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Published Papers 【 display / non-display 】

• Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program.

  Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore WC, Bleecker ER, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML

  American journal of respiratory and critical care medicine ( American journal of respiratory and critical care medicine )  207 ( 4 ) 475 - 484   2023.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Rationale: Extrapulmonary manifestations of asthma, including fatty infiltration in tissues, may reflect systemic inflammation and influence lung function and disease severity. Objectives: To determine if skeletal muscle adiposity predicts lung function trajectory in asthma. Methods: Adult SARP III (Severe Asthma Research Program III) participants with baseline computed tomography imaging and longitudinal postbronchodilator FEV1% predicted (median follow-up 5 years [1,132 person-years]) were evaluated. The mean of left and right paraspinous muscle density (PSMD) at the 12th thoracic vertebral body was calculated (Hounsfield units [HU]). Lower PSMD reflects higher muscle adiposity. We derived PSMD reference ranges from healthy control subjects without asthma. A linear multivariable mixed-effects model was constructed to evaluate associations of baseline PSMD and lung function trajectory stratified by sex. Measurements and Main Results: Participants included 219 with asthma (67% women; mean [SD] body mass index, 32.3 [8.8] kg/m2) and 37 control subjects (51% women; mean [SD] body mass index, 26.3 [4.7] kg/m2). Participants with asthma had lower adjusted PSMD than control subjects (42.2 vs. 55.8 HU; P < 0.001). In adjusted models, PSMD predicted lung function trajectory in women with asthma (β = -0.47 Δ slope per 10-HU decrease; P = 0.03) but not men (β = 0.11 Δ slope per 10-HU decrease; P = 0.77). The highest PSMD tertile predicted a 2.9% improvement whereas the lowest tertile predicted a 1.8% decline in FEV1% predicted among women with asthma over 5 years. Conclusions: Participants with asthma have lower PSMD, reflecting greater muscle fat infiltration. Baseline PSMD predicted lung function decline among women with asthma but not men. These data support an important role of metabolic dysfunction in lung function decline.

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• Kerley A-lines represent thickened septal plates between lung segments in patients with lymphangitic carcinomatosis: confirmation using 3D-CT lung segmentation analysis.

  Tsuchiya N, Tsubakimoto M, Nishie A, Murayama S

  Japanese journal of radiology ( Japanese Journal of Radiology )  40 ( 4 ) 367 - 375   2022.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: Kerley A-lines are generally apparent in patients with pulmonary edema or lymphangitic carcinomatosis. There are two main thoughts regarding the etiology of Kerley A-lines, but no general agreement. Specifically, the lines are caused by thickened interlobular septa or dilated anastomotic lymphatics. Our purpose was to determine the anatomic structure represented as Kerley A-lines using 3D-CT lung segmentation analysis. MATERIALS AND METHODS: We reviewed 139 charts of patients with lymphangitic carcinomatosis of the lung who had CT and X-ray exams with a maximum interval of 7 days. The presence of Kerley A-lines on X-ray was assessed by a radiologist. The A-lines on X-ray were defined as follows: dense; fine (< 1 mm thick); ≥ 2 cm in length, radiating from the hilum; no bifurcation; and not adjacent to the pleura. For cases with Kerley A-lines on X-ray, three radiologists agreed that the lines on CT corresponded with Kerley A-lines. The incidence of A-lines and the characteristics of the lines were investigated. The septal lines between lung segments were identified using a 3D-CT lung segmentation analysis workstation. The percentage of agreement between the A-lines on CT and lung segmental lines was assessed. RESULTS: On chest X-ray, 37 Kerley A-lines (right, 16; left, 21) were identified in the 22 cases (16%). Of these, 4 lungs with 12 lines were excluded from analysis due to technical reasons. Nineteen of the 25 lines (76%) corresponded to the septal lines on CT. Of these, 11 lines matched with automatically segmented lines (intersegmental septa, 4; intersubsegmental septa, 7) by the workstation. Two lines (8%) represented fissures. Four lines corresponded to the bronchial wall/artery (3 lines, 12%) or vein (1 line, 4%). CONCLUSION: Kerley A-lines primarily represented thickened and continued interlobular septal lines that corresponded to the septa between lung segments and subsegments.

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• A Case of Lung Adenocarcinoma with Enteric Features showing Calcification on CT

  Tsuchiya Nanae, Miyagi Kazuya, Fujita Jiro, Atsumi Eriko, Aoyama Hajime, Yasutomi Yuiko, Kusada Takeaki, Murayama Sadayuki

  Haigan ( The Japan Lung Cancer Society )  61 ( 7 ) 979 - 984   2021.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p><b><i>Background. </i></b>Pulmonary enteric-type adenocarcinoma is a rare type of non-small-cell lung cancer showing a histological pattern mimicking metastatic colorectal cancer. <b><i>Case. </i></b>A man in his 60s was referred to our hospital because of an abnormal shadow on a chest radiograph during follow-up for prostate cancer. Chest computed tomography (CT) showed a 55-mm mass with multiple small calcifications in the left upper lobe. The peripheral area of the left upper lobe showed obstructive atelectasis. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed an increased FDG uptake in the mass of the left upper lobe (maximum standardized uptake value [SUV_max] 12.7), mediastinal lymphadenopathy, and left supraclavicular lymphadenopathy. A bronchoscopy specimen showed tumors that formed ducts composed of tall columnar cells. Immunohistochemical staining demonstrated CK7 (-), CK20 (focally+), TTF-1 (-), CDX2 (+), and Napsin A (-) expression. The findings indicated pulmonary enteric-type adenocarcinoma or metastatic colorectal carcinoma. The tumor was diagnosed as adenocarcinoma with enteric features (cT2bN3M0, cStage IIIB), as no evidence of a tumor was found elsewhere by colonoscopy. He underwent chemoradiotherapy. Subsequent CT revealed shrinkage of the tumor. <b><i>Conclusion. </i></b>We encountered a case of lung adenocarcinoma with enteric features which showed calcification on CT. The CT findings of pulmonary enteric-type adenocarcinoma are similar to the imaging findings for invasive pulmonary adenocarcinoma and metastatic colorectal cancer. Distinguishing between these two entities by imaging alone is difficult.</p>

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• Computed tomography findings, temporal course, and clinical relevance of subpleural pulmonary interstitial emphysema in patients with pneumomediastinum.

  Nakamata A, Tsuchiya N, Miyara T, Shiotani M, Gibo S, Murayama S

  Acta radiologica open   10 ( 7 ) 20584601211034264   2021.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot.

  Tsuchiya N, Nagao M, Shiina Y, Miyazaki S, Inai K, Murayama S, Sakai S

  Scientific reports ( Scientific Reports )  11 ( 1 ) 11623 - 11623   2021.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  We used 4D-flow MRI to investigate circulation, an area integral of vorticity, in the main pulmonary artery (MPA) as a new hemodynamic parameter for assessing patients with a repaired Tetralogy of Fallot (TOF). We evaluated the relationship between circulation, right ventricular (RV) function and the pulmonary regurgitant fraction (PRF). Twenty patients with a repaired TOF underwent cardiac MRI. Flow-sensitive 3D-gradient sequences were used to obtain 4D-flow images. Vortex formation in the MPA was visualized, with short-axis and longitudinal vorticities calculated by software specialized for 4D flow. The RV indexed end-diastolic/end-systolic volumes (RVEDVi/RVESVi) and RV ejection fraction (RVEF) were measured by cine MRI. The PR fraction (PRF) and MPA area were measured by 2D phase-contrast MRI. Spearman ρ values were determined to assess the relationships between circulation, RV function, and PRF. Vortex formation in the MPA occurred in 15 of 20 patients (75%). The longitudinal circulation (11.7 ± 5.1 m2/s) was correlated with the RVEF (ρ = - 0.85, p = 0.0002), RVEDVi (ρ = 0.62, p = 0.03), and RVESVi (ρ = 0.76, p = 0.003) after adjusting for the MPA size. The short-axis circulation (9.4 ± 3.4 m2/s) in the proximal MPA was positively correlated with the MPA area (ρ = 0.61, p = 0.004). The relationships between the PRF and circulation or RV function were not significant. Increased longitudinal circulation in the MPA, as demonstrated by circulation analysis using 4D flow MRI, was related to RV dysfunction in patients with a repaired TOF.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• Pulmonary Functional Imaging: Basics and Clinical Applications.

  Griffin, L, Swift, A.J, Tsuchiya, N, Franchois, C, Humbert, M, Cohen, G, Schiebler,M.L ( Part: Allotment Writing ,  Multimodality Imaging of pulmonary hypertension: prognostication of therapeutic outcomes )

  Springer Nature  2020

Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• RSNA2020 Report -Chest-

  Rad Fan   19 ( 2 ) 29 - 32   2021.02

   

• 研究者の最新動向 肺高血圧症のMRI

  土屋 奈々絵, 伊藤 純二, 村山 貞之

  Precision Medicine ( (株)北隆館 )  1 ( 2 ) 229 - 233   2018.11

   

• 【実地医家のための画像診断実践ガイド】胸部 腫瘍 良性結節

  土屋 奈々絵, 村山 貞之

  Medical Practice ( (株)文光堂 )  35 ( 臨増 ) 107 - 111   2018.04

   

• 肺高血圧症のMRI

  土屋 奈々絵, 伊藤 純二, 村山 貞之

  別冊Bio Clinica: 慢性炎症と疾患 ( (株)北隆館 )  7 ( 1 ) 113 - 117   2018.02

   

• 【肺感染症のすべて-臨床,病理,画像を学ぶ-】肺寄生虫疾患

  大城 康二, 村山 貞之, 土屋 奈々絵, 宮良 哲博

  画像診断 ( (株)学研メディカル秀潤社 )  36 ( 3 ) 309 - 317   2016.02

   

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• CT findings of postoperative aortobronchial fistula

  Nanae Tsuchiya, Sadayuki Murayama, Satoko Yogi, Yuma Chinen, Kojiro Furukawa, Akihiro Nishie

  ACTI 2023  2023.06  -  2023.06 

• 4D flow MRIによるバッドキアリ症候群の血流評価：下大静脈、肝静脈、門脈、側副血行路の視認性

  Nanae Tsuchiya, Kanako Naito, Hitoshi Inafuku, Akihiro Nishie

  第82回 日本医学放射線学会総会  2023.04  -  2023.04 

• Image interpretation -chest-

  Nanae Tsuchiya

  The 57th Autumn Assembly of the Japan Radiological Society  2021.09  -  2021.09 

• Training on how to find retained sponges during and after surgery

  2020.05  -  2020.06 

• Intrathoracic abnormal air -Where abnormal air will be located and where comes from-

  Nanae Tsuchiya, Daichi Higa, Akihiro Nakamata, Junji Ito, Sadayuki Murayama

  The 105th Scientific Assembly and Annual Meeting of the Radiological Society of North  2019.12  -  2019.12 

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Gold Medal

  2021.04     Kerley's A line represents thickened septal plates between lung segments: confirmation using 3D-CT lung segmentation analysis

• Educational Exhibit Cypos Award

  2020.04   The 79th Annual Meeting of the Japan Radiological Society   Training on how to find retained sponges during and after surgery

• Scientific Poster Award

  2020.01     The role of chest CT in determining the treatment of drowning

• The Yong Investigator Scholarship

  2013   the 3rd World Congress of Thoracic Imaging  

  Winner: Tsuchiya Nanae

Other External funds 【 display / non-display 】

Other External funds 【 display / non-display 】

• Project Year: 2017.09  -  2019.09 

  Member: Tsuchiya Nanae 

  Direct: 0 (YEN)  Overheads: 0 (YEN)  Total: 0 (YEN)

• Project Year: 2013  -  2015 

  Member: Tsuchiya Nanae 

  Direct: 0 (YEN)  Overheads: 0 (YEN)  Total: 0 (YEN)