Current Affiliation Organization 【 display / non-display 】

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• Development of surgical instrument in MR environment

• Evaluation of sensory system disturbance using functional MRI

• Evaluation of sensory disturbance in Otolaryngology using functional MRI

• Inner ear dysfunction associated with the point mutation in mitochondrial genome

• Autoantibodies against innerear in patients with inner ear diseases

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Published Papers 【 display / non-display 】

• Human papillomavirus infection and EGFR exon 20 insertions in sinonasal inverted papilloma and squamous cell carcinoma

  Hitoshi Hirakawa, Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Shinya Agena, Narumi Hasegawa, Junko Kawakami, Hiroyuki, Maeda, Mikio Suzuki

  Journal of Personalized Medicine   13 ( 4 ) 657   2023.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• [Review] Spatio-temporal gene expression of human papillomavirus in laryngeal papilloma

  Taro Ikegami, Asanori Kiyuna, Norimoto Kise, Mikio Suzuki

  THE LARYNX JAPAN   33 ( 2 ) 69 - 75   2021.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• HPV関連頭頸部癌におけるmTOR経路の検討

  近藤 俊輔, 安慶名 信也, 平川 仁, 真栄田 裕行, 鈴木 幹男

  日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  59回   O40 - 1   2021.10 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

• HPV非関連進行咽頭癌におけるHIF1-αの発現と予後

  安慶名 信也, 近藤 俊輔, 平川 仁, 真栄田 裕行, 鈴木 幹男

  日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  59回   O40 - 3   2021.10 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

• A nationwide epidemiologic, clinical, genetic study of Usher syndrome in Japan

  Hidekane Yoshimura, Shin ya Nishio, Yuichi Isaka, Toru Kurokawa, Shin ichi Usami, Katada Akihiro, Noriko Ogasawara, Tomoko Shintani, Yumiko Kobayashi, Hiroaki Sato, Seiji Kakehata, Daisuke Kikuchi, Tetsuo Ikezono, Kotaro Ishikawa, Kyoko Shirai, Masahiro Takahashi, Satoshi Iwasaki, Yasuhiro Arai, Hajime Sano, Mayuri Okami, Hiroshi Nakanishi, Tomoko Esaki, Michihiko Sone, Jun Nakayama, Takayuki Okano, Yumi Ota, Hiroshi Nishimura, Yasushi Naito, Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Masuda, Kazuma Sugawara, Hiroshi Yamashita, Naoto Hato, Takashi Nakagawa, Akira Ganaha, Tetsuya Tono, Ikuyo Miyanohara, Mikio Suzuki

  Acta Oto-Laryngologica   141 ( 9 ) 841 - 846   2021 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Background: Usher syndrome (USH) typically leads to deaf-blindness, requiring the provision of extensive education and rehabilitation services. Therefore, investigating the prevalence is crucial to requests for proper government support for USH patients. Objective: The aim was to perform a nationwide epidemiologic survey of USH in Japan to estimate the prevalence of USH and reveal the relative frequency and characteristics of the three USH subtypes. Methods: To estimate the number of USH patients visiting hospitals over a 1-year period, 1,628 hospitals were randomly selected from all Departments of Otorhinolaryngology and Ophthalmology in Japan. Subsequently, we collected data regarding the clinical characteristics of each patient treated and the results of genetic testing, if performed. Results: We found that the prevalence of USH was at least 0.4 per 100,000 population. The frequency of clinical subtypes and causal genes for USH were consistent with previous reports. Also, we demonstrated the feasibility of genetic counseling for USH patients based on the results of genetic testing. Conclusion: USH is a rare disease, but requires social support due to the severity of symptoms. To minimize these issues, understanding the clinical characteristics and performing comprehensive genetic testing could allow early and accurate diagnosis as well as medical intervention.

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• Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Direct: 3,500,000 (YEN)  Overheads: 1,050,000 (YEN)  Total: 4,550,000 (YEN)

• Biomarker in relation to diagnosis and prognosis in patients with HPV-related head and neck cancer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Biomarker in relation to diagnosis and prognosis in patients with HPV-related head and neck cancer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Direct: 3,800,000 (YEN)  Overheads: 1,140,000 (YEN)  Total: 4,940,000 (YEN)

• Analysis of carcinogenesis mechanism induced by human papillomavirus using DNA methylation as an indicator

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Investigator(s): Deng Zeyi 

  Direct: 3,800,000 (YEN)  Overheads: 4,940,000 (YEN)  Total: 1,140,000 (YEN)

  　View Summary

  In this project, it was demonstrated that long control region (LCR) of HPV-16 in HPV-16 positive head and neck cancer (HNC) is often hypomethylated, and hypermethylation status of E2-binding Sites of HPV-16 frequently contributes to carcinogenesis in HNC. The extent of HPV-DNA methylation is not associated to the prognosis of HNC. Compared to HPV-DNA positive HNC, the higher level of SMG-1 mRNA expression in HPV-DNA negative HNC was observed. Lower SMG-1 mRNA expression may be associated with radiotherapy sensitivity in HNC. In addition, our findings revealed that the LCR of HPV-6 is frequently hypomethylated in laryngeal papilloma. Seven papers in English have published during 3 years of the research period.

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