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Published Papers 【 display / non-display 】

• Effectiveness of surveillance by echocardiography for cancer therapeutics-related cardiac dysfunction of patients with breast cancer

  Okushi, Y; Saijo, Y; Yamada, H; Toba, H; Zheng, RB; Seno, H; Takahashi, T; Ise, T; Yamaguchi, K; Yagi, S; Soeki, T; Wakatsuki, T; Sata, M; Kusunose, K

  JOURNAL OF CARDIOLOGY ( Journal of Cardiology )  82 ( 6 ) 467 - 472   2023.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  BACKGROUND: Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. METHODS: We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. RESULTS: The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. CONCLUSIONS: The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer.

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• The Clinical Utility of Noninvasive Forrester Classification in Acute Heart Failure from PREDICT Study

  Takahashi, T; Iwano, H; Shibayama, K; Kitai, T; Tanaka, H; Yamada, H; Sata, M; Kusunose, K

  AMERICAN JOURNAL OF CARDIOLOGY ( American Journal of Cardiology )  207   75 - 81   2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  The Forrester classification plays a crucial role in comprehending the underlying pathophysiology of heart failure (HF) and is employed to categorize the severity and predict the outcomes of patients with acute HF. Our objective was to assess the predictive value of the Forrester classification, based on noninvasive hemodynamic measurements obtained through Doppler echocardiography at admission, in forecasting the short-term prognosis posthospitalization of patients with acute HF. Patients were recruited for the Prospect trial to elucidate the utility of EchocarDIography-based Cardiac ouTput in acute heart failure (PREDICT) study, a multicenter, prospective study conducted in Japan. Participants were stratified into 4 profiles using cardiac index (CI) and early mitral filling velocity (E)/early-diastolic mitral annular velocity (e') ratio obtained from Doppler echocardiography upon admission (profile I: CI >2.2, E/e' ≤15, profile II: CI >2.2, E/e' >15, profile III: CI ≤2.2, E/e' ≤15, profile IV: CI ≤2.2, E/e' >15). The primary composite outcome of the study was all-cause mortality or worsening HF during the 14 days of hospitalization. Cox proportional hazards model analysis was employed to identify prognostic factors during the observation period. A total of 270 subjects, with a mean age of 74 ± 14 years and a male proportion of 60%, were enrolled in the study. During the 14-day period of hospitalization, 58 participants (22%) had a composite outcome. Patients with low CI (i.e., profiles III and IV) demonstrated an elevated risk of composite outcome after adjusting for confounding variables, as evidenced by the adjusted hazard ratios of 5.85 (95% confidence interval 1.17 to 29.09, p <0.01, vs profile III) and 6.50 (95% confidence interval 1.53 to 27.68, p <0.01, vs profile IV) in comparison with profile I, respectively. In conclusion, the Forrester classification, derived from noninvasive Doppler echocardiography at admission, may predict early deterioration in patients hospitalized with acute HF.

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• Innate Immune System Regulated by Stimulator of Interferon Genes, a Cytosolic DNA Sensor, Regulates Endothelial Function.

  Pham PT, Bavuu O, Kim-Kaneyama JR, Lei XF, Yamamoto T, Otsuka K, Suto K, Kusunose K, Yagi S, Yamada H, Soeki T, Shimabukuro M, Barber GN, Sata M, Fukuda D

  Journal of the American Heart Association ( Journal of the American Heart Association )  12 ( 22 ) e030084   2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Value and challenges of lung ultrasound in stratifying ST-elevation myocardial infarction risk

  Kusunose, K; Toma, Y

  HEART ( Heart )  109 ( 21 ) 1580 - 1581   2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Correlation between energy loss index and B-type natriuretic peptide: a vector flow mapping study

  Morita, S; Hirata, Y; Nishio, S; Takahashi, T; Saijo, Y; Yamada, H; Sata, M; Kusunose, K

  JOURNAL OF ECHOCARDIOGRAPHY ( Journal of Echocardiography )    2023.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  BACKGROUND: Vector Flow Mapping (VFM) and Energy Loss (EL) evaluation are emerging echocardiographic techniques that offer detailed insights into cardiac function. This study aimed to explore the relationship between EL parameters and B-type natriuretic peptide (BNP) levels, a well-established marker of heart failure severity. METHODS: Our study prospectively enrolled 62 patients experiencing shortness of breath and suspected heart failure, who underwent echocardiography and had BNP levels measured between January 2018 and August 2020. Patients were stratified based on BNP levels, and their clinical and echocardiographic characteristics were evaluated. Univariate and multivariate regression analyses were performed to assess the correlation between BNP levels and various echocardiographic variables, including VFM parameters. RESULTS: Patients were stratified into two groups based on their BNP levels: BNP < 200 pg/ml (n = 53) and BNP ≥ 200 pg/ml (n = 9). Patients with BNP ≥ 200 pg/ml presented significantly different clinical and echocardiographic characteristics, such as older age, larger left ventricular mass and volume indices, higher pulmonary artery systolic pressure, higher E/e' ratio, and larger EL parameters. Multivariate regression analysis demonstrated the E/e' ratio and ELA (EL during Atrial contraction phase/A wave ratio as significant determinants of logBNP. Receiver operating characteristic curve analysis showed ELA/A > 36.0 J/m2 as a significant predictor of high BNP with 89% sensitivity and 85% specificity. ELA/A demonstrated an incremental diagnostic value over elevated left atrial pressure for predicting high BNP (C statistic = 0.98 vs 0.74, P = 0.006). CONCLUSION: This study provides novel insights into the potential utility of EL parameters as auxiliary indicators of cardiac load, thereby enhancing our understanding of heart failure.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• 心エコーハンドブック 心不全: 竹中 克,戸出 浩之 編

  Kenya Kusunose, Hirotsugu Yamada ( Part: Other )

  KINPODO, INC.  2017.05

• Pre-capillary PH, post capillary PHの診断はどうすればいいですか?

  Kenya Kusunose, Hirotsugu Yamada ( Part: Other )

  MEDICAL VIEW CO., LTD.  2011

• 心房細動の患者さんではどのように計測すればいいですか?(EF,左室径,拡張能,弁膜症評価)

  Kenya Kusunose, Hirotsugu Yamada ( Part: Other )

  MEDICAL VIEW CO., LTD.  2011

• 心嚢液貯留がどのくらいで心タンポナーデと診断すればいいですか?

  Kenya Kusunose, Hirotsugu Yamada ( Part: Other )

  MEDICAL VIEW CO., LTD.  2011

• 左室拡張不全をきたす疾患,心膜疾患

  Kenya Kusunose, Hirotsugu Yamada ( Part: Other )

  文光堂  2010.09

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Comparison of AI models for left ventricular ejection fraction: a multicenter observational study

  高坂佳孝, 楠瀬賢也, 芳賀昭宏, 山口夏美, 竹田泰治, 田中秀和, 三宅誠, 森内健史, 山田博胤, 佐田政隆

  超音波医学 Supplement   49   2022  [Refereed]

   

  J-GLOBAL

• The Present and Future of Artificial Intelligence in Cardiovascular Imaging

  楠瀬賢也, 芳賀昭弘, 山田博胤, 西尾進, 平田有紀奈, 佐田政隆

  超音波医学 Supplement   47   2020  [Refereed]

   

  J-GLOBAL

• 深部静脈血栓症に対する各種DOACsの治療成績 下肢静脈エコー検査を用いた検討

  鳥居 裕太, 楠瀬 賢也, 西尾 進, 松本 力三, 平田 有紀奈, 天野 里江, 西條 良仁, 坂東 美佳, 山田 博胤, 佐田 政隆

  日本心臓病学会学術集会抄録 ( (一社)日本心臓病学会 )  66回   EP - 187   2018.09

   

• 活性型血液凝固第X因子が冠動脈硬化に与える影響

  福田 大受, 山口 浩司, 楠瀬 賢也, 八木 秀介, 山田 博胤, 若槻 哲三, 添木 武, 佐田 政隆

  日本心臓病学会学術集会抄録 ( (一社)日本心臓病学会 )  66回   O - 044   2018.09

   

• 未固定遺体における冠動脈壁微小管腔構造と局所心臓周囲脂肪内炎症との関連

  伊藤 浩敬, 若槻 哲三, 山口 浩司, 福田 大受, 川端 豊, 伊勢 孝之, 楠瀬 賢也, 松浦 朋美, 轟 貴史, 飛梅 威, 八木 秀介, 山田 博胤, 添木 武, 佐田 政隆

  日本心臓病学会学術集会抄録 ( (一社)日本心臓病学会 )  66回   P - 016   2018.09

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• 降圧治療が心臓および血管に与える影響

  西尾 進, Hirotsugu Yamada, Kenya Kusunose, 鈴川 理乃, 平田 有紀奈, 鳥居 裕太, 天野 里江, 山尾 雅美, 瀬野 弘光, 西條 良仁, Masataka Sata

  日本心エコー図学会第27回学術集会  (Osaka)  1900.01  -  1900.01 

• 非心臓手術前の心エコー検査は,入院期間および死亡率に影響を与えない

  鳥居 裕太, Kenya Kusunose, 西尾 進, 平田 有紀奈, 天野 里江, 山尾 雅美, 林 修司, 阿部 美保, Hirotsugu Yamada, Masataka Sata

  第64回日本心臓病学会学術集会  (Tokyo)  1900.01  -  1900.01 

• 頸動脈内膜中膜複合体厚にDPP4阻害薬シタグリプチンが及ぼす影響―アログリプチンからの切り替え試験

  amano rie, Hirotsugu Yamada, Kenya Kusunose, Susumu Nishio, 平田 有紀奈, Yuta Torii, Seno Hiromitsu, Yoshihito Saijoh, Masataka Sata

  第65回日本心臓病学会学術集会:大阪  1900.01  -  1900.01 

• Coffee and Cases: From Around the World

  楠瀬 賢也

  Echo Hawaii 2018  (Kona, USA)  1900.01  -  1900.01 

• C-type natriuretic peptide improves left ventricular diastolic dysfunction in HFpEF model rats.

  添木 武, 松浦 朋美, 福田 大受, 飛梅 威, 楠瀬 賢也, 伊勢 孝之, 山口 浩司, 八木 秀介, 山田 博胤, 若槻 哲三, 佐田 政隆

  第82回日本循環器学会  (大阪)  1900.01  -  1900.01 

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• 第65回学会 Young Investigator's Award 最優秀賞

  2017.09   The Japanese College of Cardiology   Preload Stress Echocardiography Predicts Outcomes in Patients with Preserved Ejection Fraction and Low Gradient Aortic Stenosis

  Winner: Kenya Kusunose

• Young Investigators Award 最優秀賞

  2017.09   第65回日本心臓病学会学術集会   Preload Stress Echocardiography Predicts Outcomes in Patients with Pre-served Ejection Fraction and Low Gradient Aortic Stenosis

  Winner: Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata

• 第42回日本超音波検査学会学術集会YIA

  2017.06   日本超音波検査学会   外膜下脂肪厚を用いた糖尿病患者における冠動脈狭窄の診断

  Winner: Yukina Hirata, Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Masataka Sata

• 第28回学術集会 YOUNG INVESTIGATOR'S AWARD 最優秀賞

  2017.04   日本心エコー図学会   下肢陽圧負荷心エコー図法で算出したprojected AVAiを用いた低圧較差高度大動脈弁狭窄のリスク層別化

  Winner: Kenya Kusunose

• Young Investigator's Award (Clinical Research )

  2017.03   The Japanese Circulation Society   Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity in Patients with Chronic Heart Failure

  Winner: Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 1,080,000 (YEN)  Total: 4,680,000 (YEN)

• 膠原病における潜在性肺高血圧症に対する早期治療介入の有用性

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): 楠瀬 賢也 

  Direct: 3,600,000 (YEN)  Overheads: 1,080,000 (YEN)  Total: 4,680,000 (YEN)

• Clinical application of preload stress echocardiography with leg-positive pressure in patients with chronic heart failure

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2010.04  -  2014.03 

  Investigator(s): YAMADA Hirotsugu, KUSUNOSE Kenya, TOMITA Noriko 

  Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

  　View Summary

  Preload stress echocardiography was applied with leg-positive pressure (LPP) in patients with mild heart failure. Patients were classified into 3 groups based on transmitral flow velocity pattern: restrictive or pseudontrmal (PN) at rest, impaired relaxation (IR) at rest and during LPP (stable IR), and IR at rest and PN during LPP (unstable IR). All-cause cardiac event rate was higher in unstable IR than in stable IR, and was similar in PN group. Event-free survival was lower in unstable IR than stable IR. Preload stress echocardiography provides additional prognostic information in mild heart failure patients beyond conventional echocardiographic parameters.

• Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation

  Grant-in-Aid for Young Scientists(B)

  Project Year: 2009.04  -  2010 

  Investigator(s): KUSUNOSE Kenya 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

  　View Summary

  The single-beat LS and DSr represents the average value of 15 seconds in patients with AF. These non-invasively obtained single-beat parameters are useful to assess surrogate LV systolic and diastolic function even in AF.