Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

University 【 display / non-display 】

University 【 display / non-display 】

Graduate School 【 display / non-display 】

Graduate School 【 display / non-display 】

Study abroad experiences 【 display / non-display 】

Study abroad experiences 【 display / non-display 】

Academic degree 【 display / non-display 】

Academic degree 【 display / non-display 】

External Career 【 display / non-display 】

External Career 【 display / non-display 】

display all >>

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

display all >>

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

display all >>

Research Theme 【 display / non-display 】

Research Theme 【 display / non-display 】

• Biology and Biochemistry of Reactive Oxygen, Nitrogen, Sulfur species

• Antioxidant system in Plants

• Bioremedation in Subtropical Environment

• Study on the mechanisms of coral bleaching

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Ascorbate Recycling as a Molecular Redox Capacitor: A Sulfur-Centered Perspective on Dehydroascorbate Reduction in Biological Systems

  Heshiki, R; Mizumoto, KB; Naomasa, RF; Matsumura, T; Yamasaki, H

  CELLS ( Cells )  15 ( 15 ) 1391 - 1391   2026.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Ascorbate (AsA), or vitamin C, is a central redox metabolite that functions as an antioxidant, enzyme cofactor, and electron donor. Its cellular function depends not only on biosynthesis or dietary uptake, but also on rapid recycling from its oxidized forms, monodehydroascorbate (MDHA) and dehydroascorbate (DHA). This requirement is especially evident in high-demand systems such as plant chloroplasts, which face continuous photosynthetic reactive oxygen species (ROS) production under illumination, and human neutrophils, which accumulate millimolar ascorbate to withstand NADPH oxidase-driven oxidative bursts in pathogen defense. Here, we revisit ascorbate recycling from a sulfur-centered perspective. Historical studies of plant, animal, and solution-chemistry pathways show that many DHA-reducing systems converge on sulfur chemistry, including glutathione (GSH), cysteine-dependent enzymes, H2S, and modified thiols. We propose that ascorbate recycling is organized as a multilayered system in which nonenzymatic reactions are accelerated by enzymes, localized within cellular or extracellular compartments, and integrated with broader NAD(P)H-, glutathione-, sulfur-, and diet-dependent redox networks. Within this framework, the AsA/DHA couple can be viewed as a molecular redox capacitor that buffers transient oxidative pressure. Reactive sulfur species (RSS), including persulfides and polysulfides, represent chemically plausible but experimentally unresolved contributors to DHA reduction.

  • Access this article

    DOI
  • Search related information
    PubMed

• Dietary D-Amino Acids as Context-Dependent Contronymic Molecules in Health and Oxidative Stress

  Yamasaki H.

  Nutraceuticals ( Nutraceuticals )  6 ( 1 ) 15   2026.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  • Access this article

    DOI

• Feeding behavior of the kleptoplastic sacoglossan sea slug <i>Plakobranchus ocellatus</i> type black

  Mizumoto Kakeru B., Taira Takanori K., Ueda Yuta, Hirose Euichi, Yamasaki Hideo

  Galaxea, Journal of Coral Reef Studies ( 日本サンゴ礁学会 )  28 ( 1 ) 31 - 32   2026

  Type of publication: Research paper (scientific journal)

  　View Summary

  Time-lapse chlorophyll fluorescence imaging directly visualized the removal of chloroplast-rich cytoplasm from the siphonous green alga Rhipidosiphon javensis during feeding. These observations provide clear evidence of how the kleptoplastic sacoglossan sea slug Plakobranchus ocellatus acquires chloroplasts and offer an intuitive representation of the fundamental process underlying kleptoplasty.

  • Access this article

    DOI
  • Search related information
    CiNii Research

• The Three-Body Problem in Stress Biology: The Balance Between O2, NO, and H2S in the Context of Hans Selye's Stress Concept

  Hideo Yamasaki, Riko F. Naomasa, Kakeru B. Mizumoto, Michael F. Cohen

  Stresses ( MDPI AG )  5 ( 2 ) 37 - 37   2025.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Hans Selye's stress concept, first introduced in the 1930s, has undergone substantial evolution, extending beyond biology and medicine to influence diverse academic disciplines. Initially, Selye's General Adaptation Syndrome (GAS) described nonspecific physiological responses to stressors exclusively in mammals, without addressing other biological systems. Consequently, the concept of stress developed independently in biology and medicine, shaped by distinct physiological contexts. This review provides a historical overview of stress research, highlights both parallels and divergences between the stress responses of plants and animals, and integrates insights from traditional Eastern philosophies. We propose an updated GAS framework that incorporates the dynamic balance among reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) within the broader context of oxidative stress. We highlight the ionotropic glutamate receptor (iGluR) family and the transient receptor potential (TRP) channel superfamily as minimal molecular architectures for achieving GAS. This perspective expands the classical stress paradigm, providing new insights into redox biology, interspecies stress adaptation, and evolutionary physiology.

  • Access this article

    DOI Repository

• Spatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton Homeostasis

  Yamasaki, H; Itoh, RD; Mizumoto, KB; Yoshida, YS; Otaki, JM; Cohen, MF

  ANTIOXIDANTS & REDOX SIGNALING ( Antioxidants and Redox Signaling )  42 ( 7-9 ) 421 - 441   2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  • Access this article

    DOI
  • Search related information
    PubMed

display all >>

Books 【 display / non-display 】

Books 【 display / non-display 】

• Antioxidants - Benefits, Sources, Mechanisms of Action

  Sakihama Y, Yamasaki H ( Part: Allotment Writing ,  Phytochemical Antioxidants: Past, Present and Future )

  IntechOpen  2021.01

  

• Plant organ abscission: from models to crops

  Michael F Cohen, Sushma Gurung, Giovanni Birarda, Hoi-Ying N Holman, Hideo Yamasaki ( Part: Multiple Authorship ,  Bimodal effect of hydrogen peroxide and oxidative events in nitrite-induced rapid root abscission by the water fern Azolla pinnata )

  Frontiers in Plant Science  2017

• Oxidative stress in applied basic research and clinical practice: studies on pediatric disorders

  Yamasaki H, Watanabe NS, Fukuto J, Cohen MF ( Part: Multiple Authorship ,  Nitrite-dependent nitric oxide production pathway: diversity of NO production systems, )

  Springer  2014

• New trends in Okinawan academia 4

  Oshiro S, Oshiro H, Oyakawa K, Yamasaki H, Kawamoto Y, Kina I ( Part: Joint Editing and Writing )

  Okinawa Times  2012.03

• Annual Plant Reviews Volume 42, Nitrogen Metabolism plants in the Post-Genomic Era

  Yamasaki H, Itoh RD, Bouchard JN, Dghim AA, Hossain KK, Gurung, S, Cohen MF ( Part: Multiple Authorship ,  Nitric oxide synthase-like activities in plants )

  Wiley-Blackwell Publishing  2011

display all >>

Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Pleiotropic roles of vitamin C in prevention of COVID-19: How to prevent oral infection of the novel coronavirus

  Hideo Yamasaki

    59 ( 4 ) 165 - 167   2021.04  [Refereed]

   

• Nitrate Paradox in Human Health: Research History of the Reductive Pathway for NO Production

  Hideo Yamasaki

  KASEAA   57 ( 11 ) 686 - 688   2019.11  [Refereed]

   

• Comment 1

  Hideo Yamasaki

  Journal of Tourism Sciences   8   59 - 60   2017.07

   

  DOI

• Nitric oxide research, a key to integrate life and environmental sciences

  Hideo Yamasaki

  Proceedings of US Japan Society for the Promotion of Science Alumni Association ( US JSPS Alumni Association )    14 - 15   2011.03

   

• Long-term effect of eutrophication on the growth and photosynthesis of the reef-building corals stylophora pistillata and Acropora spp.

  Yuen, TS, Yamazaki SS, Nakamura T, Yamasaki H

  琉球大学21世紀COEプログラム「サンゴ礁島嶼系の生物多様性の総合解析」報告書 ( 琉球大学21世紀COEプログラム )    2008.03

   

display all >>

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• Escaping troubled waters: An animal-like stimulus-response behavior in a model plant

  Michael F Cohen, Hideo Yamasaki

  The 12th International NO Conference  2022.10  -  2022.11 

• Yin-Yang of bioactive gaseous molecules: Bridging the gap between Western science and traditional Eastern philosophies

  Hideo Yamasaki

  Special Lecture  (Chinese Culture University, Taiwan)  2018.05  -  2018.05 

• ONS biology for bridging the gaps

  Hideo Yamasaki

  9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide  (Sendai International Center, Sendai, Japan)  2016.05  -  2016.05 

• Nitric oxide research in living organisms

  Hideo Yamasaki

  Special Lecture  (Chinese Culture University, Taiwan)  2014.11  -  2014.11 

• Nitrite as a crossroad of multidisciplines: its past, present and future

  Hideo Yamasaki

  The International Symposium on Food, Nutrition and Vascular Function 2013  ( Tokushima, Japan)  2013.12  -  2013.12 

display all >>

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Investigator(s): Hideo Yamasaki 

  Direct: 3,300,000 (YEN)  Overheads: 990,000 (YEN)  Total: 4,290,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2015.04  -  2018.03 

  Investigator(s): Hideo Yamasaki 

  Direct: 13,000,000 (YEN)  Overheads: 3,900,000 (YEN)  Total: 16,900,000 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2015.04  -  2018.03 

  Direct: 13,000,000 (YEN)  Overheads: 16,900,000 (YEN)  Total: 3,900,000 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2011.04  -  2014.03 

  Investigator(s): Hideo Yamasaki 

  Direct: 9,700,000 (YEN)  Overheads: 2,910,000 (YEN)  Total: 12,610,000 (YEN)

display all >>

Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2015.07

  -

  2017.03

• 2015.07

  -

  2017.03

• 2014.11

  　

  　

• 2014.08

  　

  　

• 2012.09

  -

  2015.03

display all >>

Media Coverage 【 display / non-display 】

Media Coverage 【 display / non-display 】

• 沖縄県自然環境再生指針検討委員会 委員長

  沖縄県  2014.7

Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 日本NO学会 

  2016.6

  　

  　

• 沖縄科学技術大学院大学(OIST) 

  2014.11

  　

  　

• 沖縄県 

  2014.8

  　

  　

• 日本植物学会 

  2013.1

  -

  2018.12

  種別： Academic society, research group, etc. 

• 沖縄県産業振興公社 

  2012.5

  -

  2013.3

display all >>