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Published Papers 【 display / non-display 】

• Direct visualization of postoperative aortobronchial fistula on computed tomography.

  Tsuchiya N, Inafuku H, Yogi S, Iraha Y, Iida G, Ando M, Nagano T, Higa S, Maeda T, Kise Y, Furukawa K, Yonemoto K, Nishie A

  World journal of radiology   16 ( 8 ) 337 - 347   2024.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• A Case of Multicentric Dedifferentiated Liposarcoma in the Stomach and Mesentery

  Journal of the Japanese College of Radiology   4 ( 0 ) 6 - 12   2024.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Survey on chest CT findings in COVID-19 patients in Okinawa, Japan: differences between the delta and omicron variants.

  Tsuchiya N, Yonamine E, Iraha S, Takara M, Oshiro Y, Tetsuhiro M, Murayama S, Kinoshita R, Sato M, Nishikuramori Y, Takara H, Akamine T, Morita H, Matayoshi T, Chinen Y, Nishie A

  Scientific reports ( Scientific Reports )  13 ( 1 ) 20373   2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Chronic thromboembolic pulmonary hypertension is associated with a loss of total lung volume on computed tomography

  Tsuchiya, N; Xu, YY; Ito, J; Yamashiro, T; Ikemiyagi, H; Mummy, D; Schiebler, ML; Yonemoto, K; Murayama, S; Nishie, A

  WORLD JOURNAL OF RADIOLOGY   15 ( 5 ) 146 - 156   2023.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  BACKGROUND: Although lung volumes are usually normal in individuals with chronic thromboembolic pulmonary hypertension (CTEPH), approximately 20%-29% of patients exhibit a restrictive pattern on pulmonary function testing. AIM: To quantify longitudinal changes in lung volume and cardiac cross-sectional area (CSA) in patients with CTEPH. METHODS: In a retrospective cohort study of patients seen in our hospital between January 2012 and December 2019, we evaluated 15 patients with CTEPH who had chest computed tomography (CT) performed at baseline and after at least 6 mo of therapy. We matched the CTEPH cohort with 45 control patients by age, sex, and observation period. CT-based lung volumes and maximum cardiac CSAs were measured and compared using the Wilcoxon signed-rank test and the Mann-Whitney u test. RESULTS: Total, right lung, and right lower lobe volumes were significantly reduced in the CTEPH cohort at follow-up vs baseline (total, P = 0.004; right lung, P = 0.003; right lower lobe; P = 0.01). In the CTEPH group, the reduction in lung volume and cardiac CSA was significantly greater than the corresponding changes in the control group (total, P = 0.01; right lung, P = 0.007; right lower lobe, P = 0.01; CSA, P = 0.0002). There was a negative correlation between lung volume change and cardiac CSA change in the control group but not in the CTEPH cohort. CONCLUSION: After at least 6 mo of treatment, CT showed an unexpected loss of total lung volume in patients with CTEPH that may reflect continued parenchymal remodeling.

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• Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program.

  Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore WC, Bleecker ER, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML

  American journal of respiratory and critical care medicine ( American journal of respiratory and critical care medicine )  207 ( 4 ) 475 - 484   2023.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Rationale: Extrapulmonary manifestations of asthma, including fatty infiltration in tissues, may reflect systemic inflammation and influence lung function and disease severity. Objectives: To determine if skeletal muscle adiposity predicts lung function trajectory in asthma. Methods: Adult SARP III (Severe Asthma Research Program III) participants with baseline computed tomography imaging and longitudinal postbronchodilator FEV1% predicted (median follow-up 5 years [1,132 person-years]) were evaluated. The mean of left and right paraspinous muscle density (PSMD) at the 12th thoracic vertebral body was calculated (Hounsfield units [HU]). Lower PSMD reflects higher muscle adiposity. We derived PSMD reference ranges from healthy control subjects without asthma. A linear multivariable mixed-effects model was constructed to evaluate associations of baseline PSMD and lung function trajectory stratified by sex. Measurements and Main Results: Participants included 219 with asthma (67% women; mean [SD] body mass index, 32.3 [8.8] kg/m2) and 37 control subjects (51% women; mean [SD] body mass index, 26.3 [4.7] kg/m2). Participants with asthma had lower adjusted PSMD than control subjects (42.2 vs. 55.8 HU; P < 0.001). In adjusted models, PSMD predicted lung function trajectory in women with asthma (β = -0.47 Δ slope per 10-HU decrease; P = 0.03) but not men (β = 0.11 Δ slope per 10-HU decrease; P = 0.77). The highest PSMD tertile predicted a 2.9% improvement whereas the lowest tertile predicted a 1.8% decline in FEV1% predicted among women with asthma over 5 years. Conclusions: Participants with asthma have lower PSMD, reflecting greater muscle fat infiltration. Baseline PSMD predicted lung function decline among women with asthma but not men. These data support an important role of metabolic dysfunction in lung function decline.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• Precision Approaches to Heterogeneity in Asthma

  Mark L. Schiebler, Nanae Tsuchiya, Andrew Hahn, Sean Fain, Loren Denlinger, Nizar Jarjour, Eric A. Hoffman ( Part: Allotment Writing ,  Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling )

  Advances in experimental medicine and biology  2023.07

• Pulmonary Functional Imaging: Basics and Clinical Applications.

  Griffin, L, Swift, A.J, Tsuchiya, N, Franchois, C, Humbert, M, Cohen, G, Schiebler,M.L ( Part: Allotment Writing ,  Multimodality Imaging of pulmonary hypertension: prognostication of therapeutic outcomes )

  Springer Nature  2020

Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• RSNA2020 Report -Chest-

  Rad Fan   19 ( 2 ) 29 - 32   2021.02

   

• 研究者の最新動向 肺高血圧症のMRI

  土屋 奈々絵, 伊藤 純二, 村山 貞之

  Precision Medicine ( (株)北隆館 )  1 ( 2 ) 229 - 233   2018.11

   

• 【実地医家のための画像診断実践ガイド】胸部 腫瘍 良性結節

  土屋 奈々絵, 村山 貞之

  Medical Practice ( (株)文光堂 )  35 ( 臨増 ) 107 - 111   2018.04

   

• 肺高血圧症のMRI

  土屋 奈々絵, 伊藤 純二, 村山 貞之

  別冊Bio Clinica: 慢性炎症と疾患 ( (株)北隆館 )  7 ( 1 ) 113 - 117   2018.02

   

• 【肺感染症のすべて-臨床,病理,画像を学ぶ-】肺寄生虫疾患

  大城 康二, 村山 貞之, 土屋 奈々絵, 宮良 哲博

  画像診断 ( (株)学研メディカル秀潤社 )  36 ( 3 ) 309 - 317   2016.02

   

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• CT findings of postoperative aortobronchial fistula

  Nanae Tsuchiya, Sadayuki Murayama, Satoko Yogi, Yuma Chinen, Kojiro Furukawa, Akihiro Nishie

  ACTI 2023  2023.06  -  2023.06 

• 4D flow MRIによるバッドキアリ症候群の血流評価：下大静脈、肝静脈、門脈、側副血行路の視認性

  Nanae Tsuchiya, Kanako Naito, Hitoshi Inafuku, Akihiro Nishie

  第82回 日本医学放射線学会総会  2023.04  -  2023.04 

• Image interpretation -chest-

  Nanae Tsuchiya

  The 57th Autumn Assembly of the Japan Radiological Society  2021.09  -  2021.09 

• Training on how to find retained sponges during and after surgery

  2020.05  -  2020.06 

• Intrathoracic abnormal air -Where abnormal air will be located and where comes from-

  Nanae Tsuchiya, Daichi Higa, Akihiro Nakamata, Junji Ito, Sadayuki Murayama

  The 105th Scientific Assembly and Annual Meeting of the Radiological Society of North  2019.12  -  2019.12 

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Gold Medal

  2021.04     Kerley's A line represents thickened septal plates between lung segments: confirmation using 3D-CT lung segmentation analysis

• Educational Exhibit Cypos Award

  2020.04   The 79th Annual Meeting of the Japan Radiological Society   Training on how to find retained sponges during and after surgery

• Scientific Poster Award

  2020.01     The role of chest CT in determining the treatment of drowning

• The Yong Investigator Scholarship

  2013   the 3rd World Congress of Thoracic Imaging  

  Winner: Tsuchiya Nanae

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2016.04  -  2019.03 

  Investigator(s): Murayamma Sadayuki 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

  　View Summary

  Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.

• Digital morphological analysis and genetic base of human anatomical traits

  Grant-in-Aid for Scientific Research(A)

  Project Year: 2013.10  -  2016.03 

  Investigator(s): ISHIDA Hajime, KIMURA Ryosuke, FUKASE Hitoshi, SAITO Naruya, SUZUKI Hiromasa, YAMAGUCHI Tetsutaro, MURAYAMA Sadayuki, TSURUMOTO Toshiyuki, MICHIKAWA Takashi, OGIWARA Naomichi, MAKI Koutaro, TSUCHIYA Nanae, SUMIYAMA Kenta 

  Direct: 34,300,000 (YEN)  Overheads: 44,590,000 (YEN)  Total: 10,290,000 (YEN)

  　View Summary

  We collected CT and genetic data from about 1000 individuals. Humans from cold/dry climate tend to possess a relatively tall, narrow, and deep nasal cavity compared with those from warm/humid environment, though the posterior choanal shape lacks such a north-south cline. The individuals with more chiseled feature have more recessed eyeballs (against orbital openings), more protruded facial cranium, thicker skin, and possibly smaller eyeball size. Using lateral cephalometric images, the Ryukyuan females clearly have the following features: 1) a shallower mandibular notch, 2) an anterior-inclined symphysis of mandible, and 3) a smaller depth from upper lip to incisors. We observed a significant association of crown size with an SNP in WNT10A (rs7349332), indicating that common variations in WNT10A have pleiotropic effects on the morphology of ectodermal appendages. We continue genome-wide search for genetic factors associated with 3D facial morphology.

Other External funds 【 display / non-display 】

Other External funds 【 display / non-display 】

• Project Year: 2017.09  -  2019.09 

  Member: Tsuchiya Nanae 

  Direct: 0 (YEN)  Overheads: 0 (YEN)  Total: 0 (YEN)

• Project Year: 2013  -  2015 

  Member: Tsuchiya Nanae 

  Direct: 0 (YEN)  Overheads: 0 (YEN)  Total: 0 (YEN)