Sakima Hirokuni

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

40625696
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Institute for Global Education   Global Health Science Program   Associate Professor  

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Published Papers 【 display / non-display 】

  • Association between enlarged perivascular spaces in the basal ganglia and the Frontal Assessment Battery: A cross-sectional study

    Kinjo, Y; Saji, N; Murotani, K; Sakima, H; Takeda, A; Sakurai, T; Kusunose, K

    JOURNAL OF ALZHEIMERS DISEASE ( Journal of Alzheimer S Disease )  108 ( 4 ) 1584 - 1592   2025.12 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • ASSOCIATION BETWEEN ENLARGED PERIVASCULAR SPACES IN THE BASAL GANGLIA AND THE FRONTAL ASSESSMENT BATTERY: A CROSS-SECTIONAL STUDY

    Kinjo, Y; Saji, N; Murotani, K; Sakima, H; Takeda, A; Sakurai, T; Kusunose, K

    INTERNATIONAL JOURNAL OF STROKE   20   334 - 334   2025.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Association of Obesity and Metabolic Health Status with Cerebral Small-Vessel Disease in Stroke-Free Individuals

    Ishida, A; Nakanishi, R; Miyagi, T; Sakima, H; Nakamura, K; Yamazato, M; Ohya, Y; Kusunose, K

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( 一般社団法人 日本動脈硬化学会 )  32 ( 10 ) 1304 - 1315   2025 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    <p> <b>Aim:</b> We investigated the association of obesity and metabolic health status with cerebral small-vessel disease (SVD), a predictor of stroke, in stroke-free participants during brain health checkups.</p><p><b>Methods:</b> An observational cross-sectional study was conducted on 6,088 stroke-free participants who underwent brain magnetic resonance imaging (MRI). Abdominal obesity was defined as a waist circumference ≥ 90 cm for men and ≥ 80 cm for women. A metabolically healthy status was defined as having none of the three components of metabolic syndrome, except abdominal obesity. The total SVD scores were derived from four MRI markers: silent lacunar infarcts, cerebral microbleeds, moderate-to-severe white-matter hyperintensity, and enlarged perivascular spaces.</p><p><b>Results:</b> The mean age of participants was 55±12 years old. Obesity was prevalent in 50% of the patients. The prevalence of a total SVD score ≥ 2 (moderate-to-severe SVD) was 348 (6%), which was elevated in metabolically unhealthy individuals regardless of obesity status. Compared with the metabolically healthy non-obese group, the metabolically unhealthy non-obese (odds ratio [OR] 2.08, [95% confidence interval {CI}, 1.33–3.27]) and metabolically unhealthy obese (OR 2.62, [95% CI, 1.70–4.04]) groups had a higher multivariable-adjusted risk for a total SVD score ≥ 2. Similar results were obtained for obesity defined as a body mass index ≥ 25 kg/m<sup>2</sup> instead of abdominal obesity.</p><p><b>Conclusions:</b> Abdominal and general obesity alone were not associated with high total SVD scores in stroke-free individuals. Metabolically unhealthy status, especially high blood pressure and hyperglycemia, are significant risk factors for moderate-to-severe SVD.</p>

  • Enlarged Perivascular Spaces Are Independently Associated with High Pulse Wave Velocity: A Cross-Sectional Study

    Kinjo, Y; Saji, N; Murotani, K; Sakima, H; Takeda, A; Sakurai, T; Ohya, Y; Kusunose, K

    JOURNAL OF ALZHEIMERS DISEASE ( Journal of Alzheimer S Disease )  101 ( 2 ) 627 - 636   2024 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Power spectral analysis of heart rate variability is useful as a screening tool for detecting sympathetic and parasympathetic nervous dysfunctions in Parkinson's disease

    Miyagi, T; Yamazato, M; Nakamura, T; Tokashiki, T; Namihira, Y; Kokuba, K; Ishihara, S; Sakima, H; Ohya, Y

    BMC NEUROLOGY ( BMC Neurology )  22 ( 1 ) 339   2022.09 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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