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• Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Kyoko Jinnai, Shu Kondo, Akira Nakamura, Yoichi Hayakawa, Ryusuke Niwa

  Proceedings of the National Academy of Sciences ( National Academy of Sciences )  127 ( 37 )   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10.

  Masaya Ono, Takashi Matsumura, Eui Jae Sung, Takashi Koyama, Masanori Ochiai, Stephen B Shears, Yoichi Hayakawa

  Insect Biochemistry and Molecular Biology ( Elsevier )  167   104086 - 104086   2024.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Growth-blocking peptide (GBP), an insect cytokine, was first found in armyworm Mythimna separata. A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species. SRP gene expression has been demonstrated to be enhanced by GBP, indicating that both cytokines are organized within a hierarchical regulatory network. Although GBP1 (CG15917) and GBP2 (CG11395) have been identified in Drosophila melanogaster, immunological functions have only been characterized for GBP1. It is expected that the biological responses of two structurally similar peptides should be coordinated, but there is little information on this topic. Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila S2 cells. Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor gene, Mthl10. Furthermore, treatment of S2 cells with GBP2 enhanced GBP1 expression levels, but GBP1 did not affect GBP2 expression. GBP2 derived enhancement of GBP1 expression was not observed in the presence of GBP1, indicating that GBP2 is an upstream expressional regulator of a GBP1/GBP2 cytokine network. GBP2-induced enhancement of GBP1 expression was not observed in Mthl10 knockdown cells. Enhancement of GBP2 expression was observed in both Drosophila larvae and S2 cells under heat stress conditions; expressional enhancement of both GBP1 and GBP2 was eliminated in Mthl10 knockdown cells and larvae. Finally, Ca2+ mobilization assay in GCaMP3-expressing S2 cells demonstrated that GBP2 mobilizes Ca2+ upstream of Mthl10. Our finding revealed that Drosophila GBP1 and GBP2 control immune responses as well as their own expression levels through a hierarchical cytokine network, indicating that Drosophila GBP1/GBP2 system can be a simple model that is useful to investigate the detailed regulatory mechanism of related cytokine complexes.

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• N‐acetyloxfenicine strongly induces mitohormesis in mice as well as in insects

  Takashi Matsumura, Masaya Ono, Satoshi Osada, Fumikazu Matsuhisa, Masanori Ochiai, Yoichi Hayakawa

  FEBS Letters ( Federation of European Biochemical Societies )    2023.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Stress-derived reactive oxygen species enable hemocytes to release activator of growth blocking peptide (GBP) processing enzyme

  Hitoshi Matsumoto, Masanori Ochiai, Erina Imai, Takashi Matsumura, Yoichi Hayakawa

  Journal of Insect Physiology ( Elsevier )  131   104225 - 104225   2021.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Abnormal increases in reactive oxygen species in dying insects infected with nematodes

  Urara Tonogawa, Takashi Matsumura, Masaya Ono, Toyoshi Yoshiga

  Archives of Insect Biochemistry and Physiology ( Wiley )  106 ( 2 )   2020.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Shu Kondo, Yoichi Hayakawa, Ryusuke Niwa

  2025.11  -  2025.11 

• Stress-induced organismal death is genetically programed by the mTOR-Zeste-Phae1 axis

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Shu Kondo, Akira Nakamura, Yoichi Hayakawa, Ryusuke Niwa

  The 16th Japanese Drosophila Research Conference  2024.09  -  2024.09 

• A genetic program promotes stress-induced organismal death in the fruit fly Drosophila melanogaster

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Shu Kondo, Akira Nakamura, Yoichi Hayakawa, Ryusuke Niwa

  XXVII International Congress of Entomology  2024.08  -  2024.08 

• The Zeste-Phae1 axis is responsible for stress-induced organismal death in the fruit fly Drosophila melanogaster

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Shu Kondo, Yoichi Hayakawa, Ryusuke Niwa

  The 67th Annual Meeting of the Japanese Society of Applied Entomology and Zoology  1900.01  -  1900.01 

• The induction of organismal death requires Zeste-mediated transcriptional up-regulation of a stress-responsive protease gene Phaedra1

  Takashi Matsumura, Masasuke Ryuda, Hitoshi Matsumoto, Takumi Kamiyama, Shu Kondo, Yoichi Hayakawa, Ryusuke Niwa

  Japan Drosophila Research Conference 15  1900.01  -  1900.01 

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• 93rd Annual Meeting of the Japanese Biochemical Society, Young Presenter Award

  2020   The Japanese Biochemical Society  

  Winner: Takashi Matsumura

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Grant-in-Aid for Scientific Research 【 display / non-display 】

• Analysis of lethal stress response in insects

  Grant-in-Aid for JSPS Fellows

  Project Year: 2021.04  -  2024.03 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

• Analysis of stress response in insects

  Grant-in-Aid for JSPS Fellows

  Project Year: 2019.04  -  2021.03 

  Direct: 2,300,000 (YEN)  Overheads: 2,300,000 (YEN)  Total: 0 (YEN)