ARAKAWA Hiroyuki

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

00870304

Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Graduate School of Medicine   Associate Professor  

External Career 【 display / non-display

  • 2005.09
    -
    2007.09

     

  • 2007.10
    -
    2010.01

     

  • 2010.02
    -
    2013.08

     

  • 2013.08
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    2014.05

     

  • 2014.05
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    2018.03

     

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Research Interests 【 display / non-display

  • Neuroscience

  • Behavioral neurobiology

Published Papers 【 display / non-display

  • Oxytocin neurons in the paraventricular nucleus of the hypothalamus circuit-dependently regulates social behavior, which malfunctions in BTBR mouse model of autism.

    Arakawa H, Higuchi Y, Ozawa A

    Research square     2023.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Faded neural projection from the posterior bed nucleus of the stria terminalis to the lateral habenula contributes to social signaling deficit in male BTBR mice as a mouse model of autism

    Yuki Higuchi, Shun-ichi Tachigori, Hiroyuki Arakawa

    Psychoneuroendocrinology ( Elsevier BV )  149   106004 - 106004   2023.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Exocrine scent marking: Coordinative role of arginine vasopressin in the systemic regulation of social signaling behaviors.

    Hiroyuki Arakawa, Yuki Higuchi

    Neuroscience and biobehavioral reviews   136   104597 - 104597   2022.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    Arginine vasopressin (AVP) is a neurohypophysial hormone that coordinatively regulates central socio-emotional behavior and peripheral control of antidiuretic fluid homeostasis. Most mammals, including rodents, utilize exocrine or urine-contained scent marking as a social signaling tool that facilitates social adaptation. The exocrine scent marking behavior is postulated to fine-tune sensory and cognitive abilities to recognize key social features via exocrine/urinary olfactory cues and subsequently control exocrine deposition or urinary marking through the mediation of osmotic fluid balance. AVP is implicated as a major player in controlling both recognition and signaling responses. This review provides constructive hypotheses on the coordinative processes of the AVP neurohypophysial circuits in the systemic regulations of fluid control and social-communicative behavior, via the expression of exocrine scent marking, and further emphasizes a potential role of AVP in a common mechanism underlying social communication in rodents. (138 words).

  • Contrasting central and systemic effects of arginine-vasopressin on urinary marking behavior as a social signal in male mice.

    Yuki Higuchi, Hiroyuki Arakawa

    Hormones and behavior   141   105128 - 105128   2022.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    Arginine-vasopressin (AVP) is a neurohypophyseal peptide that plays a critical role in the regulation of social behavior in mammals. Neuronal AVP regulates male-specific social signaling processes, such as exocrine urinary scent deposition and marking behavior in mice. In the periphery, AVP is transported to the portal bloodstream and acts as an antidiuretic hormone. These AVP dynamics imply that the central role of AVP in the stimulation of urinary marking is dissociated with the peripheral role of AVP in the retention of osmotic conditions. Using male BALB/c mice as subjects, peripheral injection of AVP decreased urinary marking and urination. In contrast, a central infusion of AVP facilitated urinary marking with no effect on urination, while an antagonist of the AVP 1a receptor inhibited marking. Centrally AVP-injected mice also exhibited typical behaviors, such as hiccough/sneeze-like reactions and flash scratching, particularly when confronted with a stimulus mouse through a wire mesh screen. Significant expression of these typical reactions in these mice resulted in the disruption of marking deposition. Further analysis of AVP synthesis illustrated that AVP levels increased in the midbrain but not in the circulation immediately after the test, particularly when confronted with a stimulus mouse. The central AVP regulates urinary marking and other typical behaviors in a dose- and situation-dependent manner. The sequential process implies that centrally synthesized AVP may be secreted into the circulation following immediate neuronal processes, and then peripheral AVP acts as an antidiuretic hormone on urinary marking behavior.

  • Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action.

    Ozawa A, Arakawa H

    Behavioural brain research ( Elsevier BV )  406   113234 - 113234   2021.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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Presentations 【 display / non-display

  • Mechanical differences in social deficit process are revealed between two mouse models of autism, BTBR T+tf/J and BALB/cJ.

    Hiroyuki Arakawa

    Society for Neuroscience  1900.01  -  1900.01 

  • Excessive self-grooming behavior of BTBR T+ltpr3tf/J mice may serve a social signaling function.

    Hiroyuki Arakawa

    International Behavioral Neuroscience Society  1900.01  -  1900.01 

  • Are balb/c mice less social? a detailed analysis of social process in two inbred mouse strains.

    Hiroyuki Arakawa

    Society for Neuroscience  1900.01  -  1900.01 

  • Central oxytocin regulates olfactory communication, scent marking, that involves affiliative signals between male mice.

    Hiroyuki Arakawa

    Society for Neuroscience  1900.01  -  1900.01 

Grant-in-Aid for Scientific Research 【 display / non-display

  • International joint research accelerated Fund (return Development Research)

    Project Year: 2019  -  2019 

    Direct: 41,400,000 (YEN)  Overheads: 53,820,000 (YEN)  Total: 12,420,000 (YEN)

  • Grant-in-Aid for JSPS Fellows

    Project Year: 2004  -  2006 

    Direct: 3,100,000 (YEN)  Overheads: 3,100,000 (YEN)