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• A case of meningitis treated with intraventricular vancomycin in an infant

  Uezato, Y; Uehara, W; Kurokawa, S; Nishiyama, N; Nakamura, S; Nakamatsu, M; Nakanishi, K; Yamamoto, K; Shiohira, H; Nakamura, K

  JOURNAL OF INFECTION AND CHEMOTHERAPY ( Journal of Infection and Chemotherapy )  31 ( 4 ) 102674   2025.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components

  Koinuma, K; Noto, K; Morita, T; Uekusa, Y; Kikuchi, H; Shimoji, M; Seki, H; Yamazaki, H; Guengerich, FP; Nakamura, K; Yamamoto, K; Imaoka, A; Akiyoshi, T; Ohtani, H

  JOURNAL OF PHARMACEUTICAL SCIENCES   114 ( 2 ) 849 - 856   2025.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Nirmatrelvir/ritonavir-induced elevation of blood tacrolimus levels in a patient in the maintenance phase post liver transplantation

  Shiohira, H; Arakaki, S; Uehara, W; Uehara, H; Yamamoto, K; Nakamura, K

  JOURNAL OF INFECTION AND CHEMOTHERAPY ( Journal of Infection and Chemotherapy )  30 ( 1 ) 77 - 80   2024.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Nirmatrelvir/ritonavir-induced elevation of blood tacrolimus levels in a patient in the maintenance phase post liver transplantation

  Shiohira H, Arakaki S, Uehara W, Uehara H, Yamamoto K, Nakamura K.

  J Infect Chemother .   30 ( １ ) 77 - 80   2024 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• A case of suspected drug-induced liver injury due to aripiprazole

  HOKAMA Noboru, SHIOHIRA Hideo, NAKAMURA Katsunori

  Annual Meeting of the Japanese Society of Toxicology ( The Japanese Society of Toxicology )  51.1 ( 0 ) O-3   2024

  Type of publication: Research paper (other science council materials etc.)

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  <p>Aripiprazole is an atypical antipsychotic drug whose main pharmacological effect is partial agonism of the dopamine D2 receptor. Its long-acting injection (LAI) formulation is used to treat schizophrenia and bipolar disorders. Medication adherence is often the key to preventing the recurrence of both diseases, and it has been noted that LAI formulations are more effective than oral formulations in preventing recurrence. Because the LAI formulation is initiated after appropriate dosing, and tolerability has been confirmed with the oral formulation of the same ingredient, it is usually assumed that the only major adverse event to observe is injection site reactions if there are no adverse reaction problems with the oral formulation.</p><p>Aripiprazole is mainly metabolized by the drug-metabolizing enzymes cytochrome P450 (CYP) 3A4 and CYP2D6.</p><p>The metabolic capacity of CYP2D6 varies among individuals and can be classified into three categories: extensive metabolizers (EM), where enzyme activity is normal; intermediate metabolizers (IM), where activity is moderately reduced; and poor metabolizers (PM). The percentage of IM in Japanese patients has been reported to be approximately 40%.</p><p>In this study, we report a case of drug-induced liver injury in a manic patient with bipolar disorder who was started on oral aripiprazole and switched to LAI formulation after confirming that the patient tolerated the drug. We report this case because genetic polymorphism of a drug-metabolizing enzyme may have contributed to the development of drug-induced injury in this patient.</p>

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• Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Investigator(s): Katsunori Nakamura 

  Direct: 3,400,000 (YEN)  Overheads: 1,020,000 (YEN)  Total: 4,420,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2016.04  -  2019.03 

  Direct: 3,800,000 (YEN)  Overheads: 1,140,000 (YEN)  Total: 4,940,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2016.03 

  Direct: 3,000 (YEN)  Overheads: 900 (YEN)  Total: 3,900 (YEN)

Preferred joint research theme 【 display / non-display 】

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• Community medicine pharmacy

  Community medicine pharmacy

• Drug metabolism and toxicity

  Toxicology

• Personalized medicine

  Pharmacogenetics

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• Oita Uenogaoka High School GS2 'Pharmacy and Chemistry Group' Study Trip Practical Research

  2022.11