TAKAESU Giichi

写真a

Title

Associate Professor

Researcher Number(JSPS Kakenhi)

60403995

Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Tropical Biosphere Research Center   Associate Professor  

  • Concurrently   University of the Ryukyus   Graduate School of Medicine  

University 【 display / non-display

  • 1992.04
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    1996.03

    Nagoya University   Faculty of Science   Department of Molecular Biology   Graduated

Graduate School 【 display / non-display

  • 1996.04
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    1998.03

    Nagoya University  Graduate School, Division of Natural Science  Division of Biological Science  Doctor's Course (first term)  Completed

  • 1998.04
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    2001.02

    Nagoya University  Graduate School, Division of Natural Science  Division of Biological Science  Doctor's Course (second term)  Completed

Study abroad experiences 【 display / non-display

  • 2001.08
    -
    2003.05

    University of Texas Southwestern Medical Center at Dallas, Postdoc  

  • 2003.06
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    2005.05

    Mount Sinai School of Medicine, Postdoc  

Academic degree 【 display / non-display

  • Nagoya University -  Ph. D. in Molecular Biology

  • Nagoya University -  M.S.

External Career 【 display / non-display

  • 2001.04
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    2001.08

    Japan Science and Technology Agency, CREST postdoc  

  • 2005.06
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    2008.12

    Kyushu University, Medical Institute of Bioregulation, Instructor  

  • 2009.01
    -
    2012.09

    Keio University, School of Medicine, Assistant Professor  

  • 2012.10
    -
    2016.04

    University of the Ryukyus, Graduate School of Medicine, Instructor  

  • 2016.05
     
     

    University of the Ryukyus, Tropical Biosphere Research Center, Associate Professor  

Affiliated academic organizations 【 display / non-display

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    Japan Society for Cell Biology 

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    Japan Society for Bacteriology 

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    Japanese Society for Host Defense Research 

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    Japanese Society for Immunology 

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    The Molecular Biology Society of Japan 

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Research Interests 【 display / non-display

  • Signal transduction

  • Innate immunity

  • Programmed cell death

  • Inflammation

  • Macrophages

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Research Areas 【 display / non-display

  • Life Science / Bacteriology

  • Life Science / Immunology

  • Life Science / Cell biology

  • Life Science / Molecular biology

  • Life Science / Bacteriology

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Published Papers 【 display / non-display

  • miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).

    Maruyama N, Umikawa M, Matsumoto H, Maruyama T, Nishihara K, Nakasone T, Matayoshi A, Goto T, Hirano F, Arasaki A, Nakamura H, Matsuzaki G, Takaesu G

    Anticancer research ( Anticancer Research )  40 ( 11 ) 6101 - 6113   2020.11 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Effects of Psidium guajava leaf extract on secretion systems of Gram-negative enteropathogenic bacteria.

    Nakasone N, Ogura Y, Higa N, Toma C, Koizumi Y, Takaesu G, Suzuki T, Yamashiro T

    Microbiology and immunology ( Microbiology and Immunology )  62 ( 7 ) 444 - 453   2018.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Involvement of IL-17A-producing TCR y delta T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection

    Umemura Masayuki, Okamoto-Yoshida Yuko, Yahagi Ayano, Nakae Susumu, Iwakura Yoichiro, Takaesu Giichi, Matsuzaki Goro

    JOURNAL OF IMMUNOLOGY   198 ( 1 )   2017.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • TAK1 regulates resident macrophages by protecting lysosomal integrity.

    Sakamachi Y, Morioka S, Mihaly SR, Takaesu G, Foley JF, Fessler MB, Ninomiya-Tsuji J

    Cell death & disease   8 ( 2 ) e2598   2017.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus.

    Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, Ninomiya-Tsuji J

    Journal of cell science   129 ( 9 ) 1855 - 65   2016.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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Other Papers 【 display / non-display

  • マイコバクテリア感染肺に誘導されるIL‐17A産生細胞の多様性

    梅村正幸, 儀間香南子, 高江洲義一, 中江進, 岩倉洋一郎, 松崎吾朗

    日本インターフェロン・サイトカイン学会学術集会抄録集   83   96   2018.07

     

  • Two types of TRAF6-dependent TAK1 activation in the IL-1 signaling pathway

    Giichi Takaesu

    Biotarget   2 ( 1 )   2018.01

     

Presentations 【 display / non-display

  • A molecular mechanism of IL-1β inhibition by mycobacterial effector protein

    Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki

    The 93rd Annual Meeting of Japanese Society for Bacteriology  2020.02  -  2020.02 

  • Identification and functional analysis of a host protein targeted by mycobacterial effector Zmp1

    Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki

    The 93rd Annual Meeting of Japanese Society for Bacteriology  2020.02  -  2020.02 

  • Mechanism of mycobacteria specific IL-17A production of BCG infected lung-derived TCRgammadelta T cells

    梅村 正幸, 飯村 澪, 藏根 友美, 高江洲 義一, 松崎 吾朗

    第48回日本免疫学会学術集会  2019.12  -  2019.12 

  • Molecular basis of a mycobacterial effector protein for the development of host-directed therapy of tuberculosis

    Giichi Takaesu, Tomomi Kurane, Kazuko Sawada, Masayuki Umemura, Goro Matsuzaki

    The 42nd Annual Meeting of the Molecular Biology Society of Japan  2019.12  -  2019.12 

  • Effects of mycobacteria-derived Zmp1 on innate and T-cell immune responses

    Masayuki Umemura, Tomokazu Kimura, Kouhei Iwahashi, Tomomi Kurane, Naoko Teruya, Masaaki Nakayama, Naoya Ohara, Giichi Takaesu, Goro Matsuzaki

    The 60th Annual Meeting for the Japanese Society of Tropical Medicine  2019.11  -  2019.11 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(B)

    Project Year: 2020.04  -  2023.03 

    Direct: 13,500,000 (YEN)  Overheads: 17,550,000 (YEN)  Total: 4,050,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2021.03 

    Direct: 3,400,000 (YEN)  Overheads: 1,020,000 (YEN)  Total: 4,420,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2021.03 

    Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2018.04  -  2021.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  • Molecular mechanisms of cell death in macrophages and foam cells

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2015.04  -  2018.03 

    Investigator(s): TAKAESU Giichi 

    Direct: 3,800,000 (YEN)  Overheads: 4,940,000 (YEN)  Total: 1,140,000 (YEN)

     View Summary

    Macrophages are the major immune cells in the atherosclerotic lesions and play important roles in disease progression. Macrophages uptake oxidized low density lipoproteins (oxLDL) and differentiate into foam cells. Foam cells eventually undergo apoptosis or necroptosis. The former is thought to be protective, but the latter is thought to be detrimental. To develop new therapeutics for atherosclerosis, it is necessary to understand the molecular mechanisms of programmed cell death in macrophages and foam cells. In this study, I have investigated the roles of TAB2 and its close homolog TAB3 in macrophages and foam cells. Tab2/3-deficient foam cells underwent necrosis. In addition, TAB2, but not TAB3, was essential for suppression of TNF-induced necroptosis, which was responsible for the inflammasome activation in LPS-primed Tab2-deficient macrophages. These findings will help to develop novel strategies to treat atherosclerosis and other inflammatory diseases.

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SDGs 【 display / non-display

  • 細菌感染症の新規治療薬の開発を目指す基盤的研究