Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation

  Hirotatsu Imai, Akio Yamashita

  BIO-PROTOCOL   14 ( 1355 ) e5091   2024.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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    DOI

• Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types

  Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada

  Vaccines   12 ( 11 ) 1239   2024.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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    DOI

• Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification

  Hirotatsu Imai, Daisuke Utsumi, Hidetsugu Torihara, Kenzo Takahashi, Hidehito Kuroyanagi, Akio Yamashita

  Nucleic Acids Research   51 ( 14 ) e76   2023.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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    DOI

• The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation

  Lei Yang, Ka-Ming Lee, Conny Wing-Heng Yu, Hirotatsu Imai, Andrew Kwok-Ho Choi, David K Banfield, Kosuke Ito, Toshio Uchiumi, Kam-Bo Wong

  Nucleic Acids Research   50 ( 9 ) 5335 - 5348   2022.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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    DOI
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• Direct visualization of translational GTPase factor pool formed around the archaeal ribosomal P-stalk by high-speed atomic force microscopy

  Hirotatsu Imai, Toshio Uchiumi, Noriyuki Kodera

  Proceedings of the National Academy of Sciences of the U. S. A.   117   32386 - 32394   2020.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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    DOI

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Recruitment of translation factors by the tentacles of ribosomes

  Imai H

  Journal of Japanese Biochemical Society   94   739 - 742   2022.10  [Refereed]

   

  DOI

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• High-speed AFM visualizes translational GTPase factor pool formed around the ribosomal P-stalk

  今井 大達, 内海 利男, 古寺 哲幸

  第60回日本生物物理学会年会  2022.09  -  2022.09 

• Direct visualization of translational GTPase factor pool formed around archaeal ribosomal P-stalk by high-speed AFM

  Hirotatsu Imai, Toshio Uchiumi, Noriyuki Kodera

  2020.12  -  2020.12 

• ATP加水分解酵素ABCE1とリボソームストークタンパク質間の機能的相互作用

  今井 大達, 阿部 高也, 三好 智博, 西川 周一, 伊東 孝祐, 内海 利男

  第20回日本RNA学会年会  2018.07  -  2018.07 

• Functional role of the ribosomal arm-like proteins.

  Hirotatsu Imai

  JSRC 2015 Research Seminar on Biology  2015.03  -  2015.03 

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Early-Career Scientists

  Project Year: 2021.04  -  2024.03 

  Investigator(s): Hirotatsu Imai 

  Direct: 3,700,000 (YEN)  Overheads: 1,110,000 (YEN)  Total: 4,810,000 (YEN)

• Grant-in-Aid for JSPS Fellows

  Project Year: 2020.04  -  2023.03 

  Direct: 3,700,000 (YEN)  Overheads: 390,000 (YEN)  Total: 4,090,000 (YEN)

• Grant-in-Aid for JSPS Fellows

  Project Year: 2016.04  -  2019.03 

  Direct: 2,800,000 (YEN)  Overheads: 0 (YEN)  Total: 2,800,000 (YEN)