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• Multi-institutional study of mesonephric-like adenocarcinoma: its clinicopathological characteristics and histogenetic association with ectopic endometrium.

  Miyama Y, Uranishi K, Hirasaki M, Tonooka A, Kawakami F, Mikami Y, Kiyokawa T, Kajiwara H, Shiraishi J, Kudo E, Ito K, Higashi M, Minamiguchi S, Okazaki N, Kondo Y, Shimada T, Maeda Y, Yasuhara Y, Kawano Y, Kawasaki Y, Hasegawa K, Yasuda M

  Virchows Archiv : an international journal of pathology ( Virchows Archiv )    2025.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  To explore the clinicopathological features and origin of mesonephric-like adenocarcinomas (MLAs), 83 cases diagnosed or suspected to be MLAs were collected from various institutions in Japan. We clearly classified 78 as MLAs (uterus: 47, ovary: 31) and 5 as non-MLAs (all ovary) based on our morphological and immunohistochemical criteria. In uterine MLAs (uMLAs), lymphovascular space invasion was an independent prognostic factor for progression-free survival (PFS) (P = 0.03). Patients with uMLAs had significantly shorter PFS and overall survival (OS) than those diagnosed with endometrial endometrioid carcinomas (EECs) (P < 0.0001 and P < 0.001, respectively) and comparable PFS and OS to those with copy number-high tumors. PFS and OS of ovarian MLAs (oMLAs) were similar to those of ovarian endometrioid carcinomas (OECs) overall but worse for patients with stage II-IV. Endometriosis was observed with oMLAs as often as with OECs (94% vs 93%, respectively). Adenomyosis was more frequently observed with uMLAs than with EECs (62% vs 28%, respectively, P = 0.0005). Six uMLAs were confined to the myometrium and adjacent to adenomyosis. In an analysis of molecularly speculated origin, among 29 oMLAs harboring a KRAS hotspot mutation, 23 (79%) instances of endometriosis in the background had the same mutation. Among 36 uMLAs carrying the KRAS hotspot mutation, common mutations were observed in 12 (33%) instances of adjacent adenomyosis (12/21 [67%] of adenomyosis). These findings suggest a histogenetic link between MLAs and ectopic endometrium, implicating both ovarian endometriosis and adenomyosis in MLA pathogenesis, with potential clinical significance.

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• Cervical adenocarcinoma risk stratification using histotype and invasion pattern: a multicenter retrospective study by the KAMOGAWA Study Group.

  Matsubara M, Otani T, Kawakami F, Koike A, Hirayama T, Yamanishi Y, Horikawa N, Emoto I, Ukita M, Sumitomo M, Sato H, Ashihara T, Murakami K, Kotani Y, Abiko K, Mikami Y, Mandai M, Matsumura N

  Gynecologic oncology ( Gynecologic Oncology )  200   112 - 121   2025.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  OBJECTIVE: To validate the clinical utility of the Silva classification (a risk-stratification system based on invasion pattern for HPV-associated cervical adenocarcinoma; HPVA) using Japanese cohort data; and to determine how HPV-independent adenocarcinoma (HPVI) should be positioned relative to Silva-classified HPVA. METHODS: We retrospectively analyzed 264 cases of surgically treated FIGO 2008 stage I-II cervical adenocarcinoma from eight institutions participating in the KAMOGAWA Study. Tumors were classified as HPVA or HPVI. HPVA cases were further categorized as low-risk or high-risk using the binary Silva classification, which incorporates invasion pattern and lymphovascular space invasion. Outcome measures included lymph node metastasis, disease-free survival (DFS), and overall survival (OS). RESULTS: Of the 264 cases, 27 % were classified as low-risk HPVA, 49 % as high-risk HPVA, and 23 % as HPVI. Lymph node metastasis was observed in 0 %, 12 %, and 38 % of cases, respectively (p < 0.001). The 5-year DFS was 98 %, 83 %, and 53 %, and the 5-year OS was 100 %, 97 %, and 63 % (both p < 0.001). Multivariable analysis showed that low-risk HPVA was associated with longer DFS (HR 0.12, 95 % CI 0.015-0.87) and HPVI was associated with shorter DFS (HR 2.76, 95 % CI 1.44-5.30), after adjusting for tumor size (≤2 cm, 2-4 cm, >4 cm) and age. Tumor size >4 cm, but not ≤2 cm was an independent prognostic factor. CONCLUSIONS: The three-tier system combining the histotype and binary Silva classification outperformed tumor size in prognostic stratification. The low-risk group showed excellent outcomes, supporting the potential for conservative management such as uterine preservation after conization.

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• Immune cell densities, HLA status, and PD-L1 expression in stage I neuroendocrine neoplasm of the uterine cervix.

  Yamada R, Kawakami F, Maeda N, Nagao S, Yamamoto M, Motohara T, Kondoh E, Mikami Y, Komohara Y

  Pathology, research and practice ( Pathology Research and Practice )  273   156146 - 156146   2025.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Neuroendocrine neoplasms (NENs) of the uterine cervix are highly malignant tumors associated with a poor prognosis. Human papillomavirus test-based uterine cervical cancer screening methods can detect early-stage uterine cervical NENs, so therapeutic strategies for the earliest stages are urgently needed. This study aimed to investigate and evaluate the prognostic significance of intratumoral and stromal immune cell densities, as well as human leukocyte antigen (HLA) and programmed cell death ligand 1 (PD-L1) expression in stage I uterine cervical NENs. Sixteen NENs were identified, including 8 large cell neuroendocrine carcinomas (LCNECs), 4 small cell neuroendocrine carcinomas (SCNECs), 3 neuroendocrine tumors (NETs), and 1 LCNEC with an SCNEC component. Only 3 cases were pure NENs, while 13 cases included a component of adenocarcinoma or squamous cell carcinoma. Eight of the 16 patients experienced postoperative recurrence. The recurrence-free group exhibited significantly higher densities of intratumoral CD3- and CD8-positive cells compared to the recurrence group (median densities: 136 vs. 48 cells/mm2, P = 0.0281 and 91 vs. 27 cells/mm2, P = 0.0359, respectively). No significant differences in clinicopathological characteristics, other immune cell densities, or expression of HLA class I, HLA-DR, or PD-L1 were observed between groups. HLA-DR expression was nearly absent in uterine cervical NENs, whereas adjacent non-NEN components displayed varying degrees of HLA-DR expression. PD-L1 expression was observed in 25 % of cases, with CD3- and CD8-positive T-cell-rich stroma. The observed modifications to tumor microenvironments could offer clues to future treatments for uterine cervical NEN. (240/250 words).

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• A Rare Case of Brain Metastasis of Gastric Neuroendocrine Carcinoma.

  Hori R, Shinojima N, Fujimoto K, Yoshii D, Uetani H, Fukugawa Y, Kawakami F, Mikami Y, Oya N, Hirai T, Mukasa A

  Cureus   17 ( 5 ) e83417   2025.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Gastric neuroendocrine carcinoma (small cell neuroendocrine carcinoma [small cell NEC]) is a rare type of gastric cancer that is rarely encountered in clinical practice. Although solitary brain metastasis from gastric cancer is exceptionally rare, we present a case of solitary brain metastasis of gastric NEC. The patient was a 71-year-old man who had undergone surgery and chemotherapy for gastric NEC two years prior. During follow-up, computed tomography (CT) scans of the neck, chest, abdomen, and pelvis, along with tumor marker evaluations, revealed no evidence of metastasis. However, he developed left homonymous hemianopsia, prompting a head CT and magnetic resonance imaging (MRI). Imaging revealed a subcortical hemorrhage in the right temporal lobe and tumors in two locations: the right temporal lobe and the upper surface of the cerebellum. Tumor resection and hematoma removal were performed for diagnostic and decompressive purposes. Histopathological examination confirmed the diagnosis of brain metastasis from gastric NEC. Brain metastases from gastric cancer are rare, and to the best of our knowledge, only one English-language case report of solitary brain metastasis from gastric NEC has been published. We report this case and provide a discussion based on the available literature.

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• A Case of Leiomyoadenomatoid Tumor of the Epididymis Mimicking Epithelioid Mesothelioma.

  Sanematsu A, Teruya K, Nabeshima K, Tanaka K, Inokuchi J, Nishie A, Kawakami F

  Pathology international ( Pathology International )  75 ( 5 ) 251 - 253   2025.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Medical DX in the Pathology Department: A Start from Glass Slide Logistics Management

  川上史, 川上史, 中谷有作, 久保山澄玲, 上田真彦, 伊豆味由紀子, 玉城真太, 瑞慶覧陽子, 和田直樹

  日本病理学会会誌   114 ( 1 )   2025  [Refereed]

   

  J-GLOBAL

• 心筋生検におけるアミロイド沈着の定量化における観察者間格差の検討(Interobserver reproducibility of quantitative amyloid load interpretation on endomyocardial biopsy)

  川上 史, 高潮 征爾, 大園 一隆, 塩田 拓也, 山田 倫, 大倉 航平, 田中 一仁, 三上 芳喜

  日本病理学会会誌 ( (一社)日本病理学会 )  113 ( 1 ) 307 - 307   2024.02  [Refereed]

   

• Pathologic Changes of Placenta from COVID-19 Patients: Study of 22 Cases

  横尾貴保, 川上史, 三上芳喜

  日本病理学会会誌   112 ( 1 ) 350 - 350   2023.03  [Refereed]

   

  J-GLOBAL

• A case of chronic histiocytic intervillositis associated with COVID-19

  横尾貴保, 山田倫, 川上史, 菰原義弘, 三上芳喜

  診断病理   39 ( 3 ) 230 - 234   2022  [Refereed]

   

  J-GLOBAL

• A case of primary peritoneal adenomatoid tumor diagnosed via intraoperative consultation

  横尾貴保, 川上史, 大園一隆, 三上芳喜

  診断病理   38 ( 1 )   2021  [Refereed]

   

  J-GLOBAL

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• Grant-in-Aid for Scientific Research(C)

  Project Year: 2025.04  -  2028.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Does the distinctive soil composition and distribution in Okinawa Prefecture influence the clinical course of idiopathic interstitial pneumonia?

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2025.04  -  2028.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Young Scientists(S)

  Project Year: 2023.04  -   

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

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• 2026.01

  　

  　

  

• 2025.10

  　

  　

  

• 2025.09

  　

  　

  

• 2025.07