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Research Theme 【 display / non-display 】

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• Elucidation of significance of the nitric oxide synthases system using mice lacking all nitric oxide synthases

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Alleviated cerebral infarction in male mice lacking all nitric oxide synthase isoforms after middle cerebral artery occlusion

  Kubota, H; Tsutsui, M; Kuniyoshi, K; Yamashita, H; Shimokawa, H; Sugahara, K; Kakinohana, M

  JOURNAL OF ANESTHESIA ( Journal of Anesthesia )  38 ( 1 ) 44 - 56   2024.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Significance of nitric oxide derived from the nitric oxide synthases system in cardiovascular inter-organ cross-talk

  Tsutsui M

  J Pharmacol Exp Ther     2024 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Role of nitric oxide synthases in respiratory health and disease: insight from triple nitric oxide synthases knockout mice

  1. Ogoshi T, Yatera K, Mukae H, Tsutsui M

  Int J Mol Sci     2024 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Preface

  Tsutsui Masato, Saito Motoaki

  Folia Pharmacologica Japonica ( The Japanese Pharmacological Society )  158 ( 5 ) 367 - 367   2023.09

  Type of publication: Research paper (scientific journal)

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• Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism

  Abidin QHZ, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, Akaike T.

  Antioxidants ( Antioxidants )  12 ( 4 ) 868 - 868   2023.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals. Various forms of reactive persulfides occur in both low-molecular-weight and protein-bound thiols. The chemical properties and great supply of these molecular species suggest a pivotal role for reactive persulfides/polysulfides in different cellular regulatory processes (e.g., energy metabolism and redox signaling). We demonstrated earlier that cysteinyl-tRNA synthetase (CARS) is a new cysteine persulfide synthase (CPERS) and is responsible for the in vivo production of most reactive persulfides (polysulfides). Some researchers continue to suggest that 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine β-synthase (CBS), and cystathionine γ-lyase (CSE) may also produce hydrogen sulfide and persulfides that may be generated during the transfer of sulfur from 3-mercaptopyruvate to the cysteine residues of 3-MST or direct synthesis from cysteine by CBS/CSE, respectively. We thus used integrated sulfur metabolome analysis, which we recently developed, with 3-MST knockout (KO) mice and CBS/CSE/3-MST triple-KO mice, to elucidate the possible contribution of 3-MST, CBS, and CSE to the production of reactive persulfides in vivo. We therefore quantified various sulfide metabolites in organs derived from these mutant mice and their wild-type littermates via this sulfur metabolome, which clearly revealed no significant difference between mutant mice and wild-type mice in terms of reactive persulfide production. This result indicates that 3-MST, CBS, and CSE are not major sources of endogenous reactive persulfide production; rather, CARS/CPERS is the principal enzyme that is actually involved in and even primarily responsible for the biosynthesis of reactive persulfides and polysulfides in vivo in mammals.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• Encyclopedia of radiation medical science

  Masaoki Kohzaki, Masato Tsutsui ( Part: Multiple Authorship )

  Asakura publishing  2019

• Heart failure

  Masato Tsutsui ( Part: Single Author )

  Nippon rinsho  2018.12

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Other Papers 【 display / non-display 】

• Pathogenetic role of exogenous nitric oxide production system in metabolic syndrome, vascular dysfunction, and sudden cardiac death

  Mika Kina, Mayuko Sakanashi, Haruaki Kubota, Akira Arasaki, Masato Tsutsui

  Blood vessel ( Japanese Society for Circulation Research )  41 ( 3 ) 9 - 18   2018.09

   

• Deficiency of nitrite and nitrate results in the development of metabolic syndrome, vascular dysfunction, and sudden cardiac death

  Mika Kina, Mayuko Sakanashi, Haruaki Kubota, Akira Arasaki, Masato Tsutsui

  Japanese Journal of Pharmacology ( Japanese Pharmacological Society )  151 ( 4 ) 148 - 154   2018.04

   

• Nitric oxide and metabolic, cardiovascular, and renal diseases: Lessons from mice lacking all three nitric oxide synthases

  Masato Tsutsui, Hiroaki Shimokawa, Akihide Tanimoto, Nobuyuki Yanagihara, Yutaka Otsuji

  Nephrology and Urology ( Science review )  2 ( 5 ) 177 - 184   2017.02

   

• Hypertension in Mice Lacking 3-Mercaptopyruvate Sulfurtransferase

  Masato Tsutsui, Yuichi Totsuka, Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Junko Nakasone, Yukio Kuniyoshi

  CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  134   2016.11

   

• CRUCIAL ROLES OF NITRIC OXIDE SYNTHASES IN beta-ADRENOCEPTOR-MEDIATED BLADDER RELAXATION IN MICE

  Yohei Satake, Yasuhiro Kaiho, Kimio Satoh, Masato Tsutsui, Hiroaki Shimokawa

  JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  195 ( 4 ) E895 - E896   2016.04

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• NO and supersulfide in cardiovascular regulation

  Tsutsui M, Ogoshi T, Kato K, Shimokawa H, Mukae H, Yatera K

  The 12th International Nitric Oxide Conference & The 22nd Nitric Oxide Society of Japan  2022.10  -  2022.10 

Other Research Activities 【 display / non-display 】

Other Research Activities 【 display / non-display 】

• Circulation Research

  Academic papers review number 

  2015.06

  -

  2019.09

• Journal of Pharmacological Sciences

  Academic papers review number 

  2012.06

  　

  　

• Arteriosclerosis, Thrombosis, and Vascular Biology

  Academic papers review number 

  2012.05

  -

  2020.12

• Circulation Journal

  Academic papers review number 

  2008.07

  　

  　

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2020

  2020.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

  Winner: Masato Tsutsui

• Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award

  2019.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

  Winner: Masato Tsutsui

• Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2020

  2017.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

  Winner: Masato Tsutsui

• Journal of Pharmacological Sciences, Excellent Reviewer Award

  2017.03.16   Journal of Pharmacological Sciences  

  Winner: Masato Tsutsui

• Arteriosclerosis, Thrombosis, and Vascular Biology, Top 10 Reviewer Award

  2016.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

  Winner: Masato Tsutsui

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(A)

  Project Year: 2024.04  -   

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -   

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Elucidation of diverse roles of nitric oxide synthases in the pathogenesis of respiratory disease

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Investigator(s): Masato Tsutsui 

  Direct: 3,300,000 (YEN)  Overheads: 990,000 (YEN)  Total: 4,290,000 (YEN)

• Elucidation of the role of the nitric oxide synthase system in the pathogenesis of respiratory diseases

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Investigator(s): Tsutsui Masato 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  　View Summary

  Three isoforms of nitric oxide (NO) synthases (nNOS,iNOS,eNOS) are expressed in human pulmonary emphysematous lesions. However, the role of the NOSs system in the pathogenesis of pulmonary emphysema remains to be elucidated. We investigated this issue in mice lacking all three NOS isoforms (triple n/i/eNOSs-/- mice). We demonstrated that the triple NOSs-/- mice exhibited spontaneous development of pulmonary emphysema, and that mRNA expression levels of Wnt/β-catenin pathway-related genes were reduced in the lung of the triple NOSs-/- mice. These results suggest that the NOSs system plays an important role in the prevention of pulmonary emphysema, and that down-regulation of the Wnt/β-catenin pathway is involved in the pathogenesis of spontaneous pulmonary emphysema in the triple NOSs-/- mice.

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Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2021.04

  　

  　

• 2021.04

  　

  　

• 2021.04

  　

  　

• 2021.04

  　

  　

• 2019.04

  　

  　

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Media Coverage 【 display / non-display 】

Media Coverage 【 display / non-display 】

• 肺気腫　原因の一つ発見　世界初、一酸化窒素が影響  Newspaper, magazine

  2021.11

• 肺高血圧の原因解明　琉大の筒井教授ら　世界初  Newspaper, magazine

  沖縄タイムス  2018.7

  Author： Myself 

Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 筒井　正人 

  2023.10

  　

  　

  種別： Academic society, research group, etc. 

• 筒井　正人 

  2023.10

  　

  　

  種別： Academic society, research group, etc. 

• [International contribution]

  2022.10

  　

  　

  種別： Peer review 

• 筒井　正人 

  2021.6

  　

  　

  種別： Academic society, research group, etc. 

• 2019.4

  　

  　

  種別： Academic society, research group, etc. 

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