UMEMURA Masayuki

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

90359985

Laboratory Address

1 Senbaru,Nishihara,Okinawa 903-0213

Mail Address

E-mail address

Homepage URL

http://w3.u-ryukyu.ac.jp/hostdefense/

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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Tropical Biosphere Research Center   Associate Professor  

  • Concurrently   University of the Ryukyus   Graduate School of Medicine   Division of Medical Science   Associate Professor  

  • Concurrently   University of the Ryukyus   Faculty of Medicine   Associate Professor  

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Academic degree 【 display / non-display 】

  • Nagoya University -  Doctor of Medicine

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External Career 【 display / non-display 】

  • 2001.04
    -
    2002.03

    Nagoya University, Postdoctoral Fellow  

  • 2001.05
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    2002.08

    Kanazawa University, Postdoctoral Fellow  

  • 2002.09
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    2007.03

    Gene Research Center, University of the Ryukyus, Research Associate  

  • 2007.04
    　
    　

    - , University of the Ryukyus, Gene Research Center, Research Associate  

  • 2007.04
    -
    2009.03

    Gene Research Center, University of the Ryukyus, Assistant Professor  

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Affiliated academic organizations 【 display / non-display 】

  • 2003.04
    -
    Now
     

    The American Association of Immunologists 

  • 1997.04
    -
    Now
     

    The Japanese Society for Immunology 

  • 1997.04
    -
    Now
     

    The Japanese Society for Virology 

  • 1997.04
    -
    Now
     

    Japanese Society for Bacteriology 

  • 2024.04
    -
    Now
     

    Japanese Society for Interferon and Cytokine Research 

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Research Interests 【 display / non-display 】

  • Immunology of host defense against infectious diseases

  • 感染症

  • サイトカイン

  • 生体防御

  • Immunology of Host Defence Against Infectious Diseases

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Research Areas 【 display / non-display 】

  • Life Science / Bacteriology

  • Life Science / Immunology

  • Life Science / Bacteriology

  • Life Science / Immunology

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Acquisition of a qualification 【 display / non-display 】

  • First Kind of Junior High School Teacher License

  • First Kind of High School Teacher License

  • Usual First Kind Pressure Vessel Handling Work Chief Person

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Research Theme 【 display / non-display 】

  • Analysis of immune response and protective mechanism against infections

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Published Papers 【 display / non-display 】

  • IL-35 May Prevent the Exacerbation of Aspiration Pneumonia Involving Porphyromonas gingivalis by Suppressing IL-17 Production

    Kawamura, S; Goto, H; Kikuchi, T; Okabe, T; Hasegawa, Y; Sugita, Y; Fujitsuka, H; Kataoka, R; Katsumata, K; Goto, R; Suzuki, Y; Hayashi, JI; Umemura, M; Mitani, A

    AMERICAN JOURNAL OF PATHOLOGY ( American Journal of Pathology )  195 ( 4 ) 652 - 662   2025.04 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • 抗酸菌感染におけるCard9の機能解析(Analysis of Card9 function in pulmonary mycobacterial infection)

    豊永 憲司, 梅村 正幸, 松崎 吾朗, 原 博満, 田中 芳彦, 山崎 晶

    日本細菌学雑誌 ( 日本細菌学会 )  77 ( 1 ) 101 - 101   2022.02 [ Peer Review Accepted ]

    Type of publication: Research paper (other science council materials etc.)

  • GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.

    Kurane, T., Matsunaga, T., Ida, T., Sawada, K., Nishimura, A., Fukui, M., Umemura, M., Nakayama, M., Ohara, N., Matsumoto, S., Akaike, T., Matsuzaki, G., Takaesu, G.

    FASEB Journal ( FASEB Journal )  36 ( 1 ) e22096   2022.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Porphyromonas gingivalis components/secretions synergistically enhance pneumonia caused by Streptococcus pneumoniae in mice

    Okabe, T., Kamiya, Y., Kikuchi, T., Goto, H., Umemura, M., Suzuki, Y., Sugita, Y., Naiki, Y., Hasegawa, Y., Hayashi, J., Kawamura, S., Sawada, N., Takayanagi, Y., Fujimura, T., Higuchi, N., Mitani, A.

    International Journal of Molecular Sciences ( International Journal of Molecular Sciences )  22 ( 23 ) 12704   2021.11 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

    Iizasa, E., Chuma, Y., Uematsu, T., Kubota, M., Kawaguchi, H., Umemura, M., Toyonaga, K., Kiyohara, H., Yano, I., Colonna, M., Sugita, M., Matsuzaki, G., Yamasaki S., Yoshida, H., Hara H.

    Nature Communications ( Nature Communications )  12 ( 1 ) 2299 - 2299   2021.04 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    　View Summary

    Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear. Here, we show that the DAP12-associated triggering receptor expressed on myeloid cells 2 (TREM2) recognizes mycobacterial cell-wall mycolic acid (MA)-containing lipids and suggest a mechanism by which mycobacteria control host immunity via TREM2. Macrophages respond to glycosylated MA-containing lipids in a Mincle/FcRγ/CARD9-dependent manner to produce inflammatory cytokines and recruit inducible nitric oxide synthase (iNOS)-positive mycobactericidal macrophages. Conversely, macrophages respond to non-glycosylated MAs in a TREM2/DAP12-dependent but CARD9-independent manner to recruit iNOS-negative mycobacterium-permissive macrophages. Furthermore, TREM2 deletion enhances Mincle-induced macrophage activation in vitro and inflammation in vivo and accelerates the elimination of mycobacterial infection, suggesting that TREM2-DAP12 signaling counteracts Mincle-FcRγ-CARD9-mediated anti-mycobacterial immunity. Mycobacteria, therefore, harness TREM2 for immune evasion.

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Other Papers 【 display / non-display 】

  • Spatially distinct roles of IL-17F in pulmonary tuberculosis

    Masayuki Umemura, Toshihiro Konno

    第99回日本細菌学会総会プログラム集 ( 本細菌学会 )    2026.03  [Refereed]

     

  • A novel pro-metastatic role of interleukin-17F in a mouse model of melanoma lung metastasis

    Masayuki Umemura, Toshihiro Konno, Kohsuke Tsuchiya, Hiroyasu Kidoya

    日本免疫学会総会・学術総会記録　第54巻　プログラム ( 日本免疫学会 )  54   2025.12  [Refereed]

     

  • hyX overexpression promotes the in vivo growth of BCG

    Ikue Tosa, Tomoyuki Yamaguchi, Goro Matsuzaki , Masayuki Umemura, Giichi Takaesu, Masaaki Nakayama, Manabu Ato, Naoya Ohara

    第98回日本細菌学会総会プログラム集 ( 日本細菌学会 )    2025.05  [Refereed]

     

  • Role of IL-35 in aspiration pneumonia involving Porphyromonas gingivalis.

    Shotaro Kawamura, Hisashi Goto, Takeshi Kikuchi Teppei Okabe, Yoshiaki Hasegawa Yoshihiko Sugita, Hirotaka Fujitsuka, Jun-ichiro Hayashi, Masayuki Umemura, Akio Mitani.

    第98回日本細菌学会総会 プログラム集 ( 日本細菌学会 )    2025.05  [Refereed]

     

  • A molecular mechanism of IL-β inhibition by mycobacterial effector protein

    藏根友美, 高江洲義一, 高江洲義一, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 梅村正幸, 赤池孝章, 松崎吾朗, 松崎吾朗

    日本生体防御学会学術総会講演抄録集   32nd   2021  [Refereed]

     

    J-GLOBAL

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Presentations 【 display / non-display 】

  • Spatially distinct roles of IL-17F in pulmonary tuberculosis

    Masayuki Umemura, Toshihiro Konno

    第99回日本細菌学会総会  (広島国際会議場（広島県広島市）)  2026.03  -  2026.03 

  • A novel pro-metastatic role of interleukin-17F in a mouse model of melanoma lung metastasis

    Masayuki Umemura, Toshihiro Konno, Kohsuke Tsuchiya, Hiroyasu Kidoya

    第54回日本免疫学会学術集会  (アクリエひめじ（兵庫県姫路市）)  2025.12  -  2025.12 

  • 歯周病原菌の菌体成分/分泌物は肺炎球菌感染により誘発される肺炎を増悪化する

    梅村正幸, 岡部徹平, 神谷洋介, 川村翔太郎, 三谷章雄

    九州微生物研究フォーラム2025,  (沖縄コンベンションセンター（沖縄県宜野湾市）)  2025.09  -  2025.09 

  • ThyX overexpression promotes the in vivo growth of BCG

    Ikue Tosa, Tomoyuki Yamaguchi, Goro Matsuzaki , Masayuki Umemura, Giichi Takaesu, Masaaki Nakayama, Manabu Ato, Naoya Ohara

    第98回日本細菌学会総会  (川県立音楽堂（石川県金沢市）)  2025.05  -  2025.05 

  • Role of IL-35 in aspiration pneumonia involving Porphyromonas gingivalis.

    Shotaro Kawamura, Hisashi Goto, Takeshi Kikuchi Teppei Okabe, Yoshiaki Hasegawa Yoshihiko Sugita, Hirotaka Fujitsuka, Jun-ichiro Hayashi, Masayuki Umemura, Akio Mitani

    第98回日本細菌学会総会  (石川県立音楽堂（石川県金沢市）)  2025.05  -  2025.05 

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Other Research Activities 【 display / non-display 】

  • 14th ITAM Workshop Organizer

    Other Research Activities 

    2026.01
    　
    　

  • "U.S.-Japan Cooperative Medical Sciences Program: Mycobacterial Diseases Panel Meeting 2024" Chairperson

    Other Research Activities 

    2024.04
    　
    　

  • Microbiology and Immunology Peer Review

    Academic papers review number 

    2002
    　
    　

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2025.04  -  2028.03 

    Investigator(s): Masayuki Umemura 

    Direct: 3,600,000 (YEN)  Overheads: 1,080,000 (YEN)  Total: 4,680,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2025.04  -  2028.03 

    Investigator(s): Goro Matsuzaki  Member: Giichi Takaesu, Masayuki Umemura

    Direct: 3,500,000 (YEN)  Overheads: 1,050,000 (YEN)  Total: 4,550,000 (YEN)

  • Grant-in-Aid for Scientific Research(B)

    Project Year: 2023.04  -  2026.03 

    Investigator(s): Hiromitsu Hara  Member: Masayuki Umemura

  • Grant-in-Aid for Scientific Research(B)

    Project Year: 2023.04  -  2026.03 

    Investigator(s): Kenji Toyonaga  Member: Masayuki Umemura

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2023.04  -  2026.03 

    Investigator(s): Yoshikazu Naiki  Member: Masayuki Umemura

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Other External funds 【 display / non-display 】

  • Project Year: 2026.01  -  2026.01 

    Offer Organization: Support Foundation of the University of the Ryukyus

    Direct: 138,000 (YEN)  Overheads: 0 (YEN)  Total: 138,000 (YEN)

  • Project Year: 2026.01  -  2026.01 

    Direct: 260,000 (YEN)  Overheads: 0 (YEN)  Total: 260,000 (YEN)

  • Project Year: 2024.04  -  2024.04 

    Direct: 500,000 (YEN)  Overheads: 0 (YEN)  Total: 500,000 (YEN)

  • Project Year: 2024.04  -  2024.04 

    Direct: 500,000 (YEN)  Overheads: 0 (YEN)  Total: 500,000 (YEN)

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SDGs 【 display / non-display 】

  • 研究テーマ「結核に対する感染防御機構の解明」

  • 県外小学生を対象とした「沖縄の自然・文化」のオンライン講座

  • 沖縄県主催「子ども科学技術人材育成事業 」等の一環教育

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Social Activity 【 display / non-display 】

  • 2005.04
    　
    　

  • 2010.04
    　
    　

  • 2005.04
    　
    　

  • 2015.04
    　
    　

  • 2025.06
    　
    　

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Media Coverage 【 display / non-display 】

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