Published Papers - Kusunose Kenya

Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients

Yamaguchi Koji, Wakatsuki Tetsuzo, Soeki Takeshi, Niki Toshiyuki, Taketani Yoshio, Oezuka Hiroyasu, Bando Sachiko, Tomita Noriko, Kusunose Kenya, Iwase Takashi, Yamada Hirotsugu, Sata Masataka

CIRCULATION   124 ( 21 )   2011.11 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite

Hiromu Yamazaki, Koji Yamaguchi, Takashi Iwase, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Fukunaga, Hideki Nakanishi, Haruhiko Maruyama, Hiroyuki Matsuoka, Masataka Sata

Journal of Cardiology Cases   4 ( 2 ) e106 - e109   2011.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A 71-year-old female had worked on a farm in the mountains and noticed itching of the left 3rd toe. She visited a local hospital due to a color change to purple in this area. Attachment of a tick was observed between the left 2nd and 3rd toes, and it was extracted. However, due to persistent pain, she was referred to our department of cardiovascular medicine for close examination and treatment. Lower extremity angiography showed that vascular visualization was poor in the area supplied by the arteries distal to the tick bite site, but the other blood vessels of the toe were clearly visualized. Toe amputation was performed and pathological examination of a surgical specimen revealed that most blood vessels near the necrosis were occluded by thrombi. We speculated that tick bite reactions were associated with thrombogenic vasculopathy. This report shows a patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite. © 2011 Japanese College of Cardiology.

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Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability

Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Sachiko Bando, Yoichiro Hirata, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

JOURNAL OF CARDIOLOGY ( ELSEVIER IRELAND LTD )  58 ( 2 ) 151 - 157   2011.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background: Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. Methods and results: We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r= 0.67, p < 0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. Conclusions: PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture. (C) 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient

Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike, Masataka Sata

INTERNATIONAL JOURNAL OF CARDIOLOGY ( ELSEVIER IRELAND LTD )  150 ( 1 ) E25 - E27   2011.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A 73-year-old woman suffering from anterior thoracic pain on exertion presented to our hospital. We performed coronary angiography and noted three stenotic legions in each coronary artery. For each angiographic finding, we implanted a bare metal stent (BMS), sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) into the right coronary artery, left anterior descending and left circumflex coronary arteries, respectively. Nine months later, she died of lung disease, and we could compare the histopathological findings among the three coronary stents. In the drug-eluting stents, very thin intima, infiltration of inflammatory cells, and fibrin deposition were observed, while thick intima and no inflammatory findings were observed in the BMS. Fibrin deposition was more marked in the PES than in the SES. This report shows marked differences in the subsequent pathological course among three stents in the same patient. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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Effect of Low-Dose (1 mg/day) Pitavastatin on Left Ventricular Diastolic Function and Albuminuria in Patients With Hyperlipidemia

Shusuke Yagi, Masashi Akaike, Ken-Ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

AMERICAN JOURNAL OF CARDIOLOGY ( EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC )  107 ( 11 ) 1644 - 1649   2011.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 +/- 31.4 to 98.2 +/- 19.4 mg/dl, p <0.01), triglycerides (from 157.7 +/- 57.2 to 140.5 +/- 60.7 mg/dl, p <0.01), E/e' (from 10.8 +/- 6.2 to 9.0 +/- 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 +/- 55.9 to 28.5 +/- 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-beta 1 (from 709 +/- 242 to 550 +/- 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 +/- 4.1 to 5.0 +/- 3.1 mu g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 +/- 14.6 to 29.4 +/- 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1644-1649)

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Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient

Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Hiroyasu Oezuka, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata

Journal of Cardiology Cases   3 ( 3 ) e111 - e114   2011.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Integrated backscatter intravascular ultrasound (IB-IVUS) capable of assessing plaque properties has recently become clinically applicable. We observed short-term atorvastatin-induced changes in coronary arterial plaque properties using IB-IVUS. The patient was a 57-year-old man who underwent coronary angiography when admitted to our hospital for cerebrovascular surgery, and lesions were observed in 2 branches: 99% and 90% stenoses in the proximal anterior descending branch (LAD) and middle region of the circumflex, respectively. Stenting was performed for the LAD on November 4, 2009 and for the circumflex on December 9. Oral atorvastatin administration at 10. mg/day was initiated on November 5 because the LDL-cholesterol level was high (160. mg/dl). A region about 5. mm in length proximal to the stent placed in the LAD was analyzed using IB-IVUS. Atorvastatin lowered the LDL cholesterol level from 160 to 79. mg/dl. On IB image analysis, although the period was as short as about 1 month, a marked decrease in the fatty component (44% → 26%) and an increase in the fibrous component (53% → 66%) were observed in the plaque. It was suggested that atorvastatin changes the tissue properties of coronary arterial plaques from a very early phase. It might be associated with the stabilization of coronary plaque. © 2011 Japanese College of Cardiology.

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Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis

Kenya Kusunose, Hirotsugu Yamada, Noriko Tomita, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

INTERNATIONAL JOURNAL OF CARDIOLOGY ( ELSEVIER IRELAND LTD )  148 ( 3 ) E47 - E50   2011.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Most cases of chronic stenosis or occlusive lesions of the pulmonary arteries are attributed to thromboembolism, and pulmonary arteritis is extremely rare as the primary cause of these entities. We report a case of pulmonary stenosis and occlusion caused by Takayasu arteritis. The patient was a 54-year-old woman who presented with dyspnea. Total occlusion of the left pulmonary artery and significant stenosis of the right pulmonary artery caused by Takayasu arteritis were confirmed by various imaging modalities including pulmonary angiography, 18fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging and real-time three-dimensional transesophageal echocardiography. After 6 weeks of steroid therapy, follow-up imaging studies showed that the stenotic lesion had resolved. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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RELATIONSHIP BETWEEN CAROTID ARTERY STIFFNESS PARAMETER ? AND BRACHIAL ARTERY FLOW-MEDIATED DILATION IN CORONARY ARTERY DISEASE

Nishio Susumu, Yamada Hirotsugu, Tamai Rina, Endo Keisuke, Hayashi Shuji, Kusunose Kenya, Tomita Noriko, Miki Junko, Bando Sachiko, Hisaoka Sahika, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Iwase Takashi, Soeki Takeshi, Wakatsuki Tetsuzo, Akaike Masashi, Sata Masataka

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 ) E1569   2011.04 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension

Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata

INTERNATIONAL JOURNAL OF CARDIOLOGY ( ELSEVIER IRELAND LTD )  148 ( 1 ) 125 - 127   2011.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.

Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

The American Journal of Cardiology   Vol.107 ( No.11 ) 1644 - 1649   2011.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 ± 31.4 to 98.2 ± 19.4 mg/dl, p <0.01), triglycerides (from 157.7 ± 57.2 to 140.5 ± 60.7 mg/dl, p <0.01), E/e' (from 10.8 ± 6.2 to 9.0 ± 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 ± 55.9 to 28.5 ± 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-1 (from 709 ± 242 to 550 ± 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 ± 4.1 to 5.0 ± 3.1 g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 ± 14.6 to 29.4 ± 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress.

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Validation of Longitudinal Peak Systolic Strain by Speckle Tracking Echocardiography With Visual Assessment and Myocardial Perfusion SPECT in Patients With Regional Asynergy

Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

CIRCULATION JOURNAL ( JAPANESE CIRCULATION SOC )  75 ( 1 ) 141 - 147   2011.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background: Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Methods and Results: Segmental LS was measured by AFI in 60 patients with MI (67 +/- 11 years) and 58 controls (71 +/- 9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of -11% <LS to identify hypokinetic segments. The overall accuracy of wall motion scoring by LS in the 2,006 segments was 96.8% (kappa=0.90) compared with visual assessment. The correlation coefficient between LS and WT was R(2)=0.65 in the 340 segments. Conclusions: Assessment of LV regional asynergy by AFI showed good agreement with visual and SPECT assessments. AFI is clinically useful for quantitative assessment of LV regional wall motion abnormalities. (Circ J 2011;75: 141-147)

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A case of renal artery stenosis in an elderly patient after nephrectomy diagnosed by ultrasound sonography, showing improvement of blood pressure and renal dysfunction after renal artery stenting

Kojiro Nagai, Kenya Kusunose, Susumu Nishio, Yoshio Taketani, Hirotsugu Yamada, Masataka Sata, Naoki Kondo, Fumi Kishi, Seiji Kishi, Toshikazu Araoka, Motokazu Matsuura, Akira Mima, Hideharu Abe, Taichi Murakami, Masayuki Nakamura, Toshio Doi

Japanese Journal of Nephrology   53 ( 1 ) 68 - 74   2011 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Arteriosclerotic renal artery stenosis is one of the increasingly common diseases that affects many aged patients. There are various non-invasive methods to diagnose renal artery stenosis, such as contrast enhanced CT or MRI. However, these methods are not appropriate for patients with renal dysfunction. Ultrasound sonography is becoming one of the promising methods to diagnose artery stenosis because of photographic improvements. In this case, a 72-year-old woman was hospitalized 7 months after nephrectomy because of severe hypertension, heart failure and kidney dysfunction. The heart failure was quite uncontrollable in spite of massive administration of diuretics, and finally, hemodialysis was started to control her volume status. In consideration of her past history and abdominal bruit, we evaluated the renal artery stenosis by ultrasound sonography and confirmed the diagnosis by renal angiography. To improve hypertension control, we performed renal artery stenting, which resulted in an impressive improvement of her blood pressure and renal function. We recognized the importance of careful causal evaluation of renal dysfunction, even though it is difficult to apply invasive therapy to patients after nephrectomy.

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Ventricular Tachycardia in Cardiac Sarcoidosis Controlled by Radiofrequency Catheter Ablation

Mika Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  50 ( 11 ) 1201 - 1206   2011 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.

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Removal of a pinched off central venous catheter.

Kusunose K, Wakatsuki T, Sata M

Heart Asia   3 ( 1 ) 32 - 32   2011 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PJ3-044 Congenital Long QT Syndrome with Compound Mutations in KCNH2 Gene

Sachiko Bando, Takeshi Soeki, Toshivuki Niki, Kenya kusunose, Koji Yamaguchi, Yoshio Taketani, Iwase Takashi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Wataru Simizu, Masataka Sata

Journal of Arrhythmia   27   2011 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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We report a case with long QT syndrome caused by compound mutations in KCNH2 gene.A 20-year-old man was referred to our hospital for evaluation of syncope. When he was a high school student, he experienced syncope. In electrocardiogram, the QT interval was prolonged to 498ms (QTc=479ms). His 22-year-old elder brother, who had syncopal episodes twice and the prolonged QT interval in electrocardiogram, suffered from ventricular fibrillation and became vegetative state on May 26, 2009. Genetic testing revealed the frameshift mutation by the insertion of 25 nucleotides causing both an altered amino acid sequence from codon 302 and a premature termination codon (i.e., TAG) at codon 339 and the missense mutation of c.1474 C&gt T (p.H492Y) in KCNH2 gene in both brothers. These mutations have not been reported previously. Family genetic screening found that their father had the same fameshift mutation and their mother and sister had the same missense mutation in KCNH2 gene. However the family members without two brothers experienced no symptoms and had no prolonged QT interval in electrocardiogram. These results suggest that the compound mutations in KCNH2 gene inherited independently from the parents made the phenotype of their sons more severe. Then we planted the implantable cardioverter defibrillator into him on March 17, 2010. © 2011, Japanese Heart Rhythm Society. All rights reserved.

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繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例

門田 宗之, Yoshio Taketani, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Toshiyuki Niki, 坂東 左知子, 久岡 白陽花, Yuka Ueda, 冨田 紀子, 竹内 秀和, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike, Masataka Sata, Kojiro Nagai, Toshio Doi

Shikoku Acta Medica   Vol.66 ( No.5, 6 ) 175 - 180   2010.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway

Soeki Takeshi, Niki Toshiyuki, Bando Sachiko, Hisaoka Sahika, Takeuchi Hidekazu, Kusunose Kenya, Yamaguchi Koji, Hirata Yoichiro, Tomita Noriko, Taketani Yoshio, Iwase Takashi, Yamada Hirotsugu, Wakatsuki Tetsuzo, Akaike Masashi, Kangawa Kenji, Sata Masataka

CIRCULATION   122 ( 21 )   2010.11 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Time-Dependent Changes of Local Coagulative Response up to Five Years After Sirolimus-Eluting Stent Implantation

Yamaguchi Koji, Wakatsuki Tetsuzo, Niki Toshiyuki, Taketani Yoshio, Bando Sachiko, Hisaoka Sahika, Kusunose Kenya, Ueta Yuka, Takeuchi Hidekazu, Iwase Takashi, Tomita Noriko, Yamada Hirotsugu, Soeki Takeshi, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010.11 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography

Kusunose Kenya, Yamada Hirotsugu, Nishio Susumu, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Hisaoka Sahika, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Iwase Takashi, Soeki Takeshi, Wakatsuki Tetsuzo, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010.11 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography

Kusunose Kenya, Yamada Hirotsugu, Nishio Susumu, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Hisaoka Sahika, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Iwase Takashi, Soeki Takeshi, Wakatsuki Tetsuzo, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010.11 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)