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• Epidemiology of Cardiovascular Diseases in Okinawa

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Association of In-Hospital Cardiac Rehabilitation on Hospital-Associated Disability for Octogenarian Patients With Acute Myocardial Infarction ― An Insight From the JROAD-DPC Database ―

  Kono, Y; Katano, S; Otaka, Y; Kanaoka, K; Sawamura, A; Motokawa, T; Miyamoto, Y; Ohya, Y; Miura, SI; Fukuma, N; Makita, S; Izawa, H

  CIRCULATION REPORTS   7 ( 1 ) 25 - 30   2025.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Efficacy and safety of early administration of remdesivir in hemodialysis patients with COVID-19: A case report and literature review

  Oshiro Nanako, Kinjo Takeshi, Aharen Daigo, Kudo Yuki, Katsuren Eisuke, Omine Kumiko, Nakamura Takuto, Zamami Ryo, Ishida Akio, Miyagi Kazuya, Nakamatsu Masashi, Yamamoto Kazuko, Kusunose Kenya, Fujita Jiro, Ohya Yusuke, Kohagura Kentaro

  Medicine ( Wolters Kluwer Health, Inc. )  103 ( 48 ) 1 - 5   2024.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Rationale: Although the mortality of severe coronavirus disease 2019 (COVID-19) has decreased after the emergence of the Omicron variant, it remains high in patients on hemodialysis (HD). Remdesivir (RDV) is considered as the first line drug for hospitalized COVID-19 patients, however the evidence regarding the usage in HD patients is lacking because clinical trials of RDV have excluded HD patients for safety reasons. Thus, accumulation of knowledge on the regimen, efficacy, and tolerability of RDV in HD patients is important. Patient concerns: A nosocomial COVID-19 cluster was occurred from August 31 to October 12 in 2021 when the Delta variant was predominant. During the cluster, 11 health-care workers and 20 inpatients including 7 HD patients were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnoses: The diagnosis of COVID-19 was confirmed by the real-time polymerase chain reaction (PCR) for SARS-CoV-2. Interventions: RDV was initiated within 16 hours after the onset of fever (≥ 37.4°C) or positive PCR result in all HD patients, and continued at 100 mg/day intravenously once daily for either consecutive 5 or 10 days. Outcomes: All patients fully recovered within 2 weeks and did not develop severe COVID-19. Two patients experienced mild liver dysfunction, but it was temporary and remitted spontaneously even continuing RDV treatment. Discontinuation of RDV therapy due to adverse events was not required in any patients. Lessons: Present cases indicated early intervention with RDV may contribute the favorable outcome and daily administration of RDV for up to 10 days was well tolerated even in HD patients. Literature review showed no previous article reported the efficacy and safety of such earlier and longer administration of remdesivir as in the present cases, therefore this report is informative for clinicians to consider the usage of RDV in HD patients.

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• Efficacy and safety of early administration of remdesivir in hemodialysis patients with COVID-19: A case report and literature review

  Oshiro, N; Kinjo, T; Aharen, D; Kudo, Y; Katsuren, E; Omine, K; Nakamura, T; Zamami, R; Ishida, A; Miyagi, K; Nakamatsu, M; Yamamoto, K; Kusunose, K; Fujita, J; Ohya, Y; Kohagura, K

  MEDICINE ( Medicine (United States) )  103 ( 48 ) e40650   2024.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Impact of in-hospital cardiac rehabilitation on hospital-associated disability after transcatheter aortic valve implantation

  Katano, S; Kono, Y; Yano, T; Kanaoka, K; Sawamura, A; Motokawa, T; Miyamoto, Y; Ohya, Y; Miura, S; Fukuma, N; Makita, S; Izawa, H

  JOURNAL OF THE AMERICAN GERIATRICS SOCIETY ( Journal of the American Geriatrics Society )    2024.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Association of obesity and metabolic health status with cerebral small vessel disease in stroke-free individuals

  Ishida, A; Nakanishi, R; Miyagi, T; Yamazato, M; Ohya, Y; Kusunose, K

  EUROPEAN HEART JOURNAL   45   2024.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• パルボウィルス感染に伴うSLE様病態と鑑別を要したループス腎炎の一例

  平良浩菜, 大城菜々子, 大嶺久美子, 砂川祥頌, 中村卓人, 金城孝典, 山里正演, 石田明夫, 古波蔵健太郎, 大屋祐輔

  日本腎臓学会誌 ( (一社)日本腎臓学会 )  61 ( 6 ) 897 - 897   2019.08  [Refereed]

   

  J-GLOBAL

• 0〜20の気圧上昇中の長軸方向ステント長の短縮と伸長(Shortening and Elongation of Longitudinal Stent Length during Expansion of 0 to 20 Atmospheric Pressure)

  潮平 朝洋, 池宮城 秀一, 山里 正演, 岩淵 成志, 大屋 祐輔

  日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  83回   PJ089 - 6   2019.03

   

• 心血管イベントのバイオマーカーとしてのアキレス腱肥厚の有用性に関する横断的研究

  新城 翔大, 池宮城 秀一, 石田 明夫, 大屋 祐輔

  琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 132 - 132   2018.12

   

• 外来通院中の高齢高血圧者における推定塩分摂取量と血圧のコントロール状況

  山里正演, 崎間敦, 田名毅, 中村義人, 石田明夫, 古波蔵健太郎, 大屋祐輔

  日本老年医学会雑誌 ( (一社)日本老年医学会 )  55 ( 4 ) 725‐726(J‐STAGE) - 726   2018.10

   

  J-GLOBAL

• 脳室内マクロファージの枯渇はアンジオテンシンII持続投与食塩負荷ラットの血圧上昇を抑制する

  山里正演, 石田明夫, 山里代利子, 中村卓人, 大屋祐輔

  日本高血圧学会総会プログラム・抄録集 ( (NPO)日本高血圧学会 )  41st (CD-ROM)   ROMBUNNO.OB06‐06 - 06   2018.09

   

  J-GLOBAL

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Cardiovascular Risk Reduction in Atrial Fibrillation Trial

  Grant-in-Aid for Scientific Research(B)

  Project Year: 2019.04  -  2023.03 

  Direct: 13,200,000 (YEN)  Overheads: 17,160,000 (YEN)  Total: 3,960,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2018.03 

  Direct: 3,700,000 (YEN)  Overheads: 1,110,000 (YEN)  Total: 4,810,000 (YEN)

• WEB-based BP data delivey system improved qualty of life and BP contorol in elderly who lives in remote islands in Okinawa.

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2018.03 

  Investigator(s): Yusuke Ohya 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

  　View Summary

  Most elderly are not familiar with information and communication technology(ICT), applications of ICT-based monitoring to elderly are limited. We used the home BP measurement device with automated transfer function via the internet to elderly who lived in seven remote islands in Okinawa (n=230, mean age; male 72 yeas old, female 80 years old). Support by health professionals enhanced their continuation of blood pressure (BP) measurement, while living alone was related with discontinuation. Use of the device did not change mean values of BP, but BP levels who had not known the importance of BP measurement before this projects decreased significantly. Use of the device improved the secure feeling of subjects and their families who lived afar. These results suggest that ICT-based BP self monitoring improved BP control and improved secure feeling of subjects and their families, but contribution of health professionals is also important.

• Contact Irreversible Electroporation of Cells and Tissues under the Control of the Electric Field and Temperature

  Grant-in-Aid for Scientific Research(A)

  Project Year: 2014.04  -  2018.03 

  Investigator(s): Takamatsu Hiroshi, SUMIMOTO Hideki, OYA Yusuke 

  Direct: 33,000,000 (YEN)  Overheads: 42,900,000 (YEN)  Total: 9,900,000 (YEN)

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  This study aimed to develop contact irreversible electroporation for treatment of superficial tumors by using electric pulses at extremely reduced voltages. We first developed a method to measure the temperature rise associated with considerably short electric pulses. We also showed that transient temperature rise during electroporation could be estimated by numerical analysis. Protein denaturation due to the excess electric pulses was detectable by using Raman spectroscopic measurement. We then fabricated comb-shaped miniature contact electrodes with the size and geometry optimized by numerical analysis. The electroporation with the electrode successfully necrotized the cells at the surface of a tissue phantom. Furthermore, the depth of the necrotized tissue was controllable by selecting the pulse parameters. We also confirmed that the use of adjuvants could reduce the magnitude of the electric field required for the treatment by up to 30%.

• Assessment of Whole Blood Rheology and Leukocyte Activity in ex vivo Microchannel Array Model to Contribute Cardiovascular Rehabilitation Research

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Investigator(s): YASU TAKANORI 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

  　View Summary

  Leucocytes play an important role in the all process of the atherosclerosis. However, clinically feasible parameters of leukocyte activation in microcirculation is limited. We developed a clinically feasible assessment method of leukocyte activity and blood rheology using a microchannel flow analyzer (MCFAN) with new designed silicon chips mimic to human microvascular network. The passage time of whole blood with heparin or EDTA-2Na+heparin through the microchannel arrays was measured using MC-FAN. Number of adhesive leukocytes (/field) was counted in offline as a gold standard of leukocyte activation. Subtraction of the passage time of blood with heparin and one with EDTA-2Na + heparin was significantly correlated with adhesive leukocyte number. The delta whole blood passage time may be a novel parameter reflecting leukocyte activity.

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