection (ICSI), early-cleavage embryo versus blastocyst transfer, fresh versus frozen-thawed embryo transfer and normal sperm versus asthenospermia. RESULTS: There were no significant differences in the sex ratio with respect to the fertilization method, transfer time, fresh embryo or frozen-thawed embryo transfer. In addition, the multiple logistic regression analysis revealed that these factors did not significantly affect the sex ratio. CONCLUSIONS: Our study indicated that the differences in the fertilization method transfer time and sperm motility rate did not affect the sex ratio of IVF live births. However, with increasing numbers of ICSI and blastocyst transfer cycles, factors possibly affecting the sex ratio need to be further investigated.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Transabdominal cerclage in early pregnancy for cervical shortening after radical trachelectomy: A case report.

Kinjyo Y, Nana Y, Chinen Y, Kinjo T, Mekaru K, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  31   e00323   2021年07月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

Radical trachelectomy (RT) is a method of fertility preservation for patients with early invasive uterine cervical cancer stage IA2 or IB1 with a tumor diameter of ≤2 cm. However, women who have undergone RT have high risks of abortion and premature birth. To prevent premature birth, cervical cerclage is performed in patients with an ultra-short cervix, but the portio vaginalis is not visible in these patients, and transvaginal uterine cervical cerclage is almost impossible. In such cases, transabdominal cerclage (TAC) is considered. The patient reported here was a 39-year-old Japanese woman, gravida 2, para 0. At 37 years, she was diagnosed with cervical cancer, stage IB1 (according to the International Federation of Gynecology and Obstetrics [FIGO] classification), so abdominal modified RT was performed. One year after the operation, she became pregnant through in vitro fertilization and embryo transfer. The cervical length was 17 mm at 13 weeks of gestation but was shortened to 5 mm at 16 weeks of gestation, so TAC was performed. An emergency cesarean section was performed because of increased genital bleeding at 34 weeks of gestation and a live baby was delivered.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

A high-risk gestational trophoblastic neoplasia derived from a complete hydatidiform mole with coexisting fetus identified by short tandem repeats analysis: A case report.

Taira Y, Shimoji Y, Nakasone T, Arakaki Y, Nakamoto T, Kinjo T, Kudaka W, Mekaru K, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  31   e00336   2021年07月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

A complete hydatidiform mole coexisting with a fetus (CHMCF) is a rare form of twin pregnancy. High-risk gestational trophoblastic neoplasia (GTN) can occur after a CHMCF pregnancy, although the frequency is low. In cases of GTN, the clinical diagnosis and that based on the International Federation of Gynecology and Obstetrics (FIGO) scoring system can differ. This case report concerns a patient with a choriocarcinoma that was initially diagnosed and treated as a low-risk stage III GTN following a live birth from a CHMCF pregnancy. We used short tandem repeat (STR) analysis to identify the causative pregnancy as the patient's earlier complete hydatidiform mole. Clinicians should anticipate a high-risk GTN when treating persistent trophoblastic disease (PTD) in patients with a non-typical course.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Critical respiratory failure in pregnancy complicated with COVID-19: A case report.

Chinen Y, Kinjyo Y, Mekaru K, Kinjo T, Higure Y, Kinjo T, Miyagi K, Yamada H, Masamoto H, Goya H, Yoshida T, Maeshiro S, Nakamatsu M, Fujita J, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  30   e00309   2021年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

The case is presented of a 29-year-old primiparous woman who was COVID-19-positive at 34 weeks of gestation and who developed severe acute respiratory distress syndrome. After a four-day history of fever and mild dyspnea, she was referred to hospital. Ciclesonide, dexamethasone, heparin sodium, and sulbactam/ampicillin were initiated, followed by remdesivir and tocilizumab. On the fourth day after admission (at 34 weeks 5 days of gestation), respiratory failure required ventilator management. An emergency cesarean section was performed and a 2565-g male infant was delivered with an Apgar score of 8/8 and negative COVID-19 status. However, on the following day the patient's respiratory condition deteriorated and mechanical ventilation was initiated. Subsequently, her respiratory condition quickly improved and mechanical ventilation was terminated 4 days after intubation. She was discharged 12 days after cesarean delivery. Our case provides additional evidence that raises concerns regarding the unfavorable maternal consequences of COVID-19 infection during pregnancy.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

特集 画像!-エキスパート直伝　産婦人科画像診断- (第2章)生殖内分泌　子宮内膜

赤嶺 こずえ, 銘苅 桂子

産科と婦人科 ( (株)診断と治療社 )  88 ( 13 ) 246 - 249   2021年03月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Sigmoid Volvulus in Pregnancy Assessed by Contrast-Enhanced Computed Tomography Scanning.

Watanabe T, Kinjo T, Kinjyo Y, Nitta H, Masamoto H, Mekaru K, Aoki Y

Case reports in obstetrics and gynecology ( Case Reports in Obstetrics and Gynecology )  2021   6692483 - 6692483   2021年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

Sigmoid volvulus requires urgent treatment, and it is particularly rare among pregnant women without a history of laparotomy. A delay in diagnosis may lead to serious consequences for the mother and fetus, and a rapid diagnosis and treatment in this setting is essential. The patient was a 19-year-old primiparous woman. She complained of repeated exacerbations and remissions of abrupt lower abdominal pain for the past 2 days and was transported to our hospital at 33 weeks of gestation. Ultrasonography revealed no placental thickening, and maternal bowel dilation was difficult to identify. Plain abdominal X-ray showed a dilated colon on the left side of the abdomen. Contrast-enhanced CT scan of the abdomen revealed a volvulus on the dorsal side of the uterus. The proximal end of the transverse to sigmoid colon was markedly dilated, and the distal end was collapsed. The elevated lactate level on blood gas analysis suggested intestinal ischemia. She was suspected of having a sigmoid volvulus at 33 weeks and 3 days of gestation. We decided to perform a cesarean section to secure the operative field for an intestinal resection following delivery. A male weighing 1840 g with Apgar scores 8/8 was delivered. The sigmoid colon was approximately 80 cm in length. A 360-degree clockwise rotation of was observed with a very distended but viable sigmoid loop. Following reduction of the volvulus, the sigmoid colon was fixed to the left side of the peritoneum. The mother had an uneventful postoperative course, and the infant was discharged without any sequelae. This case demonstrates two important lessons. First, sigmoid volvulus can occur in pregnant women even if they never had a laparotomy. Second, abdominal contrast-enhanced CT is useful for rapid diagnostic and treatment decisions relative to this pathology.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Hyperbaric Oxygen Therapy for Suburethral Vaginal Mucosal Necrosis after Interstitial Irradiation for Recurrent Cervical Cancer.

Arakaki Y, Shimoji Y, Nakasone T, Taira Y, Nakamoto T, Kudaka W, Mekaru K, Aoki Y

Case reports in obstetrics and gynecology ( Case Reports in Obstetrics and Gynecology )  2021   1737975 - 1737975   2021年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

Patients with gynecological malignancies can develop radiation injuries, such as cystitis, proctitis, and soft tissue necrosis which have approved indications for hyperbaric oxygen therapy (HBOT). A 76-year-old Japanese woman with vaginal recurrence of cervical cancer was treated with the high-dose rate interstitial brachytherapy. Twenty-one months after the irradiation, she developed radiation necrosis on the external urethral opening. Two cycles of HBOT were performed. HBOT consisted of delivering 100% oxygen for 60 minutes at 2.4 atmospheres absolute. Pressure exposure was performed once daily, 5 days a week for 6 weeks. Eventually, the necrotic mucosa was completely replaced by the normal mucosa. No adverse effects were observed. We successfully treated a case of late adverse events of radiation therapy with HBOT. It was noninvasive and appears to be a useful treatment option which should be considered standard treatment practice.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Threatened uterine rupture following laparoscopic surgery in interstitial tubal pregnancy.

Arakaki Y, Mekaru K, Shimoji Y, Nakamura R, Miyagi M, Aoki Y

The journal of obstetrics and gynaecology research ( Journal of Obstetrics and Gynaecology Research )  47 ( 2 ) 818 - 821   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Contraception is recommended for a certain period following a hysterotomy; however, no consensus exists on the required duration of contraception. A 21-year-old female was brought to the emergency room in a state of shock due to intraperitoneal bleeding. An emergency laparoscopic cornuostomy indicated for ruptured interstitial pregnancy was performed. Despite contraception, the patient got pregnant 1.5 months after surgery. At 16 weeks of gestation, threatened uterine rupture was suspected, as magnetic resonance imaging (MRI) revealed hematogenous amniotic fluid and a subchorionic hematoma near the interstitial portion of the fallopian tube. An MRI at 21 weeks showed hematoma shrinkage and disappearance of the hematogenous amniotic fluid. At 37 weeks, an elective cesarean section was performed, which resulted in a live birth. Pregnancy shortly after surgery is a risk factor for uterine rupture. In such cases, MRI could be useful in the evaluation of threatened uterine ruptures.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Evaluation of neonatal withdrawal syndrome in neonates delivered by women taking psychotropic or anticonvulsant drugs: A retrospective chart review of the effects of multiple medications and breastfeeding.

Kanemura A, Masamoto H, Kinjo T, Mekaru K, Yoshida T, Goya H, Aoki Y

European journal of obstetrics, gynecology, and reproductive biology ( European Journal of Obstetrics and Gynecology and Reproductive Biology )  254   226 - 230   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

OBJECTIVES: Neonates delivered by women who were taking psychotropic or anticonvulsant drugs during pregnancy are at increased risk of developing neonatal withdrawal syndrome. We investigated the incidence of neonatal withdrawal symptoms and the effects of multiple maternal medications and breastfeeding on neonatal withdrawal symptoms. STUDY DESIGN: This study examined the overall incidence of neonatal withdrawal symptoms in neonates delivered from 2004 to 2016 by women who were taking oral antipsychotics, antidepressants, anxiolytics, sedatives, or anticonvulsant drugs during pregnancy. Moreover, we compared the incidence of neonatal symptoms between mothers taking single drugs and multiple drugs, and between breastfed and formula-fed neonates. We scored the neonates according to the neonatal withdrawal syndrome checklist created by Isobe et al., which is widely used in Japan. RESULTS: We examined 131 mothers and their 134 neonates. Withdrawal symptoms were found in 54.5 % of neonates. Symptoms were found in 32.4 % of neonates delivered by mothers taking single drugs and 62.9 % of neonates delivered by mothers taking two or more drugs (p = 0.0019). One or more withdrawal symptoms developed in 46.4 % of breastfed neonates and 66.1 % of formula-fed neonates (p = 0.034). Five infants had a score of 8 or more points on the withdrawal checklist, which is an indication to consider treatment with pharmacotherapy. All five of these neonates were mainly formula-fed, and their mothers were taking two or more drugs. CONCLUSIONS: The incidence of withdrawal symptoms was high in neonates delivered by women taking psychotropic or anticonvulsant drugs; however, there were few serious cases. The risk increased when a mother was taking multiple drugs. Breastfeeding appeared to protect against withdrawal symptoms.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Relative dose intensity and overall treatment time in older patients with cervical cancer treated with concurrent chemoradiotherapy.

Nakamura R, Shimoji Y, Nakasone T, Taira Y, Arakaki Y, Nakamoto T, Ooyama T, Kudaka W, Mekaru K, Aoki Y

Journal of geriatric oncology ( Journal of Geriatric Oncology )  12 ( 2 ) 332 - 334   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Long-term Outcomes of Cervical Adenocarcinoma Treated With Concurrent Chemoradiotherapy Using Paclitaxel and Cisplatin.

Arakaki Y, Ariga T, Heianna J, Shimoji Y, Nakasone T, Taira Y, Nakamoto T, Ooyama T, Kudaka W, Kaneshima I, Nishihira K, Mekaru K, Aoki Y

In vivo (Athens, Greece) ( In vivo (Athens, Greece) )  34 ( 5 ) 2739 - 2743   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

© 2020 International Institute of Anticancer Research. All rights reserved. Background/Aim: We retrospectively analyzed the locally advanced adenocarcinoma (AC)/adenosquamous carcinoma (ASC) of the uterine cervix treated with concurrent chemoradiotherapy using cisplatin plus paclitaxel (TP-CCRT). Patients and Methods: Thirty patients with stage IB-IVA AC/ASC were treated with whole pelvis external beam radiotherapy. A high-dose-rate intracavitary brachytherapy was delivered once per week at a fractional dose of 6 Gy. For TP-CCRT, the patients received cisplatin and paclitaxel. Results: A complete response was achieved in 17 patients (77.3%) in the TP-CCRT group and 4 patients (50.0%) in the P-CCRT group. The 5-year OS rate in the TPCCRT and P-CCRT groups was 74.2% and 25.0% (p=0.0094), the central DFS rate was 58.0% and 12.5% (p=0.0267), and the distant DFS rate was 63.6% and 12.5% (p=0.0042), respectively. Conclusion: TP-CCRT achieves a considerably better disease control for AC of the cervix, leading to a better OS.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Malignant bowel obstruction in recurrent gynecologic cancers: who will benefit from palliative surgical intervention?

Nakamura R.

European Journal of Gynaecological Oncology ( European Journal of Gynaecological Oncology )  41 ( 4 ) 513 - 516   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

©2020 Nakamura et al. Purpose of Investigation: To define factors that assist in the selection of patients with gynecologic cancer who have malignant bowel obstruction (MBO) for those who are most likely to benefit from palliative bowel surgery. Materials and Methods: Between 2004 and 2014, 11 women who underwent surgery for bowel obstruction after a discharge for the treatment of gynecologic cancer were included. The diagnosis of MBO was confirmed by symptoms and signs of intestinal obstruction along with abdominal X-ray, or a computed tomography (CT) scan. Results: The median age of women was 58 years and the median time to surgery was six days. Colostomy was performed in seven of eleven patients, ileostomy in three, and bowel resection and anastomosis in two. Postoperative oral intake was achieved in ten of eleven cases, with a median period of 77 (range, 27–224) days. The progression free interval (PFI) of the primary cancer was < 6 months in six patients and ≥ 6 months in five. The median duration of post-operative oral intake in patients with PFI of < 6 and ≥ 6 months was 34.5 (range, 0–65), and 120 (range, 89–224) days, respectively (p = 0.0014). The median survival time after surgery in patients with PFI of < 6 and ≥ 6 months was 43 (range, 11–111), and 156 (range 94–253) days, respectively (p = 0.0206). Conclusion: PFI of primary gynecologic cancer is a good indicator that could help select for those patients who would most likely benefit from palliative bowel surgery. Surgery for MBO should be considered for patients without serious contraindications.

• この論文にアクセスする

  DOI

特集 異所性妊娠の最新診療 異所性妊娠のMRI診断

伊良波 裕子, 石神 康生, 銘苅 桂子

産科と婦人科 ( (株)診断と治療社 )  87 ( 7 ) 771 - 775   2020年07月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Hysterectomy for Recurrent/Residual Cervical Cancer Following Definitive Radiotherapy.

Nakasone T, Taira Y, Shimoji Y, Arakaki Y, Nakamoto T, Ooyama T, Kudaka W, Kaneshima I, Nishihira K, Mekaru K, Aoki Y

In vivo (Athens, Greece) ( In Vivo )  34 ( 4 ) 2173 - 2177   2020年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

© 2020 International Institute of Anticancer Research. All rights reserved. Background/Aim: Radical hysterectomy has been used for local recurrent or persistent (LR) cervical cancer after radiotherapy (RT), but the rate of serious complications is high and tolerance is low. This study determined the efficacy, safety, and prognostic factors of adjuvant simple hysterectomy in LR cervical cancer post-RT. Patients and Methods: A total of 21 patients who underwent hysterectomy for LR cervical cancer post-RT in our Department between May 2007 and September 2018 were included in the study. Primary, definitive RT was performed. Histological response by definitive RT in the extirpated uterus was classified on the basis of histological response criteria: effect (Ef) 0-3. Results: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 51.9% and 50.1%, respectively. Ef 1 was significantly associated with poorer prognosis compared to Ef 2 or Ef 3. Conclusion: Adjuvant hysterectomy could be a treatment of choice for LR cervical cancer post-RT.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

A Phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy for para-aortic lymph node positive cervical cancer

Shimoji Y.

Anticancer Research ( Anticancer Research )  40 ( 6 ) 3565 - 3570   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

A Phase II Study of Neoadjuvant Chemotherapy Followed by Extended Field Concurrent Chemoradiotherapy for Para-aortic Lymph Node Positive Cervical Cancer.

Shimoji Y, Nagai Y, Toita T, Ariga T, Heianna J, Nakasone T, Taira Y, Arakaki Y, Nakamoto T, Ooyama T, Kudaka W, Kaneshima I, Nishihira K, Mekaru K, Aoki Y

Anticancer research   40 ( 6 ) 3565 - 3570   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND/AIM: We conducted a phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy in patients with cervical cancer with para-aortic node metastasis. PATIENTS AND METHODS: Thirty-seven women with stage IB1-IVA cervical cancer were enrolled. RESULTS: The median age was 52 years. Thirty-four patients other than 3 progressive disease, proceeded to extended field concurrent chemoradiotherapy. The 3-year overall survival and progression-free survival rates were 70.1% and 48.5%, respectively. The 3-year overall survival according to stages was significantly worse in stage IIIB. Twelve of the 17 patients with stage IIIB died of the disease. CONCLUSION: Neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy may improve the prognosis of patients with stages IB and II cervical cancer with positive para-aortic node. However, new strategies should be investigated to improve a poor prognosis in stage IIIB disease with positive para-aortic node.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Development of Vaginal Pseudoaneurysm 3 Years after Cesarean Section Possibly Induced by Anticoagulant and Antiplatelet Therapies.

Kinjo Y, Kinjo T, Mekaru K, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology ( Case Reports in Obstetrics and Gynecology )  2020   6196575 - 6196575   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Pseudoaneurysms generally develop when an arterial puncture site is inadequately sealed. We encountered a case of vaginal pseudoaneurysm that developed 3 years after cesarean section in a 35-year-old gravida 7 para 4 woman who was prescribed with anticoagulant and antiplatelet drugs after surgeries for ventricular septal defect and aortic valve replacement. Pelvic computed tomography scan revealed a large mass, which showed a dappled contrast filling on the arterial phase, located in the posterior vaginal wall. The vaginal pseudoaneurysm was completely occluded by embolization of the left vaginal artery. Anticoagulation and antiplatelet therapies can be potential causes of spontaneous pseudoaneurysm rupture. Extrauterine pseudoaneurysm has a long period of time between cesarean section and pseudoaneurysm discovery. Considering that pseudoaneurysm shows different clinical features for each patient, we should always consider pseudoaneurysm when we assess a patient with postpartum hemorrhage.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Impact of the one-carbon metabolism on oocyte maturation, fertilization, embryo quality, and subsequent pregnancy

Akamine K.

Reproductive Medicine and Biology ( Reproductive Medicine and Biology )  20 ( 1 ) 76 - 82   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: To investigate impact of the one-carbon metabolism (OCM) on oocyte maturity and embryo development. Methods: This prospective study analyzed 18 women who agreed to participate. We measured the OCM biomarkers' concentrations including Vitamin B12 (VB12), folic acid (FA), and homocysteine (Hcy) in serum and follicular fluid (FF), and assessed their correlation. We also evaluated the influence of such OCM biomarker concentrations in mono-FF on oocyte maturation, fertilization, embryo quality, and consequent pregnancy after embryo transfers. Results: All biomarkers showed a high concentration variability in different follicles of each woman, but their mean levels correlated with the serum levels. Among the 106 collected oocytes, 92 were mature, 59 were fertilized, and 16 yielded good-quality embryos. We performed 26 single embryo transfers, and 7 patients achieved clinical pregnancies. VB12 concentration (FF) was significantly lower in fertilized than unfertilized oocytes by univariate analysis. In multivariate logistic analysis, a significant correlation was found between FA concentration (FF) <14.25 ng/mL and good-quality embryos and between Hcy concentration (FF) <4.9 nmol/mL and clinical pregnancy. Conclusion: OCM in FF may affect fertilization, embryo quality, and clinical pregnancy.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Tubal Pregnancy with Acute Bleeding Treated by Laparoscopic Surgery: Tips and Case Presentation

Sugiko Oishi, Keiko Mekaru, Maho Miyagi, Kozue Akamine, Chiaki Heshiki, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  10 ( 01 ) 100 - 107   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

今月の臨床 卵巣刺激・排卵誘発のすべて-どんな症例に,どのように行うのか 体外受精における卵巣刺激 long法・short法

銘苅 桂子

臨床婦人科産科 ( 株式会社医学書院 )  73 ( 7 ) 670 - 673   2019年07月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Silicone Plate for the Prevention of Postoperative Adhesions in Patients with Asherman Syndrome.

Miyagi M, Mekaru K, Oishi S, Urasoe C, Akamine K, Aoki Y

Case reports in obstetrics and gynecology   2019   5420837   2019年

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Massive Subchorionic Thrombohematoma (Breus' Mole) Associated with Fetal Growth Restriction, Oligohydramnios, and Intrauterine Fetal Death.

Miyagi M, Kinjo T, Mekaru K, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology   2019   9510936   2019年

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

A Case of Cornelia de Lange Syndrome: Difficulty in Prenatal Diagnosis.

Kinjo T, Mekaru K, Nakada M, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology   2019   4530491   2019年

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Fetal Congenital Peripheral Bronchial Atresia Diagnosed by Magnetic Resonance Imaging: Two Case Reports.

Kozaki M, Iraha Y, Masamoto H, Nitta H, Chinen Y, Kinjo T, Mekaru K, Aoki Y

AJP reports   8 ( 4 ) e201 - e205   2018年10月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Comparative study of obstetric and neonatal outcomes of live births between poor- and good-quality embryo transfers.

Akamine K, Mekaru K, Gibo K, Nagata C, Oishi S, Miyagi M, Heshiki C, Kinjo T, Masamoto H, Aoki Y

Reproductive medicine and biology ( Reproductive Medicine and Biology )  17 ( 2 ) 188 - 194   2018年04月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Multimodality imaging in secondary postpartum or postabortion hemorrhage: retained products of conception and related conditions.

Iraha Y, Okada M, Toguchi M, Azama K, Mekaru K, Kinjo T, Kudaka W, Aoki Y, Aoyama H, Matsuzaki A, Murayama S

Japanese journal of radiology ( Japanese Journal of Radiology )  36 ( 1 ) 12 - 22   2018年01月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Rectal Injury by Inserting a Vaginal Pipe for Laparoscopic Hysterectomy

Keiko Mekaru*, Sugiko Oishi, Kozue Akamine, Chiaki Heshiki, and Yoichi Aoki

ARC Journal of Gynecology and Obstetrics     2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI 学術リポジトリ

A Case of Intrathoracic Gastric Duplication Cyst Detected on Prenatal Ultrasound Examination.

Yagi H, Kinjyo Y, Chinen Y, Nitta H, Kinjo T, Mekaru K, Masamoto H, Goya H, Yoshida T, Sanabe N, Aoki Y

Case reports in obstetrics and gynecology   2018   5346920   2018年

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Polyunsaturated fatty acid concentration in the human follicular fluid may affect fertilisation

Mekaru, K; Miyagi, M; Akamine, K; Heshiki, C; Aoki, Y

HUMAN REPRODUCTION   32   213 - 213   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Does a Vanishing Twin Affect Perinatal Outcome?

Kozue Akamine*, Keiko Mekaru, Chiaki Heshiki, Yukiko Chinen, Tadatugu Kinjyo, Hitoshi Masamoto and Yoichi Aoki

Journal of Pregnancy and Child Health     2017年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI 学術リポジトリ

Spontaneous Regression of Uterine Arteriovenous Malformations with Conservative Management.

Mekaru K, Oishi S, Akamine K, Heshiki C, Aoki Y

Case reports in obstetrics and gynecology   2017   6437670   2017年

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Rectal Injury by Inserting a Vaginal Pipe for Laparoscopic Hysterectomy

Keiko Mekaru, Sugiko Oishi, Kozue Akamine, Chiaki Heshiki, Yoichi Aoki

ARC Journal of Gynecology and Obstetrics ( ARC Publications Pvt Ltd. )  2 ( 2 )   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

Cesarean Scar Pregnancy: A Report of 11 Cases and Review of the Literature Regarding Subsequent Pregnancy

Chiaki Heshiki, Keiko Mekaru, Maho Miyagi, Sugiko Oishi, Kozue Akamine, Hitoshi Sugiyama, Tadatsugu Kinjo, Hitoshi Masamoto, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  06 ( 01 ) 8 - 15   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

The Effect of Insulin Resistance on &lt;i&gt;In-Vitro&lt;/i&gt; Fertilization-Embryo Transfer in Women without Polycystic Ovary Syndrome

Keiko Mekaru, Sugiko Oishi, Kozue Akamine, Tadatsugu Kinjo, Chiaki Heshiki, Hitoshi Masamoto, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  06 ( 03 ) 157 - 166   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

Measurements of the Lower Uterine Segment at Term in Women with Previous Cesarean Delivery

Tadatsugu Kinjo, Hitoshi Masamoto, Keiko Mekaru, Yusuke Taira, Yukiko Chinen, Hayase Nitta, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  06 ( 01 ) 1 - 7   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

Six cases with borderline ovarian tumors diagnosed after laparoscopic cystectomy for benign ovarian tumor

銘苅桂子、田代朋子、安里こずえ、永山千晶、屋宜千晶、平川誠、稲嶺盛彦、上里忠和、長井裕、青木陽一屋宜千晶、平川誠、稲嶺盛彦、上里忠和、長井裕、青木陽一

日本産婦人科内視鏡学会 ( その他の出版社 )  24   365 - 369   2008年04月

掲載種別: 研究論文（その他学術会議資料等）

Thyroid function after hysterosalpingography using an oil-soluble iodinated contrast medium

Mekaru K, Kamiyama S, Masamoto H, Sakumoto K, Aoki Y

Gynecol Endocrinol ( その他の出版社 )  24   498 - 501   2008年04月

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI

Laparoscopic marsupialisation of pelvic lymphocele under transvaginal ultrasonographic guidance

Mekaru K, Kamiyama S, Masamoto H, Yagi C, Hirakawa M, Inamine M, Nagai Y, Sakumoto K, Aoki Y.

J Minim Invasive Gynecol ( その他の出版社 )  15   498 - 501   2008年04月

掲載種別: 研究論文（その他学術会議資料等）

• この論文にアクセスする

  DOI

Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy: A case report.

Mekaru K, Kamiyama S, Masamoto H, Yagi C, Hirakawa M, Inamine M, Nagai Y, Sakumoto K, Aoki Y

Arch Gynecol Obstet ( その他の出版社 )  278   287 - 290   2008年04月

掲載種別: 研究論文（その他学術会議資料等）

• この論文にアクセスする

  DOI

Thyroid function after hysterosalpingography using oil-soluble iodinated contrast media

銘苅桂子、田代朋子、安里こずえ、永山千晶、屋宜千晶、平川誠、稲嶺盛彦、上里忠和、長井裕、青木陽一

その他の掲載誌 ( その他の出版社 )    2008年

掲載種別: 研究論文（その他学術会議資料等）

Heparanase expression in endometrial cancer: Analysis of immunohistochemistry

Inamine M, Nagai Y, Hirakawa M, Mekaru K, Yagi C, Masamoto H, Aoki Y

J Obstet Gynaecol ( その他の出版社 )  28   634 - 637   2008年

掲載種別: 研究論文（その他学術会議資料等）

• この論文にアクセスする

  DOI

ガレン静脈瘤奇形：出生直後に経動脈的塞栓術を施行し救命しえた1症例.

銘苅桂子

産婦人科の実際 ( その他の出版社 )  55   577 - 583   2006年04月

掲載種別: 研究論文（その他学術会議資料等）

SLE合併妊娠-22症例のべ51妊娠に関する臨床的解析-

銘苅桂子

産婦の実際 ( その他の出版社 )  54   2309 - 2315   2005年04月

掲載種別: 研究論文（その他学術会議資料等）