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• 中枢神経系原発悪性リンパ腫の胚中心型(GCB型)についての臨床病理学的検討(Clinicopathologic analysis of GCB subtype of primary central nervous system lymphoma)

  吉井 大貴, 竹島 裕貴, 篠島 直樹, 宮里 裕子, 塩田 拓也, 川上 史, 本田 由美, 藤本 健二, 武笠 晃丈, 三上 芳喜

  日本病理学会会誌 ( (一社)日本病理学会 )  113 ( 1 ) 317 - 317   2024.02 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

• Endometrial gastric-type mucinous carcinoma: A clinicopathological study of an unfavorable histological type of endometrial carcinoma.

  Fumi Kawakami, Ken Yamaguchi, Sachiko Minamiguchi, Tamotsu Sudo, Takanori Hirose, Norihiro Teramoto, Yoshiki Mikami

  Pathology international     2023.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Comprehensive Cancer Genomic Profiling of Liver Metastasis Led to the Unexpected Identification of Colorectal Cancer.

  Hideaki Miyamoto, Fumi Kawakami, Sakiko Abe, Hiroki Sugita, Hirotaka Matsui

  Internal medicine (Tokyo, Japan)     2023.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Comprehensive genomic profiling (CGP) of a metastatic liver tumor biopsy specimen suggested that the patient, who was initially diagnosed with cholangiocarcinoma, had colorectal cancer. The identification of both FBXW7 and APC mutations is deemed characteristic of colorectal cancer. Indeed, subsequent colonoscopy revealed sigmoid colon carcinoma that led to tumor resection followed by systemic chemotherapy. CGP is principally used to identify agents that might potentially benefit the patient. However, results must be interpreted carefully to ensure consistency with the initial diagnosis.

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• Hyalinizing clear cell carcinoma with EWSR1 rearrangement in an 11-year-old girl

  Keisuke Yamana, Kenta Kawahara, Fumi Kawakami, Yumi Honda, Kohei Ishikawa, Kosuke Shinohara, Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Natsuko Kimoto, Toshitaka Nagao, Yoshiki Mikami, Hideki Nakayama

  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   35 ( 3 ) 258 - 263   2023.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Hyalinizing clear cell carcinoma is a low-grade salivary gland carcinoma of epithelial origin comprised of malignant cells with clear cytoplasm and often surrounded by hyalinizing stroma. Hyalinizing clear cell carcinoma reportedly occurs in patients with a wide range of ages; however, no reports have been published in children. We herein report a rare case of hard palate hyalinizing clear cell carcinoma with EWSR1 rearrangement in an 11-year-old girl. The patient was referred to our hospital for further evaluation of a growing tumor in the hard palate. After performing biopsy, clear cell odontogenic carcinoma was suspected, although a definitive diagnosis could not be reached. The lesion was clinically suspected to be a salivary gland tumor and resected under general anesthesia. Histopathological evaluation revealed minor salivary gland carcinoma with clear cells and hyalinizing stroma with identification of EWSR1 rearrangement by fluorescence in situ hybridization. Thus, we diagnosed this patient with hyalinizing clear cell carcinoma. Hyalinizing clear cell carcinoma in children is rare, and there has been no evidence of recurrence or metastasis in our patient at 36 months postoperatively.

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• Immunosensitivity and specificity of insulinoma-associated protein 1 (INSM1) for neuroendocrine neoplasms of the uterine cervix.

  Shiho Kuji, Akira Endo, Manabu Kubota, Atsushi Uekawa, Fumi Kawakami, Yoshiki Mikami, Junki Koike, Nao Suzuki

  Journal of gynecologic oncology     2022.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  OBJECTIVE: Previously, we reported that insulinoma-associated protein 1 (INSM1) immunohistochemistry (IHC) showed high sensitivity for neuroendocrine carcinoma of the uterine cervix and was an effective method for histopathological diagnosis, but that its specificity remained to be verified. Therefore, the aim was to verify the specificity of INSM1 IHC for a large number of non-neuroendocrine neoplasia (NEN) of the cervix. METHODS: RNA sequences were performed for cell lines of small cell carcinoma (TCYIK), squamous cell carcinoma (SiHa), and adenocarcinoma (HeLa). A total of 104 cases of formalin-fixed and paraffin-embedded specimens, 16 cases of cervical NEN and 88 cases of cervical non-NEN, were evaluated immunohistochemically for conventional neuroendocrine markers and INSM1. All processes without antigen retrieval were performed by an automated IHC system. RESULTS: The transcripts per million levels of INSM1 in RNA sequences were 1505 in TCYIK, 0 in SiHa, and HeLa. INSM1 immunoreactivity was shown only in the TCYIK. Immunohistochemical results showed that 15 cases of cervical NEN showed positive for INSM1; the positivity score of the tumor cell population and the stain strength for INSM1 were high. Two of the 88 cases of cervical non-NENs were positive for INSM1 in one case each of typical adenocarcinoma and squamous cell carcinoma. The sensitivity of INSM1 for cervical NEN was 94%; specificity, 98%; the positive predictive value, 88%; and the negative predictive value, 99%. CONCLUSION: INSM1 is an adjunctive diagnostic method with excellent specificity and sensitivity for diagnosing cervical NEN. Higher specificity can be obtained if morphological evaluation is also performed.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• A case of chronic histiocytic intervillositis associated with COVID-19

  横尾貴保, 山田倫, 川上史, 菰原義弘, 三上芳喜

  診断病理   39 ( 3 ) 230 - 234   2022  [Refereed]

   

  J-GLOBAL

• A case of primary peritoneal adenomatoid tumor diagnosed via intraoperative consultation

  横尾貴保, 川上史, 大園一隆, 三上芳喜

  診断病理   38 ( 1 )   2021  [Refereed]

   

  J-GLOBAL

• Significance of p16 immunohistochemistry to improve HSIL detection in our hospital

  大園一隆, 川上史, 三上芳喜

  日本病理学会会誌   109 ( 1 )   2020  [Refereed]

   

  J-GLOBAL

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Young Scientists(S)

  Project Year: 2023.04  -   

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2025.03 

  Direct: 3,000,000 (YEN)  Overheads: 3,900,000 (YEN)  Total: 900,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 2,200,000 (YEN)  Overheads: 2,860,000 (YEN)  Total: 660,000 (YEN)