研究者詳細 - 山崎　秀雄

論文 - 山崎　秀雄

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The Three-Body Problem in Stress Biology: The Balance Between O2, NO, and H2S in the Context of Hans Selye’s Stress Concept

Yamasaki H.

Stresses ( Stresses ) 5 ( 2 ) 37 - 37 2025年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Hans Selye’s stress concept, first introduced in the 1930s, has undergone substantial evolution, extending beyond biology and medicine to influence diverse academic disciplines. Initially, Selye’s General Adaptation Syndrome (GAS) described nonspecific physiological responses to stressors exclusively in mammals, without addressing other biological systems. Consequently, the concept of stress developed independently in biology and medicine, shaped by distinct physiological contexts. This review provides a historical overview of stress research, highlights both parallels and divergences between the stress responses of plants and animals, and integrates insights from traditional Eastern philosophies. We propose an updated GAS framework that incorporates the dynamic balance among reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) within the broader context of oxidative stress. We highlight the ionotropic glutamate receptor (iGluR) family and the transient receptor potential (TRP) channel superfamily as minimal molecular architectures for achieving GAS. This perspective expands the classical stress paradigm, providing new insights into redox biology, interspecies stress adaptation, and evolutionary physiology.

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Spatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton Homeostasis

Yamasaki, H; Itoh, RD; Mizumoto, KB; Yoshida, YS; Otaki, JM; Cohen, MF

ANTIOXIDANTS & REDOX SIGNALING ( Antioxidants and Redox Signaling ) 42 ( 7-9 ) 421 - 441 2025年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Seawater Tolerance of the Beach Bean Vigna marina (Burm.) Merrill in Comparison with Mung Bean (Vigna radiata) and Adzuki Bean (Vigna angularis)

Septiana, A; Nakamura, SP; Naomasa, RF; Yamasaki, H

AGRICULTURE-BASEL ( Agriculture (Switzerland) ) 15 ( 3 ) 228 - 228 2025年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Seawater intrusion into soils caused by global climate change and tsunami disasters is a significant factor contributing to soil salinization in coastal vegetation areas, posing a critical threat to agriculture and food security. This study aimed to evaluate the seawater tolerance of Vigna marina, a wild Vigna species, through comparative laboratory experiments with Vigna radiata (mung bean) and Vigna angularis (adzuki bean). Unlike V. radiata and V. angularis, the seeds of V. marina exhibited significant buoyancy in seawater, remaining afloat for at least 30 days. After this prolonged seawater incubation, V. marina seeds maintained a 100% germination rate, whereas V. radiata and V. angularis failed to germinate under the same conditions. The photosynthetic activity of V. marina seedlings, evaluated via the Fv/Fm parameter, remained stable even after seven days of seawater irrigation. In contrast, V. radiata and V. angularis perished under seawater irrigation. Furthermore, V. marina seedlings exhibited sustained growth under seawater irrigation, showing consistent increases in both fresh and dry weight. These findings confirm that V. marina possesses remarkable tolerance to seawater, a critical characteristic for cultivation in areas affected by seawater intrusion.

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Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling's Vitamin C Therapy.

Yamasaki H, Imai H, Tanaka A, Otaki JM

Microorganisms ( Microorganisms ) 11 ( 2 ) 397 2023年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Linus Pauling, who was awarded the Nobel Prize in Chemistry, suggested that a high dose of vitamin C (L-ascorbic acid) might work as a prevention or treatment for the common cold. Vitamin C therapy was tested in clinical trials, but clear evidence was not found at that time. Although Pauling’s proposal has been strongly criticized for a long time, vitamin C therapy has continued to be tested as a treatment for a variety of diseases, including coronavirus infectious disease 2019 (COVID-19). The pathogen of COVID-19, SARS-CoV-2, belongs to the β-coronavirus lineage, which includes human coronavirus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). This review intends to shed new light on vitamin C antiviral activity that may prevent SARS-CoV-2 infection through the chemical production of nitric oxide (NO). NO is a gaseous free radical that is largely produced by the enzyme NO synthase (NOS) in cells. NO produced by upper epidermal cells contributes to the inactivation of viruses and bacteria contained in air or aerosols. In addition to enzymatic production, NO can be gener-ated by the chemical reduction of inorganic nitrite (NO2−), an alternative mechanism for NO production in living organisms. Dietary vitamin C, largely contained in fruits and vegetables, can reduce the nitrite in saliva to produce NO in the oral cavity when chewing foods. In the stomach, salivary nitrite can also be reduced to NO by vitamin C secreted from the epidermal cells of the stomach. The strong acidic pH of gastric juice facilitates the chemical reduction of salivary nitrite to produce NO. Vitamin C contributes in multiple ways to the host innate immune system as a first-line defense mechanism against pathogens. Highlighting chemical NO production by vitamin C, we suggest that controversies on the therapeutic effects of vitamin C in previous clinical trials may partly be due to less appreciation of the pleiotropic functions of vitamin C as a universal bioreductant.

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Phytochemical Antioxidants: Past, Present and Future

Yasuko Sakihama, Hideo Yamasaki

Antioxidants - Benefits, Sources, Mechanisms of Action ( IntechOpen ) 2021年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Most diseases that are difficult to prevent and cure are “syndromes” that are governed by multiple components with complicated interactions. Whatever the cause of such diseases, overproduction of harmful reactive oxygen species (ROS) can often be observed in progression of the disease. Under such conditions, the cells may be challenged by “oxidative stress” due to excessively generated oxidants. Antioxidants can be defined as chemical compounds that scavenge ROS or free radicals over-produced in the cells under oxidative stress conditions. The plant pigments flavonoids and betalains, rich in fruits and vegetables, are reactive not only with ROS but also with reactive nitrogen species (RNS) and possibly with reactive sulfur species (RSS). Here, we provide an overview of updates on the antioxidative functions of the plant pigments along with some prospects for future research on phytochemical antioxidants.

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Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19.

Yamasaki H

Nitric oxide : biology and chemistry ( Elsevier BV ) 103 29 - 30 2020年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. In addition to the expected vasodilation effect, it has been also suggested that NO potentially prevents infection by SARS-CoV-2. Since NO is an unstable radical molecule that is easily oxidized by multiple mechanisms in the human body, it is practically difficult to control its concentration at lesions that need NO. Inorganic nitrate and/or nitrite are known as precursors of NO that can be produced through chemical as well enzymatic reduction. It appears that this NO synthase (NOS)-independent mechanism has been overlooked in the current developing of clinical treatments. Here, I suggest the missing link between nitrate and COVID-19 in terms of hypoxic NO generation.

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D-Cysteine-Induced Rapid Root Abscission in the Water Fern Azolla Pinnata: Implications for the Linkage between D-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses.

Yamasaki H, Ogura MP, Kingjoe KA, Cohen MF

Antioxidants ( Antioxidants ) 8 ( 9 ) 2019年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) have been proposed as universal signaling molecules in plant stress responses. There are a growing number of studies suggesting that hydrogen sulfide (H#D2#DRS) or Reactive Sulfur Species (RSS) are also involved in plant abiotic as well as biotic stress responses. However, it is still a matter of debate as to how plants utilize those RSS in their signaling cascades. Here, we demonstrate that d-cysteine is a novel candidate for bridging our gap in understanding. In the genus of the tiny water-floating fern #IAzolla#IR, a rapid root abscission occurs in response to a wide variety of environmental stimuli as well as chemical inducers. We tested five H#D2#DRS chemical donors, Na#D2#DRS, GYY4137, 5a, 8l, and 8o, and found that 5a showed a significant abscission activity. Root abscission also occurred with the polysulfides Na#D2#DRS#D2#DR, Na#D2#DRS#D3#DR, and Na#D2#DRS#D4#DR. Rapid root abscission comparable to other known chemical inducers was observed in the presence of d-cysteine, whereasLl-cysteine showed no effect. We suggest that D-cysteine is a physiologically relevant substrate to induce root abscission in the water fern #IAzolla#IR.

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Dynamics of nitrite content in fresh spinach leaves: evidence for nitrite formation caused by microbial nitrate reductase activity

Naoko S Watanabe, Hideo Yamasaki

Journal of Nutrition & Food Sciences 7 1 - 7 2017年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Nitrite (NO#D2#DR#U-#UR) contained in dietary foods has long been recognized for its toxicity as the causative agent of methemoglobinemia and also as a source of mutagenic nitrosamines. Because of these potential toxicities, nitrite as well as nitrate contained in foods and drinks are strictly limited by regulations in many countries. Recent studies have offered us to update our recognition of nitrite; nitrite is an important precursor for nitric oxide (NO) that is required for fundamental physiological activities including vasorelaxation. Although it is well established that green vegetables contain high amounts of nitrate, there has been controversy regarding the source of nitrite accumulation in fresh green vegetables. In this study, we investigated the dynamics of nitrite and nitrate contents in spinach leaf extracts to verify the mechanisms of nitrite formation. The time course of nitrite production in leaf extracts showed a reciprocal relationship with nitrate degradation, suggesting a conversion from nitrate to nitrite. The reaction strongly depended on temperature and it was suppressed at a low temperature. Sodium tungstate, a nitrate reductase enzyme inhibitor, was effective to suppress the conversion. Pre-sterilization by autoclaving or filter sterilization completely prevented the formation of nitrite as well as degradation of nitrate. We suggest that previous reports of nitrite accumulation can be attributed to microbial nitrate reductase activities that occur during the degradation spinach leaves.

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Biological consilience of hydrogen sulfide and nitric oxide in plants: Gases of primordial earth linking plant, microbial and animal physiologies.

Yamasaki H, Cohen MF

Nitric oxide: biology and chemistry 55-56 91 - 100 2016年05月

掲載種別: 研究論文（学術雑誌）

Hydrogen sulfide (H#D2#DRS) is produced in the mammalian body through the enzymatic activities of cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). A growing number of studies have revealed that biogenic H#D2#DRS produced in tissues is involved in a variety of physiological responses in mammals including vasorelaxation and neurotransmission. It is now evident that mammals utilize H#D2#DRS to regulate multiple signaling systems, echoing the research history of the gaseous signaling molecules nitric oxide (NO) and carbon monoxide (CO) that had previously only been recognized for their cytotoxicity. In the human diet, meats (mammals, birds and fishes) and vegetables (plants) containing cysteine and other sulfur compounds are the major dietary sources for endogenous production of H#D2#DRS. Plants are primary producers in ecosystems on the earth and they synthesize organic sulfur compounds through the activity of sulfur assimilation. Although plant H#D2#DRS-producing activities have been known for a long time, our knowledge of H#D2#DRS biology in plant systems has not been updated to the extent of mammalian studies. Here we review recent progress on H#D2#DRS studies, highlighting plants and bacteria. Scoping the future integration of H#D2#DRS, NO and O#D2#DR biology, we discuss a possible linkage between physiology, ecology and evolutional biology of gas metabolisms that may reflect the historical changes of the Earth's atmospheric composition.

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An Overview of Methods in Plant Nitric Oxide (NO) Research: Why Do We Always Need to Use Multiple Methods?

Yamasaki H, Watanabe NS, Sakihama Y, Cohen MF

Methods in molecular biology 1424 1 - 14 2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Bimodal effect of hydrogen peroxide and oxidative events in nitrite-induced rapid root abscission by the water fern Azolla pinnata.

Cohen MF, Gurung S, Birarda G, Holman HY, Yamasaki H

Frontiers in plant science 6 ( 518 ) 1 - 8 2015年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

In the genus #IAzolla#IR rapid abscission of roots from floating fronds occurs within minutes in response to a variety of stresses, including exposure to nitrite. We found that hydrogen peroxide, though itself not an inducer of root abscission, modulates nitrite-induced root abscission by #IAzolla pinnata#IR in a dose-dependent manner, with 2 mM H#D2#DRO#D2#DR significantly diminishing the responsiveness to 2 mM NaNO#D2#DR, and 10 mM H#D2#DRO#D2#DR slightly enhancing it. Hypoxia, which has been found in other plants to result in autogenic production of H#D2#DRO#D2#DR, dramatically stimulated root abscission of #IA. pinnata#IR in response to nitrite, especially for plants previously cultivated in medium containing 5 mM KNO#D3#DR compared to plants cultivated under N#D2#DR-fixing conditions without combined nitrogen. Plants, including #IAzolla#IR, produce the small signaling molecule nitric oxide (NO) from nitrite using nitrate reductase. We found #IAzolla#IR plants to display dose-dependent root abscission in response to the NO donor spermine NONOate. Treatment of plants with the thiol-modifying agents #IS#IR-methyl methanethiosulfonate or glutathione inhibited the nitrite-induced root abscission response. Synchrotron radiation-based Fourier transform infrared spectromicroscopy revealed higher levels of carbonylation in the abscission zone of dropped roots, indicative of reaction products of polysaccharides with potent free radical oxidants. We hypothesize that metabolic products of nitrite and NO react with H#D2#DRO#D2#DR in the apoplast leading to free-radical-mediated cleavage of structural polysaccharides and consequent rapid root abscission.

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Azide-dependent NO emission from the water fern Azolla pinnata

Sushma Gurung, Michael F Cohen, Hideo Yamasaki

Russian Journal of Plant Physiology 61 543 - 547 2014年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Nitric oxide (NO) is involved in versatile functions in plant growth and development as a signaling molecule. To date, plants have been reported to produce NO following exposure to nitrite (NO#D2#DR#U-#UR) the amino acid L-arginine, hydroxylamine, or polyamines. Here we demonstrate azide-dependent NO production in plants. The water fern #IAzolla pinnata#IR emitted NO into air upon exposure to sodium azide (NaN#D3#DR). The NO production was dependent on azide concentration and was strongly inhibited by potassium cyanide (KCN). Incubation of #IA. pinnata#IR with the catalase inhibitor 3-aminotriazole (3-AT) abolished the azide-dependent NO production. Although nitrite-dependent NO production was inhibited by sodium azide, azide-dependent NO production was not affected by nitrite. These results indicate that #IA. pinnata#IR enzymatically produces NO using azide as a substrate. We suggest that plants are also capable of producing NO from azide by the action of catalase as previously reported in animals.

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Controlled free radical attack in the apoplast: A hypothesis for roles of O, N and S species in regulatory and polysaccharide cleavage events during rapid abscission by Azolla

Michael F Cohen, Sushma Gurung, Jon M. Fukuto, Hideo Yamasaki

Plant Science 217-218 120 - 126 2014年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Shedding of organs by abscission is a key terminal step in plant development and stress responses. Cell wall (CW) loosening at the abscission zone can occur through a combination chain breakage of apoplastic polysaccharides and tension release of cellulose microfibrils. Two distinctly regulated abscission cleavage events are amenable to study in small water ferns of the genus Azolla; one is a rapid abscission induced by environmental stimuli such as heat or chemicals, and the other is an ethylene-induced process occurring more slowly through the action of hydrolytic enzymes. Although free radicals are suggested to be involved in the induction of rapid root abscission, its mechanism is not fully understood. The apoplast contains peroxidases, metal-binding proteins and phenolic compounds that potentially generate free radicals from H#D2#DRO#D2#DR to cleave polysaccharides in the CW and middle lamella. Effects of various thiol-reactive agents implicate the action of apoplastic peroxidases having accessible cysteine thiols in rapid abscission. The Ca#D2#DR#U+ #UR dependency of rapid abscission may reflect the stabilization Ca#D2#DR#U+#UR confers to peroxidase structure and binding to pectin. To spur further investigation, we present a hypothetical model for small signaling molecules H#D2#DRO#D2#DR and NO and their derivatives in regulating, via modification of putative protein thiols, free radical attack of apoplastic polysaccharides.

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Sulfate-reducing bacteria in the skeleton of the massive coral Goniastrea aspera from the great barrier reef.

Yeong Shyan Yuen, Seitaro S Yamazaki, Andrew H Baird, Takashi Nakamura, Hideo Yamasaki

Galaxea, Journal of Coral Reef Studies Special issue 160 - 165 2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Differential influence of water-flow on photoinhibition of photosynthesis in endosymbiotic algae among shallow-inhabiting scleractinian corals

Takashi Nakamura, Hideo Yamasaki

Galaxea, Journal of Coral Reef Studies Special issue 366 - 372 2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Evolution of thermal thresholds: Can corals adapt to projected rates of change in sea surface temperature?

Andrew BAIRD, Takashi NAKAMURA, Hideo YAMASAKI

Galaxea, Journal of Coral Reef Studies Special issue 160 - 165 2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Polyamine-Induced Rapid Root Abscission in Azolla pinnata.

Sushma Gurung, Michael F Cohen, Jon Fukuto, Hideo Yamasaki

Journal of Amino Acids 493209 1 - 9 2012年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Floating ferns of the genus #IAzolla#IR detach their roots under stress conditions, a unique adaptive response termed rapid root abscission. We found that #IAzolla pinnata#IR plants exhibited dose-dependent rapid root abscission in response to the polyamines spermidine and spermine after a substantial time lag (>20 min). The duration of the time lag decreased in response to high pH and high temperature whereas high light intensity increased the time lag and markedly lowered the rate of abscission. The oxidation products of polyamines, 1,3-diaminopropane, β-alanine and hydrogen peroxide all failed to initiate root abscission, and hydroxyethyl hydrazine, an inhibitor of polyamine oxidase, did not inhibit spermine-induced root abscission. Exposure of #IA. pinnata#IR to the polyamines did not result in detectable release of NO and did not affect nitrite-dependent NO production. The finding of polyamine-induced rapid root abscission provides a facile assay for further study of the mode of action of polyamines in plant stress responses.

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Ontogenetic change in the lipid and fatty acid composition of scleractinian coral larvae.

. Figueiredo, A H Baird, M F Cohen, J-F Flot, . Kamiki, T Meziane, M Tsuchiya, H Yamasaki

Coral Reefs 31 613 - 619 2012年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Some scleractinian coral larvae have an extraordinary capacity to delay metamorphosis, and this is reflected in the large geographic range of many species. Coral eggs typically contain a high proportion of wax esters, which have been hypothesized to provide a source of energy for long-distance dispersal. To better understand the role of lipids in the dispersal of broadcast spawning coral larvae, ontogenetic changes in the lipid and fatty acid composition of #IGoniastrea retiformis#IR were measured from the eggs until larvae were 30 days old. Egg biomass was 78.8 ± 0.5% lipids, 86.3 ± 0.2% of which were wax esters, 9.3 ± 0.0% polar lipids, 4.1 ± 0.2% sterols, and 0.3 ± 0.1% triacylglycerols. The biomass of wax esters declined significantly through time, while polar lipids, sterols and triacylglycerols remained relatively constant, suggesting that wax esters are the prime source of energy for development. The most prevalent fatty acid in the eggs was palmitic acid, a marker of the dinoflagellate #ISymbiodinium#IR, highlighting the importance of symbiosis in coral reproductive ecology. The proportion of polyunsaturated fatty acids declined through time, suggesting that they are essential for larval development. Interestingly, triacylglycerols are only abundant in the propagules that contain #ISymbiodinium#IR, suggesting important differences in the energetic of dispersal among species with vertical and horizontal transmission of symbionts.

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Phenotypic Variations in Croton Codiaeum variegatum (L.) Blume Characterized by Digital Image-Based Procedure

AS Mollick, H Yamasaki

Acta Horticulturae 937 393 - 400 2012年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Phenotypic Variations in Croton Codiaeum variegatum (L.) Blume Characterized by Digital Image-Based Procedure

Mollick, AS; Yamasaki, H

XXVIII INTERNATIONAL HORTICULTURAL CONGRESS ON SCIENCE AND HORTICULTURE FOR PEOPLE (IHC2010): INTERNATIONAL SYMPOSIUM ON ADVANCES IN ORNAMENTALS, LANDSCAPE AND URBAN HORTICULTURE 937 393 - 400 2012年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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