Tsutsui Masato

写真a

Title

Professor

Researcher Number(JSPS Kakenhi)

70309962

Laboratory Address

1076 Kiyuna, Ginowan 901-2720

Mail Address

E-mail address

Laboratory Phone number

+81-98-894-5372

Laboratory Fax number

+81-98-894-5379

Homepage URL

https://pharmaco.skr.u-ryukyu.ac.jp/

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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Graduate School of Medicine   Professor  

  • Concurrently   University of the Ryukyus   Faculty of Medicine   School of Medicine   Professor  

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University 【 display / non-display 】

  • 1982.04
    -
    1988.03

    University of Occupational and Environmental Health, Japan   Faculty of Medicine   Graduated

  • 　
    -
    1995

    University of Occupational and Environmental Health, Japan   Graduate School, Division of Medicine   Graduated

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Graduate School 【 display / non-display 】

  • 1991.04
    -
    1995.03

    University of Occupational and Environmental Health, Japan  Graduate School, Division of Medicine  Doctor's Course  Completed

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Academic degree 【 display / non-display 】

  • University of Occupational and Environmental Health, Japan -  Doctor of Medical Sciences

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External Career 【 display / non-display 】

  • 1900.01
    　
    　

    Associate Professor in the Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan  

  • 1900.01
    　
    　

    Research Fellow in the Department of Anesthesiology and Pharmacology, Mayo Clinic, USA (Professor Zvonimir S. Katusic's Laboratory)  

  • 1900.01
    　
    　

    Research Assistant in the Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan  

  • 1988.07
    -
    1990.06

     

  • 1995.06
    -
    1997.05

    Research Fellow of the Department of Anesthesiology and Pharmacology, Mayo Clinic, USA (Professor Zvonimir S. Katusic's Laboratory)  

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Affiliated academic organizations 【 display / non-display 】

  • 1999.02
    -
    Now
     

    Japanese Association of Cardiovascular Pharmacology 

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Research Interests 【 display / non-display 】

  • 一酸化窒素

  • 活性硫黄

  • 薬理学

  • Cardiovascular Medicine

  • Respiratory Medicine

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Research Areas 【 display / non-display 】

  • Life Science / Pharmacology

  • Life Science / Cardiology

  • Life Science / Physiology

  • Life Science / Respiratory medicine

  • Life Science / General internal medicine

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Acquisition of a qualification 【 display / non-display 】

  • Doctor

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Research Theme 【 display / non-display 】

  • Elucidation of significance of the nitric oxide synthases system using mice lacking all nitric oxide synthases

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Published Papers 【 display / non-display 】

  • Two Faces of Cardiovascular Actions of Testosterone Dependent on the Presence or Absence of Nitric Oxide Synthases in Mice

    Higa, S; Sakanashi, M; Tsutsui, M; Tasaki, T; Tanimoto, A; Taira, Y; Shimokawa, H; Kuniyoshi, Y; Furukawa, K

    CIRCULATION JOURNAL ( 一般社団法人 日本循環器学会 )  90 ( 5 ) 549 - 558   2026.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    　View Summary

    <p><b><i>Background:</i></b> Previous clinical studies reported that testosterone replacement therapy unexpectedly increased cardiovascular (CV) events in elderly men, through an unknown underlying mechanism. Because nitric oxide (NO) production is reduced in elderly men, we hypothesized that testosterone exerts harmful CV effects under reduced NO production, and examined this hypothesis using a 2/3 nephrectomized triple neuronal/inducible/endothelial NO synthases (NOS)-knockout (NX-TKO) mouse model that causes death from myocardial infarction (MI).</p><p><b><i>Methods and Results:</i></b> The survival rate was markedly worse in male NX-TKO mice than in male NX-wild-type (NX-WT) mice. Orchiectomy (ORX) significantly aggravated the survival rate in NX-WT mice, but significantly improved it in NX-TKO mice. In the NX-TKO-ORX mice, long-term subcutaneous treatment with testosterone significantly deteriorated the survival rate, the incidence of MI, and CV risk factors. Furthermore, testosterone-induced aortic relaxations were significantly more impaired in the TKO than in the WT mice. RNA sequencing in the hearts of TKO-ORX mice without and with testosterone treatment indicated possible involvements of immunity- and inflammation-mediated mechanisms in the harmful CV effects of testosterone.</p><p><b><i>Conclusions:</i></b> These results provide the first evidence that testosterone exerts harmful CV effects, including shorter survival, increased incidence of MI, impaired arterial relaxation, and exacerbated cardiovascular risk factors, in the absence of NOS in mice. Our findings may explain in part why testosterone replacement therapy increases CV events in elderly men.</p>

  • Elucidating the Urothelial-Dependent and -Independent Mechanisms Involved in the Mouse Bladder Contractility Alterations by Acute Methylglyoxal Exposure

    Oliveira, AL; Medeiros, ML; Fuguhara, V; Hermawan, I; Shimokawa, H; Tsutsui, M; De Nucci, G; Antunes, E

    BIOMEDICINES ( Biomedicines )  14 ( 5 )   2026.04 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • 6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation

    Britto-Júnior, J; Godoy, PRC; Lima, DO; de Souza, VB; Schenka, AA; Mariano, FV; Jacintho, FF; Hermawan, I; Shimokawa, H; Tsutsui, M; Chiavegatto, S; Antunes, E; De Nucci, G

    PHARMACOLOGY RESEARCH & PERSPECTIVES ( Pharmacology Research and Perspectives )  13 ( 5 ) e70167   2025.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

    Morikawa, T; Fujita, S; Sugiura, Y; Tamaki, S; Haraguchi, M; Shiroshita, K; Watanuki, S; Kobayashi, H; Kanai-Sudo, H; Naito, Y; Hayakawa, N; Matsuura, T; Hishiki, T; Matsui, M; Tsutsui, M; Suematsu, M; Takubo, K

    NATURE COMMUNICATIONS ( Nature Communications )  16 ( 1 ) 5475   2025.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies.

    Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H

    Communications Biology   8 ( 1 ) 817   2025.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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Books 【 display / non-display 】

  • Oceanic Japan : the archipelago in Pacific and global history

    Huebner Stefan, Heé Nadin, Miller Ian Jared, Tsutsui William M. ( Part: Single Author )

    University of Hawaiʻi  2025

  • Encyclopedia of radiation medical science

    Masaoki Kohzaki, Masato Tsutsui ( Part: Multiple Authorship )

    Asakura publishing  2019

  • Heart failure

    Masato Tsutsui ( Part: Single Author )

    Nippon rinsho  2018.12

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Other Papers 【 display / non-display 】

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Presentations 【 display / non-display 】

  • NO and supersulfide in cardiovascular regulation

    Tsutsui M, Ogoshi T, Kato K, Shimokawa H, Mukae H, Yatera K

    The 12th International Nitric Oxide Conference & The 22nd Nitric Oxide Society of Japan  2022.10  -  2022.10 

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Other Research Activities 【 display / non-display 】

  • Circulation Research

    Academic papers review number 

    2015.06
    -
    2019.09

  • Journal of Pharmacological Sciences

    Academic papers review number 

    2012.06
    　
    　

  • Arteriosclerosis, Thrombosis, and Vascular Biology

    Academic papers review number 

    2012.05
    -
    2020.12

  • Circulation Journal

    Academic papers review number 

    2008.07
    　
    　

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Academic Awards 【 display / non-display 】

  • Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2020

    2020.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

    Winner: Masato Tsutsui

  • Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award

    2019.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

    Winner: Masato Tsutsui

  • Arteriosclerosis, Thrombosis, and Vascular Biology, Top Reviewer Award 2020

    2017.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

    Winner: Masato Tsutsui

  • Journal of Pharmacological Sciences, Excellent Reviewer Award

    2017.03.16   Journal of Pharmacological Sciences  

    Winner: Masato Tsutsui

  • Arteriosclerosis, Thrombosis, and Vascular Biology, Top 10 Reviewer Award

    2016.11   Arteriosclerosis, Thrombosis, and Vascular Biology  

    Winner: Masato Tsutsui

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2025.04  -  2029.03 

    Direct: 360 (YEN)  Overheads: 108 (YEN)  Total: 468 (YEN)

  • Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health

    Grant-in-Aid for Scientific Research(A)

    Project Year: 2024.04  -  2028.03 

    Direct: 7,900,000 (YEN)  Overheads: 2,370,000 (YEN)  Total: 10,270,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2024.04  -  2025.03 

    Direct: 1,000,000 (YEN)  Overheads: 300,000 (YEN)  Total: 1,300,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2023.04  -  2024.03 

    Direct: 1,000,000 (YEN)  Overheads: 300,000 (YEN)  Total: 1,300,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2023.03 

    Direct: 1,000,000 (YEN)  Overheads: 300,000 (YEN)  Total: 1,300,000 (YEN)

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Social Activity 【 display / non-display 】

  • 2025.01
    　
    　

  • 2021.04
    -
    2025.03

  • 2021.04
    -
    2025.03

  • 2021.04
    -
    2025.03

  • 2021.04
    -
    2025.03

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Media Coverage 【 display / non-display 】

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Academic Activities 【 display / non-display 】

  • 筒井　正人 

    2023.10
    　
    　

    種別： Academic society, research group, etc. 

  • 筒井　正人 

    2023.10
    　
    　

    種別： Academic society, research group, etc. 

  • [International contribution]

    2022.10
    　
    　

    種別： Peer review 

  • 筒井　正人 

    2021.6
    　
    　

    種別： Academic society, research group, etc. 

  • 2019.4
    　
    　

    種別： Academic society, research group, etc. 

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