荒川 礼行 (アラカワ ヒロユキ)

ARAKAWA Hiroyuki

写真a

職名

准教授

科研費研究者番号

00870304

ホームページ

https://www.ryukyu-system-physiology.jp

現在の所属組織 【 表示 / 非表示

  • 専任   琉球大学   医学研究科   准教授  

研究キーワード 【 表示 / 非表示

  • 神経科学

  • 行動神経生物学

論文 【 表示 / 非表示

  • Exocrine scent marking: Coordinative role of arginine vasopressin in the systemic regulation of social signaling behaviors

    Arakawa Hiroyuki, Higuchi Yuki

    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS   136   104597 - 104597   2022年05月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Arginine vasopressin (AVP) is a neurohypophysial hormone that coordinatively regulates central socio-emotional behavior and peripheral control of antidiuretic fluid homeostasis. Most mammals, including rodents, utilize exocrine or urine-contained scent marking as a social signaling tool that facilitates social adaptation. The exocrine scent marking behavior is postulated to fine-tune sensory and cognitive abilities to recognize key social features via exocrine/urinary olfactory cues and subsequently control exocrine deposition or urinary marking through the mediation of osmotic fluid balance. AVP is implicated as a major player in controlling both recognition and signaling responses. This review provides constructive hypotheses on the coordinative processes of the AVP neurohypophysial circuits in the systemic regulations of fluid control and social-communicative behavior, via the expression of exocrine scent marking, and further emphasizes a potential role of AVP in a common mechanism underlying social communication in rodents. (138 words).

  • Contrasting central and systemic effects of arginine-vasopressin on urinary marking behavior as a social signal in male mice

    Higuchi Yuki, Arakawa Hiroyuki

    HORMONES AND BEHAVIOR   141   105128 - 105128   2022年05月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Arginine-vasopressin (AVP) is a neurohypophyseal peptide that plays a critical role in the regulation of social behavior in mammals. Neuronal AVP regulates male-specific social signaling processes, such as exocrine urinary scent deposition and marking behavior in mice. In the periphery, AVP is transported to the portal bloodstream and acts as an antidiuretic hormone. These AVP dynamics imply that the central role of AVP in the stimulation of urinary marking is dissociated with the peripheral role of AVP in the retention of osmotic conditions. Using male BALB/c mice as subjects, peripheral injection of AVP decreased urinary marking and urination. In contrast, a central infusion of AVP facilitated urinary marking with no effect on urination, while an antagonist of the AVP 1a receptor inhibited marking. Centrally AVP-injected mice also exhibited typical behaviors, such as hiccough/sneeze-like reactions and flash scratching, particularly when confronted with a stimulus mouse through a wire mesh screen. Significant expression of these typical reactions in these mice resulted in the disruption of marking deposition. Further analysis of AVP synthesis illustrated that AVP levels increased in the midbrain but not in the circulation immediately after the test, particularly when confronted with a stimulus mouse. The central AVP regulates urinary marking and other typical behaviors in a dose- and situation-dependent manner. The sequential process implies that centrally synthesized AVP may be secreted into the circulation following immediate neuronal processes, and then peripheral AVP acts as an antidiuretic hormone on urinary marking behavior.

  • Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action.

    Ozawa A, Arakawa H

    Behavioural brain research ( Elsevier BV )  406   113234 - 113234   2021年05月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

  • Implication of the social function of excessive self-grooming behavior in BTBR T<sup>+</sup>ltpr3<sup>tf</sup>/J mice as an idiopathic model of autism.

    Arakawa H

    Physiology & behavior   237   113432 - 113432   2021年04月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Autism spectrum disorder (ASD) is defined by two core behavioral characteristics, namely, restricted repetitive behaviors and impaired social-communicative functioning. BTBR T+ltpr3tf/J (BTBR) mice provide a valuable animal model for ASD to elucidate the underlying mechanisms of these two behavioral characteristics of ASD. This study examined the social function of excessive grooming behavior in BTBR mice as a phenotype of restricted repetitive behaviors. Compared to the control C57BL/6J (B6) strain, BTBR mice showed increased self-grooming when placed alone in a test apparatus, and this behavior was even more evident when confronted with a stimulus mouse (either B6 or BTBR) in a three-chamber test apparatus. While B6 mice tended to groom their face/snout region on the empty side of the chamber, BTBR mice showed excessive grooming with frequent transitions among grooming body regions on the side of the chamber containing a social stimulus. Acute systemic injection of buspirone,a serotonin 1A receptor agonist, as an anxiolytic, facilitated approach behavior toward social stimuli in the three-chamber setting in both B6 and BTBR mice. However, this treatment did not affect grooming behavior in B6 mice and significantly enhanced self-grooming in BTBR mice. These behaviors in BTBR mice suggest a potential signaling function of grooming in response to social stimuli, in which bodywide grooming of BTBR mice expressed in the proximity of social opponents may stimulate the release of olfactory (possibly dismissive) signals. Consequently, the putative neural mechanisms underlying excessive grooming may differ from those regulating social approaches that are associated with anxiolytic mechanisms.

  • Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models

    Hiroyuki Arakawa

    Current Research in Neurobiology ( Elsevier BV )  2   100011 - 100011   2021年04月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

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研究発表等の成果普及活動 【 表示 / 非表示

  • Mechanical differences in social deficit process are revealed between two mouse models of autism, BTBR T+tf/J and BALB/cJ.

    Hiroyuki Arakawa

    Society for Neuroscience  1900年01月  -  1900年01月   

  • Excessive self-grooming behavior of BTBR T+ltpr3tf/J mice may serve a social signaling function.

    Hiroyuki Arakawa

    International Behavioral Neuroscience Society  1900年01月  -  1900年01月   

  • Are balb/c mice less social? a detailed analysis of social process in two inbred mouse strains.

    Hiroyuki Arakawa

    Society for Neuroscience  1900年01月  -  1900年01月   

  • Central oxytocin regulates olfactory communication, scent marking, that involves affiliative signals between male mice.

    Hiroyuki Arakawa

    Society for Neuroscience  1900年01月  -  1900年01月