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• Input integration around the dendritic branches in hippocampal dentate granule cells

  2014年03月 

  DOI PubMed

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• Influence of cerebral infarction on both bladder and urethral activities and changes after tramadol administration in rats.

  Nagamine S, Kamijo TC, Ashikari A, Miyazato M

  Neurourology and urodynamics ( Neurourology and Urodynamics )    2022年09月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  AIMS: We investigated the changes in bladder and urethral function after cerebral infarction (CI) and the influence of tramadol on these functions. METHODS: Twenty-eight female Sprague Dawley rats were divided into normal and CI groups. In the awake condition, metabolic cage study and blood pressure were evaluated. Under urethane anesthesia, the intravenous effect of tramadol (0.01-1 mg/kg), which has both µ-opioid receptor stimulation and inhibition of norepinephrine and serotonin reuptake, on continuous cystometry, and simultaneous measurements of bladder and urethral perfusion pressure (UPP) were recorded. Infarcted lesions were examined by staining with triphenyltetrazolium chloride, a marker of mitochondrial enzyme activity. RESULTS: CI rats showed impaired sympathetic activity with Horner's syndrome and lower blood pressure. In metabolic cage study, urinary frequency during the dark phase was increased in CI rats. On bladder activity, in CI rats, the baseline pressure threshold for inducing bladder contractions was significantly lower (p < 0.01), and the intercontraction interval was prolonged after tramadol administration. On urethral activity, the baseline UPP was significantly lower in CI rats than in normal rats and it did not change after tramadol administration. Residual urine rate was significantly increased in normal rats, but not in CI rats. CI rats showed brain infarction including the cortex and hypothalamus, which is a center of the autonomic nervous system. CONCLUSIONS: CI-induced ischemic brain damage results in impairment of both bladder and urethral functions, in addition to decreased sympathetic activity. Bladder overactivity after CI can be improved by tramadol; however, urethral activity cannot be improved by it.

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• Evaluation of the Influence of a History of Childhood Nocturnal Enuresis on Nighttime Urinary Frequency and the Causes of Nocturia in Adults.

  Miyazato M, Gakiya M, Ashikari A, Kamijo TC, Kagawa H, Matsuo T, Miyata Y, Oshiro Y, Arai K, Machida N, Shinzato H, Chinen Y, Iwata H, Ueda S, Saito S

  Urology ( Urology )  164   106 - 111   2022年06月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  OBJECTIVE: To examine whether a history of nocturnal enuresis affects nighttime urinary frequency and to evaluate nocturia etiologies in adults. MATERIALS AND METHODS: A total of 143 participants with at least one episode of nocturia per night were included in this study. The self-reported questionnaire collected data on demographic characteristics, medical history, history of nocturnal enuresis in elementary school, lower urinary tract symptoms, and frequency-volume charts. RESULTS: A history of nocturnal enuresis was observed in 52.4% of participants. However, night-time urinary frequency was significantly lower in participants with a history of nocturnal enuresis in elementary school than in those without such history. On multivariate analysis, a history of nocturnal enuresis was also negatively associated with nighttime urinary frequency (P <.01). There was a collinearity effect between age and nighttime urinary frequency. A history of nocturnal enuresis did not affect the presence of nocturnal polyuria or overactive bladder in participants. However, sleep disturbances were fewer in participants with a history of nocturnal enuresis (odds ratio 0.404). CONCLUSION: A history of nocturnal enuresis might be negatively associated with nighttime urinary frequency due to fewer sleep disturbances. Further, progression of nocturia may depend on conditions, such as age and acquired diseases.

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• Non-linear interaction between two inputs depending on an intrinsic factor in hippocampal granule cells

  Nakajima Naoki, Kamijo Tadanobu, Aihara Takeshi, Hayakawa Hirofumi

  Nonlinear Theory and Its Applications, IEICE ( 一般社団法人 電子情報通信学会 )  13 ( 2 ) 471 - 476   2022年 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  <p>To investigate the role of the nonlinearity of input interactions in the neural network, we examined the influence of acetylcholine as a top-down input on the interaction between bottom-up inputs in dentate granule cells in the hippocampus. The results showed that nonlinearity in the interaction between bottom-up inputs was modulated by the top-down input and was related to inhibitory cells. Our findings suggest that nonlinearity in the interaction of inputs plays a key role in coincidence detection, which is regulated by the top-down input. This indicates a crucial role for nonlinearity in the neurodynamics of the hippocampal local network.</p>

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    CiNii Research

• Evaluation of anatomy training for nursing students using unfixed lung, trachea, and larynx of swine

  Takayanagi M, Sugahara M, Nozaki M, Kobayashi S, Kawashima T, Hoshi H, Kamijo TC, Sato F

  Journal of Ergonomic Technology   17   1 - 11   2017年01月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

• Outcome model analysis-based results of actual tissue anatomy exercise for nursing students using non-fixed pig organs

  Takayanagi M, Nozaki M, Kawashima T, Hoshi H, Kamijo TC, Sato F

  Journal of Ergonomic Technology   16   8 - 14   2016年09月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

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• 母子隔離ストレスによる脳内可塑性変化と下部尿路機能障害発症機序の解明

  ■■■

  課題番号: 00000000

  研究期間: 2021年02月  -  2022年01月 

• 母子隔離ストレスモデルによる海馬可塑性変化と下部尿路機能障害発症機序の解明

  研究活動スタート支援

  課題番号: 20K23256

  研究期間: 2020年09月  -  2022年03月 

  代表者: 上條 中庸 

  直接経費: 2,200,000（円）  間接経費: 2,860,000（円）  金額合計: 660,000（円）

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• 母子隔離ストレスによる脳内可塑性変化と下部尿路機能障害発症機序の解明

  研究費種類: 財団・社団法人等の民間助成金  参画方法: 研究代表者

  研究種別: 研究助成  事業名: 令和2年度 研究助成

  研究期間: 2021年02月  -  2022年03月 

  代表者: 上條中庸  資金配分機関: 公益財団法人沖縄県医科学研究財団

  直接経費: 200,000（円）  間接経費: 0（円）  金額合計: 200,000（円）