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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Japanese Encephalitis With a Characteristic Neuropathological Distribution Following Early MRI-Based Diagnosis: An Autopsy Case.

  Okada Y, Oshima T, Nakahara K, Okazaki N, Kawakami F, Nishimura H, Mizutani H, Ueda M

  Neuropathology : official journal of the Japanese Society of Neuropathology ( Neuropathology )  46 ( 4 ) e70068   2026.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Management of a Complex Orbital Post-transplantation Lymphoproliferative Disorder: A Case Report and Literature Review.

  Maruyama T, Hokama Y, Kishaba K, Kuninaka T, Kobayashi S, Nagamine H, Miyahira H, Tanaka K, Morichika K, Kawakami F, Tomita M, Wada N, Yogi A, Masuzaki H, Hamasaki T

  In vivo (Athens, Greece) ( In Vivo )  40 ( 3 ) 1824 - 1831   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND/AIM: Post-transplantation lymphoproliferative disorder (PTLD) is an uncommon but serious complication of organ transplantation. Management often requires multiple treatment modalities and reduction in immunosuppressant treatment (RIT). Orbital involvement is rare, and optimal diagnostic and therapeutic approaches remain uncertain. CASE REPORT: Here, we report a case of localized orbital PTLD that was successfully treated with RIT alone. A 62-year-old man, who had undergone kidney transplantation 18 years prior, presented with left eye pain and proptosis. Imaging revealed an enhancing intraorbital mass extending to the optic nerve and adjacent intracranial structures. Transcranial biopsy confirmed B-cell-type PTLD. The lesion regressed with stepwise RIT alone without additional therapy. The patient showed clear clinical improvement and remained in remission for more than 13 months. CONCLUSION: This case suggests the potential role of a conservative, individualized, stepwise approach in selected patients with localized orbital PTLD, and may inform management strategies for other localized forms of PTLD.

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• Carcinoma of unknown primary with a lung cancer profile in mediastinal and/or hilar lymph nodes: EGFR-mutant cases and a literature review of actionable drivers.

  Tome R, Furugen M, Chinen S, Arakaki W, Miyagi K, Shuri Y, Kawakami F, Wada N, Yamamoto K

  Respiratory investigation ( Respiratory Investigation )  64 ( 3 ) 101399 - 101399   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  We report two cases of carcinoma of unknown primary (CUP) with a lung cancer profile harboring epidermal growth factor receptor (EGFR) mutations. Case 1 was node-limited and achieved a durable partial response for at least 15 months with osimertinib. Case 2 harbored an EGFR exon 20 insertion and showed disease progression despite therapy. While responses to first- and second-generation EGFR tyrosine kinase inhibitors have been reported in EGFR-mutant CUP, evidence for the third-generation EGFR-TKI osimertinib remains limited. These cases highlight that early molecular profiling can identify actionable targets and enable lung cancer-standard therapies even when the primary lesion remains undetected.

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• A Case of Myxoid Solitary Fibrous Tumor With Villiform Histology in Pterygopalatine Fossa.

  Kobashigawa S, Nakayoshi H, Maeda H, Iraha Y, Nishie A, Kawakami F

  Pathology international ( Pathology International )  76 ( 5 ) e70123   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Multi-institutional study of mesonephric-like adenocarcinoma: its clinicopathological characteristics and histogenetic association with ectopic endometrium.

  Miyama Y, Uranishi K, Hirasaki M, Tonooka A, Kawakami F, Mikami Y, Kiyokawa T, Kajiwara H, Shiraishi J, Kudo E, Ito K, Higashi M, Minamiguchi S, Okazaki N, Kondo Y, Shimada T, Maeda Y, Yasuhara Y, Kawano Y, Kawasaki Y, Hasegawa K, Yasuda M

  Virchows Archiv : an international journal of pathology ( Virchows Archiv )    2025.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  To explore the clinicopathological features and origin of mesonephric-like adenocarcinomas (MLAs), 83 cases diagnosed or suspected to be MLAs were collected from various institutions in Japan. We clearly classified 78 as MLAs (uterus: 47, ovary: 31) and 5 as non-MLAs (all ovary) based on our morphological and immunohistochemical criteria. In uterine MLAs (uMLAs), lymphovascular space invasion was an independent prognostic factor for progression-free survival (PFS) (P = 0.03). Patients with uMLAs had significantly shorter PFS and overall survival (OS) than those diagnosed with endometrial endometrioid carcinomas (EECs) (P < 0.0001 and P < 0.001, respectively) and comparable PFS and OS to those with copy number-high tumors. PFS and OS of ovarian MLAs (oMLAs) were similar to those of ovarian endometrioid carcinomas (OECs) overall but worse for patients with stage II-IV. Endometriosis was observed with oMLAs as often as with OECs (94% vs 93%, respectively). Adenomyosis was more frequently observed with uMLAs than with EECs (62% vs 28%, respectively, P = 0.0005). Six uMLAs were confined to the myometrium and adjacent to adenomyosis. In an analysis of molecularly speculated origin, among 29 oMLAs harboring a KRAS hotspot mutation, 23 (79%) instances of endometriosis in the background had the same mutation. Among 36 uMLAs carrying the KRAS hotspot mutation, common mutations were observed in 12 (33%) instances of adjacent adenomyosis (12/21 [67%] of adenomyosis). These findings suggest a histogenetic link between MLAs and ectopic endometrium, implicating both ovarian endometriosis and adenomyosis in MLA pathogenesis, with potential clinical significance.

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• Medical DX in the Pathology Department: A Start from Glass Slide Logistics Management

  川上史, 川上史, 中谷有作, 久保山澄玲, 上田真彦, 伊豆味由紀子, 玉城真太, 瑞慶覧陽子, 和田直樹

  日本病理学会会誌   114 ( 1 )   2025  [Refereed]

   

  J-GLOBAL

• 心筋生検におけるアミロイド沈着の定量化における観察者間格差の検討(Interobserver reproducibility of quantitative amyloid load interpretation on endomyocardial biopsy)

  川上 史, 高潮 征爾, 大園 一隆, 塩田 拓也, 山田 倫, 大倉 航平, 田中 一仁, 三上 芳喜

  日本病理学会会誌 ( (一社)日本病理学会 )  113 ( 1 ) 307 - 307   2024.02  [Refereed]

   

• Mesonephric-like Adenocarcinoma of the Uterine Corpus: Study of 5 Cases

  岡崎菜紗, 岡崎菜紗, 川上史, 安里嗣晴, 三上芳喜

  診断病理   41 ( 2 )   2024  [Refereed]

   

  J-GLOBAL

• Pathologic Changes of Placenta from COVID-19 Patients: Study of 22 Cases

  横尾貴保, 川上史, 三上芳喜

  日本病理学会会誌   112 ( 1 ) 350 - 350   2023.03  [Refereed]

   

  J-GLOBAL

• A retrospective study of 5 cases of intrahepatic cholangiocarcinoma with FGFR2 gene abnormality

  吉井大貴, 川上史, 三上芳喜

  日本病理学会会誌   112 ( 2 )   2023

   

  J-GLOBAL

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Other Research Activities 【 display / non-display 】

Other Research Activities 【 display / non-display 】

• Journal of Gynecologic Oncology

  Editing academic journals etc. 

  2026.07

  　

  　

• Frontiers in Oncology

  Editing academic journals etc. 

  2026.05

  　

  　

• Discover Oncology

  Editing academic journals etc. 

  2026.05

  　

  　

• Pathology Research and Practice

  Editing academic journals etc. 

  2025.07

  　

  　

• Medical Molecular Morphology

  Editing academic journals etc. 

  2024.10

  　

  　

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2025.04  -  2028.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Does the distinctive soil composition and distribution in Okinawa Prefecture influence the clinical course of idiopathic interstitial pneumonia?

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2025.04  -  2028.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Young Scientists(S)

  Project Year: 2023.04  -   

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

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Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2026.01

  　

  　

  

• 2025.10

  　

  　

  

• 2025.09

  　

  　

  

• 2025.07