前本 均 (マエモト ヒトシ)

MAEMOTO HITOSHI

写真a

職名

助教

科研費研究者番号

70774470

現在の所属組織 【 表示 / 非表示

  • 専任   琉球大学   医学部   附属病院   助教  

出身大学 【 表示 / 非表示

  • 2013年04月
    -
    2017年03月

    琉球大学   医学研究科   医科学専攻   卒業

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  • 琉球大学 -  博士(医学)  医学

所属学会・委員会 【 表示 / 非表示

  •  
     
     
     

    日本放射線腫瘍学会

  •  
     
     
     

    日本医学放射線学会

研究キーワード 【 表示 / 非表示

  • 放射線腫瘍学

  • 腫瘍

  • 放射線治療

研究分野 【 表示 / 非表示

  • ライフサイエンス / ゲノム生物学

  • ライフサイエンス / 腫瘍診断、治療学

論文 【 表示 / 非表示

  • Therapeutic efficacy of selective intraarterial chemoradiotherapy with docetaxel and nedaplatin for human papilloma virus-negative oropharyngeal cancer.

    Heianna J, Makino W, Hirakawa H, Agena S, Tomita H, Ariga T, Ishikawa K, Takehara S, Kusada T, Maemoto H, Maeda H, Murayama S

    Auris, nasus, larynx ( Auris Nasus Larynx )  49 ( 3 ) 468 - 476   2022年06月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    OBJECTIVE: Human papilloma virus-negative oropharyngeal cancer has not achieved satisfactory outcomes compared with those of human papilloma virus-positive oropharyngeal cancer. This study evaluated the therapeutic efficacy of selective intraarterial chemoradiotherapy with the docetaxel and nedaplatin regimen for human papilloma virus-negative oropharyngeal cancer. METHODS: Twenty-two consecutive patients with human papilloma virus-negative oropharyngeal cancer who had undergone selective intraarterial chemoradiotherapy were retrospectively analyzed. The primary tumor and whole neck were irradiated (50 Gy). Subsequently, the primary site and metastatic lymph nodes were boosted by 20 Gy. The intraarterial chemotherapy regimen comprised a combination of nedaplatin (80 mg/m2) and docetaxel (60 mg/m2), which was initially administered at the start of radiotherapy and was given every 4 weeks for three sessions. Each intraarterial dose of an anticancer agent was determined according to the percentage of the tumor volume supplied by the target artery to the total tumor volume, which was intraoperatively measured via cone-beam computed tomography. The outcome measures were locoregional control, disease-free survival, and overall survival rates and adverse events. Statistical analyses were performed using the Kaplan-Meier method. RESULTS: The median follow-up period was 59 (range, 15-103) months. The T stage was T1/T2 in 5 patients (23%), T3 in 5 patients (23%), and T4 in 12 patients (54%). Cervical lymph node metastasis was staged as ≥N2c in 7 (32%) patients. Complete response was achieved in all patients at the first imaging examination after intraarterial chemoradiotherapy. The 5-year locoregional control, disease-free survival, and overall survival rates were 96% (95% confidence interval, 0.72-0.99), 91% (95% confidence interval, 0.68-0.98), and 100% (95% confidence interval, not available), respectively. Regarding serious acute adverse events, grade 4 laryngeal edema and leukopenia were observed in 1 (5%) and 11 patients (50%), respectively. No other serious acute adverse events were observed. CONCLUSION: Selective intraarterial chemoradiotherapy with docetaxel and nedaplatin has the potential to achieve favorable locoregional control, disease-free survival, and overall survival rates in human papilloma virus-negative oropharyngeal cancer.

  • Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer.

    Maemoto H, Ogura T, Toita T, Ariga T, Hashimoto S, Kawakami Y, Ishikawa K, Takehara S, Heianna J, Kudaka W, Aoki Y, Nishie A

    Journal of radiation research ( Oxford University Press (OUP) )  63 ( 1 ) 107 - 114   2022年01月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    <title>Abstract</title> Oral administration of a water-soluble iodine contrast agent (gastrografin) was reported to assist in the appropriate contouring of the small intestine on computed tomography (CT)-based radiotherapy (RT) planning. The efficacy and optimal dose of gastrografin in CT-based image-guided brachytherapy (IGBT) for cervical cancer remain unknown. This study aimed to investigate the efficacy of pretreatment oral administration of gastrografin at a small dose of 50 ml in CT-based IGBT for cervical cancer. A total of 422 sessions in 137 patients who underwent CT-based IGBT with 50 ml of oral gastrografin (concentration, 3% or 4%) were analyzed. Preparation of gastrografin was judged as effective when the small intestine was contrast-enhanced at the area where the small intestine was in contact with the uterus/adnexa. About 287 out of 422 sessions (68%) were judged as effective with gastrografin preparation. The 135 ineffective sessions were considered as follows: (i) the contrast enhancement of the small intestine was not confirmed (n = 36), (ii) the small intestine was not in contact with the uterus/adnexa despite the confirmation of the contrast enhancement of the small intestine (n = 34), and (iii) gastrografin was absent in the small intestine at the area in contact with the uterus/adnexa, even when gastrografin was observed in the small intestine at the area not in contact with the uterus/adnexa (n = 65). In conclusion, pretreatment oral administration of a small dose gastrografin achieved moderate efficacy for accurate contouring of the small intestine close to the uterus/adnexa in CT-based IGBT for cervical cancer.

  • Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma.

    Makino W, Heianna J, Ishikawa K, Kusada T, Maemoto H, Ariga T, Matayoshi A, Nakasone T, Hirakawa H, Agena S, Yamashita Y, Maeda H, Murayama S

    Journal of the Egyptian National Cancer Institute ( Journal of the Egyptian National Cancer Institute )  33 ( 1 ) 40   2021年12月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    <title>Abstract</title><sec> <title>Background</title> Postoperative chemoradiotherapy is recommended for patients with head and neck squamous cell carcinoma with positive margins or extracapsular extension at high risk of recurrence. However, high-dose radiotherapy in the head and neck region often causes severe acute and late radiation-related adversities. In our institution, the radiation dose has been relatively lower than that used in Western countries to reduce radiation-related toxicities. Therefore, in this study, we examined the treatment outcomes of low-dose postoperative chemoradiotherapy. </sec><sec> <title>Methods</title> The outcomes of 90 consecutive head and neck squamous cell carcinoma patients who received postoperative radiotherapy between June 2009 and December 2016 were retrospectively analyzed. All patients received postoperative three-dimensional conformal radiotherapy with or without concurrent systemic chemotherapy. The median patient age was 65 years. Concurrent chemoradiotherapy was administered at a total dose of 50.4 Gy in 28 fractions (daily fraction, 1.8 Gy). High-risk patients received 10.8 Gy of boost irradiation in six fractions. For radiotherapy alone, the irradiation dose was up to 54 Gy in 30 fractions and 64.8 Gy in 36 fractions for high-risk patients to increase the treatment intensity. </sec><sec> <title>Results</title> The median follow-up period was 40.5 months. The 3-year locoregional control and overall survival rates were 67.5% and 82.7%, respectively. A significantly higher proportion of patients with oral cavity carcinoma experienced locoregional failure (<italic>p</italic> = 0.004). The acute adverse events were mild, and the only late adverse event was grade 3 dysphagia (<italic>n</italic> = 3). </sec><sec> <title>Conclusion</title> This study suggests that de-escalation of the postoperative radiation dose can potentially reduce the severe adverse events of irradiation in patients while ensuring its effectiveness. In patients with oral cavity carcinoma, it might be necessary to increase the radiation dose. </sec>

  • Therapeutic efficacy of selective intra-arterial chemoradiotherapy with docetaxel and nedaplatin for fixed bulky nodal disease in head and neck cancer of unknown primary.

    Heianna J, Makino W, Hirakawa H, Agena S, Tomita H, Ariga T, Ishikawa K, Takehara S, Maemoto H, Murayama S

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery ( European Archives of Oto-Rhino-Laryngology )    2021年10月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

  • Chemoembolization for Symptomatic Metastatic Epidural Spinal Cord Compression Refractory to Re-radiotherapy.

    Heianna J, Makino W, Toguchi M, Kusada T, Iraha T, Ishikawa K, Takehara S, Maemoto H, Ariga T, Murayama S

    Cardiovascular and interventional radiology ( CardioVascular and Interventional Radiology )    2021年08月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

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