宮里 実 (ミヤザト ミノル)

Miyazato Minoru

写真a

職名

教授

科研費研究者番号

70301398

研究室住所

〒901-0213 沖縄県中頭郡西原町字千原1番地

現在の所属組織 【 表示 / 非表示

  • 専任   琉球大学   医学研究科   教授  

出身大学 【 表示 / 非表示

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    -
    1993年03月

    琉球大学   医学部   卒業

留学歴 【 表示 / 非表示

  • 2006年06月
    -
    2008年05月

    アメリカ ピッツバーグ  

取得学位 【 表示 / 非表示

  • 琉球大学 -  博士(医学)  医学

職歴 【 表示 / 非表示

  • 2011年08月
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    2015年03月

      琉球大学医学部附属病院 講師  

  • 2011年08月
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    2015年03月

      琉球大学 医学部附属病院 講師  

  • 2015年04月
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    2019年03月

      球大学大学院医学研究科 腎泌尿器外科学講座 准教授  

  • 2015年04月
    -
    2019年03月

      琉球大学大学院医学研究科 腎泌尿器外科学講座 准教授  

  • 2019年04月
    -
    継続中

      琉球大学大学院医学研究科 システム生理学講座 教授  

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所属学会・委員会 【 表示 / 非表示

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    日本泌尿器科学会

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    日本排尿機能学会

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    日本生理学会

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    日本骨盤臓器脱手術学会

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    日本透析医学会

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研究分野 【 表示 / 非表示

  • 泌尿器科、排尿学、神経科学、リハビリテーション

  • ライフサイエンス / リハビリテーション科学

論文 【 表示 / 非表示

  • Influence of cerebral infarction on both bladder and urethral activities and changes after tramadol administration in rats.

    Nagamine S, Kamijo TC, Ashikari A, Miyazato M

    Neurourology and urodynamics ( Neurourology and Urodynamics )    2022年09月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

  • Evaluation of the Influence of a History of Childhood Nocturnal Enuresis on Nighttime Urinary Frequency and the Causes of Nocturia in Adults.

    Miyazato M, Gakiya M, Ashikari A, Kamijo TC, Kagawa H, Matsuo T, Miyata Y, Oshiro Y, Arai K, Machida N, Shinzato H, Chinen Y, Iwata H, Ueda S, Saito S

    Urology ( Urology )  164   106 - 111   2022年06月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    OBJECTIVES: To examine whether a history of nocturnal enuresis affects nighttime urinary frequency and to evaluate nocturia etiologies in adults. METHODS: A total of 143 participants with at least one episode of nocturia per night were included in this study. The self-reported questionnaire collected data on demographic characteristics, medical history, history of nocturnal enuresis in elementary school, lower urinary tract symptoms, and frequency-volume charts. RESULTS: A history of nocturnal enuresis was observed in 52.4% of participants. However, night-time urinary frequency was significantly lower in participants with a history of nocturnal enuresis in elementary school than in those without such history. On multivariate analysis, a history of nocturnal enuresis was also negatively associated with nighttime urinary frequency (p<0.01). There was a collinearity effect between age and nighttime urinary frequency. A history of nocturnal enuresis did not affect the presence of nocturnal polyuria or overactive bladder in participants. However, sleep disturbances were fewer in participants with a history of nocturnal enuresis (odds ratio 0.404). CONCLUSIONS: A history of nocturnal enuresis might be negatively associated with nighttime urinary frequency due to fewer sleep disturbances. Further, progression of nocturia may depend on conditions, such as age and acquired diseases.

  • Obesity and Voiding Parameters in a Community-Based Population of Okinawa, Japan: Kumejima Digital Health Project (KDHP).

    Ashikari A, Miyazato M, Nakamura K, Yamashiro K, Nakamura T, Uema T, Uehara M, Masuzaki H, Saito S, Maeda S, Ishida H, Matsushita M

    Metabolites ( Metabolites )  12 ( 5 )   2022年05月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    (1) Background: Evidence has accumulated regarding the etiology of lower urinary tract symptoms associated with obesity and metabolic syndrome. Therefore, the present study aimed to identify which subjectively and objectively measured voiding parameters were associated with obesity in a community-based population. (2) Methods: Voiding parameters on a self-administered questionnaire and a digital self-health monitoring system for urine excretion (s-HMSU) were compared between participants with and without obesity, defined as a body mass index ≥ 25 kg/m2 (n = 30 and 29, respectively), from a community in Okinawa, Japan. Logistic regression analysis was employed to calculate the odds ratios of abnormalities in voiding parameters for the obese group, with the non-obese group serving as a reference. (3) Results: The obese group had odds ratios of 5.17 (95% confidence interval: 1.33-20.0) for shortened hours of undisturbed sleep (&lt;302 min) by s-HMSU and 7.65 (1.88-31.1) for nighttime urinary frequency by a questionnaire after adjusting for age and sex. In addition, the obese group had an adjusted odds ratio of 2.27 (0.76-6.78) for decreased maximum bladder capacity (&lt;212 mL) by s-HMSU. (4) Conclusion: the results of the present study suggest that nocturia and shortened hours of undisturbed sleep are signs of obesity.

  • Coexisting congenital mid-ureteral stricture and megaureter due to ureterovesical junction obstruction: A case report.

    Nakanishi S, Miyazato M, Tanaka K, Uema N, Saito S

    Urology case reports ( Urology Case Reports )  40   101877 - 101877   2022年01月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Congenital mid-ureteral strictures (CMS) are rare. Most congenital strictures occur at the ureteropelvic junction or ureterovesical junction, with mid-ureteral strictures accounting for only 4-5% of all cases of ureteral obstruction in children. Furthermore, there are very few reports of coexisting mid-ureteral stricture and ureterovesical junction obstruction (UVJO). Here, we report a case of coexisting UVJO and CMS. CMS was not detected on preoperative magnetic resonance imaging, and hydronephrosis remained after ureteroneocystostomy. Therefore, MRI was repeated and CMS was diagnosed, for which we performed ureteroureterostomy. Intraoperative retrograde pyelography (RGP) aids definitive diagnosis of UVJO.

  • Age-associated bladder and urethral coordination impairment and changes in urethral oxidative stress in rats.

    Otsubo A, Miyazato M, Oshiro T, Kimura R, Matsuo T, Miyata Y, Sakai H

    Life sciences ( Life Sciences )  279   119690 - 119690   2021年08月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    AIMS: We examined age-associated changes in bladder and urethral coordination involving the nitric oxide (NO)/soluble guanylyl cyclase (sGC) system, which induces urethral smooth muscle relaxation, and urethral ischemic/oxidative stress changes in rats. MAIN METHODS: Sixteen female Sprague-Dawley rats were divided into young (3 months old) and middle-aged (12-15 months old) groups. Urethral activity was evaluated by simultaneously recording intravesical pressure under isovolumetric conditions and urethral perfusion pressure (UPP) under urethane anesthesia. Sodium nitroprusside (SNP, 0.1 mg/kg), an NO donor, and BAY 41-2272, a novel NO-independent stimulator of sGC (0.1 mg/kg), were administered intravenously to both groups. N-nitro-l-arginine methyl ester hydrochloride (l-NAME, 100 mg/kg) was also injected intravenously, to inhibit NO synthase activity in both groups. Staining for the ischemic marker, hypoxia-inducible factor-1α (HIF-1α), and the oxidative stress markers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), was performed on tissue sections of the urethra, in both groups. KEY FINDINGS: Baseline UPP and UPP changes were significantly lower in middle-aged rats than in young rats. After administration of SNP and BAY 41-2272, baseline UPP and UPP nadir were significantly decreased in both groups. After administration of l-NAME, UPP change/bladder contraction amplitude in young rats was still lower than at baseline but was completely restored to control levels in middle-aged rats. Immunoreactivity of HIF-1α, 8-OHdG, and MDA was higher in middle-aged rats than in young rats. SIGNIFICANCE: Age-associated ischemic and oxidative stress in the urethra might be correlated with impairment of the NO/sGC system and with coordination of the bladder and urethra.

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特許等知的財産 【 表示 / 非表示

  • 脊髄オピオイドμ受容体を介した新規腹圧性尿失禁薬剤

    特願 特願2017-235701  (2017年12月08日)

    宮里実、芦刈明日香

科研費獲得情報 【 表示 / 非表示

  • 加齢膀胱の神経ネットワーク変化とニューロモデュレーションによる脳内可塑性誘導

    基盤研究(C)

    課題番号: 22K11420

    研究期間: 2022年04月  -  2025年03月 

    代表者: 宮里 実 

    直接経費: 3,200,000(円)  間接経費: 4,160,000(円)  金額合計: 960,000(円)

  • 加齢膀胱の神経ネットワーク変化とニューロモデュレーションによる脳内可塑性誘導

    基盤研究(C)

    課題番号: 22K11420

    研究期間: 2022年04月  -  2025年03月 

    代表者: 宮里 実 

    直接経費: 3,200,000(円)  間接経費: 4,160,000(円)  金額合計: 960,000(円)

  • 低出力体外衝撃波治療による膀胱アンチエイジング効果―排尿障害への新しい展望―

    基盤研究(C)

    課題番号: 21K11218

    研究期間: 2021年04月  -  2024年03月 

    代表者: 大城 琢磨, 宮里 実 

    直接経費: 2,900,000(円)  間接経費: 3,770,000(円)  金額合計: 870,000(円)

  • 低出力体外衝撃波治療による膀胱アンチエイジング効果―排尿障害への新しい展望―

    基盤研究(C)

    課題番号: 21K11218

    研究期間: 2021年04月  -  2024年03月 

    代表者: 大城 琢磨, 宮里 実 

    直接経費: 2,900,000(円)  間接経費: 3,770,000(円)  金額合計: 870,000(円)

  • 低出力体外衝撃波治療による膀胱アンチエイジング効果―排尿障害への新しい展望―

    基盤研究(C)

    課題番号: 21K11218

    研究期間: 2021年04月  -  2024年03月 

    代表者: 大城 琢磨, 宮里 実 

    直接経費: 2,900,000(円)  間接経費: 3,770,000(円)  金額合計: 870,000(円)

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