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• 脳神経外科学

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• Early-generated preplate neurons in the developing telencephalon: inward migration into the developing striatum. Cerebral Cortex 11(5):474-84, 2001.

  2001年03月 

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• A Consideration of Optimal Head Position in Transsylvian Selective Amygdalohippocampectomy.

  Tadashi Hamasaki, Hiroki Uchikawa, Tatsuya Kawano, Keitaro Kai, Tastuya Takezaki, Akitake Mukasa

  Neurologia medico-chirurgica   63 ( 7 ) 265 - 272   2023年07月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  Transsylvian selective amygdalohippocampectomy (TSA) is one of the predominant surgical options for drug-resistant mesial temporal lobe epilepsy. The purpose of this article is to highlight the unique features of TSA and determine the setting to perform safe and secure TSA with special reference to the optimal head position. TSA should be performed via a small surgical corridor in the temporal stem that contains functionally important fiber tracts, including the uncinate fasciculus, the inferior fronto-occipital fasciculus, and the optic radiation. Graphical simulations proposed that low-degree (<30°) head rotation had the advantage of sufficiently opening the surgical field in TSA and may help surgical procedures within the limited exposure of the medial temporal structures. Inspection of the surgical videos implied that the collapse of the inferior horn was prevented in low-degree rotation, probably because the deformation due to the brain shift was minimized in the medial temporal structures. A simulation also implied that chin-up position had the advantage of resecting the tail of the hippocampus in a straightforward manner. We suggest that the setting is optimized in TSA with low-degree rotation and chin-up head position.

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• Accelerating TOF-MRA: The impact of the combined use of compressed sensitivity encoding and spiral imaging.

  Kosuke Morita, Hiroyuki Uetani, Takeshi Nakaura, Masami Yoneyama, Yasunori Nagayama, Masafumi Kidoh, Naoki Shinojima, Tadashi Hamasaki, Akitake Mukasa, Toshinori Hirai

  Magnetic resonance imaging   103   28 - 36   2023年07月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  PURPOSE: To evaluate the image quality of the combined technique of compressed sensitivity encoding (CS) and spiral imaging in time-of-flight magnetic resonance angiography (TOF-MRA), which is approximately 2.5 times faster than conventional methods. METHODS: Twenty volunteers underwent four TOF-MRA sequences: sensitivity encoding (SENSE) with acceleration factor of 4 (acquisition time: 4:55 min), CS with acceleration factor of 10.9, and spiral and CS-spiral (both 1:55 min). A quantitative image analysis (signal-to-noise ratio [SNR], contrast, and full width at half maximum [FWHM] edge criterion measurements) was performed on four TOF sequences. For qualitative image analysis, two board-certified radiologists evaluated the overall depiction of the proximal, intermediate, and distal branches in CS, spiral, and CS-spiral images using SENSE as a reference. RESULTS: The SNR of BA in spiral and CS-spiral imaging was significantly lower than that in SENSE (p = 0.009). The contrasts of ACA and BA in CS-spiral were significantly higher and those in spiral were significantly lower than those in SENSE (p < 0.001). The FWHM in the CS image was significantly higher than that of SENSE; however, no significant differences were observed between the spiral or CS-spiral and SENSE. In qualitative analysis, the depiction of proximal vascular branches was significantly impaired in spiral than in others and that of distal vascular branches was significantly impaired in CS than in others (p < 0.001). CONCLUSIONS: In TOF-MRA, which is approximately 2.5 times faster than conventional methods, the combined use of CS and spiral imaging demonstrated an improvement in image quality compared to either CS or spiral imaging alone. SUMMARY STATEMENT: The image quality of Compressed SENSE and spiral imaging is particularly poor in the proximal and distal vascular branches, respectively at an extremely high acceleration factor; however, CS-spiral provided stable image quality in all regions as compared with the SENSE technique.

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• Importance of Age and Noncontrast-Enhancing Tumor as Biomarkers for Isocitrate Dehydrogenase-Mutant Glioblastoma: A Multicenter Study.

  Hiroyuki Uetani, Minako Azuma, Zaw Aung Khant, Yoshiyuki Watanabe, Kohsuke Kudo, Yoshihito Kadota, Kiyotaka Yokogami, Hideo Takeshima, Jun-Ichiro Kuroda, Naoki Shinojima, Tadashi Hamasaki, Akitake Mukasa, Toshinori Hirai

  Journal of computer assisted tomography     2023年02月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  PURPOSE: This study aimed to investigate the most useful clinical and magnetic resonance imaging (MRI) parameters for differentiating isocitrate dehydrogenase (IDH)-mutant and -wildtype glioblastomas in the 2016 World Health Organization Classification of Tumors of the Central Nervous System. METHODS: This multicenter study included 327 patients with IDH-mutant or IDH-wildtype glioblastoma in the 2016 World Health Organization classification who preoperatively underwent MRI. Isocitrate dehydrogenase mutation status was determined by immunohistochemistry, high-resolution melting analysis, and/or IDH1/2 sequencing. Three radiologists independently reviewed the tumor location, tumor contrast enhancement, noncontrast-enhancing tumor (nCET), and peritumoral edema. Two radiologists independently measured the maximum tumor size and mean and minimum apparent diffusion coefficients of the tumor. Univariate and multivariate logistic regression analyses with an odds ratio (OR) were performed. RESULTS: The tumors were IDH-wildtype glioblastoma in 306 cases and IDH-mutant glioblastoma in 21. Interobserver agreement for both qualitative and quantitative evaluations was moderate to excellent. The univariate analyses revealed a significant difference in age, seizure, tumor contrast enhancement, and nCET (P < 0.05). The multivariate analysis revealed significant difference in age for all 3 readers (reader 1, odds ratio [OR] = 0.960, P = 0.012; reader 2, OR = 0.966, P = 0.048; reader 3, OR = 0.964, P = 0.026) and nCET for 2 readers (reader 1, OR = 3.082, P = 0.080; reader 2, OR = 4.500, P = 0.003; reader 3, OR = 3.078, P = 0.022). CONCLUSIONS: Age and nCET are the most useful parameters among the clinical and MRI parameters for differentiating IDH-mutant and IDH-wildtype glioblastomas.

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• An epileptogenic intracranial cystic lesion lined with fallopian tube-type epithelium: illustrative case.

  Yuji Dekita, Yushin Takemoto, Kazutaka Ozono, Tadashi Hamasaki, Rin Yamada, Yoshiki Mikami, Jun-Ichiro Kuroda, Nobuyuki Tsubota, Akitake Mukasa

  Journal of neurosurgery. Case lessons   5 ( 3 )   2023年01月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  BACKGROUND: Intracranial cystic lesions are often a trigger for epileptic seizures. However, there has never been a report of a cystic lesion lined with fallopian tube-type epithelium. OBSERVATIONS: A 48-year-old female presented with a cystic lesion in the right occipital lobe, which gradually grew over 8 years. Right occipital lobe epilepsy was diagnosed based on visual aura, convulsive seizures, and electroencephalogram findings and the cyst was surgically removed. Further examination revealed the cyst was lined with ciliated cells, which had morphological and immunohistochemical features similar to those of fallopian tube epithelium. LESSONS: The characteristics of the cyst did not conform to any known types of benign cystic lesion. To the authors' knowledge, no such cyst has been reported before. The authors discuss the origins and pathogenesis of this unfamiliar cystic lesion.

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• Whole Tumor Radiomics Analysis for Risk Factors Associated With Rapid Growth of Vestibular Schwannoma in Contrast-Enhanced T1-Weighted Images.

  Takashi Itoyama, Takeshi Nakaura, Tadashi Hamasaki, Tatsuya Takezaki, Hiroyuki Uentani, Toshinori Hirai, Akitake Mukasa

  World neurosurgery   166   e572-e582 - e582   2022年10月 [ 査読有り ]

  掲載種別: 研究論文（学術雑誌）

  　概要を見る

  OBJECTIVE: To investigate the features associated with rapid growth of vestibular schwannoma using radiomics analysis on magnetic resonance imaging (MRI) together with clinical factors. METHODS: From August 2005 to February 2019, 67 patients with vestibular schwannoma underwent contrast-enhanced T1-weighted MRI at least twice as part of their diagnosis. After excluding 3 cases with an extremely short follow-up period of 15 days or less, 64 patients were finally enrolled in this study. Ninety-three texture features were extracted from the tumor image data using 3D Slicer software (http://www.slicer.org/). We determined the texture features that significantly affected maximal tumor diameter growth of more than 2 mm/year using Random Forest and Bounty. We also analyzed age and tumor size as clinical factors. We calculated the areas under the curve (AUCs) using receiver operating characteristic analysis for prediction models using texture, clinical, and mixed factors by Random Forest and 5-fold cross-validation. RESULTS: Two texture features, low minimum signal and high inverse difference moment normalized (Idmn), were significantly associated with rapid growth of vestibular schwannoma. The mixed model of texture features and clinical factors offered the highest AUC (0.69), followed by the pure texture (0.67), and pure clinical (0.63) models. The minimum signal was the most important variable followed by tumor size, Idmn, and age. CONCLUSIONS: Our radiomics analysis found that texture features were significantly associated with the rapid growth of vestibular schwannoma in contrast-enhanced T1-weighted images. The mixed model offered a higher diagnostic performance than the pure texture or clinical models.

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• スマートホスピタルに実装する脳神経疾患急性期患者の状態急変監視システムの開発

  基盤研究(C)

  課題番号: 23K11873

  研究期間: 2023年04月  -  2027年03月 

  代表者: 浜崎 禎, 岳元 裕臣, 山川 俊貴 

  直接経費: 3,700,000（円）  間接経費: 4,810,000（円）  金額合計: 1,110,000（円）