Published Papers - Yonemoto Koji

Generalization of a clinical diagnosis support tool for lumbar spinal stenosis: Can the ankle brachial pressure index be replaced by palpation of the posterior tibial artery in the lumbar spinal stenosis diagnostic support tool? (DISTO project).

Nikaido T, Sekiguchi M, Yonemoto K, Kakuma T, Watanabe K, Kato K, Kobayashi H, Tominaga R, Otani K, Yabuki S, Kikuchi SI, Konno SI, DISTO-Project Working Group

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association ( Journal of Orthopaedic Science )  28 ( 3 ) 543 - 546   2023.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community.

Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T

Scientific reports ( Scientific Reports )  12 ( 1 ) 12427 - 12427   2022.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007-2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.

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Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis.

Kitagawa K, Arima H, Yamamoto Y, Ueda S, Rakugi H, Kohro T, Yonemoto K, Matsumoto M, Saruta T, Shimada K, Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study Group

Hypertension research : official journal of the Japanese Society of Hypertension ( Hypertension research : official journal of the Japanese Society of Hypertension )  45 ( 4 ) 591 - 601   2022.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Diagnostic accuracy of the lumbar spinal stenosis-diagnosis support tool and the lumbar spinal stenosis-self-administered, self-reported history questionnaire.

Tominaga R, Kurita N, Sekiguchi M, Yonemoto K, Kakuma T, Konno SI

PloS one ( PLoS ONE )  17 ( 5 ) e0267892 - e0267892   2022 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Despite the applicability of the lumbar spinal stenosis (LSS)-diagnosis support tool (DST) and the LSS-self-administered, self-reported history questionnaire (SSHQ), their diagnostic accuracy has never been compared with that of the well-known North American Spine Society (NASS) clinical description of LSS. This study aimed to compare the diagnostic accuracy of the two diagnostic tools with that of the NASS guidelines’ clinical description of LSS in a Japanese secondary care hospital setting. This multicenter cross-sectional study used data from the lumbar spinal stenosis diagnostic support tool (DISTO) project, which was conducted from December 1, 2011 to December 31, 2012. Japanese adults with low back pain (LBP) aged ≥20 years were consecutively included. The reference standard was LSS diagnosed by orthopedic physicians. The diagnostic accuracy of the two support tools was compared. Of 3,331 patients, 1,416 (42.5%) patients were diagnosed with LSS. The NASS clinical description of LSS had a sensitivity of 63.9% and specificity of 89.5%. The LSS-DST and LSS-SSHQ had sensitivities of 91.3% and 83.8% and specificities of 76.0% and 57.6%, respectively, with substantial improvements in sensitivity (P < 0.0001). Similar results were obtained when we limited included patients to those aged >60 years. These findings indicated that the LSS-DST and LSS-SSHQ were more sensitive in screening patients with LBP for a diagnosis of LSS than the NASS clinical description of LSS. This study strongly supports prioritizing the use of either of these two diagnostic support tools for screening.

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Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).

Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y, JPSFC-AD Study Group.

Environmental health and preventive medicine ( Environmental health and preventive medicine )  25 ( 1 ) 64 - 64   2020.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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© 2020, The Author(s). Background: The burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction. Methods: The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, population-based prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses. Results: The baseline survey was conducted from 2016 to 2018. The follow-up surveys are ongoing. A total of 11,410 individuals aged 65 years or older participated in the study. The mean age was 74.4 years, and 41.9% were male. The prevalence of dementia at baseline was 8.5% in overall participants. However, it was 16.4% among three sites where additional home visit and/or nursing home visit surveys were performed. Approximately two-thirds of dementia cases at baseline were Alzheimer’s disease. Conclusions: The prospective cohort data from the JPSC-AD will provide valuable insights regarding the risk factors and etiology of dementia as well as for the development of predictive models and diagnostic markers for the future onset of dementia. The findings of this study will improve our understanding of dementia and provide helpful information to establish effective preventive strategies for dementia in Japan.

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Clinical characteristics of hoarding disorder in Japanese patients.

Kuwano M, Nakao T, Yonemoto K, Yamada S, Murayama K, Okada K, Honda S, Ikari K, Tomiyama H, Hasuzawa S, Kanba S

Heliyon ( Heliyon )  6 ( 3 ) e03527   2020.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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© 2020 The Author(s) Previous studies have reported clinical characteristics of hoarding disorder (HD), such as early onset, a chronic course, familiality, high unmarried rate, and high rates of comorbidities. However, clinical research targeting Japanese HD patients has been very limited. As a result, there is a low recognition of HD in Japan, leading to insufficient evaluation and treatment of Japanese HD patients. The aim of the current study was to delineate the clinical characteristics of Japanese HD patients. Thirty HD patients, 20 obsessive-compulsive disorder (OCD) patients, and 21 normal controls (NC) were targeted in this study. The HD group had a tendency toward higher familiality, earlier onset, and longer disease duration compared to the OCD group. In addition, the HD group showed a significantly higher unmarried rate than the NC group. The top two comorbidities in the HD group were major depressive disorder (56.7%) and attention-deficit/hyperactivity disorder (26.7%). The HD group had significantly higher scores on hoarding rating scales and lower scores on the Global Assessment of Functioning Scale than the other two groups. The current study showed a clinical trend in Japanese HD patients similar to previous studies in various countries, suggesting that HD may be a universal disease with consistent clinical symptoms.

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Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia.

Yamauchi M, Kinjo T, Parrott G, Miyagi K, Haranaga S, Nakayama Y, Chibana K, Fujita K, Nakamoto A, Higa F, Owan I, Yonemoto K, Fujita J

PloS one ( PLoS ONE )  15 ( 1 ) e0227636   2020

Type of publication: Research paper (scientific journal)

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Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis.

Kitagawa K, Yamamoto Y, Arima H, Maeda T, Sunami N, Kanzawa T, Eguchi K, Kamiyama K, Minematsu K, Ueda S, Rakugi H, Ohya Y, Kohro T, Yonemoto K, Okada Y, Higaki J, Tanahashi N, Kimura G, Umemura S, Matsumoto M, Shimamoto K, Ito S, Saruta T, Shimada K, Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study Group.

JAMA neurology ( JAMA Neurology )  76 ( 11 ) 1309 - 1318   2019.07

Type of publication: Research paper (scientific journal)

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Reference values of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire in patients with lumbar spinal stenosis and characteristics of deterioration of QOL: Lumbar Spinal Stenosis Diagnosis Support Tool: DISTO project.

Kobayashi H, Sekiguchi M, Yonemoto K, Kakuma T, Tominaga R, Kato K, Watanabe K, Nikaido T, Otani K, Yabuki S, Kikuchi SI, Konno SI, DISTO project working group.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association ( Journal of Orthopaedic Science )  24 ( 4 ) 584 - 589   2019.07

Type of publication: Research paper (scientific journal)

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Validation of a novel digital health monitoring system to measure the volume of voided urine.

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourology and urodynamics ( Neurourology and Urodynamics )  38 ( 4 ) 1106 - 1110   2019.04

Type of publication: Research paper (scientific journal)

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Longitudinal Changes of Physical Activity and Sedentary Time in the Middle-Aged and Older Japanese Population: The Hisayama Study.

Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S

Journal of physical activity & health ( Journal of Physical Activity and Health )  16 ( 2 ) 165 - 171   2019.02

Type of publication: Research paper (scientific journal)

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新生児集中治療室における末梢挿入型中心静脈カテーテル関連血流感染のリスク因子の検討：単施設後ろ向きコホート研究

川野 佐由里, 米本 孝二, 崎浜 智子

日本環境感染学会誌 ( 一般社団法人 日本環境感染学会 )  34 ( 6 ) 287 - 295   2019 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<p>新生児集中治療室（Neonatal Intensive Care Unit：NICU）における末梢挿入型中心静脈カテーテル関連血流感染（Peripherally Inserted Central venous Catheter Bloodstream Infection：PICC-BSI）のリスク因子について，後ろ向きコホート研究にて検討した．対象は，単施設のNICUで2008年～2015年の8年間に，初回PICC挿入を受けた507例とした．結果，PICC-BSIは臨床的敗血症33例を含む40例（7.9%）に発生し，発生率は5.9/1000device-daysであった．単変量解析で関連が確認された12変数（在胎週数，出生体重，性別，染色体異常，先天性心疾患，先天性消化器疾患，挿入部位，ルーメン数，手袋使用，輸血療法，Total Parenteral Nutrition：TPN，ステロイド剤）を候補に，変数間の時間的前後関係を考慮した多変量ロジスティックモデルで解析した．PICC-BSIのリスク因子として，男児，先天性心疾患，在胎週数（短いほど），出生体重（軽いほど），挿入者の手袋使用無し，TPNの使用が示唆された．NICUでのPICC挿入者の手袋使用を含む無菌操作や，TPNの適正使用，薬液調製環境の改善が望まれる．</p>

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Race and nodal disease status are prognostic factors in patients with stage IVB cervical cancer.

Nishio S, Matsuo K, Yonemoto K, Shimokawa M, Hosaka M, Kodama M, Miyake TM, Ushijima K, Kamura T, Westin SN, Soliman PT, Coleman RL

Oncotarget   9 ( 64 ) 32321 - 32330   2018.08

Type of publication: Research paper (scientific journal)

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Establishment of reference scores and interquartile ranges for the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) in patients with low back pain.

Tominaga R, Sekiguchi M, Yonemoto K, Kakuma T, Konno SI

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association ( Journal of Orthopaedic Science )  23 ( 4 ) 643 - 648   2018.07

Type of publication: Research paper (scientific journal)

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Development and validation of a risk assessment tool for gastric cancer in a general Japanese population.

Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association ( Gastric Cancer )  21 ( 3 ) 383 - 390   2018.05

Type of publication: Research paper (scientific journal)

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Augmented Association Between Blood Pressure and Proteinuria in Hyperuricemic Patients With Nonnephrotic Chronic Kidney Disease.

Kohagura K, Kochi M, Miyagi T, Zamami R, Nagahama K, Yonemoto K, Ohya Y

American journal of hypertension ( American Journal of Hypertension )  31 ( 4 ) 480 - 485   2018.03

Type of publication: Research paper (scientific journal)

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Surface electromyographic evaluation of the neuromuscular activation of the inspiratory muscles during progressively increased inspiratory flow under inspiratory-resistive loading

Sekiguchi H.

Physiology International ( Physiology International )  105 ( 1 ) 86 - 99   2018.03

Type of publication: Research paper (scientific journal)

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Prognostic implications of HER2 heterogeneity in gastric cancer.

Motoshima S, Yonemoto K, Kamei H, Morita M, Yamaguchi R

Oncotarget ( Oncotarget )  9 ( 10 ) 9262 - 9272   2018.02

Type of publication: Research paper (scientific journal)

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Risk of malignancies in autoimmune hepatitis type 1 patients with a long-term follow-up in Japan.

Arinaga-Hino T, Ide T, Miyajima I, Ogata K, Kuwahara R, Amano K, Kawaguchi T, Nakamura T, Kawaguchi T, Koga H, Yonemoto K, Torimura T, Kurume Autoimmune Hepatitis Study Group.

Hepatology research : the official journal of the Japan Society of Hepatology   48 ( 3 ) E222 - E231   2018.02

Type of publication: Research paper (scientific journal)

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White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study.

Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T

Hypertension research : official journal of the Japanese Society of Hypertension   40 ( 11 ) 937 - 943   2017.11

Type of publication: Research paper (scientific journal)

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