Details of a Researcher

Suzuki Mikio

写真a

Title	Professor
Researcher Number(JSPS Kakenhi)	00226557
Laboratory Address	1076 Kiyuna, Ginowan, Okinawa
Mail Address
Laboratory Phone number	+81-98-894-1423

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Current Affiliation Organization 【 display / non-display 】

Duty University of the Ryukyus Graduate School of Medicine Professor

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Academic degree 【 display / non-display 】

Shiga University of Medical Science - Doctor of Medical Science

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External Career 【 display / non-display 】

2010.04

　

　

University of the Ryukyus, Graduate School of Medicine, Professor
2010.04

　

　

University of the Ryukyus, Graduate School of Medicine, Professor
2015.04

　

　

University Hospital, University of the Ryukyus
2017.04

　

　

University of the Ryukyus
2019.04

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Research Interests 【 display / non-display 】

脳機能画像
endoscopic sinus surgery
内耳疾患
低侵襲外科
human papillomavirus

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Research Areas 【 display / non-display 】

Life Science / Otorhinolaryngology
Life Science / Otorhinolaryngology

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Research Theme 【 display / non-display 】

Development of surgical instrument in MR environment
Evaluation of sensory system disturbance using functional MRI
Evaluation of sensory disturbance in Otolaryngology using functional MRI
Inner ear dysfunction associated with the point mutation in mitochondrial genome
Autoantibodies against innerear in patients with inner ear diseases

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Published Papers 【 display / non-display 】

Analysis of reconstructed oropharynx shape after total glossolaryngectomy reconstruction using a free rectus abdominis musculocutaneous flap

Takahiro Hirayama, Yusuke Shimizu, Hidetoshi Kinjo, Shinya Agena, Hitoshi Hirakawa, Hiroyuki Maeda, Mikio Suzuki, Ryogo Kuba, Shohei Ishihara, Naoki Matsuura

JPRAS Open ( Elsevier BV ) 41 52 - 60 2024.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)
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Feasibility of Near-infrared Photoimmunotherapy Combined With Immune Checkpoint Inhibitor Therapy in Unresectable Head and Neck Cancer

HITOSHI HIRAKAWA, TARO IKEGAMI, HIDETOSHI KINJYO, YOSHIKAZU HAYASHI, SHINYA AGENA, TERUYUKI HIGA, SHUNSUKE KONDO, MASATOMO TOYAMA, HIROYUKI MAEDA, MIKIO SUZUKI

Anticancer Research ( Anticancer Research USA Inc. ) 44 ( 9 ) 3907 - 3912 2024.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)
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Butyrate inhibits type 2 inflammation in eosinophilic chronic rhinosinusitis.

Masatomo Toyama, Hideaki Kouzaki, Takeshi Shimizu, Hitoshi Hirakawa, Mikio Suzuki

Biochemical and biophysical research communications 714 149967 - 149967 2024.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Butyrate and other Short-chain fatty acids (SCFAs) are microbial metabolites from Bacteroides and Clostridium species that may suppress type 2 inflammation. However, the mechanisms of SCFAs in the nasal sinuses are not fully understood. We aimed to clarify the in vitro and in vivo roles of SCFAs in eosinophilic chronic rhinosinusitis (ECRS) pathophysiology. We investigated whether SCFAs induced changes in type 2 cytokines, IgE, and apoptosis and the roles of GPR41, GPR43, and histone deacetylase. Analysis of the control subjects demonstrated that butyrate of SCFAs effectively inhibited type 2 cytokine production in PBMCs, ILC2s, and CD4+ T cells and IgE production in CD19+ B cells. In annexin V analysis, butyrate also induced late apoptosis of PBMCs. The butyrate-induced inhibition of type 2 cytokines appeared involved in histone deacetylase inhibition but not in GPR41 or GPR43. In an analysis of ECRS in humans, butyrate inhibited type 2 cytokine production in PBMCs and nasal polyp-derived cells. The butyrate concentration in nasal lavage fluid was significantly decreased in ECRS patients compared to controls and non-ECRS patients. Our findings confirm that butyrate can inhibit type 2 inflammation and may be a potential therapeutic target for ECRS.
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Utility of Ultrahigh-Resolution Computed Tomography for Laryngeal Reconstructive Surgery.

Norimoto Kise, Hitoshi Hirakawa, Soya Aniya, Taiyo Ooshiro, Shunsuke Kondo, Atsushi Tomoda, Yoshiki Oyakawa, Asanori Kiyuna, Mikio Suzuki

The Laryngoscope 2024.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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OBJECTIVE: Unilateral vocal fold paralysis (UVFP) presents as incomplete glottal closure and leads to breathy hoarseness. Various treatments, including laryngeal framework surgery (type 1 thyroplasty [TP1] and arytenoid adduction [AA]), have been devised to correct this condition. Ultrahigh-resolution computed tomography (U-HRCT) allows detailed three-dimensional imaging of the larynx, which aids our understanding of vocal fold motion disorders. This study assessed whether U-HRCT is beneficial for correct diagnosis and surgical planning. METHODS: The participants were 26 UVFP patients who underwent laryngeal framework surgery (TP1 and/or AA). U-HRCT was used to measure the vocal fold volume (VFV) and level difference (LD). The need to combine AA with TP1 to obtain satisfactory surgical outcomes was evaluated by U-HRCT and various voice function tests. RESULTS: VFV was smaller in paralyzed folds than in unaffected folds. LD correlated strongly with voice parameters and showed high intra-rater and inter-rater reliability. The surgical outcome of the laryngeal framework surgery performed was judged to be excellent for improving voice function. Comparison of LD between the TP1 group and TP1 + AA group indicated that LD is an excellent parameter to determine the need to combine AA with TP1. CONCLUSION: These findings underscore the value of preoperative U-HRCT, especially LD, in surgical decision-making and afford insights for optimal phonosurgery and individualized intervention. Patients with LD >1.0 mm may benefit from thyroplasty with AA. LEVEL OF EVIDENCE: Level 3 (case-control study) Laryngoscope, 2024.
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Tracheal Mucoepidermoid Carcinoma Complicated with Papillary Thyroid Carcinoma

Igei Masaki, Kise Norimoto, Miyahira Hirohumi, Tamaki Tomoko, Hirakawa Hitoshi, Maeda Hiroyuki, Suzuki Mikio

Koutou (THE LARYNX JAPAN) ( THE JAPAN LARYNGOLOGICAL ASSOCIATION ) 36 ( 1 ) 43 - 47 2024.06

Type of publication: Research paper (other science council materials etc.)

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Primary tracheal carcinoma is a rare malignant tumor; among all malignant tumors, it is reported to occur account for 0.04% of malignancies in Japan and 0.1% in Europe and the United States, with squamous cell carcinoma, accounting for 45%, and adenoid cystic carcinoma, accounting for 41%. We report the case of a 79-year-old woman with papillary thyroid carcinoma, cT4aN0M0 (right recurrent), with laryngeal nerve and tracheal wall invasion, The patient underwent total thyroidectomy, right recurrent laryngeal nerve resection, and tracheal fenestration. On the 16th postoperative day, when attempting to remove the cannula, dyspnea developed, and the bilateral vocal cords were observed. The patient was diagnosed with paralysis. This did not improve despite follow-up. The patient was referred to our hospital for glottis surgery. Preoperative computed tomography (CT) images showed a mass protruding from the left wall of the trachea into the lumen, and pretracheal lymphadenopathy, suggesting intratracheal recurrence of papillary thyroid carcinoma and cervical lymph node metastasis. Therefore, glottis surgery was temporarily suspended and tumor resection (tumor resection including combined resection of the trachea and reconstruction of the tracheal wall using a DP flap) was planned and the operation was performed. A pathological examination revealed papillary carcinoma lymph node metastasis in the pretracheal lymph nodes, but the tumor tissue in the trachea was found to be low-grade mucoepidermoid. carcinoma, not papillary carcinoma. In the present case an intratracheal lesion after surgery for papillary thyroid carcinoma was identified as primary mucoepidermoid carcinoma of the trachea.
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