Researcher Number(JSPS Kakenhi)


Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Graduate School of Medicine   Professor  

  • Concurrently   University of the Ryukyus   Faculty of Medicine   Professor  

University 【 display / non-display


    Keio University   Faculty of Medicine   Graduated

Study abroad experiences 【 display / non-display

  • 1996.03

    Section of Neurobiology, Yale University School of Medicine  

Academic degree 【 display / non-display

  • Hokkaido University -  Doctor of Medical Scinece

External Career 【 display / non-display

  • 1987.04

    Department of Anatomy, Hokkaido University School of Medicine, Research Assistants  

  • 1995.11

    Department of Anatomy, Hokkaido University School of Medicine, Senir Assistant  

  • 2000.04

    Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Senir Assistant  

  • 2003.01

    Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Associate Professor  

  • 2007.04

    University of the Ryukyus, Faculty of Medicine, Medicine, Department of Physiological Sciences,Professor  

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Affiliated academic organizations 【 display / non-display

  • 1987.05

    The Japanese Association of Anatomists 

  • 1990.04

    Japan Neuroscience Society 

  • 2004.04

    The Japanese Association of Anatomists    Scientific Councillor

  • 2007.04

    The Japanese Association of Anatomists    Scientific Councillor

  • 2007.04

    Okinawa Medical Science Research Foundation 

Research Interests 【 display / non-display

  • Histology

  • Embryology

  • Gross Anatomy

  • Neuroscience

  • Neuroanatomy

Research Areas 【 display / non-display

  • Life Science / Neuroscience-general

  • Life Science / Anatomy and histopathology of nervous system

Research Theme 【 display / non-display

  • GABA roles in development, plastisity and regeneration

  • Molecular and morphologica analysis in GABAergic Signaling in the Developing Brain

Thesis 【 display / non-display

  • Altered Distribution of Inhibitory Synaptic Terminals in Reeler Cerebellum with Special Reference to Malposition of GABAergic Neurons



Published Papers 【 display / non-display

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Books 【 display / non-display

  • Factors Affecting Neurodevelopment

    Shiori Kobayashi, Chigusa Shimizu-Okabe, Jeongtae Kim, Yoshinori Kosaka, Masanobu Sunagawa, Akihito Okabe, Chitoshi Takayama ( Part: Multiple Authorship ,  Development of the GABAergic network in the mouse spinal cord )

    Academic Press is an imprint of Elsevier  2021

     View Summary

    Gamma-amino butyric acid (GABA) is one of the predominant inhibitory neurotransmitters in the spinal cord and negatively regulates neuronal activity. In this chapter, we describe the mature GABAergic system in the spinal cord and its developmental process from the viewpoints of GABAergic neurons and terminals, GABA receptors, GABAergic action, and the GABA removal system based on morphological studies. A ventral-to-dorsal developmental direction exists in the localization of GABAergic neurons and terminals, shift of GABAergic action from excitatory to inhibitory, and formation of the GABA removal system. Changes in GABAergic action and maturation of the GABA removal system parallel the formation of GABAergic synapses. In the ventral horn, the number of the GABAergic synapses peaks on the day of birth, and these synapses gradually shift to glycinergic synapses after birth. In the dorsal horn, GABAergic synapses continue to increase in number until postnatal day 21, and some become GABA and glycine coreleasing synapses during postnatal development.

  • GABA in autism and related disorders

    Takayama C ( Part: Single Author ,  GABAergic signaling in the developing cerebellum )

    Elsevier Academic Press  2006.04

     View Summary

    The chapter reviews the GABAergic system, the system in which neurons produce gamma-aminobutyric acid (GABA) as their output, in the cerebellum and the developmental changes in GABAergic signaling, and discusses the way in which GABA exerts its effect on immature neurons during development. The establishment of GABAergic synapses is crucial for the expression of normal and higher brain functions. The key factors for the formation of functional GABAergic synapses are presented and the mechanisms underlying the formation of GABAergic synapses and networks are discussed. GABAergic input plays important roles in cerebellar functions because GABAergic neurons regulate the neuronal activity of Purkinje cells and granule cells that organize the major stream of neural circuitry in the cerebellar cortex. The neuroanatomical analysis of the cerebellar local circuit suggests that GABAergic neurons play a role in lateral inhibition and negative feedback mechanisms on the Purkinje and granule cells. The elimination of GABAergic input from the Golgi cells in the cerebellar granular layer causes overexcitation of granule cells resulting in severe ataxia during the acute phase. Therefore, GABAergic input plays a role in the regulation of glutamatergic hyperexcitation and could be involved in motor coordination. In addition, neuroimaging and biochemical studies indicate a dysfunction in the GABAergic system in the cerebellum of autistic patients. This result suggests that the GABAergic network in the cerebellum might be involved in not only motor function, but also higher brain functions.