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Published Papers 【 display / non-display 】

• Time-dependent bladder activity changes in streptozotocin-induced female diabetic rats

  Izumi, K; Kamijo, TC; Oshiro, T; Kimura, R; Ashikari, A; Kurobe, M; Akimoto, T; Miyazato, M

  PHYSIOLOGICAL REPORTS ( Physiological Reports )  13 ( 4 ) e70220   2025.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  This study aimed to investigate the long-term physiological and morphological changes in the bladders of diabetic rats. Sixty-nine female Sprague-Dawley rats were divided into a control and six diabetic (3 days and 2, 4, 8, 12, and 24 weeks after induction of type 1 diabetes) groups. Metabolic cages and cystometry were used to evaluate bladder function. Bladder contractility was assessed using an organ bath test, and Masson's trichrome staining was performed. In the metabolic cage study, the urination frequency during the dark period significantly increased in the early stages at 3 days of diabetes (p < 0.05). The voiding interval significantly increased (p < 0.05) at 8-12 weeks of diabetes, while the residual urine volume and voiding efficiency worsened at 24 weeks. In the organ bath study, the dose-response curve of carbachol for median effective concentration did not change; however, the bladder contractile force was enhanced at 8 weeks (p = 0.028). Histological analysis revealed increased fibrosis at 4 weeks of diabetes. Diabetic bladder dysfunction is characterized by storage and voiding bladder activity changes in the early stages that induces urinary frequency and reduced voiding efficiency in the late phase; this turning point occurs at 8 weeks after diabetes.

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• Genome-wide association studies for pelvic organ prolapse in the Japanese population

  Matsunami, M; Imamura, M; Ashikari, A; Liu, XX; Tomizuka, K; Hikino, K; Miwa, K; Kadekawa, K; Suda, T; Matsuda, K; Miyazato, M; Terao, C; Maeda, S

  COMMUNICATIONS BIOLOGY ( Nature Research )  7 ( 1 ) 1188 - 9   2024.09

  Type of publication: Research paper (scientific journal)

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  Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by thedescent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wideassociation study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in theJapanese population. We identified a significant association of WT1 locus with POP in the Japanesepopulation; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29–1.68,P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data andpreviously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04–1.08,P = 4.11 × 10−8). We also observed consistent directions of the effects for 21 out of 24 European GWASderived loci (binomial test P = 2.8 × 10−4), indicating that most of susceptibility loci for POP are sharedacross the Japanese and European populations.

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• Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study

  Uema, T; Tsukita, M; Okamoto, S; Uehara, M; Honma, KI; Nakayama, Y; Tamaki, A; Miyazato, M; Ashikari, A; Maeda, S; Imamura, M; Matsushita, M; Nakamura, K; Masuzaki, H

  DIABETES RESEARCH AND CLINICAL PRACTICE ( Diabetes Research and Clinical Practice )  213   111747 - 111747   2024.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIM: The present cohort study explored whether specific gut microbiota (GM) profile would predict the development of impaired glucose tolerance (IGT) in individuals with normal glucose tolerance (NGT). METHODS: A total of 114 study subjects with NGT in Kumejima island, Japan participated in the present study and underwent 75 g oral glucose tolerance tests at baseline and one year later. We compared the profile of GM at baseline between individuals who consistently maintained NGT (NRN, n = 108) and those who transitioned from NGT to IGT (NTI, n = 6). RESULTS: Within-individual bacterial richness and evenness as well as inter-individual bacterial composition showed no significant differences between NRN and NTI. Of note, however, partial least squares discriminant analyses revealed distinct compositions of GM between groups, with no overlap in their 95 % confidence interval ellipses. Multi-factor analyses at the genus level demonstrated that the proportions of CF231, Corynebacterium, Succinivibrio, and Geobacillus were significantly elevated in NTI compared to NRN (p < 0.005, FDR < 0.1, respectively) after adjusting for age, sex, HbA1c level, and BMI. CONCLUSIONS: Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.

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• Effects of low-intensity extracorporeal shock wave on bladder and urethral dysfunction in spinal cord injured rats

  Kawase, K; Kamijo, TC; Kusakabe, N; Nakane, K; Koie, T; Miyazato, M

  INTERNATIONAL UROLOGY AND NEPHROLOGY ( International Urology and Nephrology )  56 ( 12 ) 3773 - 3781   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Effects of low-intensity extracorporeal shock wave therapy on lipopolysaccharide cystitis in a rat model of interstitial cystitis/bladder pain syndrome

  Kusakabe, N; Kamijo, TC; Wada, N; Chiba, H; Shinohara, N; Miyazato, M

  INTERNATIONAL UROLOGY AND NEPHROLOGY ( International Urology and Nephrology )  56 ( 1 ) 77 - 86   2024.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: To investigate the effect of low-intensity extracorporeal shock wave therapy (LiESWT) on lipopolysaccharide (LPS)-induced cystitis in an animal model of interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: Sprague-Dawley rats were divided into three groups: control, cystitis (LPS group, intravesical injection of LPS (1 mg) twice), and cystitis with LiESWT (LiESWT group). On the third and fourth days, LiESWT was administered (0.12 mJ/mm2, 300 shots each time) on the lower abdomen toward the bladder. On the seventh day, the rats underwent pain assessment and a metabolic cage study. Subsequently, a continuous cystometrogram (CMG) was performed under urethane anaesthesia. Immunohistochemical studies were also performed, including S-100 staining, an immunohistochemical marker of Schwann cells in the bladder. RESULTS: In the LPS group, the pain threshold in the lower abdomen was significantly lower than that in the control group. In the metabolic cage study, the mean voided volume in the LPS group significantly increased. The CMG also revealed a significant decrease in bladder contraction amplitude, compatible with detrusor underactivity in the LPS group. Immunohistochemical studies showed inflammatory changes in the submucosa, increased fibrosis, and decreased S-100 stain-positive areas in the muscle layer of the LPS group. In the LiESWT group, tactile allodynia and bladder function were ameliorated, and S-100 stain-positive areas were increased. CONCLUSION: By restoring nerve damage, LiESWT improved lower abdominal pain sensitivity and bladder function in an LPS-induced cystitis rat model. This study suggests that LiESWT may be a new therapeutic modality for IC/BPS.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 前立腺癌に対するホルモン療法は腎機能障害を引き起こすか?

  三塚 浩二, 喜屋武 淳, 佐藤 友紀, 折笠 一彦, 青木 大志, 宮里 実, 荒井 陽一

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  104回   PP1 - 088   2016.04

   

• PDE5阻害剤タダラフィルのラット尿禁制反射への作用

  泉 秀明, 海法 康裕, 川守田 直樹, 宮里 実, 中川 晴夫, 荒井 陽一

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  104回   PP3 - 114   2016.04

   

• 年齢が前立腺癌ホルモン療法による代謝の変化に与える影響についての検討

  三塚 浩二, 喜屋武 淳, 佐藤 友紀, 折笠 一彦, 宮里 実, 青木 大志, 栫井 成彦, 福士 泰夫, 浪間 孝重, 荒井 陽一

  日本老年泌尿器科学会誌 ( 日本老年泌尿器科学会 )  28   47 - 47   2015.12

   

• 前立腺癌内分泌療法に伴うsarcopenic obesityの検討 CTによる脂肪・筋肉量測定に基づく解析

  三塚 浩二, 喜屋武 淳, 佐藤 友紀, 折笠 一彦, 浪間 孝重, 宮里 実, 荒井 陽一

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  103回   501 - 501   2015.04

   

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

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