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Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• A novel cell source for therapy of knee osteoarthritis using atelocollagen microsphere-adhered adipose-derived stem cells: Impact of synovial fluid exposure on cell activity

  Sakamoto, T; Fuku, A; Horie, T; Kitajima, H; Nakamura, Y; Tanida, I; Sunami, H; Hirata, H; Tachi, Y; Iida, Y; Yamada, S; Yamamoto, N; Shimizu, Y; Ishigaki, Y; Ichiseki, T; Kaneuji, A; Osawa, S; Kawahara, N

  REGENERATIVE THERAPY ( Regenerative Therapy )  27   408 - 418   2024.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Analysis of reconstructed oropharynx shape after total glossolaryngectomy reconstruction using a free rectus abdominis musculocutaneous flap

  Hirayama, T; Shimizu, Y; Kinjo, H; Agena, S; Hirakawa, H; Maeda, H; Suzuki, M; Kuba, R; Ishihara, S; Matsuura, N

  JPRAS OPEN ( JPRAS Open )  41   52 - 60   2024.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Subpial transplantation of adipose-derived stem cells alleviates paraplegia in a rat model of aortic occlusion/reperfusion-induced spinal cord infarction

  Takahara, E; Kamizato, K; Kakinohana, M; Sunami, H; Kise, Y; Furukawa, K; Ntege, EH; Shimizu, Y

  REGENERATIVE THERAPY ( Regenerative Therapy )  26   611 - 619   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Optimizing mesenchymal stem cell extracellular vesicles for chronic wound healing: Bioengineering, standardization, and safety

  Shimizu, Y; Ntege, EH; Inoue, Y; Matsuura, N; Sunami, H; Sowa, Y

  REGENERATIVE THERAPY ( Regenerative Therapy )  26   260 - 274   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Chronic wounds represent a significant global burden, afflicting millions with debilitating complications. Despite standard care, impaired healing persists due to factors like persistent inflammation and impaired tissue regeneration. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) offer an innovative regenerative medicine approach, delivering stem cell-derived therapeutic cargo in engineered nanoscale delivery systems. This review examines pioneering bioengineering strategies to engineer MSC-EVs into precision nanotherapeutics for chronic wounds. Emerging technologies like CRISPR gene editing, microfluidic manufacturing, and biomimetic delivery systems are highlighted for their potential to enhance MSC-EV targeting, optimize therapeutic cargo enrichment, and ensure consistent clinical-grade production. However, key hurdles remain, including batch variability, rigorous safety assessment for potential tumorigenicity, immunogenicity, and biodistribution profiling. Crucially, collaborative frameworks harmonizing regulatory science with bioengineering and patient advocacy hold the key to expediting global clinical translation. By overcoming these challenges, engineered MSC-EVs could catalyze a new era of off-the-shelf regenerative therapies, restoring hope and healing for millions afflicted by non-healing wounds.

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• Exploring SSEA3 as an emerging biomarker for assessing the regenerative potential of dental pulp-derived stem cells

  Shirakawa, J; Ntege, EH; Takemura, M; Miyamoto, S; Kawano, T; Sampei, C; Kawabata, H; Nakamura, H; Sunami, H; Hayata, T; Shimizu, Y

  REGENERATIVE THERAPY ( Regenerative Therapy )  26   71 - 79   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Books 【 display / non-display 】

Books 【 display / non-display 】

• Adipose tissue-derived regenerative cell-based therapies: Current optimisation strategies for effective treatment in aesthetic surgery.

  Yusuke Shimizu, Ntege Edward, Hiroshi Sunami ( Part: Multiple Authorship )

  Handbook of Stem Cell Therapy. Springer Nature  2022

• Veins of the face and neck

  Yusuke Shimizu ( Part: Multiple Authorship )

  Anatomy for plastic surgery of the face, head and neck. Thieme Medical Publishers Inc.  2016

• Section 3. Surgery. Surgical treatment of blepharoptosis in myasthenic patients.

  Yusuke Shimizu ( Part: Other )

  Novel Challenges in Myasthenia Gravis. Nova Science Publishers.  2015

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Best paper for Archives of Plastic Surgery (APS) award

  2022    

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2029.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Three-dimensional Morphological Visualization of Human Collective Lymphatic Vessels to Elucidate Lymphedema Mechanisms

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Optimizing lymphatic vessel regeneration through adipose-derived stromal cell-mediated organelle transfer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

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