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Published Papers 【 display / non-display 】

• Scleral thickness in the fellow eyes of patients with unilateral central serous chorioretinopathy.

  Aichi T, Terao N, Imanaga N, Sawaguchi S, Wakugawa S, Miyara Y, Oshiro A, Yamauchi Y, Koizumi H

  Retina (Philadelphia, Pa.)     2023.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: The sclera is reportedly thicker in eyes with central serous chorioretinopathy (CSC) than in healthy control eyes. We compared the scleral thicknesses of the affected and unaffected fellow eyes of patients with unilateral CSC. METHODS: We retrospectively examined the findings of 115 patients with unilateral CSC. Comparisons of the spherical equivalent (SE), axial length, anterior chamber depth (ACD), subfoveal choroidal thickness (SCT), scleral thickness, and presence of peripheral ciliochoroidal effusion (CE) of the affected and fellow eyes were made. Using anterior segment optical coherence tomography, scleral thickness was measured vertically, 6 mm posterior to the scleral spur in the superior, temporal, inferior, and nasal directions. RESULTS: No significant differences in scleral thickness in all four directions, SE, axial length, ACD, and frequency of CE were found between the affected and unaffected fellow eyes. The only significant difference between the affected and fellow eyes was observed in the SCT (398.8 µm vs. 346.6 µm, P < 0.001). CONCLUSION: A thickened choroid seems to have a direct effect on CSC development. In contrast, the affected and fellow eyes showed no significant difference in scleral thickness, indicating that scleral thickening may be a predisposing factor for the development of CSC.

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• Relationship Between Scleral Thickness and Choroidal Structure in Central Serous Chorioretinopathy.

  Imanaga N, Terao N, Sonoda S, Sawaguchi S, Yamauchi Y, Sakamoto T, Koizumi H

  Investigative ophthalmology & visual science ( Investigative ophthalmology &amp; visual science )  64 ( 1 ) 16 - 16   2023.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: Central serous chorioretinopathy (CSC) is a retinal disorder characterized by serous retinal detachment with or without pigment epithelial detachment in the posterior pole of the eye. We aimed to elucidate the relationship between scleral thickness and choroidal structure in CSC eyes. METHODS: This single-center retrospective study included 111 eyes of 111 CSC patients. Using swept-source optical coherence tomography, the horizontal cross-sectional images of the posterior choroid were converted to binary images by semiautomated software. The luminal and stromal areas of the choroid were measured, and the luminal/stromal (L/S) ratios of the whole choroid (WC), inner choroid, and outer choroid (OC) at 1500 µm, 3000 µm, and 7500 µm ranges centered on the fovea were calculated. Correlations of L/S ratio and age, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness were determined. Scleral thickness was measured vertically, 6 mm posterior to the scleral spur in four directions. RESULTS: SCT and mean scleral thickness were significantly positively correlated with the L/S ratio in all ranges of WC and OC. Multiple regression analysis found that SCT and mean scleral thickness were significantly correlated with the L/S ratio, and the strength of correlation of mean scleral thickness (WC: 0.386, P < 0.001; OC: 0.391, P < 0.001) was greater than that of SCT (WC: 0.368, P < 0.001; OC: 0.383, P < 0.001) in 7500 µm range. CONCLUSIONS: Thick sclera appeared to play a role in an increase in the luminal component of the posterior choroid in CSC eyes.

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• Reply to "Comment on Clinical Factors Related to Loculation of Fluid in Central Serous Chorioretinopathy".

  Imanaga N, Koizumi H

  American journal of ophthalmology ( American Journal of Ophthalmology )  241   295   2022.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy.

  Sawaguchi S, Terao N, Imanaga N, Wakugawa S, Tamashiro T, Yamauchi Y, Koizumi H

  Ophthalmology science ( Ophthalmology Science )  2 ( 2 ) 100124 - 100124   2022.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Purpose: To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT. Design: Retrospective, comparative study. Participants: One hundred ten eyes of 110 patients with central serous chorioretinopathy. Methods: We classified the patients into iCSC and sCSC groups and compared age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. We measured scleral thickness 6 mm posterior to the scleral spur in 4 directions. Main Outcome Measure: Scleral thickness in sCSC eyes. Results: We enrolled 96 and 14 eyes in the iCSC and sCSC groups, respectively. The sCSC group included a greater proportion of women than the iCSC group (42.9% and 13.5%, respectively; P = 0.020). We observed no between-group differences in age, spherical equivalent, axial length, or SCT. Univariate analysis revealed that the sCSC group had a significantly thinner sclera at the superior (423.4 μm vs. 346.6 μm; P < 0.001), temporal (440.1 μm vs. 399.4 μm; P = 0.020), inferior (450.1 μm vs. 395.3 μm; P = 0.001), and nasal (436.6 μm vs. 391.9 μm; P = 0.002) points than the iCSC group. Multivariate analyses revealed that female sex (odds ratio, 4.322; 95% confidence interval, 1.025-18.224; P = 0.046) and mean scleral thickness (odds ratio, 0.972; 95% confidence interval, 0.955-0.990; P = 0.002) were significantly associated with sCSC. Conclusions: The scleral thickness of eyes in the sCSC group was significantly thinner than that in the iCSC group. This suggests that the sclera has less involvement in the pathogenesis of sCSC than in that of iCSC.

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• CILIOCHOROIDAL EFFUSION IN CENTRAL SEROUS CHORIORETINOPATHY.

  Terao N, Imanaga N, Wakugawa S, Sawaguchi S, Tamashiro T, Yamauchi Y, Koizumi H

  Retina (Philadelphia, Pa.) ( Retina )  42 ( 4 ) 730 - 737   2022.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: To investigate the prevalence of ciliochoroidal effusion (CE) in central serous chorioretinopathy (CSC) using anterior-segment optical coherence tomography and its association with the clinical features of CSC. METHODS: Overall, 164 eyes of 164 patients with CSC and 51 eyes of 51 age- and sex-matched normal control participants were retrospectively examined. Anterior-segment optical coherence tomography was used to assess patients with CSC and control subjects for CE and scleral thickness. Central serous chorioretinopathy eyes were divided into two groups: eyes with CE (CE group) and eyes without CE (non-CE group). Scleral thickness was measured at the point that was 6 mm posterior to the scleral spur in four directions. RESULTS: Among the 164 eyes with CSC, 32 eyes (19.5%) displayed CE, and this proportion was significantly higher than that in control subjects (2.0%) (P = 0.001). Scleral thickness was significantly greater in the CE group compared with the non-CE group at all four directions (P < 0.05 for all). Multivariable analysis revealed that the mean scleral thickness (odds ratio: 1.01; 95% confidence interval: 1.00-1.02; P = 0.007) was significantly associated with the incidence of CE. CONCLUSION: Central serous chorioretinopathy may accompany fluid accumulation in the anterior segment more frequently than previously expected in association with thick sclera.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Scleral thickness in the new classification of central serous chorioretinopathy

  今永直也, 寺尾信宏, 寺尾信宏, 澤口翔太, 玉城環, 玉城環, 山内遵秀, 古泉英貴

  日本眼科学会雑誌   126   2022

   

  J-GLOBAL

• 自発蛍光で読み解く 眼底疾患 加齢黄斑変性と眼底自発蛍光

  今永直也, 古泉英貴

  眼科グラフィック ( (株)メディカ出版 )  8 ( 5 ) 547‐559 - 559   2019.10

   

  J-GLOBAL

• 中心性漿液性脈絡網膜症における強膜厚の検討

  今永直也, 仲嶺盛, 玉城環, 湧川空子, 澤口桂子, 酒井寛, 古泉英貴

  日本眼循環学会講演抄録集   36th   87   2019

   

  J-GLOBAL

• 網膜静脈分枝閉塞症に対する抗血管内皮増殖因子薬投与後に急速な増殖性変化を生じた一例

  大城綾乃, 今永直也, 仲嶺盛, 江夏亮, 山内遵秀, 目取真興道, 古泉英貴

  日本眼循環学会講演抄録集   36th   108   2019

   

  J-GLOBAL

• 所見からみた診断の進め方 7)網膜硝子体 1)網膜剥離

  今永直也, 古泉英貴

  眼科   60 ( 10 ) 1251‐1255   2018.09

   

  DOI J-GLOBAL

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