Chinen Takashi

写真a

Title

Special Lecturer
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Hospital   Special Lecturer  

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Published Papers 【 display / non-display 】

  • Prognostic factors of second-line nivolumab monotherapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study for 184 cases.

    Sho Sato, Takashi Suzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Tsutomu Sato, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

    Journal of gastroenterology     2024.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    BACKGROUND: The real-world efficacy, prognostic factors, and adverse events of second-line nivolumab monotherapy and subsequent third-line therapy for unresectable or metastatic esophageal cancer have not been fully evaluated. METHODS: This multi-institutional retrospective cohort study evaluated 184 consecutive patients treated with second-line nivolumab monotherapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, adverse events, long-term survival, and prognostic factors. RESULTS: Among 128 patients with measurable lesions, the response rate was 23% and the disease control rate for all enrolled patients was 45%. The incidence of grade 3 or higher adverse events was 14%, but no treatment-related deaths presented. Median progression-free survival was 5.1 months and overall survival was 14 months, respectively. C-reactive protein level and performance status were identified as significant prognostic factors of overall survival through Cox proportional hazards analysis. The group with two favorable prognostic factors showed better overall survival than the groups with either one or zero prognostic factors (median overall survival: 22, 15, and 4.4 months, respectively). Among 69 patients who received third-line taxane anticancer agents, the progression-free survival was 6.7 months. CONCLUSIONS: Our study demonstrated that the real-world outcomes of second-line nivolumab monotherapy were comparable to those of previous randomized clinical trials in terms of tumor response, safety, and long-term survival. Furthermore, a good performance status and low C-reactive protein levels may identify patients who are likely to benefit from therapy. Third-line chemotherapy after nivolumab treatment may have an enhanced effect; however, further prospective studies are required to confirm this finding.

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  • Combined Intraperitoneal Paclitaxel and Systemic Chemotherapy for Patients with Massive Malignant Ascites Secondary to Pancreatic Cancer: A Report of Two Patients.

    Yoshiyuki Meguro, Hironori Yamaguchi, Hideki Sasanuma, Kentaro Shimodaira, Yuichi Aoki, Takashi Chinen, Kazue Morishima, Hideyo Miyato, Atsushi Miki, Kazuhiro Endo, Alan Kawarai Lefor, Joji Kitayama, Naohiro Sata

    Internal medicine (Tokyo, Japan)   63 ( 14 ) 2015 - 2021   2024.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    The prognosis of patients with peritoneal metastases from pancreatic cancer is poor, largely due to massive ascites, which precludes systemic treatment. Two patients with a poor performance status and malignant ascites were treated with cell-free and concentrated ascites reinfusion therapy followed by combined chemotherapy with intraperitoneal paclitaxel, intravenous gemcitabine, and nab-paclitaxel. These patients achieved a survival of 19 and 36 weeks with a relatively good quality of life. Combined intraperitoneal paclitaxel and systemic chemotherapy may provide effective palliative management for some patients with peritoneal metastases from pancreatic cancer.

  • The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study.

    Sho Sato, Takashi Ssuzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Chikara Kunisaki, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

    International journal of clinical oncology   29 ( 7 ) 994 - 1001   2024.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    BACKGROUND: The real-world efficacy, feasibility, and prognostic factors of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer are not fully established. METHODS: This multi-institutional retrospective cohort study evaluated 71 consecutive patients treated with immune-checkpoint inhibitor combination therapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, safety, and long-term survival. RESULTS: In patients with measurable lesions, the response rate was 58%, and the disease control rate for all enrolled patients was 80%. Five patients (7.0%) underwent successful conversion surgery. Grade 3 or higher immune-related adverse events occurred in 13% of patients, and one patient (1.4%) died due to cholangitis. Median progression-free survival was 9.7 (95% confidence interval: 6.5-not reached). C-reactive protein levels and performance status were identified as significant predictors of progression-free survival through Cox proportional hazards analysis. CONCLUSIONS: Immune-checkpoint inhibitor combination therapy for esophageal cancer demonstrated comparable tumor response, safety, and long-term survival to previous randomized clinical trials. Patients with good performance status and low C-reactive protein levels may be suitable candidates for this treatment.

  • 膵癌による大量の悪性腹水を認める患者に対する腹腔内パクリタキセルと全身化学療法の併用　2症例報告(Combined Intraperitoneal Paclitaxel and Systemic Chemotherapy for Patients with Massive Malignant Ascites Secondary to Pancreatic Cancer: A Report of Two Patients)

    Meguro Yoshiyuki, Yamaguchi Hironori, Sasanuma Hideki, Shimodaira Kentaro, Aoki Yuichi, Chinen Takashi, Morishima Kazue, Miyato Hideyo, Miki Atsushi, Endo Kazuhiro, Kawarai Lefor Alan, Kitayama Joji, Sata Naohiro

    Internal Medicine ( (一社)日本内科学会 )  63 ( 14 ) 2015 - 2021   2024.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    症例1は57歳女性で、進行膵癌で、大量の腹水を認め、腹膜癌腫症が明らかとなった。ECOG PSは2であった。無細胞腹水濾過濃縮再静注法(CART)を実施後、ゲムシタビン+nab-パクリタキセル静注と腹腔内パクリタキセル投与による併用化学療法を行った。併用化学療法を2コース実施後、病勢安定を達成した。併用化学療法は16週で4コースを実施後に中止し、その3週後に死亡した。治療開始からの生存期間は19週であった。症例2は58歳男性で、進行膵癌と悪性腹水を認め、腹膜癌腫症が明らかとなった。ECOG PSは3であった。利尿薬投与、CART、エドキサバン投与を実施後、ECOG PSが2に改善したため、ゲムシタビン+nab-パクリタキセル静注と腹腔内パクリタキセル投与による併用化学療法を行った。2ヵ月後、部分奏効を達成した。併用化学療法は30週で8コースを実施後に中止し、その4週後に死亡した。治療開始からの生存期間は36週であった。

  • Successful Prompt Diagnosis of Strongyloidiasis in an Outpatient Setting at Amami Oshima Island in Japan: A Case Report.

    Takashi Chinen, Manabu Kameyama, Kensuke Minami

    Cureus   16 ( 4 ) e58851   2024.04 [ Peer Review Accepted ]

    Type of publication: Research paper (other science council materials etc.)

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    Strongyloidiasis is a parasitic infection caused by the nematode Strongyloides stercoralis that presents with a variety of nonspecific symptoms. Diagnosis is challenging unless physicians suspect this disease and perform sensitivity tests. We report a case of strongyloidiasis with protein-losing gastroenteropathy-like symptoms in a 92-year-old Japanese female with lower extremity edema and hypoalbuminemia. In this case, the patient refused invasive tests for a complete examination; however, an agar plate culture of a stool sample was used to diagnose strongyloidiasis. The patient was treated with ivermectin during the second visit. One month later, leg edema and hypoproteinemia improved. When the cause of the symptoms is unclear, physicians should be aware of the possibility of strongyloidiasis in a person residing in a tropical or subtropical environment, where human feces are used as fertilizer and individuals frequently go barefoot in agricultural settings.

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Presentations 【 display / non-display 】

  • 胃癌腹膜播種に対するパクリタキセル腹腔内投与併用化学療法

    山口 博紀, 風當 ゆりえ, 加賀谷 丈紘, 金丸 理人, 高橋 和也, 松本 志郎, 倉科 憲太郎, 齋藤 心, 知念 崇, 宮戸 秀世, 大澤 英之, 細谷 好則, 北山 丈二, 佐田 尚宏

    日本癌治療学会学術集会抄録集  1900.01  -  1900.01 

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