Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Areas 【 display / non-display 】

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Published Papers 【 display / non-display 】

• A transfer RNA methyltransferase with an unusual domain composition catalyzes 2'-O-methylation at position 6 in tRNA

  Teppei Matsuda, Yamagami Ryota, Aoi Ihara, Takeoi Suzuk, Akira Hirata, Hiroyuki Hori

  Nucleic Acids Research     2025.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth

  Xuewei Zhao, Ding Ma, Kensuke Ishiguro, Hironori Saito, Shinichiro Akichika, Ikuya Matsuzawa, Mari Mito, Toru Irie, Kota Ishibashi, Kimi Wakabayashi, Yuriko Sakaguchi, Takeshi Yokoyama, Yuichiro Mishima, Mikako Shirouzu, Shintaro Iwasaki, Takeo Suzuki, Tsutomu Suzuki

  Cell ( Elsevier BV )    2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases

  Tomoda, E. Nagao, A. Shirai, Y. Asano, K. Suzuki, T. Battersby, B. J. Suzuki, T.

  Nucleic Acids Res     2023.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Mass Spectrometric Analysis of Mitochondrial RNA Modifications

  Yuma Ishigami, Tsutomu Suzuki, Takeo Suzuki

  Methods in Molecular Biology ( Springer US )  2192   89 - 101   2021

  Type of publication: Research paper (other science council materials etc.)

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• Complete chemical structures of human mitochondrial tRNAs.

  Takeo Suzuki, Yuka Yashiro, Ittoku Kikuchi, Yuma Ishigami, Hironori Saito, Ikuya Matsuzawa, Shunpei Okada, Mari Mito, Shintaro Iwasaki, Ding Ma, Xuewei Zhao, Kana Asano, Huan Lin, Yohei Kirino, Yuriko Sakaguchi, Tsutomu Suzuki

  Nature communications   11 ( 1 ) 4269 - 4269   2020.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are required for deciphering genetic code accurately, as well as stabilizing tRNA. Loss of tRNA modifications frequently results in severe pathological consequences. Here, we perform a comprehensive analysis of post-transcriptional modifications of all human mt-tRNAs, including 14 previously-uncharacterized species. In total, we find 18 kinds of RNA modifications at 137 positions (8.7% in 1575 nucleobases) in 22 species of human mt-tRNAs. An up-to-date list of 34 genes responsible for mt-tRNA modifications are provided. We identify two genes required for queuosine (Q) formation in mt-tRNAs. Our results provide insight into the molecular mechanisms underlying the decoding system and could help to elucidate the molecular pathogenesis of human mitochondrial diseases caused by aberrant tRNA modifications.

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