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• Central serous chorioretinopathy and the sclera: what we have learned so far.

  Koizumi H, Imanaga N, Terao N

  Japanese journal of ophthalmology ( Japanese Journal of Ophthalmology )  68 ( 5 ) 419 - 428   2024.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Central serous chorioretinopathy (CSC) is a common disorder characterized by serous retinal detachment. Several studies using indocyanine green angiography (ICGA) have revealed that choroidal filling delay, choroidal vascular dilation, and choroidal vascular hyperpermeability are the characteristic findings of CSC. These ICGA findings confirm that choroidal circulatory disturbances are the primary factors in the pathogenesis of CSC. With advancements in optical coherence tomography (OCT), choroidal thickness has been found to be significantly greater in eyes with CSC than in normal eyes. Dilated large choroidal vessels reportedly account for the thickened choroid in eyes with CSC. Although many possible mechanisms and risk factors have been suggested, the pathophysiologic features of choroidal circulatory disturbances and choroidal thickening in eyes with CSC have not yet been fully elucidated. Recently, using anterior segment OCT, we proposed that the sclera may induce choroidal circulatory disturbances since CSC eyes have significantly thicker sclera than do normal eyes. This review summarizes updated information on the close relationship between CSC pathogenesis and the sclera.

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• CHANGES IN SCLERAL THICKNESS IN THE ACUTE PHASE OF VOGT-KOYANAGI-HARADA DISEASE.

  Oshiro A, Imanaga N, Terao N, Koizumi H

  Retina (Philadelphia, Pa.) ( Retina )  44 ( 8 ) 1344 - 1350   2024.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: To evaluate changes in scleral thickness in Vogt-Koyanagi-Harada (VKH) disease. METHODS: This study included 34 eyes of 17 treatment-naïve patients with acute-phase VKH disease. Scleral thickness and the presence of ciliochoroidal effusion were examined using anterior segment optical coherence tomography at baseline and 1 week, 2 weeks, and 12 weeks after the start of corticosteroid treatment. Scleral thickness was measured 6 mm posterior to the scleral spur in four directions. RESULTS: Twenty-eight eyes (82.4%) initially had ciliochoroidal effusion, but this rapidly decreased to nine eyes (26.5%) after 1 week. The sclera with ciliochoroidal effusion became thinner from baseline to 1 week at the superior (400.2 ± 46.9-353.5 ± 47.9 µm), temporal (428.4 ± 53.6-387.8 ± 56.1 µm), inferior (451.5 ± 71.0-400.5 ± 50.5 µm), and nasal (452.4 ± 78.0-407.6 ± 62.9 µm) points (P < 0.01 for all), and no further changes were observed. The sclera without ciliochoroidal effusion remained unchanged. CONCLUSION: In VKH disease, eyes with ciliochoroidal effusion exhibited the maximum scleral thickness during the acute phase. This thickening responded rapidly to treatment and became thinner within 1 week. Inflammation in VKH disease may affect not only the choroid but also the sclera.

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• One-year choroidal thickness changes after photodynamic therapy for central serous chorioretinopathy evaluated by widefield optical coherence tomography.

  Sawaguchi S, Terao N, Imanaga N, Wakugawa S, Miyara Y, Oshiro A, Maehira M, Yamauchi Y, Koizumi H

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie ( Graefe's Archive for Clinical and Experimental Ophthalmology )    2024.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: To evaluate the changes in choroidal thickness 1 year after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using widefield swept-source optical coherence tomography. METHODS: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes. RESULTS: All 21 treated eyes showed complete resolution of subretinal fluid at 3 months after PDT, without any recurrence at 12 months. The mean choroidal thickness in all nine areas significantly decreased after PDT at 3 months (P < 0.05) and remained unchanged at 12 months (P < 0.05) compared with that at baseline. However, the subtracted choroidal thickness maps between 3 and 12 months detected significant variations among the cases, classified into an enhanced pattern in 10 eyes (47.6%), an attenuated pattern in six eyes (28.6%), and a stable pattern in five eyes (23.8%). The 21 untreated fellow eyes also showed a decrease in mean choroidal thickness in three of the nine subdivided areas at 12 months (P < 0.05), but this decrease was limited posteriorly. CONCLUSION: The reduction in mean choroidal thickness after half-dose PDT for CSC was extensively maintained for 1 year. However, subclinical hemodynamic changes in the entire choroid occurred longitudinally even in the absence of disease recurrence.

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• Scleral Thickness in Simple Versus Complex Central Serous Chorioretinopathy.

  Imanaga N, Terao N, Wakugawa S, Miyara Y, Sawaguchi S, Oshiro A, Yamauchi Y, Koizumi H

  American journal of ophthalmology ( American Journal of Ophthalmology )  261   103 - 111   2024.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: To evaluate the association between scleral thickness and a newly developed multimodal imaging-based classification of central serous chorioretinopathy (CSC). DESIGN: Retrospective, cross-sectional study. METHODS: This study included 217 eyes of 217 patients classified as simple or complex CSC based on the established protocols. Clinical and anatomical factors were compared between the 2 types. The scleral thickness was measured at 4 locations using anterior-segment optical coherence tomography. RESULTS: Of the 217 eyes, 167 were classified as simple CSC and 50 as complex CSC. The complex CSC group showed older age (P = .011), higher male ratio (P = .001), more bilateral involvement (P < .001), poorer visual acuity (P < .001), greater subfoveal choroidal thickness (P = .025), and higher frequency of loculation of fluid (P < .001) and ciliochoroidal effusion (P < .001) than the simple CSC group. The complex CSC group had significantly greater scleral thicknesses in the superior, temporal, inferior, and nasal directions (all P < .001) than the simple CSC group. Multivariable analysis revealed that older age (odds ratio [OR] 1.054, 95% confidence interval [CI] 1.013-1.097, P < .001), male sex (OR 10.445, 95% CI 1.151-94.778, P < .001), bilateral involvement (OR 7.641, 95% CI 3.316-17.607, P < .001), and the mean value of scleral thicknesses in 4 directions (OR 1.022, 95% CI 1.012-1.032, P < .001) were significantly associated with the complex CSC. CONCLUSIONS: Older age, male sex, bilateral involvement, and thick sclera were associated with the complex CSC. Scleral thickness seemed to determine the clinical manifestations of CSC.

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• Renal coloboma syndrome/dominant optic atrophy with severe retinal atrophy and de novo digenic mutations in PAX2 and OPA1.

  Shimabukuro W, Chinen Y, Imanaga N, Yanagi K, Kaname T, Nakanishi K

  Pediatric nephrology (Berlin, Germany) ( Pediatric Nephrology )  39 ( 8 ) 2351 - 2353   2024.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Scleral thickness in the new classification of central serous chorioretinopathy

  今永直也, 寺尾信宏, 寺尾信宏, 澤口翔太, 玉城環, 玉城環, 山内遵秀, 古泉英貴

  日本眼科学会雑誌   126   2022

   

  J-GLOBAL

• 自発蛍光で読み解く 眼底疾患 加齢黄斑変性と眼底自発蛍光

  今永直也, 古泉英貴

  眼科グラフィック ( (株)メディカ出版 )  8 ( 5 ) 547‐559 - 559   2019.10

   

  J-GLOBAL

• 中心性漿液性脈絡網膜症における強膜厚の検討

  今永直也, 仲嶺盛, 玉城環, 湧川空子, 澤口桂子, 酒井寛, 古泉英貴

  日本眼循環学会講演抄録集   36th   87   2019

   

  J-GLOBAL

• 網膜静脈分枝閉塞症に対する抗血管内皮増殖因子薬投与後に急速な増殖性変化を生じた一例

  大城綾乃, 今永直也, 仲嶺盛, 江夏亮, 山内遵秀, 目取真興道, 古泉英貴

  日本眼循環学会講演抄録集   36th   108   2019

   

  J-GLOBAL

• 所見からみた診断の進め方 7)網膜硝子体 1)網膜剥離

  今永直也, 古泉英貴

  眼科   60 ( 10 ) 1251‐1255   2018.09

   

  DOI J-GLOBAL

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