Published Papers - Suzuki Mikio

The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan

Masahiro Okada, Naohito Hato, Shin-ya Nishio, Ryosuke Kitoh, Kaoru Ogawa, Sho Kanzaki, Michihiko Sone, Satoshi Fukuda, Akira Hara, Tetsuo Ikezono, Kotaro Ishikawa, Satoshi Iwasaki, Kimitaka Kaga, Seiji Kakehata, Atsushi Matsubara, Tatsuo Matsunaga, Takaaki Murata, Yasushi Naito, Takashi Nakagawa, Kazunori Nishizaki, Yoshihiro Noguchi, Hajime Sano, Hiroaki Sato, Mikio Suzuki, Hideo Shojaku, Haruo Takahashi, Hidehiko Takeda, Tetsuya Tono, Hiroshi Yamashita, Tatsuya Yamasoba, Shin-ichi Usami

ACTA OTO-LARYNGOLOGICA ( TAYLOR & FRANCIS LTD )  137 ( sup565 ) S30 - S33   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (>= 60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.

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Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report

Hiroyuki Maeda, Zeyi Deng, Taro Ikegami, Sen Matayoshi, Shinya Agena, Asanori Kiyuna, Yukashi Yamashita, Takayuki Uehara, Akira Ganaha, Mikio Suzuki

ONCOLOGY LETTERS ( SPANDIDOS PUBL LTD )  12 ( 3 ) 2087 - 2091   2016.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Branchiogenic carcinoma (BC) usually appears as a mass lesion with a predominant cystic component. Since lymph node metastasis from oropharyngeal carcinoma (OPC) has a cystic appearance, it is occasionally difficult to distinguish between BC and nodal metastases from clinically silent OPC. Factors associated with the malignant transformation process in BC remain obscure. The present study reports the case of a 56-year-old man with a right cystic cervical mass that was diagnosed as squamous cell carcinoma based on examination by fine-needle aspiration biopsy. The primary tumor could not be detected despite several imaging examinations, a pan-endoscopy of the head and neck, esophagus and stomach, biopsies of the head and neck regions, and bilateral tonsillectomies. The pathological findings of the surgical specimens from a radical neck dissection were consistent with the histological characteristics of BC, with evidence of transition from dysplasia through intraepithelial carcinoma to invasive carcinoma. Normal squamous epithelium and dysplastic and cancerous portions in the BC showed strong p16(INK4a) immunoreactivity. The expression of p16(INK4a) was also observed in all 9 nodal metastases in the neck dissection specimens. The cystic formation observed in the BC was not observed in the nodal metastases. As the presence of human papillomavirus-16 in the tumor was confirmed by polymerase chain reaction, quantitative polymerase chain reaction was employed for the measurement of human papillomavirus-16 viral load and integration. The results showed that the viral load of human papillomavirus-16 was 3.01x107/50 ng genomic DNA, and the E2/E6 ratio was 0.13, so the integration state was judged to be the mixed type. To the best of our knowledge, this is the first report of BC associated with high-risk-type human papillomavirus infection. The study indicates that a human papillomavirus-positive neck mass may not necessarily be OPC, but that it could be BC with a poor prognosis. This report lends support to the existence of BC and proposes that the etiology is human papillomavirus infection.

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頭頸部癌の診断と治療

鈴木 幹男, 上原 貴行, 山下 懐, 真栄田 裕行, 平川 仁

沖縄県医師会報 ( (一社)沖縄県医師会 )  52 ( 6 ) 804 - 809   2016.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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頭頸部癌は全癌の部位別罹病率で6番目であり,決して多い癌腫ではないが,頭頸部は呼吸,嚥下,発声,容貌などに関係するため一旦癌に罹患するとQOLが著しく障害される.頭頸部扁平上皮癌の2大発生要因は喫煙とアルコール過剰摂取であり,多発・多重癌が多い.これ以外に上咽頭癌ではEpstein-Barrウイルス,中咽頭癌ではヒト乳頭腫ウイルス(HPV)の感染が発癌に関係している.本論文では現在のトピックスである頭頸部癌のHPV感染と癌の早期診断・治療について解説した.HPV関連中咽頭癌は若年発症(30〜50歳),飲酒歴がない,喫煙歴がない特徴を持つ.治療予後はHPV陰性癌と比較すると良好であり,治療強度を下げるための臨床研究が現在進行中である.頭頸部癌は進行して発症する例が多いが,最近では経鼻上部消化管内視鏡検査とPET-CT検査の普及により,症状がない時期に早期診断される例が増えている.このような症例では低侵襲な経口的手術が開発されており,QOL,治療予後の両者を満足させることができる.(著者抄録)

Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma

Hitoshi Hirakawa, Nobuhiro Hanai, Taijiro Ozawa, Hidenori Suzuki, Daisuke Nishikawa, Sen Matayoshi, Mikio Suzuki, Yasuhisa Hasegawa

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK ( WILEY-BLACKWELL )  38   E1305 - E1311   2016.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background. The significance of neoadjuvant chemotherapy followed by definitive surgery for sinonasal squamous cell carcinoma (SCC) was investigated using surgical specimens. Methods. Surgery was performed in 58 patients, including 43 patients who had received neoadjuvant chemotherapy. The pathological response was classified as grades 0 (no effect), 1 (slight effect), 2 (moderate effect), and 3 (marked effect), and its correlation with prognosis was investigated. Results. Grade 2 or 3 response was observed in 34.9% of cases that received neoadjuvant chemotherapy. Overall survival (OS), disease-free survival (DFS), locoregional control, and freedom from distant metastasis were significantly better in the effective neoadjuvant chemotherapy group (grades 2 and 3) than in the less effective neoadjuvant chemotherapy group (grades 0 and 1) and the non-neoadjuvant chemotherapy group combined. Conclusion. Pathological response to neoadjuvant chemotherapy in sinonasal SCC was related to disease prognosis. (C) 2016 Wiley Periodicals, Inc.

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Squamous cell carcinoma antigen as a diagnostic marker of nasal inverted papilloma

Yukashi Yamashita, Takayuki Uehara, Masahiro Hasegawa, Zeyi Deng, Sen Matayoshi, Asanori Kiyuna, Shunsuke Kondo, Hiroyuki Maeda, Akira Ganaha, Mikio Suzuki

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY ( OCEAN SIDE PUBLICATIONS INC )  30 ( 2 ) 122 - 127   2016.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background: Serum squamous cell carcinoma antigen (SCCA) levels are elevated in sinonasal inverted papilloma (IP). However, the relationship between tumor volume and SCCA level, and the influence of skin or pulmonary diseases in which the SCCA level is high, have not been established. Objective: To clarify whether the level of serum SCCA can be used as a diagnostic marker of IP. Methods: Serum SCCA level was measured in 30 patients with IP (IP group) and 57 with inflammatory disease (inflammatory group). Results: Overall, 83.3% in the IP group showed elevated serum SCCA levels regardless of whether they were new patients or patients with recurrent IP, and SCCA levels rapidly decreased after surgery. Only 5.3% had elevated SCCA levels in the inflammatory group. Before surgery, the IP group had a median preoperative SCCA level of 2.4 ng/mL, whereas the median preoperative SCCA level was 0.9 ng/mL in the inflammatory group. Pre-and postoperative SCCA levels were significantly different in the IP group. With regard to the IP diagnosis in the IP and inflammatory groups based on the SCCA level (<= 1.5 ng/mL), sensitivity and specificity were 83.3% and 94.7%, respectively. There was no significant correlation between SCCA elevation and respiratory function, and skin disease in the two groups, except for smoking in the IP group. Preoperative SCCA levels were significantly higher in smokers than in never-smokers in the IP group. Tumor volume was significantly correlated with SCCA level in IP. Multivariable logistic analysis showed that tumor volume was a predictor of preoperative SCCA elevation (p = 0.036; 95% confidence interval, 1.027-2.176). Conclusion: Serum SCCA level is a reliable diagnostic marker to distinguish new and recurrent IP from inflammatory disease. Because smokers tended to have higher SCCA levels in IP, a different cutoff level might be needed. Although respiratory dysfunction and skin disease were not related to SCCA level, they should be taken into consideration when evaluating SCCA level.

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Is there a higher prevalence of human papillomavirus infection in Chinese laryngeal cancer patients? A systematic review and meta-analysis

Chunlin Zhang, Zeyi Deng, Yuehong Chen, Mikio Suzuki, Minqiang Xie

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY ( SPRINGER )  273 ( 2 ) 295 - 303   2016.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Accumulating evidence suggests that persistent human papillomavirus (HPV) infection is closely related to the risk of certain types of head and neck squamous cell carcinoma types, including laryngeal cancer (LC). Some reports indicated a higher HPV prevalence in Chinese LC patients, which remains to be established due to small study sample sizes. The aim of this study was to estimate the HPV infection rate in Chinese LC patients and assess the LC risk conferred by high-risk subtype HPV infection by meta-analysis. We searched MEDLINE, the Embase Database, Chinese National Knowledge Infrastructure, Wanfang Database, and VIP Database for studies published in either English or Chinese up to October 2013, and systematically reviewed 28 original research articles that met the inclusion criteria. Both the HPV infection rate in the LC group (all 28 studies) and the LC risk from high-risk HPV infection (a subgroup of 12 case-control studies) were analyzed by R 3.0 software. Overall HPV, HPV-16/18, and HPV-6/11 infection rates were 32 % (95 % CI 22-44 %), 30 % (95 % CI 24-37 %), and 12 % (95 % CI 9-17 %), respectively. There was a strong association between high-risk HPV-16/18 infection and LC (P < 0.01; OR = 8.07, 95 % CI 5.67-11.48). Our research indicates that there is a higher HPV prevalence in Chinese LC patients compared to LC patients outside of China and that HPV infection significantly increases LC risk.

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[Maxillary Cancer with Metastasis to the Rouviere Nodes -- Complete Response to Chemoradiotherapy Using a Selective Intra-Arterial Infusion Technique].

Yamashiro K, Heianna J, Azama K, Iraha Y, Yamashiro T, Kinoshita R, Toita T, Toyama M, Agena S, Maeda H, Suzuki M, Murayama S

Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 2 ) 243 - 246   2016.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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We report a case of advanced maxillary cancer with multiple lymph node metastases, including metastasis to the Rouviere nodes, which were successfully treated with chemoradiotherapy using a selective intra-arterial infusion technique.A 71-yearold man presented to our hospital with complaints of a staggering gait and epistaxis.He was diagnosed with maxillary cancer (squamous cell carcinoma)classified as T4a disease.Because multiple lymph node metastases were detected, including metastasis to the Rouviere nodes, radical surgical treatment was considered inadequate.Thus, the patient was treated with concurrent chemoradiotherapy with selective intra-arterial infusion of nedaplatin and docetaxel.After chemoradiotherapy, the maxillary cancer and lymph metastasis nearly resolved and the patient achieved a complete response.No additional surgery was needed, and the patient was discharged.We suggest that chemoradiotherapy using a selective intra-arterial infusion technique is a highly effective treatment option for patients with maxillary cancer and metastasis to the Rouviere nodes.

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Effects of Methylation Status of CpG Sites within the HPV16 Long Control Region on HPV16-Positive Head and Neck Cancer Cells

Chunlin Zhang, Zeyi Deng, Xiaoli Pan, Takayuki Uehara, Mikio Suzuki, Minqiang Xie

PLOS ONE ( PUBLIC LIBRARY SCIENCE )  10 ( 10 ) e0141245   2015.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Objective To map comprehensively the methylation status of the CpG sites within the HPV16 long control region (LCR) in HPV-positive cancer cells, and to explore further the effects of methylation status of HPV16 LCR on cell bioactivity and E6 and E7 expression. In addition, to analyze the methylation status of the LCR in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) patients. Methods and Materials Methylation patterns of HPV16 LCR in UM-SCC47, CaSki, and SiHa cells and HPV16-positiive OPSCC specimens were detected by bisulfite-sequencing PCR and TA cloning. For cells treated with 5-aza-2'-deoxycytidine and E6 and E7 knockdown, MTS and trypan blue staining, annexin-V and 7-AAD staining, and prodidium iodide were used to evaluate cell growth and cell proliferation, cell apoptosis, and cell cycle arrest, respectively. E6 and E7 mRNA and protein expression were analyzed by quantitative real-time PCR and immunocytochemistry, respectively. Results Hypermethylation status of the LCR in UM-SCC47 (79.8%) and CaSki cells (90.0%) and unmethylation status of the LCR in SiHa cells (0%) were observed. Upon demethylation, the cells with different methylation levels responded differently during growth, apoptosis, and cell cycle arrest, as well as in terms of their E6 and E7 expression. In HPV16-positive OPSCC patients, the methylation rates were 9.5% in the entire LCR region, 13.9% in the 5'-LCR, 6.0% in the E6 enhancer, and 9.5% in the p97 promoter, and hypermethylation of p97 promoter was found in a subset of cases (20.0%, 2/10). Conclusions Our study revealed two different methylation levels of the LCR in HPV16-positive cancer cells and OPSCC patients, which may represent different carcinogenesis mechanisms of HPV-positive cancers cells. Demethylating the meCpGs in HPV16 LCR might be a potential target for a subgroup of HPV16-positive patients with head and neck squamous cell carcinoma.

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Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases

Yukashi Yamashita, Masahiro Hasegawa, Zeyi Deng, Hiroyuki Maeda, Shunsuke Kondo, Asanori Kyuna, Sen Matayoshi, Shinya Agena, Takayuki Uehara, Hideaki Kouzaki, Takeshi Shimizu, Taro Ikegami, Akira Ganaha, Mikio Suzuki

INFECTIOUS AGENTS AND CANCER ( BIOMED CENTRAL LTD )  10   23   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background: We aimed to clarify the possible role of human papillomavirus (HPV) infection in the malignant transformation of sinonasal inverted papilloma (IP). Methods: Subjects comprised 32 patients with chronic rhinosinusitis (CRS), 17 with IP, 5 with IP and squamous cell carcinoma (IP + SCC), and 16 with primary sinonasal SCC. HPV presence, viral loads, and physical status were investigated using polymerase chain reaction. Retinoblastoma (pRb), p53, and p16(INK4a) gene products were investigated by immunohistochemistry. Results: HPV DNA was detected in 6.3 % of cases with CRS, 29.4 % with IP, 40 % with IP + SCC, and 25 % with SCC. IP cases had significantly higher HPV presence than CRS cases (p = 0.04). High-risk HPV-16 was the most frequently encountered subtype (10/13, 76.9 %). HPV-16 viral loads varied from 2.5 to 7953 E6 copies/50 ng genomic DNA. Patients in the SCC and IP + SCC groups had significantly higher viral loads than those in the IP and CRS groups (p < 0.01). All SCC and IP + SCC patients with HPV-16 demonstrated mixed-type integration, whereas 4 of 5 HPV-16 patients in the IP and CRS groups showed episomal type infection (p = 0.04). Positivity to pRb was found in 78.1 % of CRS, 35.3 % of IP, and 68.8 % of SCC cases. The presence of HPV DNA negatively correlated with pRb expression in SCC (p = 0.029) and IP (P = 0.049) groups. Although 62.5 % of SCC cases exhibited p53 positivity, only 5.9 % of IP, and no CRS cases were positive. Regardless of HPV status, p16(INK4a) positivity was frequently detected in IP cases (82.4 %), less in SCC (12.5 %) cases, and was not detected in the CRS group. Neither the IP nor SCC cohorts showed any correlation between HPV presence and the expression of either p53 or p16(INK4a). Conclusions: HPV infection was more frequent in the IP, IP + SCC, and SCC groups than the CRS group. Higher viral loads and integration observed in the IP + SCC and SCC groups, and an inverse correlation between HPV presence and positive pRb indicated that persistent infection and integration play a part in tumorigenesis and malignant transformation in certain IP cases. However, p16(INK4a) is not a reliable surrogate marker for HPV infection in IP.

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頭頸部骨軟部肉腫13例の検討

安慶名 信也, 上原 貴行, 山下 懐, 又吉 宣, 長谷川 昌宏, 真栄田 裕行, 鈴木 幹男

耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 )  108 ( 2 ) 145 - 152   2015.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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2007年8月〜2014年5月の間に著者らの施設にある耳鼻咽喉科にて一次治療を行った頭頸部骨軟骨部肉腫13症例(男性10例,女性3例,年齢9〜77歳,平均年齢45歳,経過観察期間4〜50ヵ月,平均24ヵ月)の治療経過について検討した.その結果,1)原発部位は鼻副鼻腔が6例(46%),口腔・中咽頭が3例,顔面・頸部・喉頭・中耳が各1例の順であった.2)組織型は黄紋筋肉腫が3例,骨肉腫・平滑筋肉腫・undifferentiated pleomorphic sarcoma・分類不能肉腫が各2例,滑膜肉腫・血管肉腫が各1例であった.3)初診から病理診断確定までの期間は20〜165日(平均41日,中央値23日)であり,AJCCステージ分類ではステージIが4例,IIIが8例,IVが1例で,ステージIの4例中2例が無病生存中であった.また,FNCLCC分類ではGrade 1は4例,Grade 2が6例,Grade 3が3例で,無病生存3例はGrade 1が2例,Grade 2;1例であった.4)一次治療においては12例に対して根治治療が行われ,姑息治療は1例のみであった.尚,,一次治療後の再発病変に対する治療は手術治療を3例に行なわれたが,サルベージできたものは1例であった.5)13例の3年生存率は35.2%で,本調査最終観察時点で無病生存している症例は3例のみであった.一方,死亡10例において死亡時原発部位,頸部再発転移がなかったのは1例のみで,9例では原発部位または頸部に再発していた.

[Neck pain].

Suzuki M

Nihon Jibiinkoka Gakkai kaiho   118 ( 2 ) 107 - 114   2015.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Identification of two novel mutations in the NOG gene associated with congenital stapes ankylosis and symphalangism

Akira Ganaha, Tadashi Kaname, Yukinori Akazawa, Teruyuki Higa, Ayano Shinjou, Kenji Naritomi, Mikio Suzuki

JOURNAL OF HUMAN GENETICS ( NATURE PUBLISHING GROUP )  60 ( 1 ) 27 - 34   2015.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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In this study, we describe three unrelated Japanese patients with hearing loss and symphalangism who were diagnosed with proximal symphalangism (SYM1), atypical multiple synostosis syndrome (atypical SYNS1) and stapes ankylosis with broad thumb and toes (SABTT), respectively, based on the clinical features. Surgical findings in the middle ear were similar among the patients. By next-generation and Sanger sequencing analyses, we identified two novel mutations, c.559C>G (p. P178A) and c. 682T>A (p. C228S), in the SYM1 and atypical SYNS1 families, respectively. No pathogenic changes were found in the protein-coding regions, exon-intron boundaries or promoter regions of the NOG, GDF5 or FGF9 genes in the SABTT family. Such negative molecular data suggest there may be further genetic heterogeneity underlying SYNS1, with the involvement of at least one additional gene. Stapedotomy resulted in good hearing in all patients over the long term, indicating no correlation between genotype and surgical outcome. Given the overlap of the clinical features of these syndromes in our patients and the molecular findings, the diagnostic term 'NOG-related-symphalangism spectrum disorder (NOG-SSD)' is advocated and an unidentified gene may be responsible for this disorder.

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Clinical outcome of palliative radiotherapy in patients with head and neck cancer

Takayuki Uehara, Hiroyuki Maeda, Yukashi Yamashita, Masahiro Hasegawa, Shinya Agena, Mikio Suzuki

Practica Oto-Rhino-Laryngologica ( Society of Practical Otolaryngology )  108 ( 6 ) 475 - 481   2015 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Patient profiles, compliance with palliative radiotherapy and the treatment outcomes were investigated in head and neck cancer patients who received palliative radiotherapy from 2006 to 2012. Clinicians selected patients who received palliative radiotherapy considering the clinical stage and the general body condition. There were no patients with severe acute or late toxicities during treatment and the completion rate of palliative radiotherapy was 79.3%. The palliative irradiation group showed significantly better overall survival rates as compared to the no-treatment group. Paliative irradiation of the primary tumor and lymph node metastases at the dose of over 50 Gy contributed to long-term disease-free survival and improvement of the quality of life (QOL), including reduction of tumorigenic pain and dysphasia. Thus, palliative radiotherapy may be a useful treatment option for patients with advanced head and neck cancer under the careful management.

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A study on 13 cases of bone and soft tissue sarcomas in the head and neck

Shinya Agena, Takayuki Uehara, Yukashi Yamashita, Sen Matayoshi, Masahiro Hasegawa, Hiroyuki Maeda, Mikio Suzuki

Practica Oto-Rhino-Laryngologica ( Society of Practical Otolaryngology )  108 ( 2 ) 145 - 152   2015 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Since bone and soft tissue sarcomas arising from the head and neck region are very rare, the standard treatment protocol has yet to be established. In the present study, 13 cases with bone and soft tissue sarcomas treated from 2007 to 2014 were analyzed. The mean period from initial visit to final pathological diagnosis was approximately 3 weeks, and 38.5% of the cases needed several biopsies for an accurate diagnosis. Death occurred early for those cases in which more than 40 days was needed to obtain the histological diagnosis. The 3-year overall survival in 13 cases was 35.2%. As the cause of death was uncontrolled local lesion, the locoregional control was more important than distant metastasis control for the prognosis. Tumor location, TNM stage, and histological grade affected the prognosis of the sarcomas. Radiation therapy including heavy ion and proton beam radiotherapy was not so effective as the primary treatment, as was the case with salvage treatment of sarcomas in the head and neck. Although the primary treatment of sarcomas was surgical treatment with an adequate margin, an efficient treatment protocol should be established to obtain a better prognosis.

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Two cases of anisakis allergy

Shunsuke Kondo, Takema Sakota, Kei Nakahara, Tadao Enomoto, Yukinori Akazawa, Mikio Suzuki

Practica Otologica, Supplement ( Society of Practical Otolaryngology )  141   114 - 115   2015 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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We experienced two cases of immediate allergy due to anisakis. Case 1: A 30-year-old man ingested a boiled mackerel, two hours after which he developed urticaria and dyspnea. Six hours later, these symptoms had diminished. He consulted our hospital several days after that. He had three urticaria episodes after ingestion of mackerel. Serum Immuno CAP was positive for anisakis, but negative for mackerel or sardine. Case 2: A 71-year-old woman ingested a boiled flatfish for dinner. The next morning she noticed pharyngeal edema and dyspnea. She came to our hospital and one day after treatment with steroids and antibiotics, her symptoms had resolved. Serum Immuno CAP was positive for anisakis. These two cases show that, patients diagnosed as having a fish-related or idiopathic allergy should be examined for evidence of Anisakis-induced allergy.

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Autoantibodies against inner ear proteins in patients with delayed endolymphatic hydrops and unilateral juvenile deafness

Suzuki M, Hanamitsu M, Kitanishi T, Kohzaki H, Kitano H

Acta Otolaryngol ( その他の出版社 )  126 ( 2 ) 117 - 121   2006.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Use of real-time magnetic resonance image guidance in endoscopic sinus surgery

M. Suzuki, H. Sakurai, T. Kitanishi, T. Shimizu, Y. Nishida, H. Morikawa, T. Inubushi, H. Kitano

Minim Invaseive Ther Allied Technol ( その他の出版社 )  14 ( 3 ) 376 - 384   2005.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat

H. Kouzaki, M. Suzuki, T. Shimizu, Y. Aimi, R. Arai

Brain Research ( その他の出版社 )  1055 ( 42737 ) 202 - 207   2005.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Magnetic resonance spectroscopic determination of a neuronal and axonal marker in white matter predicts reversibility of deficits In secondary normal pressure hydrocephalus

A. Shiino, Y. Nishida, H. Yasuda, M. Suzuki, M. Matsuda, T. Inubushi

J Neurol Neurosurg Psychiatry ( その他の出版社 )  75 ( 8 ) 1141 - 1148   2004.08

Type of publication: Research paper (scientific journal)

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Cavernous haemangioma of the internal auditory canal: a case report

M. Hanamitsu, K. Okumura, Y. Yazawa, J. Fukui, M. Suzuki

J Clin Neurosci ( その他の出版社 )  11 ( 3 ) 337 - 340   2004.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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