Oshiro Ayano

写真a

Title

Assistant Professor
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Hospital   Assistant Professor  

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Published Papers 【 display / non-display 】

  • Evaluation of Melanin Changes in Acute Vogt-Koyanagi-Harada Disease Using Polarization-Sensitive Optical Coherence Tomography.

    Oshiro A, Imanaga N, Terao N, Yamanari M, Totani K, Sugiyama S, Koizumi H

    Investigative ophthalmology & visual science ( Investigative Ophthalmology and Visual Science )  67 ( 1 ) 7 - 7   2026.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    PURPOSE: To examine melanin changes in the RPE and choroid during the acute phase of Vogt-Koyanagi-Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). METHODS: This study included 15 eyes of 8 patients with new-onset VKH disease and 5 eyes of 3 patients with posterior scleritis. PS-OCT captured a 12 × 12 mm area centered on the fovea, and en face images were created for the RPE and choroid. Polarimetric entropy within a 6-mm diameter circle centered on the fovea was calculated and compared between groups. RESULTS: Choroidal polarimetric entropy was significantly lower in eyes with VKH disease than in those with posterior scleritis at baseline (0.296 ± 0.047 vs. 0.392 ± 0.050; P = 0.005; r = 0.64; 95% confidence interval, 0.42-0.74). One month after starting treatment, eyes with VKH disease showed a significant increase in choroidal polarimetric entropy (0.296 ± 0.047 to 0.350 ± 0.075; P = 0.001; r = 0.85; 95% confidence interval, 0.61-0.95), whereas no significant change was observed in eyes with posterior scleritis. RPE polarimetric entropy showed no significant changes between baseline and 1 month, with no differences between groups. CONCLUSIONS: PS-OCT revealed that choroidal melanin density decreased during the acute phase of VKH disease and significantly increased after treatment. PS-OCT provides a noninvasive method for observing melanin dynamics in VKH disease and aids in differentiating it from posterior scleritis. PS-OCT could offer valuable insights into the pathology of VKH disease and its potential implications for management.

  • Polarization-Sensitive OCT Reveals Acute Melanin Changes in Vogt-Koyanagi-Harada Disease

    Oshiro, A; Imanaga, N; Terao, N; Miyara, Y; Maehira, M; Yamanari, M; Totani, K; Sugiyama, S; Koizumi, H

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   66 ( 8 )   2025.06 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • One-year choroidal thickness changes after photodynamic therapy for central serous chorioretinopathy evaluated by widefield optical coherence tomography

    Sawaguchi, S; Terao, N; Imanaga, N; Wakugawa, S; Miyara, Y; Oshiro, A; Maehira, M; Yamauchi, Y; Koizumi, H

    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY ( Graefe S Archive for Clinical and Experimental Ophthalmology )  262 ( 12 ) 3805 - 3814   2024.12 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    PURPOSE: To evaluate the changes in choroidal thickness 1 year after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using widefield swept-source optical coherence tomography. METHODS: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes. RESULTS: All 21 treated eyes showed complete resolution of subretinal fluid at 3 months after PDT, without any recurrence at 12 months. The mean choroidal thickness in all nine areas significantly decreased after PDT at 3 months (P < 0.05) and remained unchanged at 12 months (P < 0.05) compared with that at baseline. However, the subtracted choroidal thickness maps between 3 and 12 months detected significant variations among the cases, classified into an enhanced pattern in 10 eyes (47.6%), an attenuated pattern in six eyes (28.6%), and a stable pattern in five eyes (23.8%). The 21 untreated fellow eyes also showed a decrease in mean choroidal thickness in three of the nine subdivided areas at 12 months (P < 0.05), but this decrease was limited posteriorly. CONCLUSION: The reduction in mean choroidal thickness after half-dose PDT for CSC was extensively maintained for 1 year. However, subclinical hemodynamic changes in the entire choroid occurred longitudinally even in the absence of disease recurrence.

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  • CHANGES IN SCLERAL THICKNESS IN THE ACUTE PHASE OF VOGT-KOYANAGI-HARADA DISEASE

    Oshiro, A; Imanaga, N; Terao, N; Koizumi, H

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  44 ( 8 ) 1344 - 1350   2024.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    PURPOSE: To evaluate changes in scleral thickness in Vogt-Koyanagi-Harada (VKH) disease. METHODS: This study included 34 eyes of 17 treatment-naïve patients with acute-phase VKH disease. Scleral thickness and the presence of ciliochoroidal effusion were examined using anterior segment optical coherence tomography at baseline and 1 week, 2 weeks, and 12 weeks after the start of corticosteroid treatment. Scleral thickness was measured 6 mm posterior to the scleral spur in four directions. RESULTS: Twenty-eight eyes (82.4%) initially had ciliochoroidal effusion, but this rapidly decreased to nine eyes (26.5%) after 1 week. The sclera with ciliochoroidal effusion became thinner from baseline to 1 week at the superior (400.2 ± 46.9-353.5 ± 47.9 µm), temporal (428.4 ± 53.6-387.8 ± 56.1 µm), inferior (451.5 ± 71.0-400.5 ± 50.5 µm), and nasal (452.4 ± 78.0-407.6 ± 62.9 µm) points (P < 0.01 for all), and no further changes were observed. The sclera without ciliochoroidal effusion remained unchanged. CONCLUSION: In VKH disease, eyes with ciliochoroidal effusion exhibited the maximum scleral thickness during the acute phase. This thickening responded rapidly to treatment and became thinner within 1 week. Inflammation in VKH disease may affect not only the choroid but also the sclera.

  • Scleral Thickness in Simple Versus Complex Central Serous Chorioretinopathy

    Imanaga, N; Terao, N; Wakugawa, S; Miyara, Y; Sawaguchi, S; Oshiro, A; Yamauchi, Y; Koizumi, H

    AMERICAN JOURNAL OF OPHTHALMOLOGY ( American Journal of Ophthalmology )  261   103 - 111   2024.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    PURPOSE: To evaluate the association between scleral thickness and a newly developed multimodal imaging-based classification of central serous chorioretinopathy (CSC). DESIGN: Retrospective, cross-sectional study. METHODS: This study included 217 eyes of 217 patients classified as simple or complex CSC based on the established protocols. Clinical and anatomical factors were compared between the 2 types. The scleral thickness was measured at 4 locations using anterior-segment optical coherence tomography. RESULTS: Of the 217 eyes, 167 were classified as simple CSC and 50 as complex CSC. The complex CSC group showed older age (P = .011), higher male ratio (P = .001), more bilateral involvement (P < .001), poorer visual acuity (P < .001), greater subfoveal choroidal thickness (P = .025), and higher frequency of loculation of fluid (P < .001) and ciliochoroidal effusion (P < .001) than the simple CSC group. The complex CSC group had significantly greater scleral thicknesses in the superior, temporal, inferior, and nasal directions (all P < .001) than the simple CSC group. Multivariable analysis revealed that older age (odds ratio [OR] 1.054, 95% confidence interval [CI] 1.013-1.097, P < .001), male sex (OR 10.445, 95% CI 1.151-94.778, P < .001), bilateral involvement (OR 7.641, 95% CI 3.316-17.607, P < .001), and the mean value of scleral thicknesses in 4 directions (OR 1.022, 95% CI 1.012-1.032, P < .001) were significantly associated with the complex CSC. CONCLUSIONS: Older age, male sex, bilateral involvement, and thick sclera were associated with the complex CSC. Scleral thickness seemed to determine the clinical manifestations of CSC.

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Research Activity start-up

    Project Year: 2025.07  -  2027.03 

    Direct: 2,100,000 (YEN)  Overheads: 2,730,000 (YEN)  Total: 630,000 (YEN)

  • Grant-in-Aid for Research Activity start-up

    Project Year: 2025.07  -  2027.03 

    Direct: 2,100,000 (YEN)  Overheads: 2,730,000 (YEN)  Total: 630,000 (YEN)

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