白川 純平 (シラカワ ジュンペイ)

SHIRAKAWA JUMPEI

写真a

職歴 【 表示 / 非表示

  • 2014年05月
    -
    2015年03月

      東京医科歯科大学  

  • 2015年04月
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    2016年03月

      東京医科歯科大学  

  • 2016年06月
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    2017年03月

      鶴見大学  

  • 2017年04月
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    2019年01月

      University of Pennsylvania  

  • 2019年02月
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    2020年08月

      Hospital for Special Surgery  

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所属学会・委員会 【 表示 / 非表示

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    日本骨代謝学会

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    日本口腔科学会

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    日本口腔感染症学会

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    日本口腔外科学会

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    日本口腔内科学会

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研究キーワード 【 表示 / 非表示

  • 骨芽細胞

  • 骨代謝

  • 組織再生

  • 破骨細胞

  • 癌幹細胞

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研究分野 【 表示 / 非表示

  • 癌幹細胞

  • 歯髄幹細胞

論文 【 表示 / 非表示

  • An unusual case of oral surgical management in a patient with isovaleric acidemia and schizophrenia: A case report.

    Miyamoto S, Ntege EH, Chinen Y, Goto T, Shirakawa J, Goto S, Kawano T, Shimizu Y, Nakanishi K, Nakamura H

    Biomedical reports ( Biomedical Reports )  17 ( 2 ) 64   2022年08月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Oral/dental surgical care in patients with chronic medical comorbidities, such as isovaleric acidemia (IVA), can be challenging. In addition to technical complications, different comorbidities also present a complex range of concerning factors/challenges, which can increase the incidence of morbidity and mortality associated with surgery. IVA, a congenital error of metabolism, is a rare organic acidemia with a predisposition towards acute acidosis and life-threatening metabolic decompensation during stressful conditions, such as prolonged fasting and surgery. In addition, schizophrenia, a major neurological disorder, can result in manifestation of severe dental or periodontal conditions, including pericoronitis. The condition is associated with significant risk factors of postoperative complications, such as dangerous behaviors and adverse interactions between antipsychotic drugs and anesthetic agents. A case of comorbid dental disease with two coexisting chronic and life-threatening medical conditions, one of which is rare, is an unusual encounter in oral/dental surgery that is seldomly published. Moreover, implementing a safe and effective surgical intervention in such patients requires several informed considerations. However, only a few reported experiences or guidelines exist, reporting appropriate perioperative management strategies to minimize risks. Hence, in this case report, our experience of managing one of these rare encounters of a 20-year-old man who suffered from bilaterally partially erupted third molars, associated with chronic pericoronitis and dental caries of both the maxilla wisdom teeth with coexisting IVA and schizophrenia comorbidities is described. Additionally, the presentation and anticipated complications of the comorbid disorders of the patient are briefly reviewed. In this case, the pericoronitis and dental caries were treated by surgically removing the impacted third molars and the antagonist maxilla wisdom teeth under regional anesthesia and application of antibiotics for 3 days. The patient recovered without any postoperative complications after 1 year of follow-up.

  • Peripheral dentinogenic ghost cell tumor in the mandibular anterior region

    Miyamoto S.

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology )  34 ( 4 ) 436 - 439   2022年07月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    A dentinogenic ghost cell tumor (DGCT), the rarest locally invasive odontogenic tumor, is considered a solid variant of the calcifying odontogenic cyst. Histopathologically, DGCT is characterized by ameloblastoma-like islands of epithelial cells in a mature connective tissue stroma and aberrant keratinization in the form of ghost cells associated with varying amounts of dysplastic dentin. DGCT is classified into the intraosseous type (central) and the extraosseous type (peripheral). The peripheral type is even rarer than the central type. We describe a case of peripheral DGCT measuring a size of 33 x 28 x 19 mmin the mandibular anterior region in a 61-year old woman. The tumor was diagnosed as a peripheral DGCT based on biopsy findings and radiographic images. Under general anesthesia, the lesion was excised by detaching it from the bone on the periosteum with a safety margin, and the bone in contact with the tumor was curetted and shaped. The wound was covered with poly glycolic acid-absorbable reinforcement material and fibrin glue spray. At approximately one year postoperatively, the patient remains recurrence-free.

  • Inhibitory effect of 405-nm blue LED light on the growth of Candida albicans and Streptococcus mutans dual-species biofilms on denture base resin.

    Tsutsumi-Arai C, Arai Y, Terada-Ito C, Imamura T, Tatehara S, Ide S, Shirakawa J, Wakabayashi N, Satomura K

    Lasers in medical science ( Lasers in Medical Science )  37 ( 4 ) 2311 - 2319   2022年06月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    We investigated whether irradiation with 405-nm blue LED light could inhibit the growth of not only single- but dual-species biofilms formed by Candida albicans and Streptococcus mutans on denture base resin and cause the alteration in gene expression related to adhesion and biofilm formation. C. albicans and S. mutans single-/dual-species biofilms were formed on the denture base specimens. The biofilms were irradiated with 405-nm blue LED light (power density output: 280 mW/cm2) for 0 (control) and 40 min. Dual-species biofilms were analyzed using CFU assay and fluorescence microscopy, and single-/dual-species biofilms were analyzed using alamarBlue assays and gene expression analysis. To assess the inhibitory effect of irradiation on dual-species biofilms, specimens after irradiation were aerobically incubated for 12 h. After incubation, the inhibition of growth was assessed using CFU assays and fluorescence microscopy. Data were analyzed using the Mann-Whitney U or Student's t test (p < 0.05). Irradiation produced a significant inhibitory effect on biofilms. Fluorescence microscopy revealed that almost all C. albicans and S. mutans cells were killed by irradiation, and there was no notable difference in biofilm thickness immediately after irradiation and after irradiation and incubation for 12 h. alamarBlue assays indicated the growth of the biofilms was inhibited for 12-13 h. The expression of genes associated with adhesion and biofilm formation-als1 in C. albicans and ftf, gtfC, and gtfB in S. mutans-significantly reduced by irradiation. Irradiation with 405-nm blue LED light effectively inhibited the growth of C. albicans and S. mutans dual-species biofilms for 12 h.

  • IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95.

    Kim H, Takegahara N, Walsh MC, Middleton SA, Yu J, Shirakawa J, Ueda J, Fujihara Y, Ikawa M, Ishii M, Kim J, Choi Y

    Bone research ( NATURE PUBLISHING GROUP )  8 ( 1 ) 5 - 5   2020年 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand (RANKL) stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast maturation. Here, we demonstrate that immunoglobulin superfamily member 11 (IgSF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95 (PSD-95), a scaffold protein with multiple protein interaction domains. IgSF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, IgSF11-deficient mice exhibit increased bone mass. Using in vitro osteoclast culture systems, we show that IgSF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in IgSF11-deficient cells is rescued by full-length IgSF11 and that the IgSF11-PSD-95 interaction requires the 75 C-terminal amino acids of IgSF11. Our findings reveal a critical role for IgSF11 during osteoclast differentiation and suggest a role for IgSF11 in a receptor- and signal transduction molecule-containing protein complex.

  • Flrt2 is involved in fine-tuning of osteoclast multinucleation.

    Shirakawa J, Takegahara N, Kim H, Lee SH, Sato K, Yamagishi S, Choi Y

    BMB reports   52 ( 8 ) 514 - 519   2019年08月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

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MISC(その他業績・査読無し論文等) 【 表示 / 非表示

  • 慢性皮膚粘膜カンジダ症に続発した重複自己免疫疾患患者の多数歯抜歯の経験

    白川 純平, 中村 博幸

    日本口腔感染症学会雑誌 ( (一社)日本口腔感染症学会 )  29 ( 1 ) 38 - 38   2022年06月  [査読有り]

     

  • 琉球大学病院 歯科衛生士による病棟看護師OJTを通して

    長浜 妙子, 又吉 亮, 濱川 恵理子, 玉那覇 星, 大城 美智子, 浜里 緑, 幸喜 奈緒子, 伊波 和可乃, 白川 純平, 後藤 尊広, 仲宗根 敏幸, 中村 博幸

    日本口腔ケア学会雑誌 ( (一社)日本口腔ケア学会 )  16 ( 3 ) 196 - 196   2022年04月

     

  • 骨微小環境におけるFlrt2細胞間相互作用の可能性と癌骨浸潤の解明

    白川 純平, 江面 陽一, 中村 博幸

    日本骨代謝学会学術集会プログラム抄録集 ( (一社)日本骨代謝学会 )  39回   127 - 127   2021年10月  [査読有り]

     

  • アクチン重合の制御因子プロフィリン1を欠損するマウス破骨細胞は遊走・分化・骨吸収の亢進により溶骨症性骨変形を生じさせる

    梶川 修平, 白川 純平, 早田 匡芳, 伊豆 弥生, ベッチャー・ラルフ, 野田 政樹, 江面 陽一

    日本骨代謝学会学術集会プログラム抄録集 ( (一社)日本骨代謝学会 )  36回   157 - 157   2018年07月  [査読有り]

     

  • 破骨細胞遊走を抑制するプロフィリン1の遺伝子欠損は骨吸収亢進を伴う骨格形成障害を引き起こす

    江面 陽一, 白川 純平, ベッチャー・ラルフ, 早田 匡芳, 野田 政樹

    生命科学系学会合同年次大会 ( 生命科学系学会合同年次大会運営事務局 )  2017年度   [3LBA - 065]   2017年12月

     

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学術関係受賞 【 表示 / 非表示

  • 第35回研究交流助成金

    2021年02月   金原一郎記念医学医療振興財団  

    受賞者: ■■■

科研費獲得情報 【 表示 / 非表示

  • FLRT2を介した癌骨浸潤・転移機構の解明とその制御による骨転移予防の可能性

    研究活動スタート支援

    課題番号: 21K21071

    研究期間: 2021年08月  -  2023年03月 

    代表者: 白川 純平 

    直接経費: 2,400,000(円)  間接経費: 3,120,000(円)  金額合計: 720,000(円)

  • FLRT2を介した癌骨浸潤・転移機構の解明とその制御による骨転移予防の可能性

    研究活動スタート支援

    課題番号: 21K21071

    研究期間: 2021年08月  -  2023年03月 

    代表者: 白川 純平 

    直接経費: 2,400,000(円)  間接経費: 3,120,000(円)  金額合計: 720,000(円)