山里　正演 (ヤマザト　マサノブ)

Yamazato Masanobu

写真a

職名

助教

科研費研究者番号

90347138
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  • 専任   琉球大学   医学研究科   助教  

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  • 琉球大学 -  博士(医学)  医学

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  • 2010年04月
    -
    継続中

      琉球大学　医学研究科　助教  

  • 2020年09月
    　
    　

      琉球大学病院  

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  • ライフサイエンス / 腎臓内科学

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  • Power spectral analysis of heart rate variability is useful as a screening tool for detecting sympathetic and parasympathetic nervous dysfunctions in Parkinson's disease.

    Miyagi T, Yamazato M, Nakamura T, Tokashiki T, Namihira Y, Kokuba K, Ishihara S, Sakima H, Ohya Y

    BMC neurology ( BMC Neurology )  22 ( 1 ) 339 - 339   2022年09月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder that causes motor symptoms and autonomic dysfunction. However, autonomic function tests commonly performed in PD can only evaluate either the sympathetic or parasympathetic nervous system. Therefore, the purpose of this pilot study is to investigate whether power spectral analysis of heart rate variability could detect both sympathetic and parasympathetic nervous dysfunctions in patients with PD. METHODS: Seventeen patients with PD and 11 healthy control subjects underwent electrocardiogram recording for the spectral analysis of heart rate variability to obtain values of low-frequency (LF) (0.04-0.15 Hz) and high-frequency (HF) (0.15-0.4 Hz) powers. Moreover, we examined the coefficient of variation of R-R intervals (CVRR) as a parameter of parasympathetic function in all participants and performed 123I-metaiodobenzylguanidine scintigraphy to measure the heart-to-mediastinum ratio as a parameter of cardiac sympathetic innervation in patients with PD. RESULTS: The median age of control subjects and PD patients was 63 and 66 years old, respectively. The median Hoehn and Yahr scale of PD patients was stage 2. The values of resting LF and HF powers widely varied. The median values of resting LF powers of control subjects and PD patients and those of HF powers were 169 and 70 ms2, 279 and 65 ms2, respectively, the difference was statistically insignificant. Approximately 41% of patients with PD had values below the first quartile of resting LF powers (< 58 ms2) or HF powers (< 50 ms2); however, no control subject had such low values. Positive correlations were found between resting LF powers and heart-to-mediastinum ratios of 123I-metaiodobenzylguanidine uptake (r = 0.6) and between resting HF powers and CVRRs (r = 0.7). The resting LF power was also associated with CVRRs and constipation. Furthermore, a positive correlation was observed between resting LF powers and resting HF powers in patients with PD (r = 0.8). CONCLUSIONS: The power spectral analysis of heart rate variability may be useful as a screening tool for detecting autonomic dysfunctions by detecting low resting LF and HF powers in patients with PD. Sympathetic and parasympathetic nerves may be concurrently damaged in patients with PD.

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  • Acquired factor V inhibitor with erythema and eosinophilia in a patient with end-stage renal disease.

    Katsuren E, Kohagura K, Kinjyo T, Zamami R, Nakamura T, Oshiro N, Sunagawa Y, Omine K, Kudo Y, Shinzato Y, Osaki T, Souri M, Ichinose A, Yamazato M, Ishida A, Ohya Y

    CEN case reports     2022年08月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    Autoimmune factor V deficiency (AiFVD) is a rare bleeding disorder caused by factor V inhibitors. In this report, we present the case of an 89-year-old man who developed bleeding tendency during surgery to create arteriovenous fistula for hemodialysis. The bleeding tendency developed with prolongation of activated partial thromboplastin and prothrombin time, following drug-induced eruption and eosinophilia. Significant reduction in coagulation factor activity and inhibitory pattern in cross-mixing tests suggested the presence of inhibitors to coagulation factors. Subsequently, we detected a factor V inhibitor and anti-factor V autoantibodies was confirmed using enzyme-linked immunosorbent assay with purified human plasma factor V. Thus, the patient was 'definitely diagnosed' with AiFVD in accordance with the diagnostic criteria enacted by the Japanese Ministry of Health, Labor, and Welfare. The bleeding tendency improved after initiating oral prednisolone 50 mg (1 mg/kg) followed by normalization of activated partial thromboplastin time and prothrombin time at the 34th day. After improving the coagulation system prolongation, the inhibitor and autoantibodies has been eradicated. Since it is suggested that drug-induced immune response can cause AiFVD, AiFVD should be considered in patients who undergo hemodialysis and develop failure of hemostasis and drug-induced eruption.

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  • Salt and potassium intake evaluated with spot urine and brief questionnaires in combination with blood pressure control status in hypertensive outpatients in a real-world setting.

    Yamazato M, Sakima A, Ishida A, Kohagura K, Matayoshi T, Tana T, Tamashiro M, Hata Y, Naka T, Nakamura Y, Ohya Y

    Hypertension research : official journal of the Japanese Society of Hypertension ( Hypertension Research )  44 ( 10 ) 1316 - 1325   2021年10月 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    Reducing salt and increasing potassium intake are recommended lifestyle modifications for patients with hypertension. The estimated 24-h urinary salt excretion value from spot urine using Tanaka's formula and the salt check-sheet scores, questionnaire-based scores of salt intake, are practical indices of daily salt intake. However, few studies have evaluated salt intake with these methods in hypertensive outpatients. We examined salt and potassium intake with the spot urine method and the salt check-sheet scores of hypertensive outpatients in a multi-facility, real-world setting and examined whether the salt or potassium intake evaluated with these methods related to inadequate blood pressure control. Hypertensive outpatients from 12 medical facilities in the Okinawa prefecture were enrolled from November 2011 to April 2014 (n = 1559, mean age 63.9 years, 46% women). The mean blood pressure, urinary salt excretion value, urinary potassium excretion value, and total score on the salt check-sheet were 129/75 mmHg, 8.7 g/day, 1.6 g/day, and 10.4 points, respectively. The urinary salt excretion value and total score on the salt check-sheet but not urinary potassium excretion value were associated with inadequate blood pressure control (≥140/90 mmHg). Higher body mass index, estimated glomerular filtration rate, urinary potassium excretion value, total score on the salt check-sheet, and presence of inadequate blood pressure control were associated with high urinary salt excretion (≥10.2 g/day). In conclusion, hypertensive outpatients with high urinary salt excretion values estimated using Tanaka's formula or with high scores on the salt check sheet may be candidates for more intensive salt reduction guidance.

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  • Publisher Correction: Salt and potassium intake evaluated with spot urine and brief questionnaires in combination with blood pressure control status in hypertensive outpatients in a real-world setting.

    Yamazato M, Sakima A, Ishida A, Kohagura K, Matayoshi T, Tana T, Tamashiro M, Hata Y, Naka T, Nakamura Y, Ohya Y

    Hypertension research : official journal of the Japanese Society of Hypertension ( Hypertension Research )  44 ( 10 ) 1362 - 1362   2021年10月 [ 査読有り ]

    掲載種別: 研究論文（その他学術会議資料等）

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  • The Association between Glomerular Diameter and Secondary Focal Segmental Glomerulosclerosis in Chronic Kidney Disease.

    Zamami R, Kohagura K, Kinjyo K, Nakamura T, Kinjo T, Yamazato M, Ishida A, Ohya Y

    Kidney & blood pressure research ( Kidney and Blood Pressure Research )  46 ( 4 ) 433 - 440   2021年 [ 査読有り ]

    掲載種別: 研究論文（学術雑誌）

    　概要を見る

    INTRODUCTION: When nephron loss occurs, the glomerular filtration rate (GFR) is suggested to be maintained by glomerular hypertrophy, but excessive hypertrophy can rather lead to the formation of focal segmental glomerulosclerosis (FSGS), thereby causing progressive kidney damage. However, it is not clear how much glomerular hypertrophy leads to the formation of FSGS. We examined the association between glomerular diameter and FSGS lesions in chronic kidney disease (CKD) patients. METHODS: We recruited 77 patients who underwent renal biopsy during 2016-2017; however, those identified with primary FSGS and glomerulonephritis with active glomerular lesion were excluded. We evaluated the maximal glomerular diameter (Max GD), an indicator of glomerular size, in each renal biopsy specimen and examined its association with FSGS lesion. RESULTS: The median age, blood pressure, and estimated GFR of the patients were 53 years, 122/70 mm Hg, and 65 mL/min/1.73 m2, respectively. The optimal cutoff threshold of Max GD for predicting the presence of FSGS lesions, assessed by receiver operating characteristic curve analysis, was determined to be at 224 μm (area under the curve, 0.81; sensitivity, 81%; specificity, 72%). Multivariate logistic regression analyses demonstrated that Max GD ≥224 μm was significantly associated with the presence of FSGS lesions, independent of other confounding factors (odds ratio, 11.70; 95% confidence interval, 1.93-70.84). DISCUSSION/CONCLUSION: Glomerular hypertrophy (Max GD ≥224 μm) has been associated with FSGS lesions in CKD patients and may reflect the limits of the compensatory process.

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  • Parkinson病(PD)の自律神経評価における心拍変動解析(HRV)の有用性

    宮城 朋, 中村 卓人, 波平 幸裕, 山里 正演, 渡嘉敷 崇, 大屋 祐輔

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集 ( Movement Disorder Society of Japan (MDSJ) )  14回   99 - 99   2021年02月  [査読有り]

     

  • 当院独自の透析導入・非導入の意思決定支援ツールを用いて血液透析を導入した悪性腫瘍終末期患者の一例

    金城 興次郎, 平良 浩菜, 中村 卓人, 座間味 亮, 金城 孝典, 又吉 哲太郎, 山里 正演, 古波蔵 健太郎, 石田 明夫, 大屋 祐輔

    日本透析医学会雑誌 ( (一社)日本透析医学会 )  53 ( Suppl.1 ) 370 - 370   2020年10月  [査読有り]

     

  • 自己免疫性後天性凝固第V因子欠乏症を発症した末期腎不全患者の一例

    勝連 英亮, 平良 浩菜, 新里 勇樹, 金城 孝典, 山里 正演, 石田 明夫, 古波蔵 健太郎, 大屋 祐輔

    日本透析医学会雑誌 ( (一社)日本透析医学会 )  53 ( Suppl.1 ) 464 - 464   2020年10月  [査読有り]

     

  • 糸球体肥大による二次性巣状分節性糸球体硬化症の発症閾値の検討

    座間味 亮, 古波蔵 健太郎, 山里 正演, 石田 明夫, 大屋 祐輔

    日本腎臓学会誌 ( (一社)日本腎臓学会 )  62 ( 4 ) 280 - 280   2020年07月  [査読有り]

     

  • 慢性腎臓病患者における肥満と糸球体密度及び糸球体径との関連

    座間味 亮, 古波蔵 健太郎, 山里 正演, 石田 明夫, 大屋 祐輔

    日本高血圧学会総会プログラム・抄録集 ( (NPO)日本高血圧学会 )  42回   344 - 344   2019年10月  [査読有り]

     

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  • 10th Hypertension Research Award

    2019年10月   The Japanese Society of Hypertension  

    受賞者: 山里 正演

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