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• Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer.

  Tanaka K, Hirakawa H, Suzuki M, Higa T, Agena S, Hasegawa N, Kawakami J, Toyama M, Higa T, Kinjyo H, Kise N, Kondo S, Maeda H, Ikegami T

  Current oncology (Toronto, Ont.) ( Current Oncology )  30 ( 6 ) 5409 - 5424   2023年06月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

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    DOI
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    PubMed

• 発症から2ヵ月経過し摘出に難渋した傍咽頭間隙金属異物例

  武田 翔吾, 真栄田 裕行, 喜瀬 乗基, 安慶名 信也, 田中 克典, 鈴木 幹男

  耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 )  116 ( 5 ) 449 - 453   2023年05月 [ 査読有り ]

  掲載種別: 研究論文（その他学術会議資料等）

• Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.

  Hirakawa H, Ikegami T, Kise N, Kinjyo H, Kondo S, Agena S, Hasegawa N, Kawakami J, Maeda H, Suzuki M

  Journal of personalized medicine ( Journal of Personalized Medicine )  13 ( 4 ) 657   2023年04月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

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• Brain Activity in Patients With Unilateral Vocal Fold Paralysis Detected by Functional Magnetic Resonance Imaging.

  Kiyuna A, Kise N, Hiratsuka M, Maeda H, Hirakawa H, Ganaha A, Suzuki M

  Journal of voice : official journal of the Voice Foundation ( Journal of Voice )  36 ( 5 ) 738.e1 - 738.e9   2022年09月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  OBJECTIVES: Understanding brain activity in response to unilateral vocal fold paralysis is essential to determine the neural compensatory mechanism underlying adaptation to voice disorders and to develop novel and improved rehabilitation programs for these disorders. We aimed to clarify brain activity during phonation (prolonged vowel, |i:|) in patients with chronic left vocal fold paralysis (LVFP) and compare with that in normal controls. STUDY DESIGN: Case-control study. METHODS: This functional magnetic resonance imaging (fMRI) study of an event-related task comprised 12 individuals with LVFP of more than 6 months duration and 12 healthy controls. The experimental task alternated phonation (prolonged vowel, |i:|) and no phonation (rest) conditions. The functional images obtained were single-shot gradient-echo echo-planar imaging. The volumes were acquired parallel to the anterior-posterior commissure plane and were sensitive to BOLD contrast. Data sets were processed and statistically analyzed using Statistical Parametric Mapping 8 software. Within-group analyses were conducted by applying the one-sample t test (P < 0.001, uncorrected). A random-effects analysis was used for group comparison. RESULTS: The LVFP group showed significantly higher brain activity in the right premotor areas, left parietal lobule, right primary somatosensory areas, and bilateral supplementary motor area and lower brain activity in the auditory-related areas of the superior temporal gyrus. There were no significant correlations of the percent signal change on fMRI with disease duration, maximum phonation time, or age. CONCLUSION: Patients with chronic unilateral vocal fold paralysis have stronger activity during voluntary phonation in various central networks. More detailed information on the central nervous system regions related to voluntary phonation from early to chronic phase is needed to understand the compensatory mechanisms in vocal fold paralysis and to establish an effective rehabilitation program. This is the first report to investigate brain activity in chronic unilateral vocal fold paralysis.

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• 喉頭乳頭腫におけるHPVの時空間的遺伝子発現

  池上 太郎, 喜友名 朝則, 喜瀬 乗基, 鈴木 幹男

  喉頭 ( 日本喉頭科学会 )  33 ( 02 ) 69 - 75   2021年12月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  <p>Laryngeal papilloma (LP) is a tumor caused by infection of the larynx with human papillomavirus type 6 or 11 (HPV-6 or HPV-11) and is a multiple, recurrent, and refractory disease. HPV-6 and HPV-11 have nine genes, but the detailed functions of these genes in the formation of recurrent and refractory LP have not been elucidated. We examined the viral DNA load and mRNA expression as well as the <I>in situ</I> localization in HPV-6-infected LP. Our novel phage display method produced a monoclonal antibody against the viral E4 protein as <I>E4</I> mRNA was found to be the most highly expressed of the nine viral mRNAs. The average viral load was 4.80 × 10⁵ ± 1.86 × 10⁵ copies/ng DNA. <I>E4, E5a</I>, and <I>E5b</I> mRNAs accounted for 96% of the expression of the 9 mRNAs. The changes in the viral DNA load and expression of the nine mRNAs showed a similar curve during recurrence. The <I>E4, E5a</I>, and <I>E5b</I> mRNAs were co-expressed in the middle to the upper part of the epithelium. These results suggest that individual viral genes are coordinately expressed for viral replication, virus release, and immunosurveillance avoidance. Antibody against HPV-6 E4 shows high sensitivity and specificity in western blotting and immunohistochemistry and can be used for further functional studies and clinical applications.</p>

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    CiNii Research

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• 鼻腔に発生した平滑筋肉腫の1例

  杉田 早知子, 真栄田 裕行, 又吉 宣, 安慶名 信也, 喜瀬 乗基, 鈴木 幹男

  耳鼻咽喉科臨床 補冊 ( 耳鼻咽喉科臨床学会 )  ( 補冊146 ) 115 - 115   2016年06月  [査読有り]